Rui Wei, Xiaoyu Zhang, Xiaoxiao Li, Jian Wen, Hongyang Liu, Jiqiang Fu, Li Li, Wenyi Zhang, Zhen Liu, Yang Yang, Kang Zou
BACKGROUND: The scarcity of pluripotent stem cells poses a major challenge to the clinical application, given ethical and biosafety considerations. While germline stem cells commit to gamete differentiation throughout life, studies demonstrated the spontaneous acquisition of pluripotency by spermatogonial stem cells (SSCs) from neonatal testes at a low frequency (1 in 1.5 × 107 ). Notably, this process occurs without exogenous oncogenes or chemical supplementation. However, while knockout of the p53 gene accelerates the transformation of SSCs, it also increases risk and hampers their clinical use...
December 1, 2023: Cell & Bioscience