keyword
https://read.qxmd.com/read/33621984/gestational-and-age-specific-cystatin-c-reference-intervals-for-newborns
#1
Chao Tong, Yalan Liu, Yanqiu Wu, Qiong Li, Yipin Wu, Lin Wang, Yan Chen
OBJECTIVE:  Cystatin C (CysC) references are useful for the monitoring of renal function in neonates. However, the standard CysC references in newborn infants have not been determined. The aim of this study was to establish a useful reference range for CysC in newborns. STUDY DESIGN:  Serum CysC levels were measured in 1,919 blood samples from 1,044 newborns during their first 28 days of life. CysC levels were analyzed for associations between subgroups dichotomized by postnatal age (PA) and gestational age (GA)...
February 23, 2021: American Journal of Perinatology
https://read.qxmd.com/read/33621983/postextubation-noninvasive-ventilation-in-respiratory-distress-syndrome-a-randomized-controlled-trial
#2
Rania A El-Farrash, Robert M DiBlasi, Eman A AbdEL-Aziz, Adham M El-Tahry, Mohammed S Eladawy, Mourad A Tadros, Mohamed A Koriesh, John V Farid, Riham S AbdElwahab, Medhat A Elsayed, Noha M Barakat
OBJECTIVE:  Successful extubation and prevention of reintubation remain primary goals in neonatal ventilation. Our aim was to compare three modalities of postextubation respiratory support-noninvasive positive pressure ventilation (NIPPV), nasal bilevel positive airway pressure (N-BiPAP), and nasal continuous positive airway pressure (NCPAP)-using the RAM cannula in preterm neonates with respiratory distress syndrome (RDS). Our secondary aim was to define the predictors of successful extubation...
February 23, 2021: American Journal of Perinatology
https://read.qxmd.com/read/33621976/necrostatin-1-analog-dimo-exerts-cardioprotective-effect-against-ischemia-reperfusion-injury-by-suppressing-necroptosis-via-autophagic-pathway-in-rats
#3
Shigang Qiao, Wen-Jie Zhao, Huan-Qiu Li, Gui-Zhen Ao, Jian-Zhong An, Chen Wang, Hui-Ling Zhang
AIM: It has been reported that necrostatin-1 (Nec-1) is a specific necroptosis inhibitor that could attenuate programmed cell death induced by myocardial ischemia/reperfusion (I/R) injury. This study aimed to observe the effect and mechanism of novel Nec-1 analog (Z)-5-(3,5-dimethoxybenzyl)-2-imine-1-methylimidazolin-4-1 (DIMO) on myocardial I/R injury. METHODS: Male SD rats underwent I/R injury with or without different doses of DIMO (1, 2, or 4 mg/kg) treatment...
February 23, 2021: Pharmacology
https://read.qxmd.com/read/33621745/risk-factors-for-hemolysis-during-extracorporeal-life-support-for-congenital-diaphragmatic-hernia
#4
Yigit S Guner, Patrick T Delaplain, John Schomberg, Matteo Di Nardo, Peter T Yu, Danny Lam, Tim Jancelewicz, Matthew T Harting, Joanne P Starr, Danh V Nguyen
BACKGROUND: Neonates receiving extracorporeal life support (ECLS) for congenital diaphragmatic hernia (CDH) require prolonged support compared with neonates with other forms of respiratory failure. Hemolysis is a complication that can be seen during ECLS and can lead to renal failure and potentially to worse outcomes. The purpose of this study was to identify risk factors for the development of hemolysis in CDH patients treated with ECLS. METHODS: The Extracorporeal Life Support Organization database was used to identify infants with CDH (2000-2015)...
February 20, 2021: Journal of Surgical Research
https://read.qxmd.com/read/33621713/maternal-and-perinatal-outcomes-in-high-vs-low-risk-pregnancies-affected-by-sars-cov-2-infection-phase-2-the-wapm-world-association-of-perinatal-medicine-working-group-on-covid-19
#5
Francesco D'Antonio, Cihat Sen, Daniele DI Mascio, Alberto Galindo, Cecilia Villalain, Ignacio Herraiz, Resul Arısoy, Ali Ovayolu, Hasan Eroğlu, Manuel Guerra Canales, Subhashini Ladella, Liviu Cojocaru, Ozhan Turan, Sifa Turan, Eran Hadar, Noa A Brzezinski-Sinai, Sarah Dollinger, Ozlem Uyaniklar, Sakine Rahimli Ocakouglu, Zeliha Atak, Tanja Premru-Srsen, Lilijana Kornhauser-Cerar, Mirjam Druškovič, Liana Ples, Reyhan Gündüz, Elif Ağaçayak, Javier Alfonso Schvartzman, Mercedes Negri Malbran, Marco Liberati, Francesca Di Sebastiano, Ludovica Oronzi, Chiara Cerra, Danilo Buca, Angelo Cagnacci, Arianna Ramone, Fabio Barra, Andrea Carosso, Chiara Benedetto, Stefano Cosma, Axelle Pintiaux, Caroline Daelemans, Elena Costa, Ayşegül Özel, Murat Muhçu, Jesús S Jimenez Lopez, Clara Alvarado, Anna Luengo Piqueras, Dolores Esteban Oliva, Giovanni Battista Luca Schera, Nicola Volpe, Tiziana Frusca, Igor Samardjiski, Slagjana Simeonova, Irena Aleksioska Papestiev, Javier Hojman, Ilgin Turkcuoglu, Antonella Cromi, Antonio Simone Laganà, Fabio Ghezzi, Angelo Sirico, Alessandra Familiari, Giovanni Scambia, Zulfiya Khodjaeva Gennady T Sukhikh, Ksenia A Gorina, Renato Augusto Moreira de Sa, Mariana Vaz, Otto Henrique May Feuerschuette, Anna Nunzia Della Gatta, Aly Youssef, Gaetana Di Donna, Alicia Martinez-Varea, Gabriela Loscalzo, José Morales Roselló, Vedran Stefanovic, Irmeli Nupponen, Kaisa Nelskylä, Rodrigo Ayala, Rebeca Garrote Molpeceres, Asunción Pino Vázquez, Fabrizio Sandri, Ilaria Cataneo, Marinella Lenzi, Esra Tustas Haberal, Erasmo Huertas, Amadeo Sanchez, Pedro Arango, Amanda Bermejo, María Monica Gonzalez Alcantara, Gökhan Göynümer, Erhan Okuyan, Ciuhodaru Madalina, Ana Concheiro Guisan, Alejandra Martínez Schulte, Valentina Esposito, Valentina De Robertis, Snezana Zdjelar, Milan Lackovic, Sladjana Mihajlovic, Nelly Jekova, Gabriele Saccone, Mehmet Musa Aslan, Maria Carmela Di Dedda, Maisuri Chalid, Jose Enrique Moros Canache, George Daskalakis, Panos Antsaklis, Enrique Criado Vega, Elisa Cueto, Chiara Taccaliti, Alicia Yeliz Aykanat, Şerife Özlem Genç, Bernd Froessler, Petya Angelova Radulova, Danila Morano, Beatrice Bianchi, Maria Giulia Lombana Marino, Gabriella Meccariello, Bindu Rohatgi, Antonio Schiattarella, Maddalena Morlando, Nicola Colacurci, Andrea Villasco, Nicoletta Biglia, Ana Luiza Santos Marques, Alessandra Gatti, Daniela Luvero, Roberto Angioli, Alejandro Pittaro, Albert Lila, Blanka Zlatohlávková
OBJECTIVES: To evaluate maternal and perinatal outcomes in high compared to low-risk pregnancies complicated by SARS-COV-2 infection. METHODS: This was a multinational retrospective cohort study including women with laboratory-confirmed SARS-COV-2 from 76 centers from 25 different countries in Europe, United States, South America, Asia and Australia from 04 April 2020 till 28 October 2020. The primary outcome was a composite measure of maternal mortality and morbidity including admission to intensive care unit (ICU), use of mechanical ventilation, or death...
February 20, 2021: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/33621680/an-initiative-to-increase-resident-performance-of-operative-vaginal-deliveries
#6
Constance Cottrell, Sarah Clausen, David Sullivan, James Bena, David Biats
The objective of this single-centre, action research study was to increase resident experience performing operative vaginal deliveries. The secondary objective was to assess the incidence of maternal and neonatal complications. The rate of forceps deliveries increased in the post-training period (1.8%-4.0%; P < 0.001) but the overall rate of operative vaginal delivery did not change. The composite maternal complications rate following forceps delivery was lower in the post- training period (P = 0.006)...
February 20, 2021: Journal of Obstetrics and Gynaecology Canada: JOGC
https://read.qxmd.com/read/33621678/the-accuracy-of-sonographic-fetal-head-circumference-in-twin-pregnancies
#7
Rinat Gabbay-Benziv, Saja Anabusi, Erez Nadir, Dalit Kamar, Mordechai Hallak, Alon Shrim
OBJECTIVE: To assess the accuracy of sonographic estimation of fetal head circumference in twin gestations. METHODS: A retrospective analysis of sonographic evaluations of twin gestations >34 weeks, performed within 7 days of delivery, in a single university-affiliated medical centre. Sonographic head circumference was compared with neonatal head circumference. Measures of accuracy included systematic error, random error, proportion of estimates within 5% of neonatal head circumference, and reliability analysis...
February 20, 2021: Journal of Obstetrics and Gynaecology Canada: JOGC
https://read.qxmd.com/read/33621433/predictors-of-home-oxygen-duration-in-chronic-neonatal-lung-disease
#8
Matthew D Wong, Melissa Neylan, Gordon Williams, Syeda F Zahir, Jasneek Chawla
AIMS: In infants with chronic neonatal lung disease (CNLD), we aimed to identify predictors of home oxygen duration, predictors of discharge oxygen flow rates, and the association of oxygen flow rates with respiratory outcomes. METHODS: Infants with CNLD requiring home oxygen in 2016 and 2017 were retrospectively reviewed. Hazard ratios (HR) were estimated from Cox proportional hazards regression models in the cohort. A multinomial logistic regression model examined the effects of maternal and infant variables on discharge oxygen flow rates...
February 23, 2021: Pediatric Pulmonology
https://read.qxmd.com/read/33620714/increasing-prenatal-care-compliance-in-at-risk-black-women-findings-from-a-rct-of-patient-navigation-and-behavioral-incentives
#9
Dace S Svikis, Sydney S Kelpin, Lori Keyser-Marcus, Diane L Bishop, Anna Beth Parlier-Ahmad, Heather Jones, Gabriela Villalobos, Sara B Varner, Susan M Lanni, Nicole W Karjane, Lauretta A Cathers, Diane M Langhorst, Saba W Masho
BACKGROUND: In the USA, infant mortality remains a major public health concern, particularly for Black women and their infants who continue to experience disproportionately high mortality rates. Prenatal care is a key determinant of infant health, with inadequate prenatal care increasing risk for prematurity, stillbirth, neonatal loss, and infant death. The aim of the present study was to determine if concurrent delivery of patient navigation and behavioral incentives to at-risk Black pregnant women could improve prenatal care attendance and associated maternal and infant outcomes...
February 23, 2021: Journal of Racial and Ethnic Health Disparities
https://read.qxmd.com/read/33620551/a-randomized-double-blind-study-of-iodine-supplementation-during-pregnancy-in-sweden-pilot-evaluation-of-maternal-iodine-status-and-thyroid-function
#10
Sofia Manousou, Robert Eggertsen, Lena Hulthén, Helena Filipsson Nyström
PURPOSE: Pregnant women in Sweden are mildly iodine deficient. We investigated the effect of daily iodine supplementation on the iodine and thyroid status of pregnant women. METHODS: In this pilot, randomized, double-blind trial, 200 thyroid-healthy pregnant women were recruited at mean (standard deviation) pregnancy week 8.85 (1.62) and assigned (1:1) to daily intake of a multivitamin tablet with or without 150 μg of iodine. Urine and serum samples were collected at baseline and once during the second and third trimesters...
February 23, 2021: European Journal of Nutrition
https://read.qxmd.com/read/33620266/evaluating-the-risk-of-manganese-induced-neurotoxicity-of-parenteral-nutrition-review-of-the-current-literature
#11
Airton C Martins, Silvana Ruella Oliveira, Fernando Barbosa, Alexey A Tinkov, Anatoly V, Abel Santamaría, Eunsook Lee, Aaron B Bowman, Michael Aschner
INTRODUCTION: : Trace elements are required for biological and metabolic processes. Several diseases and clinical conditions can affect enteral nutrition and adequate gastrointestinal uptake of these trace elements. In this respect, parenteral nutrition (PN) is necessary for the provision of deficient trace elements. However, some essential elements, such as manganese (Mn) may be toxic to children and adults when parenterally administered in excess, leading to toxic, especially neurotoxic, effects...
February 23, 2021: Expert Opinion on Drug Metabolism & Toxicology
https://read.qxmd.com/read/33620258/early-tracheostomy-change-in-neonates-feasibility-and-benefits
#12
Denna Zebda, Brady Anderson, Zhen Huang, Sancak Yuksel, Soham Roy, Zi Yang Jiang
OBJECTIVES: To compare outcomes of early and late tracheostomy change in neonatal patients. Early tracheostomy change (ETC) occurred 3 to 4 days after surgery, and late tracheostomy change (LTC) occurred 5 to 7 days after surgery. STUDY DESIGN: Retrospective cohort. SETTING: Tertiary neonatal/pediatric intensive care unit. METHODS: A retrospective review of patients who underwent tracheostomy from 2015 to 2019 was performed for infants <1 year old...
February 23, 2021: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/33620113/pregnancy-and-neonatal-outcomes-of-covid-19-co-reporting-of-common-outcomes-from-pan-covid-and-aap-sonpm-registries
#13
Edward Mullins, Mark L Hudak, Jayanta Banerjee, Trace Getzlaff, Julia Townson, Kim Barnette, Rebecca Playle, Tom Bourne, Christoph Lees
OBJECTIVE: Few large cohort studies have reported data on maternal, fetal, perinatal and neonatal outcomes associated with SARS-CoV-2 infection in pregnancy. We report the outcome of infected pregnancies from a collaboration formed early during the pandemic between the investigators of two registries, the UK and global Pregnancy and Neonatal outcomes in COVID-19 (PAN-COVID) study and the US American Academy of Pediatrics Section on Neonatal Perinatal Medicine (AAP SONPM) National Perinatal COVID-19 Registry...
February 23, 2021: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/33620090/high-versus-low-medium-chain-triglyceride-content-of-formula-for-promoting-short-term-growth-of-preterm-infants
#14
REVIEW
Laura Perretta, Laila Ouldibbat, James I Hagadorn, Heather L Brumberg
BACKGROUND: In-hospital growth of preterm infants remains a challenge in clinical practice. The high nutrient demands of preterm infants often lead to growth faltering. For preterm infants who cannot be fed maternal or donor breast milk or may require supplementation, preterm formulas with fat in the form of medium chain triglycerides (MCTs) or long chain triglycerides (LCTs) may be chosen to support nutrient utilization and to improve growth. MCTs are easily accessible to the preterm infant with an immature digestive system, and LCTs are beneficial for central nervous system development and visual function...
February 23, 2021: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/33619983/peripheral-intravenous-cannulae-in-neonates-to-splint-or-not
#15
Tiroumourougane Serane V, Rathnapratheep Rajasekaran, Vijayasankar Vijayadevagaran, Bhuvaneswari Kothendaraman
OBJECTIVE: To determine the effect of splint on the dwell time of peripheral intravenous cannula in neonates. SETTING: Level II Neonatal Intensive Care Unit (NICU). PATIENTS: Consecutive babies with presumed need of peripheral intravenous access of at least 24 h. METHODS: Enrolled subjects were randomized to "splint" or "splint-less" group. Insertion site was cleaned with Isopropyl alcohol and 2% Chlorhexidine and peripheral intravenous catheter was inserted under strict asepsis...
February 23, 2021: Journal of Vascular Access
https://read.qxmd.com/read/33619844/coagulation-inflammation-and-cd46-transgene-expression-in-neonatal-porcine-islet-xenotransplantation
#16
Mingqing Song, Zachary W Fitch, Kannan P Samy, Benjamin M Martin, Qimeng Gao, Robert Patrick Davis, Francis V Leopardi, Niki Huffman, Robin Schmitz, Gayathri R Devi, Bradley H Collins, Allan D Kirk
BACKGROUND: Thrombosis is a known consequence of intraportal islet transplantation, particularly for xenogeneic islets. To define the origins of thrombosis after islet xenotransplantation and relate it to early inflammation, we examined porcine islets transplanted into non-human primates using a dual-transplant model to directly compare islet characteristics. METHODS: α1,3-Galactosyltransferase gene-knockout (GTKO) islets with and without expression of the human complement regulatory transgene CD46 (hCD46) were studied...
February 22, 2021: Xenotransplantation
https://read.qxmd.com/read/33619593/the-effect-of-automated-oxygen-control-on-clinical-outcomes-in-preterm-infants-a-pre-and-post-implementation-cohort-study
#17
H H Salverda, N J Oldenburger, M Rijken, S C Pauws, P A Dargaville, A B Te Pas
Several studies demonstrated an increase in time spent within target range when automated oxygen control (AOC) is used. However the effect on clinical outcome remains unclear. We compared clinical outcomes of preterm infants born before and after implementation of AOC as standard of care. In a retrospective pre-post implementation cohort study of outcomes for infants of 24-29 weeks gestational age receiving respiratory support before (2012-2015) and after (2015-2018) implementation of AOC as standard of care were compared...
February 23, 2021: European Journal of Pediatrics
https://read.qxmd.com/read/33619578/preventing-early-onset-group-b-streptococcal-sepsis-clinical-risk-factor-based-screening-or-culture-based-screening
#18
Jiun Lee, Krishnamoorthy Naiduvaje, Ka Lip Chew, Natasha Charan, Yiong Huak Chan, Raymond Tzer-Pin Lin, Eu Leong Yong
INTRODUCTION: Two strategies are available for prevention of early-onset group B streptococcal (GBS) sepsis - clinical risk factor-based screening and routine culture-based screening of pregnant women for GBS colonisation. In our hospital, we switched from the former to the latter approach in 2014. METHODS: We compared the incidence of early-onset GBS sepsis during 2001-2015 between infants born to pregnant women who were screened for GBS colonisation and those born to women who were not screened...
January 2021: Singapore Medical Journal
https://read.qxmd.com/read/33619572/a-review-of-umbilical-venous-catheter-related-complications-at-a-tertiary-neonatal-unit-in-singapore
#19
Sharon Si Min Goh, Sheau Yun Kan, Srabani Bharadwaj, Woei Bing Poon
INTRODUCTION: Umbilical venous catheters (UVCs), commonly inserted in neonates for vascular access, are not without complications. METHODS: A single-centre retrospective cohort study that reviewed complications related to UVC insertion in neonates was conducted in a tertiary neonatal unit in Singapore from January 2016 to July 2017. Ideal UVC position was defined as catheter tip within 0.5 cm above or below the diaphragm. Catheter-related sepsis was defined as clinical or biochemical abnormalities suggesting any new-onset or worsening sepsis 72 hours before or after removal of UVCs, with or without positive culture...
January 2021: Singapore Medical Journal
https://read.qxmd.com/read/33619561/quality-of-maternal-and-newborn-hospital-care-in-brazil-a-quality-improvement-cycle-using-the-who-assessment-and-quality-tool
#20
Emanuelle Pessa Valente, Fabio Barbone, Tereza Rebecca de Melo E Lima, Paula Ferdinanda Conceição de Mascena Diniz Maia, Francesca Vezzini, Giorgio Tamburlini
BACKGROUND: Increasing efforts towards quality improvement are necessary in low and middle-income countries to reduce maternal and perinatal mortality and morbidity, and to promote respectful care. In Brazil, perinatal health indicators are below targets in several States despite universal access to perinatal services and very high rates of institutional births, indicating poor quality of care (QoC) as a key issue to be addressed. However, research efforts to develop and test QoC improvement interventions are scarce...
February 23, 2021: International Journal for Quality in Health Care
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