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JOURNAL ARTICLE
Teresa Vezza, Jose Alberto Molina-Tijeras, Alba Rodríguez-Nogales, Jose Garrido-Mesa, María de la Luz Cádiz-Gurrea, Antonio Segura-Carretero, María Reyes González-Tejero, María Elena Rodríguez-Cabezas, Julio Gálvez, Francesca Algieri
Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammation with unpredictable symptom fluctuations. While there is no effective cure for IBD, various treatments aim to manage symptoms and improve the quality of life for affected individuals. In recent years, there has been growing interest in the potential benefits of certain natural plants and herbs in the management of IBD. In this regard, this study aimed to evaluate the immunomodulatory and anti-inflammatory effects of a well-characterized extract of Salvia verbenaca ( S...
December 2, 2023: Antioxidants (Basel, Switzerland)
#22
JOURNAL ARTICLE
Ramkumar Thiyagarajan, Mary Taub
Cystinosis is an autosomal recessive disease resulting from mutations in ctns , which encodes for cystinosin, a proton-coupled cystine transporter that exports cystine from lysosomes. The major clinical form, infantile cystinosis, is associated with renal failure due to the malfunctioning of the renal proximal tubule (RPT). To examine the hypothesis that the malfunctioning of the cystinotic RPT arises from defective differentiation, human-induced pluripotent stem cells (hiPSCs) were generated from human dermal fibroblasts from an individual with infantile cystinosis, as well as a normal individual...
November 30, 2023: International Journal of Molecular Sciences
#23
JOURNAL ARTICLE
Rajesh Krishnamurthy, Garima Suman, Sherwin S Chan, Jacobo Kirsch, Ramesh S Iyer, Michael A Bolen, Richard K J Brown, Ahmed H El-Sherief, Mauricio S Galizia, Kate Hanneman, Joe Y Hsu, Veronica Lenge de Rosen, Prabhakar Shantha Rajiah, Rahul D Renapurkar, Raymond R Russell, Margaret Samyn, Jody Shen, Todd C Villines, Jessica J Wall, Cynthia K Rigsby, Suhny Abbara
Pediatric heart disease is a large and diverse field with an overall prevalence estimated at 6 to 13 per 1,000 live births. This document discusses appropriateness of advanced imaging for a broad range of variants. Diseases covered include tetralogy of Fallot, transposition of great arteries, congenital or acquired pediatric coronary artery abnormality, single ventricle, aortopathy, anomalous pulmonary venous return, aortopathy and aortic coarctation, with indications for advanced imaging spanning the entire natural history of the disease in children and adults, including initial diagnosis, treatment planning, treatment monitoring, and early detection of complications...
November 2023: Journal of the American College of Radiology: JACR
#24
JOURNAL ARTICLE
Kristen R Lednovich, Sophie Gough, Medha Priyadarshini, Nupur Pandya, Chioma Nnyamah, Kai Xu, Barton Wicksteed, Sidharth Mishra, Shalini Jain, Joseph L Zapater, Jose Cordoba-Chacon, Hariom Yadav, Brian Layden
Short-chain fatty acids (SCFAs) are key nutrients that play a diverse set of roles in physiological function, including regulating metabolic homeostasis. Generated through the fermentation of dietary fibers in the distal colon by the gut microbiome, SCFAs and their effects are partially mediated by their cognate receptors, including free fatty acid receptor 2 (FFA2). FFA2 is highly expressed in the intestinal epithelial, where its putative functions are controversial, with numerous in vivo studies relying on global knockout mouse models to characterize intestine-specific roles of the receptor...
November 1, 2023: Journal of Endocrinology
#25
JOURNAL ARTICLE
Minhua Li, Weiping Zheng
RATIONALE: The majority of rectal malignancies are primary tumors, secondary tumors are unusual. The rectal metastasis of endometrial carcinoma is reported to be extremely rare, especially in the absence of endometriosis. PATIENT CONCERNS: Herein we present a rare case of a 68-year-old postmenopausal woman with a history of endometrial adenocarcinoma, metastasizing to the rectum 5 years after a hysterectomy and bilateral salpingo-oophorectomy treatments with pelvic lymphadenectomy were performed...
November 17, 2023: Medicine (Baltimore)
#26
JOURNAL ARTICLE
Yang-Kun Wang, Dong-Mei Ran, Ying-Ying Li, Chao-Ya Zhu, Ren-Bing Zhang, Bo Jiang, Su-Nan Wang
OBJECTIVE: To explore the histopathological features of glandular atrophy of the lamina propria of gastric mucosa during its occurrence and development. METHOD: We performed detailed histological observation and immunohistochemical examination on the endoscopic biopsy and ESD endoscopic resection specimens of 896 patients with glandular atrophy of the lamina propria of gastric mucosa. The EnVision two-step method was used for immunohistochemical staining, and the slices were incubated with primary antibody CK7, CK20, villin, CDX2, MUC5AC, MUC6, p53 and ki-67...
November 15, 2023: BMC Gastroenterology
#27
JOURNAL ARTICLE
Maria A Ilomäki, Lauri Polari, Carl-Gustaf A Stenvall, Mina Tayyab, Kirah Kähärä, Karen M Ridge, Diana M Toivola
Keratins are epithelial intermediate filament proteins that play a crucial role in cellular stress protection, with K8 being the most abundant in the colon. The intestinal epithelial-specific K8-deficient mouse model (K8flox/flox ;Villin-Cre) exhibits characteristics of inflammatory bowel disease, including diarrhea, crypt erosion, hyperproliferation and decreased barrier function. Nevertheless, the order in which these events occur and whether they are a direct cause of K8 loss or a consequence of one event inducing another remains unexplored...
November 14, 2023: American Journal of Physiology. Gastrointestinal and Liver Physiology
#28
JOURNAL ARTICLE
Haohao Fu, Han Liu, Jingya Xing, Tong Zhao, Xueguang Shao, Wensheng Cai
We present a novel strategy to explore conformational changes and identify stable states of molecular objects, eliminating the need for a priori knowledge. The approach applies a deep learning method to extract information about the movement modes of the molecular object from a short, high-dimensional, and parameter-free preliminary enhanced-sampling simulation. The gathered information is described by a small set of deep-learning-based collective variables (dCVs), which steer the production-enhanced-sampling simulation...
November 10, 2023: Journal of Physical Chemistry. B
#29
Rebecca Jonas, Toral Patel, Tami R Crabtree, Robert S Jennings, Ran Heo, Hyung-Bok Park, Hugo Marques, Hyuk-Jae Chang, Wijnand J Stuijfzand, Alexander R van Rosendael, Jung Hyun Choi, Joon-Hyung Doh, Ae-Young Her, Bon-Kwon Koo, Chang-Wook Nam, Sang-Hoon Shin, Jason Cole, Alessia Gimelli, Muhammad Akram Khan, Bin Lu, Yang Gao, Faisal Nabi, Mouaz H Al-Mallah, Ryo Nakazato, U Joseph Schoepf, Roel S Driessen, Michiel J Bom, Randall C Thompson, James J Jang, Michael Ridner, Chris Rowan, Erick Avelar, Philippe Généreux, Paul Knaapen, Guus A de Waard, Gianluca Pontone, Daniele Andreini, Jeroen J Bax, Andrew D Choi, James P Earls, Udo Hoffmann, James K Min, Todd C Villines
No abstract text is available yet for this article.
November 15, 2023: American Journal of Cardiology
#30
JOURNAL ARTICLE
Cole B Hirschfeld, Sharmila Dorbala, Leslee J Shaw, Todd C Villines, Andrew D Choi, Nathan Better, Rodrigo J Cerci, Ganesan Karthikeyan, João V Vitola, Michelle C Williams, Mouaz Al-Mallah, Daniel S Berman, Adam Bernheim, Robert W Biederman, Paco E Bravo, Matthew J Budoff, Renee P Bullock-Palmer, Marcus Y Chen, Michael P DiLorenzo, Rami Doukky, Maros Ferencik, Jeffrey B Geske, Fadi G Hage, Robert C Hendel, Lynne Koweek, Venkatesh L Murthy, Jagat Narula, Patricia F Rodriguez Lozano, Nishant R Shah, Amee Shah, Prem Soman, Randall C Thompson, David Wolinsky, Yosef A Cohen, Eli Malkovskiy, Michael J Randazzo, Juan Lopez-Mattei, Purvi Parwani, Mrinali Shetty, Thomas N B Pascual, Yaroslav Pynda, Maurizio Dondi, Diana Paez, Andrew J Einstein
PURPOSE: To characterize the recovery of diagnostic cardiovascular procedure volumes in U.S. and non-U.S. facilities in the year following the initial COVID-19 outbreak. MATERIALS AND METHODS: The International Atomic Energy Agency (IAEA) coordinated a worldwide study called the IAEA Noninvasive Cardiology Protocols Study of COVID-19 2 (INCAPS COVID 2), collecting data from 669 facilities in 107 countries, including 93 facilities in 34 U.S. states, to determine the impact of the pandemic on diagnostic cardiovascular procedure volumes...
October 2023: Radiology. Cardiothoracic imaging
#31
JOURNAL ARTICLE
Sheila Bandyopadhyay, Xiao Zhang, Andrea Ascura, Karen L Edelblum, Edward M Bonder, Nan Gao
Human enterocytes are primary targets of infection by invasive bacterium Salmonella Typhimurium, and studies using nonintestinal epithelial cells established that S. Typhimurium activates Rho family GTPases, primarily CDC42, to modulate the actin cytoskeletal network for invasion. The host intracellular protein network that engages CDC42 and influences the pathogen's invasive capacity are relatively unclear. Here, proteomic analyses of canonical and variant CDC42 interactomes identified a poorly characterized CDC42 interacting protein, CDC42EP1, whose intracellular localization is rapidly redistributed and aggregated around the invading bacteria...
October 25, 2023: Journal of Cellular Physiology
#32
JOURNAL ARTICLE
Koubova Katerina, Cizkova Katerina, Burianova Adela, Tauber Zdenek
Intestinal epithelial differentiation is a highly organised process. It is influenced by a variety of signalling pathways and enzymes, such as the PI3K pathway and soluble epoxide hydrolase (sEH) from arachidonic acid metabolism. We investigated the changes in the expression of enzymes and lipid messenger from the PI3K pathway, including PTEN, during intestinal cell differentiation in vitro using HT-29 and Caco2 cells and compared them with immunohistochemical patterns of these proteins in human colon. To investigate the possible crosstalk between the PI3K pathway and sEH, we treated HT-29 and Caco2 cells with the sEH inhibitor TPPU...
October 20, 2023: Biochimica et Biophysica Acta. General Subjects
#33
JOURNAL ARTICLE
Hongyan Gou, Chi Chun Wong, Huarong Chen, Haiyun Shang, Hao Su, Jianning Zhai, Weixin Liu, Wenxiu Liu, Donglei Sun, Xin Wang, Jun Yu
Metastasis is the primary cause of death in colorectal cancer (CRC). Thyroid hormone receptor interacting protein 6 (TRIP6) is an adaptor protein that regulates cell motility. Here, we aim to elucidate the role of TRIP6 in driving CRC tumorigenesis and metastasis and evaluate its potential as a therapeutic target. TRIP6 mRNA is up-regulated in CRC compared to adjacent normal tissues in three independent cohorts (all P < 0.0001), especially in liver metastases (P < 0.01). High TRIP6 expression predicts poor prognosis of CRC patients in our cohort (P = 0...
October 10, 2023: Cancer Letters
#34
JOURNAL ARTICLE
Sumati Hasani, Lyndsay E A Young, Warren Van Nort, Moumita Banerjee, Dylan R Rivas, Jinhwan Kim, Xiaopeng Xiong, Ramon C Sun, Matthew S Gentry, Hiromi Sesaki, Tianyan Gao
Metabolic reprogramming has been recognized as one of the major mechanisms that fuel tumor initiation and progression. Our previous studies demonstrate that activation of Drp1 promotes fatty acid oxidation and downstream Wnt signaling. Here we investigate the role of Drp1 in regulating glycogen metabolism in colon cancer. Knockdown of Drp1 decreases mitochondrial respiration without increasing glycolysis. Analysis of cellular metabolites reveals that the levels of glucose-6-phosphate, a precursor for glycogenesis, are significantly elevated whereas pyruvate and other TCA cycle metabolites remain unchanged in Drp1 knockdown cells...
October 10, 2023: Cell Death & Disease
#35
JOURNAL ARTICLE
Lal Krishan Kumar, Surya Kant Verma, Rajeev Chandel, Meet Thumar, Dheer Singh, Suneel Kumar Onteru
Aflatoxin M1 (AFM1) is a mycotoxin that is commonly found as a milk contaminant, and its presence in milk has been linked to cytotoxicity. The present study aimed to evaluate the acute cytotoxic effects of AFM1 on intestinal Caco-2 cells. Initially, we checked the morphology and viability of Caco-2 cells after treatment with different concentrations of AFM1 (5 ng/L, 50 ng/L, 250 ng/L, 500 ng/L, 1000 ng/L, and 2000 ng/L) for different time intervals (6 h, 12 h, and 24 h)...
October 4, 2023: Mycotoxin Research
#36
JOURNAL ARTICLE
Changlin Gong, Claudia Saborit, Xin Long, Ao Wang, Beishi Zheng, Howard Chung, Suzanne K Lewis, Suneeta Krishnareddy, Govind Bhagat, Peter H R Green, Xiao-Fei Kong
INTRODUCTION: Persistent villous atrophy (VA) is not uncommon in celiac disease (CeD) while patients take a gluten-free diet (GFD). METHODS: We conducted a retrospective study with 122 serum samples collected from controls and CeD patients either at the initial diagnosis or follow-up during endoscopy. These samples were assigned to three groups: non-celiac control, non-VA CeD (Marsh score 0-2), and VA CeD (Marsh score 3a-3c). We established an in-house multiplex assay to identify potential serological biomarkers for villous atrophy...
September 27, 2023: Clinical and Translational Gastroenterology
#37
JOURNAL ARTICLE
Srijita Paul, Parbati Biswas
Carbon nanotubes (CNTs) are identified as potential candidates for drug and biomolecular loading and delivery. CNTs of different chiralities have different diameters, which may significantly affect their abilities to interact with different types of biomolecules. Herein, we employ classical molecular dynamics simulation to provide insight into the curvature-dependent interactions between a model protein, chicken villin headpiece subdomain (HP36), with CNTs having chiralities (8,8), (12,12), and (20,20). It is revealed that, with increasing radii, the protein encounters more aromatic carbon atoms on the surface of the CNT, leading to its increasing strength of adsorption...
September 21, 2023: Physical Chemistry Chemical Physics: PCCP
#38
JOURNAL ARTICLE
Yanru Ma, Xinyu Zhang, Baoqin Xuan, Danjie Li, Nan Yin, Lijun Ning, Yi-Lu Zhou, Yuqing Yan, Tianying Tong, Xiaoqiang Zhu, Xiaowen Huang, Muni Hu, Zhenhua Wang, Zhe Cui, Huabin Li, Jiqiu Wang, Jing-Yuan Fang, Ruixin Liu, Haoyan Chen, Jie Hong
BACKGROUND AND AIMS: Deregulation of RNA N6-methyladenosine (m6 A) modification in intestinal epithelial cells (IECs) influences intestinal immune cells and leads to intestinal inflammation. We studied the function of fat mass-and obesity-associated protein (FTO), one of the m6 A demethylases, in patients with ulcerative colitis (UC). METHODS: We analysed colon tissues of Ftoflox/flox ; Villin-cre mice and their Ftoflox/flox littermates with dextran sulfate sodium (DSS) using real-time PCR and 16s rRNA sequencing...
January 5, 2024: Gut
#39
JOURNAL ARTICLE
Haisu Liu, Hang Zhang, Qianxun Yu, Sanshan Zhang, Xiao Tu, Fenghong Zhuang, Shengli Fu
Lead (Pb) is a hazardous pollutant in water environments that can cause significant damage to aquatic animals and humans. In this study, crucian carp ( Carassius auratus ) were exposed to waterborne Pb for 96 h; then, histopathological analysis, quantitative qPCR analysis, and 16S high-throughput sequencing were performed to explore the effects of Pb on intestinal bioaccumulation, structural damage, oxidative stress, immune response, and microbiota imbalance of C. auratus . After Pb exposure, the intestinal morphology was obviously damaged, including significantly increasing the thickness of the intestinal wall and the number of goblet cells and reducing the depth of intestinal crypts...
2023: Frontiers in Microbiology
#40
JOURNAL ARTICLE
Clinicopathological features and differential diagnosis of gastric pleomorphic giant cell carcinoma.
Yang-Kun Wang, Li Ma, Zhi-Qiang Wang, Yue Wang, Ping Li, Bo Jiang, Su-Nan Wang
The aim of this study was to investigate the clinicopathological features and differential diagnosis of gastric pleomorphic giant cell carcinoma. Histopathology, immunohistochemistry, and human epidermal growth factor receptor 2 (HER2) gene testing were conducted for seven cases of gastric pleomorphic giant cell carcinoma. In histomorphological terms, all seven cases involved pleomorphic giant cell carcinoma, accounting for more than 10% of the entire tumor, with pleomorphic spindle cells and giant cells mixed with various histomorphological structures of adenocarcinoma with high, intermediate, and low differentiation...
2023: Open Life Sciences
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