Danni Zhang, Huiying Wang, Ana Liu, Shan Wang, Cuifang Xu, Ke Lan, Wenqing Xiang, Kun Zhu, Yingping Xiao, Junfen Fu, Runqiu Jiang, Wenlian Chen, Yan Ni
Excessive fructose intake is associated with the rising prevalence of nonalcoholic fatty liver disease (NAFLD). The gut microbiome (GM) and bile acids (BAs) are involved in the pathogenesis of NAFLD, but the impact of fructose on their cross-talk is unclear. In this study, adult male C57BL/6J mice were fed a normal diet with tap water (ND) or with 4% fructose in the drinking water (Fru), 60% high-fat diet with tap water (HF) or with 4% fructose solution (HFF) for 12 weeks. Targeted BA analysis was performed in five anatomical sites including the liver, ileum contents, portal serum, cecum contents, and feces...
November 2023: Journal of Nutritional Biochemistry