Zhaoxin Yang, Zhirang Zhang, Liyan Li, Zhangyan Jing, Yumeng Ma, Tianyu Lan, Yuan Li, Zhongda Lin, Wenli Fang, Jinxie Zhang, Jinling Zhang, Xin Liang, Benqing Wu, Yi Zheng, Xudong Zhang
An important factor in the development of Type 1 diabetes (T1D) is the deficiency of inhibitory immune checkpoint ligands, specifically programmed cell death ligand 1 (PD-L1) and Galectin-9 (Gal-9), in β-cells. Hence, modulation of the pancreas infiltrated T lymphocytes by exogenous PD-L1 or Gal-9 is an ideal approach for treating the new-onset T1D. Herein, we genetic engineered the macrophage cells to generate artificial extracellular vesicles (aEVs) overexpressing PD-L1 and Gal-9, which could restrict the islets autoreactive T lymphocytes and protect β-cells from destruction...
May 21, 2024: Diabetes