Christina Thomou, Markus Nussbaumer, Eleni Grammenou, Chrysoula Komini, Angeliki-Maria Vlaikou, Maria P Papageorgiou, Michaela D Filiou
Early handling (EH), the brief separation of pups from their mother during early life, has been shown to exert beneficial effects. However, the impact of EH in a high anxiety background as well as the role of brain mitochondria in shaping EH-driven responses remain elusive.Here, we used a high (HAB) vs. normal (NAB) anxiety-related behavior mouse model to study how EH affects pup and dam behavior in divergent anxiety backgrounds. We also investigated EH-induced effects at the protein and mRNA levels in adult male HAB mice in the hypothalamus, the prefrontal cortex, and the hippocampus by examining the same mitochondrial/energy pathways and mitochondrial dynamics mechanisms (fission, fusion, biogenesis, and mitophagy) in all three brain regions...
May 18, 2024: Molecular Neurobiology
Christian F Poets, Patricia Roller, Ann-Cathrine Neukamm, Mirja Quante
AIM: We wanted to investigate whether an electric rocking device (Swing2Sleep, Neumünster, Germany), sold with the claim to promote infant sleep, would increase total sleep time or reduce sleep latency once infants are put therein. METHODS: In a randomised crossover design, 20 infants (median gestational age at birth 31.7 weeks, range 25-39) were placed to sleep either first with the device rocking, then not rocking (or vice versa) for 5-7 h each...
May 17, 2024: Acta Paediatrica
Yanping Yang, Yang Li, Wenyi Yang, Xueying Yang, Man Luo, Ling Qin, Junchao Zhu
BACKGROUND: Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the most common neurological problems occurring in the perinatal period. However, there still is not a promising approach to reduce long-term neurodevelopmental outcomes of HIE. Recently, itaconate has been found to exhibit anti-oxidative and anti-inflammatory effects. However, the therapeutic efficacy of itaconate in HIE remains inconclusive. Therefore, this study attempts to explore the pathophysiological mechanisms of oxidative stress and inflammatory responses in HIE as well as the potential therapeutic role of a derivative of itaconate, 4-octyl itaconate (4OI)...
May 17, 2024: Journal of Neuroinflammation
Silas Selorm Daniels-Donkor, Agani Afaya, Dennis Bomansang Daliri, Timothy Tienbia Laari, Solomon Mohammed Salia, Mabel Apaanye Avane, Richard Adongo Afaya, Vida Nyagre Yakong, Martin Amogre Ayanore, Robert Kaba Alhassan
BACKGROUND: A significant factor impacting the incidence of maternal and neonatal fatalities is the timely initiation of antenatal care (ANC) services in healthcare facilities. Despite the recommendations by the World Health Organization and the numerous benefits of timely initiation of ANC, studies have revealed that the overall prevalence of timely ANC initiation in 36 sub-Saharan African countries remains low and women in The Gambia also initiate ANC late. However, no known study in The Gambia has focused on assessing the factors associated with timely initiation of ANC at the time of writing this paper...
May 17, 2024: Archives of Public Health, Archives Belges de Santé Publique
María L Couce, María-Dolores Bóveda, Daisy E Castiñeiras, María-Eugenia Vázquez-Mosquera, Sofía Barbosa-Gouveia, María-José De Castro, Agustin J Iglesias-Rodríguez, Cristóbal Colón, José A Cocho, Paula Sánchez
BACKGROUND: There is a notable lack of harmonisation in newborn screening (NBS) programmes worldwide. The Galician programme for early detection of inborn errors of metabolism (IEM) was one of the first NBS programmes in Europe to incorporate mass spectrometry (July 2000). This programme currently screens for 26 IEMs in dried blood and urine samples collected 24-72 h after birth. RESULTS: In its 22-year history, this programme has analysed samples from 440,723 neonates and identified 326 cases of IEM with a prevalence of 1:1351...
May 17, 2024: Orphanet Journal of Rare Diseases
Junguo Li, Shenglin Ye, Xinyuan Huang, Guolong Yang, Yijin Wang, Jianghui Zeng, Chunhui Lai
OBJECTIVE: This study aimed to discuss the distinctive features of the intestinal microbiota in neonates with hyperbilirubinemia and to comprehensively analyse the composition of the intestinal microbiota as well as the levels of free amino acids and acylcarnitines in the peripheral blood of neonates experiencing hyperbilirubinemia. RESULTS: At the phylum level, Proteobacteria, Firmicutes, Actinobacteria, Bacteroidetes, and Chloroflexi were the five predominant microbial groups identified in both the hyperbilirubinemia and control groups...
May 18, 2024: BMC Microbiology
Meng Yang, Zhongqiang Cao, Wanting Zhu, Xiaoyuan Feng, Jieqiong Zhou, Jiuying Liu, Yuanyuan Zhong, Yan Zhou, Hong Mei, Xiaonan Cai, Liqin Hu, Aifen Zhou, Han Xiao
BACKGROUND: Limited evidence exists regarding the association between gestational diabetes mellitus (GDM) and elevated levels of thyroid-stimulating hormone (TSH) in newborns. Therefore, this study aimed to investigate the potential risk of elevated TSH levels in infants exposed to maternal GDM, considering the type and number of abnormal values obtained from the 75-gram oral glucose tolerance test (OGTT). METHODS: A population-based, prospective birth cohort study was conducted in Wuhan, China...
May 17, 2024: BMC Pregnancy and Childbirth
Elizabeth R Schinkel, Elizabeth R Nelson, Jae H Kim, Maryanne T Perrin, Roger Dyer, Rajavel Elango, Lars Bode, David C Dallas, Jiraporn Lueangsakulthai, Carrie-Ellen Briere, Sarah N Taylor
OBJECTIVE: Preterm infants need enrichment of human milk (HM) for optimal growth. This study evaluated a novel, point-of-care human milk concentration (HMC) process for water removal from fresh HM samples by passive osmotic concentration. STUDY DESIGN: Nineteen fresh HM samples were concentrated by incubation with the HMC devices for 3 h at 4 °C. Pre- and post-concentration HM samples were compared by HM properties for: pH, osmolality, macronutrients, enzyme activity, bioactive, and total cell viability...
May 17, 2024: Journal of Perinatology: Official Journal of the California Perinatal Association
Maria Williany Silva Ventura, Glaubervania Alves Lima, Viviane Martins da Silva, Marcos Venícios de Oliveira Lopes, Francisca Elisângela Teixeira Lima
OBJECTIVE: To analyze the concept of Neonatal Near Miss (NNM) using Walker and Avant's method. METHOD: This study employs conceptual analysis following Walker and Avant's model, involving concept selection, objective definition, identification of potential uses, determination of attributes, model case creation, additional case consideration, antecedent identification, consequent analysis, and empirical reference examination. To elucidate the concept, a scoping review was conducted across journals indexed in scientific databases such as Web of Science, EMBASE, SCOPUS, and MEDLINE/PubMed...
May 16, 2024: Journal of Pediatric Nursing
Paria Amanpour, Zohre Eftekhari, Akram Eidi, Parvin Khodarahmi
Cadmium (Cd) exposure in mothers can cause respiratory issues in newborns, but the exact toxicity mechanisms are not fully understood. Vitamin D deficiency in Cd-exposed rats is associated with increased cadmium accumulation in tissues. Finding a cost-effective medication that is vital for the body while also reducing the effects of poisoning is crucial in treating poisonings. To investigate the mechanisms of Cd-induced lung toxicity, we examined the impact of prolonged Cd exposure in female rats before pregnancy on newborn lung health, focusing on sera TNF-α level, lung P53, Foxo1 mRNA, and lung VEGF, and BMP-4 protein level...
May 10, 2024: Journal of Trace Elements in Medicine and Biology
Alexandrea L Craft, Marie Camerota, Cynthia Loncar, Brian S Carter, Jennifer Check, Jennifer B Helderman, Julie A Hofheimer, Elisabeth C McGowan, Charles R Neal, T Michael O'Shea, Steven L Pastyrnak, Lynne M Smith, Lynne M Dansereau, Sheri A DellaGrotta, Carmen Marsit, Barry M Lester
OBJECTIVE: Understand how high-risk infants' development changes over time. Examine whether NICU Network Neurobehavioral Scale (NNNS) profiles are associated with decrements in developmental outcomes between ages 2 and 3 years in infants born very preterm. STUDY DESIGN: The Neonatal Outcomes for Very preterm Infants (NOVI) cohort is a multisite prospective study of 704 preterm infants born <30 weeks' gestation across nine university and VON affiliated NICUs...
May 14, 2024: Early Human Development
Xiaoli Feng, Yihui Zheng, Niping Mao, Ming Shen, Liuxi Chu, Yu Fang, Mengdan Pang, Zhouguang Wang, Zhenlang Lin
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) is a major contributor to neonatal mortality and neurodevelopmental disorders, but currently there is no effective therapy drug for HIE. Mitochondrial dysfunction plays a pivotal role in hypoxic-ischemic brain damage(HIBD). Menaquinone-4 (MK-4), a subtype of vitamin K2 prevalent in the brain, has been shown to enhance mitochondrial function and exhibit protective effects against ischemia-reperfusion injury. However, the impact and underlying molecular mechanism of MK-4 in HIE have not been fully elucidated...
May 16, 2024: International Immunopharmacology
Yoann Le Basle, Jérémy Pinguet, Yassine Bouattour, Philip Chennell, Valérie Sautou, Bénédicte Mailhot-Jensen
Peripherally inserted central catheters (PICC-lines) used in neonatology are made of thermoplastic polyurethane (TPU) or silicone. These materials usually contain substances that may leach into drug vehicles or blood. In this extractables study, we determined the optimal extraction conditions using TPU films containing defined amounts of butylhydroxytoluene (BHT) and then applied them on unused and explanted PICC-lines. Maceration and sonication tests were carried out with hexane, acetone and water as the extraction solvents...
May 11, 2024: Journal of Pharmaceutical and Biomedical Analysis
M Mansouri, K Servatyari, K Rahmani, S Sheikhahmadi, S Hemmatpour, A Eskandarifar, M Rahimzadeh
INTRODUCTION: Respiratory Distress Syndrome (RDS) is the most common respiratory disorder among premature infants. The use of surfactant has significantly reduced respiratory complications and mortality. There are two conventional methods for administering surfactant: Intubate-Surfactant-Extubate (INSURE) and Less Invasive Surfactant Administration (LISA). This study aims to compare the effects of surfactant administration using these two methods on the treatment outcomes of premature newborns...
2024: Journal of Neonatal-perinatal Medicine
H Boskabadi, M H Ataee Nakhaei, G A Maamouri, N Saghafi
BACKGROUND: Vitamin D deficiency has been suggested to be a risk factor for neonatal respiratory distress syndrome (RDS). This study aimed to evaluate the effect of 25 (OH) D administrations in pregnant women with findings of preterm labor on the incidence of RDS in their preterm neonates. MATERIALS AND METHODS: A randomized controlled clinical trial was conducted on pregnant mothers with gestational age (GA) of less than 34 weeks at risk of preterm delivery. 175 subjects were randomly assigned into two groups, including intervention (intramuscular injection of 50,000 units of 25(OH) D during 72 hours before delivery) and control (no injections)...
2024: Journal of Neonatal-perinatal Medicine
M Zakerihamidi, A Moradi, A Ramazani, H Boskabadi
OBJECTIVES: Hypernatremia may facilitate the diffusion of bilirubin through the blood-brain barrier and increase the risk of bilirubin encephalopathy. This study was conducted to compare the prognosis of jaundice infants with those with jaundice and hypernatremia. METHODS: A total of 615 term infants with idiopathic jaundice with or without hypernatremia were enrolled in this cohort study with 24-months follow-up at Ghaem Hospital, Mashhad, Iran, between 2010 and 2022...
2024: Journal of Neonatal-perinatal Medicine
M S Elfarargy, T A Alruwaili, A R Ahmad, D H Elbadry
Coronavirus disease 2019 (COVID-19) is considered an infectious disease which is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Neonatal COVID-19 had been occurred in many countries which would indicate the need of effective and safe treatment for these vulnerable group. In this study, we showed symptoms of corona virus in neonates, investigation of coronavirus in neonates and radiological features of neonatal COVID-19. In addition, we discussed management of neonates with COVI-19, antiviral treatment, monoclonal antibodies administration, immunomodulatory therapy, antibiotics, vitamins, and minerals in the treatment of neonatal COVID-19, and also telemedicine in neonatal COVID-19 and feeding the newborn of COVID-19 mother...
May 11, 2024: Journal of Neonatal-perinatal Medicine
Safaa ELMeneza, Abeer Kadom, Heba Gafar
BACKGROUND: Neonatal resuscitation is one of the most critical and risky events that requires a high level of individual skill and team performance. OBJECTIVE: To evaluate the effect of training of resuscitation teams on the frequency and type of medical errors (ME) that result from neonatal resuscitation. METHODS: A prospective observational study was performed using a checklist to detect ME related to neonatal resuscitation. RESULTS: The rate of ME was 24...
May 15, 2024: International Journal of Risk & Safety in Medicine
Chun-Yu Wang, Chen Ling, Juan-Juan Yang, Li-Sha Guan, Xiao-Qing Wang
To explore the influence of perinatal-related factors on meconium aspiration syndrome (MAS) in full-term neonates and construct a nomogram prediction model for risk stratification of neonatal MAS and adoption of preventive measures. A total of 424 newborns and their mothers who were regularly examined at our hospital between January 2020 and December 2023 who had meconium-contaminated amniotic fluid during delivery were retrospectively selected as participants. Neonates were divided into MAS and non-MAS groups based on whether MAS occurred within 3 days after birth...
May 17, 2024: Medicine (Baltimore)
Lynn T Singer, Jeffrey M Albert, Sonia Minnes, Meeyoung O Min, June-Yung Kim
IMPORTANCE: Linking prenatal drug exposures to both infant behavior and adult cognitive outcomes may improve early interventions. OBJECTIVE: To assess whether neonatal physical, neurobehavioral, and infant cognitive measures mediate the association between prenatal cocaine exposure (PCE) and adult perceptual reasoning IQ. DESIGN, SETTING, AND PARTICIPANTS: This study used data from a longitudinal, prospective birth cohort study with follow-up from 1994 to 2018 until offspring were 21 years post partum...
May 1, 2024: JAMA Network Open
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