keyword
https://read.qxmd.com/read/33224097/cyclic-vomiting-syndrome-in-children
#1
Umberto Raucci, Osvaldo Borrelli, Giovanni Di Nardo, Renato Tambucci, Piero Pavone, Silvia Salvatore, Maria Elisabetta Baldassarre, Duccio Maria Cordelli, Raffaele Falsaperla, Enrico Felici, Michela Ada Noris Ferilli, Salvatore Grosso, Saverio Mallardo, Diego Martinelli, Paolo Quitadamo, Licia Pensabene, Claudio Romano, Salvatore Savasta, Alberto Spalice, Caterina Strisciuglio, Agnese Suppiej, Massimiliano Valeriani, Letizia Zenzeri, Alberto Verrotti, Annamaria Staiano, Maria Pia Villa, Martino Ruggieri, Pasquale Striano, Pasquale Parisi
Cyclic Vomiting Syndrome (CVS) is an underdiagnosed episodic syndrome characterized by frequent hospitalizations, multiple comorbidities, and poor quality of life. It is often misdiagnosed due to the unappreciated pattern of recurrence and lack of confirmatory testing. CVS mainly occurs in pre-school or early school-age, but infants and elderly onset have been also described. The etiopathogenesis is largely unknown, but it is likely to be multifactorial. Recent evidence suggests that aberrant brain-gut pathways, mitochondrial enzymopathies, gastrointestinal motility disorders, calcium channel abnormalities, and hyperactivity of the hypothalamic-pituitary-adrenal axis in response to a triggering environmental stimulus are involved...
2020: Frontiers in Neurology
https://read.qxmd.com/read/33127240/pediatric-cannabinoid-hyperemesis-a-single-institution-10-year-case-series
#2
Hannah Lonsdale, Kathryn M Kimsey, Jerry M Brown, Aditi Dey, Jacquelin Peck, Sorany Son, Michael Wilsey
PURPOSE: Cannabis hyperemesis (CH) is an under-recognized condition in patients with chronic or cyclic vomiting and who regularly use cannabis. Once thought to be rare, it is now increasingly recognized in both adults and children. We report a case series of adolescent patients with CH who presented at a single institution over 10 years. METHODS: Patients were included if they had a diagnosis code of cannabis-related or cyclic vomiting, experienced the onset of regular vomiting after starting to regularly use cannabis, and if no other diagnosis was found to better explain the presentation...
October 27, 2020: Journal of Adolescent Health
https://read.qxmd.com/read/33105467/diagnosis-and-treatment-of-headache-in-a-pediatric-emergency-department
#3
Francisca M Costa, Inês P Ferreira, Inês F Mascarenhas, Cláudio F Alves, Vanda A Bento, Helena C Loureiro
OBJECTIVES: The aims of the study were (1) to analyze the etiology and clinical management of headaches in children in the emergency department and (2) to analyze the treatment used in children diagnosed with headaches and with migraines. METHODS: Retrospective study of all the patients who were admitted to the pediatric emergency department of Hospital Professor Doutor Fernando Fonseca, Lisbon, in 2014, with a chief complaint of headaches or the primary discharge diagnosis was headache/migraine...
October 22, 2020: Pediatric Emergency Care
https://read.qxmd.com/read/32706744/smartphone-app-to-self-monitor-nausea-during-pediatric-chemotherapy-treatment-user-centered-design-process
#4
Astrid Eliasen, Mikkel Kramme Abildtoft, Niels Steen Krogh, Catherine Rechnitzer, Jesper Sune Brok, René Mathiasen, Kjeld Schmiegelow, Kim Peder Dalhoff
BACKGROUND: Nausea and vomiting are common and distressing side effects for children receiving chemotherapy. Limited evidence is available to guide antiemetic recommendations; therefore, prospective and reliable evaluation of antiemetic efficacy is needed. Smartphone apps can be used to effortlessly and precisely collect patient-reported outcomes in real time. OBJECTIVE: Our objective was to develop a smartphone app to monitor nausea and vomiting episodes in pediatric cancer patients aged 0 to 18 years and to test its usability and adherence to its use...
July 20, 2020: JMIR MHealth and UHealth
https://read.qxmd.com/read/32568452/olanzapine-versus-metoclopramide-for-the-treatment-of-breakthrough-chemotherapy-induced-vomiting-in-children-an-open-label-randomized-phase-3-trial
#5
Venkatraman Radhakrishnan, Vishwajeeth Pai, Swaminathan Rajaraman, Nikita Mehra, Trivadi Ganesan, Manikandan Dhanushkodi, Jayachandran Perumal Kalaiyarasi, Arun Kumar Rajan, Gangothri Selvarajan, Rama Ranganathan, Parathan Karunakaran, Tenali G Sagar
BACKGROUND: Breakthrough chemotherapy-induced vomiting (CIV) is defined as CIV occurring after adequate antiemetic prophylaxis. Olanzapine and metoclopramide are two drugs recommended for the treatment of breakthrough CIV in children, without adequate evidence. We conducted an open-label, single-center, phase 3 randomized controlled trial comparing the safety and efficacy of olanzapine and metoclopramide for treating breakthrough CIV. PROCEDURE: Children aged 5-18 years who developed breakthrough CIV after receiving highly emetogenic chemotherapy or moderately emetogenic chemotherapy were randomly assigned to the metoclopramide or olanzapine arm...
June 22, 2020: Pediatric Blood & Cancer
https://read.qxmd.com/read/32056007/antiemetic-prophylaxis-with-fosaprepitant-and-granisetron-in-pediatric-patients-undergoing-allogeneic-hematopoietic-stem-cell-transplantation
#6
Karin Melanie Cabanillas Stanchi, Julia Vek, Patrick Schlegel, Joachim Vincent Rupprecht, Tim Flaadt, Simone Weber, Sebastian Michaelis, Peter Lang, Rupert Handgretinger, Michaela Döring
BACKGROUND: Chemotherapy-induced nausea and vomiting (CINV) is a severe and distressing complication during allogeneic hematopoietic stem cell transplantation (alloHSCT). The antiemetic fosaprepitant has shown favorable results in pediatric and adult patients receiving chemotherapy. Data on fosaprepitant in children and adolescents undergoing alloHSCT are missing. METHODS: In this non-interventional observation study, 120 children and adolescents with a median age of 11...
February 13, 2020: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/31974769/guideline-concordant-care-for-prevention-of-acute-chemotherapy-induced-nausea-and-vomiting-in-children-adolescents-and-young-adults
#7
Melissa Beauchemin, Lillian Sung, Dawn L Hershman, Chunhua Weng, L Lee Dupuis, Rebecca Schnall
PURPOSE: Prescribing guideline-recommended anti-emetics is an effective strategy to prevent CINV. However, the rate of guideline-concordant care is not well-understood. The purpose of this study was to describe the proportion of pediatric, adolescent, and young adult patients receiving HEC or MEC who received guideline-concordant antiemetic prophylaxis for acute CINV and to identify potential predictors of guideline-concordant antiemetic prophylaxis. METHODS: Using electronic health record data from 2016 through 2018, a retrospective single-institution cohort study was conducted to investigate how often patients less than 26 years of age receiving moderately or highly emetogenic chemotherapy receive guideline-concordant prophylaxis for acute CINV...
January 23, 2020: Supportive Care in Cancer
https://read.qxmd.com/read/31819673/perioperative-administration-of-emend-%C3%A2-aprepitant-at-a-tertiary-care-children-s-hospital-a-12-month-survey
#8
Anuradha Kanaparthi, Sarah Kukura, Natalie Slenkovich, Faris AlGhamdi, Shabana Z Shafy, Mohammed Hakim, Joseph D Tobias
Introduction: Aprepitant (Emend® ) is a novel antiemetic agent that works through antagonism of neurokinin-1 (NK-1) receptors. To date, there are limited data regarding its use to prevent postoperative nausea and vomiting (PONV) in children. We retrospectively reviewed our initial 12-months experience with aprepitant after it was made available for perioperative use. Methods: The anesthetic records of patients who received aprepitant were retrospectively reviewed and demographic, surgical, and medication data retrieved...
2019: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/31700742/oral-ondansetron-versus-domperidone-for-acute-gastroenteritis-associated-vomiting-in-young-children
#9
Hamza Hanif, Hassam Jaffry, Fatima Jamshed, Fnu Amreek, Naresh Kumar, Wajid Hussain, Amber Rizwan
Introduction The management of vomiting and antiemetic therapy in young children with acute gastroenteritis (AGE) has not been standardized by any management guidelines. Antiemetic drugs including promethazine, prochlorperazine, metoclopramide, ondansetron, and domperidone are readily used in the emergency departments (EDs). The aim of this study was to compare the efficacy of ondansetron with domperidone in cessation of vomiting in pediatric AGE. Methods This open-label, two-arm trial was conducted in a pediatric ED in Pakistan...
September 12, 2019: Curēus
https://read.qxmd.com/read/31694979/oral-ondansetron-administration-to-dehydrated-children-in-pakistan-a-randomized-clinical-trial
#10
RANDOMIZED CONTROLLED TRIAL
Stephen B Freedman, Sajid B Soofi, Andrew R Willan, Sarah Williamson-Urquhart, Emaduddin Siddiqui, Jianling Xie, Fady Dawoud, Zulfiqar A Bhutta
BACKGROUND: Ondansetron is an effective antiemetic employed to prevent vomiting in children with gastroenteritis in high-income countries; data from low- and middle-income countries are sparse. METHODS: We conducted a randomized, double-blind, placebo-controlled superiority trial in 2 pediatric emergency departments in Pakistan. Dehydrated children aged 6 to 60 months with ≥1 diarrheal (ie, loose or liquid) stool and ≥1 vomiting episode within the preceding 4 hours were eligible to participate...
December 2019: Pediatrics
https://read.qxmd.com/read/31555567/management-of-acute-gastroenteritis-in-children-a-survey-among-members-of-the-korean-society-of-pediatric-gastroenterology-hepatology-and-nutrition
#11
Ji-Hyun Seo, Jung Ok Shim, Byung-Ho Choe, Jin Su Moon, Ki-Soo Kang, Ju-Young Chung
Purpose: No national survey has yet described the guidelines followed by Korean pediatricians to treat acute gastroenteritis (AGE). An online survey was performed to investigate the management of AGE followed by members of The Korean Society of Pediatric Gastroenterology, Hepatology, and Nutrition, and the results were compared between pediatric gastroenterologists (PG) and general pediatricians (GP). Methods: Questionnaires were sent to pediatricians between June 2 and 4, 2018 regarding the type of hospital, indications for admission, antiemetic and antidiarrheal drugs and antibiotics prescribed, and dietary changes advised...
September 2019: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/31144404/impact-of-paediatric-tonsillectomy-perioperative-management-on-pain-nausea-and-recovery-a-prospective-cohort-study
#12
Julianne Richards, Mary Lang, Elizabeth Andresen, Kathryn O'Leary, Jacqueline Jauncey-Cooke, Nicole Anderson, Hannah Burns, Nicola Slee, Amanda J Ullman, Marie Cooke
AIM: Tonsillectomy procedures are a core element of paediatrics; however, perioperative management differs. This study aimed to describe tonsillectomy management, including the burden of pain, nausea and delayed recovery. METHODS: A prospective cohort study was undertaken through an audit of tonsillectomy perioperative practice and recovery and survey interviews with family members 7-14 days post-surgery. The study was undertaken at an Australian tertiary referral paediatric hospital between June and September 2016...
May 29, 2019: Journal of Paediatrics and Child Health
https://read.qxmd.com/read/31094795/clinical-use-of-the-pictorial-baxter-retching-faces-scale-for-the-measurement-of-postoperative-nausea-in-children
#13
Mehernoor F Watcha, Andrew D Lee, Eduardo Medellin, M Toni Felberg, Sudha A Bidani
BACKGROUND: Because nausea is difficult to evaluate in children, vomiting is used as the objective clinical end point in managing pediatric postoperative nausea and vomiting and postdischarge nausea and vomiting (PDNV). The recently developed pictorial Baxter Retching Faces (BARF) scale has content, construct, and convergent validity in quantifying pediatric nausea intensity. We determined its clinical usefulness in assessing pediatric postoperative nausea and vomiting and PDNV, establishing the lowest age associated with consistently reliable use, the score at which patients identify a need for therapy, and the minimum clinically relevant change in scores, and examined its test-retest reliability...
June 2019: Anesthesia and Analgesia
https://read.qxmd.com/read/30900392/pharmacokinetics-pharmacodynamics-safety-and-tolerability-of-fosaprepitant-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting-in-pediatric-cancer-patients
#14
RANDOMIZED CONTROLLED TRIAL
Jaume Mora, Miguel Valero, Cara DiCristina, Mandy Jin, Anne Chain, Kara Bickham
BACKGROUND: Current antiemetic regimens are less effective in children than in adults. Fosaprepitant was recently approved for prevention of chemotherapy-induced nausea and vomiting (CINV) in children aged six months and older. PROCEDURE: The pharmacokinetic (PK)/pharmacodynamic (PD) profile, safety, and tolerability of a single intravenous dose of fosaprepitant administered concomitantly with ondansetron with/without dexamethasone were evaluated in pediatric patients with cancer receiving emetogenic chemotherapy...
June 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30397904/randomized-trial-of-acupuncture-with-antiemetics-for-reducing-postoperative-nausea-in-children
#15
RANDOMIZED CONTROLLED TRIAL
Christine S Martin, Sarah E Deverman, Daniel C Norvell, Jordan C Cusick, Angela Kendrick, Jeffrey Koh
BACKGROUND: Postoperative nausea and vomiting (PONV) is common after tonsillectomy in children. There is evidence that perioperative acupuncture at the pericardium 6 (P6) point is effective for preventing PONV in adults. Our goal was to determine if intraoperative acupuncture at the P6 point, in addition to usual antiemetics, is more effective than antiemetics alone in preventing PONV in children. METHODS: In a randomized double-blind trial, 161 children age 3 through 9 years undergoing tonsillectomy with or without adenoidectomy were randomized to either bilateral acupuncture at P6 plus antiemetics (n = 86) or antiemetics only (n = 75)...
March 2019: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/30320642/clinical-use-of-the-pictorial-baxter-retching-faces-scale-for-the-measurement-of-postoperative-nausea-in-children
#16
Mehernoor F Watcha, Andrew D Lee, Eduardo Medellin, M Toni Felberg, Sudha A Bidani
BACKGROUND: Because nausea is difficult to evaluate in children, vomiting is used as the objective clinical end point in managing pediatric postoperative nausea and vomiting and postdischarge nausea and vomiting (PDNV). The recently developed pictorial Baxter Retching Faces (BARF) scale has content, construct, and convergent validity in quantifying pediatric nausea intensity. We determined its clinical usefulness in assessing pediatric postoperative nausea and vomiting and PDNV, establishing the lowest age associated with consistently reliable use, the score at which patients identify a need for therapy, and the minimum clinically relevant change in scores, and examined its test-retest reliability...
October 12, 2018: Anesthesia and Analgesia
https://read.qxmd.com/read/30230225/revised-antiemetics-guidelines-and-the-impact-on-nutritional-status-during-induction-chemotherapy-in-children-with-high-risk-neuroblastoma
#17
Catherine Carroll, Frieda Clinton, Aisling Smith, Aine Fox, Michael Capra, Jane Pears, Cormac Owens
BACKGROUND: High-risk neuroblastoma (HR NBL) treatment requires intensive induction chemotherapy. The profoundly emetogenic agents used can compromise nutritional status. Our institution introduced a new antiemetic guideline in 2010 incorporating regular dexamethasone, in addition to ondansetron, for all highly emetogenic protocols. PROCEDURE: A retrospective comparative review of pediatric patients diagnosed with HR NBL who received rapid COJEC induction chemotherapy as per HR-SIOPEN NBL trial...
December 2018: Pediatric Blood & Cancer
https://read.qxmd.com/read/30076469/managing-cyclic-vomiting-syndrome-in-children-beyond-the-guidelines
#18
REVIEW
B U K Li
Cyclic vomiting syndrome (CVS) in children is characterized by frequent hospitalizations, multiple comorbidities, and poor quality of life. In the absence of robust data, the treatment of CVS remains largely empiric starting with the 2008 NASPGHAN Consensus Statement recommendations of cyproheptadine for children < 5 years of age and amitriptyline for those ≥ 5 years with propranolol serving as the second-line agent. Comprehensive management begins with lifestyle alterations, and extends to medications, supplements, and stress reduction therapies...
October 2018: European Journal of Pediatrics
https://read.qxmd.com/read/30066198/impact-of-adjuvant-lorazepam-with-granisetron-on-chemotherapy-induced-nausea-and-vomiting-in-pediatric-patients-with-acute-lymphoblastic-leukemia
#19
Akane Ono, Kenji Kishimoto, Daiichiro Hasegawa, Ran D Goldman, Yoshiyuki Kosaka
PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) affects quality of life for patients with cancer undergoing chemotherapy. We aimed to assess the effect of lorazepam with granisetron on CINV in children with acute lymphoblastic leukemia (ALL). METHODS: We reviewed the records of 71 consecutive patients with newly diagnosed ALL who received chemotherapy including vincristine, anthracycline, and systemic steroids between January 2011 and December 2016 in our hospital...
July 31, 2018: Supportive Care in Cancer
https://read.qxmd.com/read/30051617/safety-and-efficacy-of-nabilone-for-acute-chemotherapy-induced-vomiting-prophylaxis-in-pediatric-patients-a-multicenter-retrospective-review
#20
Samantha Polito, Tamara MacDonald, Marcel Romanick, Jennifer Jupp, John Wiernikowski, Ashlee Vennettilli, Mila Khanna, Priya Patel, Winnie Ning, Lillian Sung, L Lee Dupuis
OBJECTIVES: To describe the safety and efficacy of nabilone given to pediatric patients to prevent acute chemotherapy-induced nausea and vomiting (CINV). METHODS: A multicenter, retrospective review of pediatric patients who received nabilone for acute CINV prophylaxis between December 1, 2010 and August 1, 2015 was undertaken. One course of nabilone was evaluated per patient. Adverse effects associated with nabilone use were noted. The proportion of patients who experienced complete acute chemotherapy-induced vomiting (CIV) control during the acute phase was determined...
December 2018: Pediatric Blood & Cancer
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