Zer Vue, Kit Neikirk, Larry Vang, Edgar Garza-Lopez, Trace A Christensen, Jianqiang Shao, Jacob Lam, Heather K Beasley, Andrea G Marshall, Amber Crabtree, Josephs Anudokem, Benjamin Rodriguez, Benjamin Kirk, Serif Bacevac, Taylor Barongan, Bryanna Shao, Dominique C Stephens, Kinuthia Kabugi, Ho-Jin Koh, Alice Koh, Chantell S Evans, Brittany Taylor, Anilkumar K Reddy, Tyne Miller-Fleming, Ky'Era V Actkins, Elma Zaganjor, Nastaran Daneshgar, Sandra A Murray, Bret C Mobley, Steven Damo, Jennifer A Gaddy, Blake Riggs, Celestine Wanjalla, Annet Kirabo, Melanie McReynolds, Jose A Gomez, Mark A Phillips, Vernat Exil, Dao-Fu Dai, Antentor Hinton
With sparse treatment options, cardiac disease remains a significant cause of death among humans. As a person ages, mitochondria break down and the heart becomes less efficient. Heart failure is linked to many mitochondria-associated processes, including endoplasmic reticulum stress, mitochondrial bioenergetics, insulin signaling, autophagy, and oxidative stress. The roles of key mitochondrial complexes that dictate the ultrastructure, such as the mitochondrial contact site and cristae organizing system (MICOS), in aging cardiac muscle are poorly understood...
August 25, 2023: American Journal of Physiology. Heart and Circulatory Physiology