Andreas Møller Jensen, Sanne Marie Thysen, Oides Furtado, Claudino Correia, Stéphane Helleringer, Jacob von Bornemann Hjelmborg, Ane Baerent Fisker
OBJECTIVE: Child mortality and stillbirth rates (SBR) remain high in low-income countries but may be underestimated due to incomplete reporting of child deaths in retrospective pregnancy/birth histories. The aim of this study is to compare stillbirth and mortality estimates derived using two different methods: the method assuming full information and the prospective method. METHODS: Bandim Health Project's Health and Demographic Surveillance Systems (HDSS) follows women of reproductive age and children under five through routine home visits every 1, 2 or 6 months...
June 2, 2023: Tropical Medicine & International Health
Yubin Li, Qiyuan Chang, Qingyun Mai
BACKGROUND: Monozygotic twins (MZTs) are associated with high risks of maternal and fetal complications. Even with the widely used elective single embryo transfer (SET), the risk of MZTs following assisted reproductive technology (ART) treatments remains. However, most studies of MZTs focused on the relevant etiology, with few studies describing pregnancy and neonatal outcomes. METHODS: This retrospective cohort study included 19,081 SET cycles resulting from in-vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), preimplantation genetic testing (PGT) and testicular sperm aspiration (TESA) performed between January 2010 and July 2020 in a single university-based center...
June 2, 2023: Reproductive Biology and Endocrinology: RB&E
Yoshinori Aoki, Hongmei Dai, Fumika Furuta, Tomohisa Akamatsu, Takuya Oshima, Naoto Takahashi, Yu-Ichi Goto, Akira Oka, Masayuki Itoh
BACKGROUND: Microglial cells play an important role in the immune system in the brain. Activated microglial cells are not only injurious but also neuroprotective. We confirmed marked lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expression in microglial cells in pathological lesions in the neonatal hypoxic-ischemic encephalopathy (nHIE) model brain. LOX-1 is known to be an activator of cytokines and chemokines through intracellular pathways. Here, we investigated a novel role of LOX-1 and the molecular mechanism of LOX-1 gene transcription microglial cells under hypoxic and ischemic conditions...
June 2, 2023: Cell Communication and Signaling: CCS
Elizabeth Adjoa Kumah, Raoul Djou Fopa, Saeed Harati, Paul Boadu, Fatemeh Vida Zohoori, Tannaz Pak
Use of nanoparticles have established benefits in a wide range of applications, however, the effects of exposure to nanoparticles on health and the environmental risks associated with the production and use of nanoparticles are less well-established. The present study addresses this gap in knowledge by examining, through a scoping review of the current literature, the effects of nanoparticles on human health and the environment. We searched relevant databases including Medline, Web of Science, ScienceDirect, Scopus, CINAHL, Embase, and SAGE journals, as well as Google, Google Scholar, and grey literature from June 2021 to July 2021...
June 3, 2023: BMC Public Health
Yanlin Yang, Jing Lv, Yajiao Li, Changping Gan, Peng Ji
BACKGROUND: Intracardiac thrombosis (ICT) is a rare complication after the cardiopulmonary surgery for interrupted aortic arch (IAA) or total anomalous pulmonary venous connection (TAPVC) without previous records. There are still no general guidelines regarding as the mechanism or management of postoperative ICT in neonates and younger infants. CASE PRESENTATION: We reported the conservative and surgical therapies in two neonates with intra-ventricular and intra-atrial thrombosis after the anatomical repair for IAA and TAPVC, respectively...
June 2, 2023: BMC Pediatrics
Yenlik Rakhanova, Wassim Y Almawi, Gulzhanat Aimagambetova, Dieter Riethmacher
BACKGROUND: An increase in vascular resistance of uterine vessels is associated with intrauterine growth restriction (IUGR). Sildenafil citrate, a phosphodiesterase-5 inhibitor that stabilizes cyclic guanosine monophosphate (cGMP) and increases nitric oxide levels, improves placental perfusion by dilation of spiral arteries and is beneficial in managing IUGR. This study aims to determine the effectiveness of sildenafil citrate in improving perinatal outcomes in IUGR pregnancies. METHODS: Meta-analysis was performed on data extracted from all studies specific to sildenafil citrate in IUGR management, searching relevant articles on PubMed, Medline, Google Scholar, Embase, and Cochrane databases...
June 2, 2023: BMC Pregnancy and Childbirth
Shirin Faraji Azad, Akbar Biglarian, Maryam Rostami, Razieh Bidhendi-Yarandi
Class membership is a critical issue in health data sciences. Different types of statistical models have been widely applied to identify participants within a population with heterogeneous longitudinal trajectories. This study aims to identify latent longitudinal trajectories of maternal weight associated with adverse pregnancy outcomes using smoothing mixture model (SMM). Data were collected from the Khuzestan Vitamin D Deficiency Screening Program in Pregnancy. We applied the data of 877 pregnant women living in Shooshtar city, whose weights during the nine months of pregnancy were available...
June 2, 2023: Scientific Reports
Rachel Filler, Mina Yeganeh, Bo Li, Carol Lee, Mashriq Alganabi, Alison Hock, George Biouss, Felicia Balsamo, Dorothy Lee, Hiromu Miyake, Agostino Pierro
PURPOSE: Necrotizing enterocolitis (NEC), an inflammatory intestinal disease common in premature infants, has been associated with the development of lung damage. Toll-like receptor 4 has been shown to regulate inflammation in the NEC lungs, however, other important inflammatory mechanisms have not been thoroughly investigated. In addition, we reported that milk-derived exosomes were able to attenuate intestinal injury and inflammation in experimental NEC. This study aims to (i) investigate the role of the NLRP3 inflammasome and NF-κB pathway in regulating lung damage during experimental NEC; and (ii) evaluate the therapeutic potential of bovine milk exosomes in reducing lung inflammation and injury during NEC...
June 3, 2023: Pediatric Surgery International
Jie Ding, Sung-Jin Lee, Lukas Vlahos, Kanako Yuki, Cara C Rada, Vincent van Unen, Meghah Vuppalapaty, Hui Chen, Asmiti Sura, Aaron K McCormick, Madeline Tomaske, Samira Alwahabi, Huy Nguyen, William Nowatzke, Lily Kim, Lisa Kelly, Douglas Vollrath, Andrea Califano, Wen-Chen Yeh, Yang Li, Calvin J Kuo
Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The Norrin/FZD4 /TSPAN12 pathway activates WNT/β-catenin signaling, which is essential for BBB and BRB function. However, systemic pharmacologic FZD4 stimulation is hindered by obligate palmitoylation and insolubility of native WNTs and suboptimal properties of the FZD4 -selective ligand Norrin. Here, we develop L6-F4-2, a non-lipidated, FZD4 -specific surrogate which significantly improves subpicomolar affinity versus native Norrin...
June 2, 2023: Nature Communications
Kellen R Oliveira, Antônio P O Neto, Caio A Diamantino, Isabela O Eiterer, Renato D Araújo, Yamê F R Sancler-Silva, Alex L Silva, Marcio S Duarte, Polyana P Rotta
This study aimed to evaluate the effects of differential average daily gain targets of dairy heifers throughout gestation on placental hemodynamics, uterine involution, colostrum production of the heifers, and impacts on newborn calf weight and immunity transfer. Fourteen Holstein × Gyr heifers with an average body weight of 446 ± 46.7 kg and age of 25 ± 3.9 mo were randomly assigned to the following treatments: moderate body weight gain (MOD, n = 7), where heifers were fed to achieve 0.50 kg/d; and high body weight gain (HIG, n = 7), where heifers were fed to achieve 0...
May 31, 2023: Journal of Dairy Science
K S Hare, K M Wood, Y Mustapha, K C Swanson, M A Steele
The objectives of this study were to evaluate how varying colostral insulin concentrations influenced small intestinal development and peripheral metabolism in neonatal Holstein bulls. Insulin was supplemented to approximately 5× (70.0 μg/L; n = 16) or 10× (149.7 μg/L; n = 16) the basal colostrum insulin (12.9 μg/L; BI, n = 16) concentration to maintain equivalent macronutrient intake (crude fat: 4.1 ± 0.06%; crude protein: 11.7 ± 0.05%; and lactose: 1.9 ± 0.01%) among treatments...
May 31, 2023: Journal of Dairy Science
Rafael Bandeira Fabres, Débora Sterzeck Cardoso, Brian Aranibar Aragón, Bruna Petrucelli Arruda, Pamela Pinheiro Martins, Juliane Midori Ikebara, Alexander Drobyshevsky, Alexandre Hiroaki Kihara, Luciano Stürmer de Fraga, Carlos Alexandre Netto, Silvia Honda Takada
Oxygen deprivation is one of the main causes of morbidity and mortality in newborns, occurring with a higher prevalence in preterm infants, reaching 20 % to 50 % mortality in newborns in the perinatal period. When they survive, 25 % exhibit neuropsychological pathologies, such as learning difficulties, epilepsy, and cerebral palsy. White matter injury is one of the main features found in oxygen deprivation injury, which can lead to long-term functional impairments, including cognitive delay and motor deficits...
May 31, 2023: Molecular and Cellular Neurosciences
Qianting Deng, Chongyun Wu, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang
Neonatal hypoxic-ischemic encephalopathy (HIE) is the primary reason for neonatal mortality and prolonged disablement. Currently, hypothermia is the only approved clinical treatment available for HIE. However, hypothermia's limited therapeutic efficacy and adverse effects suggest an urgent need to advance our knowledge of its molecular pathogenesis and develop novel therapies. The leading cause of HIE is impaired cerebral blood flow and oxygen deprivation-initiated primary and secondary energy failure. Lactate was traditionally regarded as a marker of energy failure or a waste product of anaerobic glycolysis...
May 31, 2023: Experimental Neurology
Yanan Cao, Tianzi Zang, Tianlai Qiu, Zhihu Xu, Xiangxu Chen, Xiaoxiao Fan, Qianping Zhang, Yingjuan Huang, Jun Liu, Ni Wu, Natalie Shen, Jinbing Bai, Guoxing Li, Jing Huang, Yanqun Liu
BACKGROUND: Ambient air pollutant exposure can change the composition of gut microbiota at 6-months of age, but there is no epidemiological evidence on the impacts of exposure to particulate matter with an aerodynamic diameter ≤1 μm (PM1 ) during pregnancy on gut microbiota in mothers and neonates. We aimed to determine if gestational PM1 exposure is associated with the gut microbiota of mothers and neonates. METHODS: Leveraging a mother-infant cohort from the central region of China, we estimated the exposure concentrations of PM1 during pregnancy based on residential address records...
May 31, 2023: Environmental Research
Thibaut Sériès, Mireille Guillot, Georgina Angoa, Etienne Pronovost, Aissatou Bintou Khairy Thilor Ndiaye, Ibrahim Mohamed, David Simonyan, Pascal M Lavoie, Anne Synnes, Isabelle Marc
OBJECTIVE: To determine how neonatal growth velocity affects the association between birth weight (BW) and neurodevelopmental outcomes in infants born preterm. STUDY DESIGN: This study is a secondary analysis of the MOBYDIck randomized multicenter trial conducted in breastfed infants born at <29 weeks' gestational age (GA), whose mothers were supplemented with docosahexaenoic acid or placebo during the neonatal period. Neurodevelopmental outcomes were assessed at 18 to 22 months of corrected age using the Bayley-III Cognitive and Language composite scores...
May 31, 2023: Journal of Pediatrics
Latoya A Stewart, Rebecca R Hernan, Christopher Mardy, Eunice Hahn, Wendy K Chung, Emile A Bacha, Ganga Krishnamurthy, Vincent P Duron, Usha S Krishnan
OBJECTIVES: To describe the types of congenital heart disease (CHD) in a congenital diaphragmatic hernia (CDH) cohort in a large volume center and evaluate surgical decision making and outcomes based on complexity of CHD and associated conditions. STUDY DESIGN: A retrospective review of patients with CHD and CDH diagnosed by echocardiogram between 01/01/2005 and 07/31/2021. The cohort was divided into two groups based on survival at discharge. RESULTS: Clinically important CHD was diagnosed in 19% (62/326) of CDH patients...
May 31, 2023: Journal of Pediatrics
Khaled Alomar, Hasan Mansour, Safaa Qatleesh, Nader Eid, Mohammed Abd Alkader, Husam Al Dalati
INTRODUCTION AND IMPORTANCE: Duodenal duplication cysts are a rare subtype of alimentary tract duplications cysts, consisting of 7 % of all the duplications. The clinical presentation is variable, depending on the size, location and mass effect. Most duodenal duplication cysts abut the second or third portion of the native duodenum. The standard treatment of choice for symptomatic enteric duplication cysts is complete surgical removal. In our case, by examining the abdomen, ectopic pancreatic tissue was found on the wall of the transverse colon, along with Meckel's diverticulum, 50 cm from the ileocecal junction...
May 30, 2023: International Journal of Surgery Case Reports
Gina Lepore, Theresa Morley-McLaughlin, Natalie Davidson, Caitlin Han, Cynthia Masese, Grace Reynolds, Victoria Saltz, Shivon A Robinson
The rising prevalence of early-life opioid exposure has become a pressing public health issue in the U.S. Neonates exposed to opioids in utero are at risk of experiencing a constellation of postpartum withdrawal symptoms commonly referred to as neonatal opioid withdrawal syndrome (NOWS). Buprenorphine (BPN), a partial agonist at the mu-opioid receptor (MOR) and antagonist at the kappa-opioid receptor (KOR), is currently approved to treat opioid use disorder in adult populations. Recent research suggests that BPN may also be effective in reducing withdrawal symptoms in neonates who were exposed to opioids in utero...
May 22, 2023: Drug and Alcohol Dependence
Devin E Banks, Andrea Fentem, Xiao Li, Maria Paschke, Lindsey Filiatreau, Candice Woolfolk, Patricia Cavazos-Rehg
OBJECTIVES: Pregnant and postpartum women and people (PPWP) who use opioids experience higher rates of morbidity, preterm labor, and stillbirth than those who do not. Although medication for opioid use disorder (MOUD) is the standard of treatment, utilization among PPWP has remained low because of MOUD stigma and misconceptions. The current report examined general and pregnancy-related MOUD attitudes, norms, and self-efficacy among PPWP seeking treatment. METHODS: Participants (n = 33) receiving MOUD at a Midwestern clinic reported beliefs about MOUD in general using the Attitudes toward Methadone Questionnaire (modified to include all MOUD) and during pregnancy/postpartum using an investigator-generated scale based on previous research...
May 2023: Journal of Addiction Medicine
Kristin C Prewitt, Sarena Hayer, Bharti Garg, Ashley E Benson, Madeline A Hedges, Aaron B Caughey, Jamie O Lo
OBJECTIVES: With legislative changes to cannabis legalization and increasing prevalence of use, cannabis is the most commonly used federally illicit drug in pregnancy. Our study aims to assess the perinatal outcomes associated with prenatal cannabis use disorder. METHODS: We conducted a retrospective cohort study using California linked hospital discharge-vital statistics data and included singleton, nonanomalous births occurring between 23 and 42 weeks of gestational age...
May 2023: Journal of Addiction Medicine
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.