Sara Consonni, Isadora Vaglio Tessitore, Claudia Conti, Cristina Plevani, Manuela Condo', Ferruccio Torcasio, Armando Pintucci, Anna Locatelli
AIM: To evaluate the effect of different strategies to improve placental transfusion in cesarean section (CS). METHODS: Retrospective analysis of all singleton term pregnancies that underwent CS over 6 months. Delayed umbilical cord clamping (dUCC) was defined as one done at least 60 s after birth. Umbilical cord milking (UCM) was an option when waiting 60 s was deemed unsafe. The two strategies were compared against early (<60 s) umbilical cord clamping (eUCC) without milking...
September 22, 2020: Journal of Obstetrics and Gynaecology Research
Hye Nam Lee, Jae Kyun Park, Soo Kyung Paek, Ji Hyun Byun, Haengseok Song, Hee Jun Lee, Eun Mi Chang, Ji Won Kim, Woo Sik Lee, Sang Woo Lyu
OBJECTIVE: To evaluate the effects of the duration of cryostorage on clinical outcomes after embryo transfer of vitrified blastocysts stored in an open-device slush-nitrogen (SN2 ) system. METHODS: A retrospective cohort study was carried out on 1632 autologous vitrified-warmed blastocyst transfer cycles between January 2013 and June 2014. Duration of cryostorage was divided into four groups: Group I: 0-6 months (n=937); Group II: 7-12 months (n=299); Group III: 13-24 months (n=165); and Group IV: ≥25 months (n=231)...
September 22, 2020: International Journal of Gynaecology and Obstetrics
Karel Allegaert, Anne Smits, Djalila Mekahli, John N van den Anker
BACKGROUND: Serum creatinine (Scr) in early neonatal life (first week of life) displays extensive variability; hence, a better understanding is needed to use Scr as a diagnostic biomarker for acute kidney injury (AKI). OBJECTIVE: The objective of this study was to explore Scr trends and its covariates in early neonatal life. METHODS: Analysis of a rich, pooled Scr dataset (enzymatic assay) of 4,509 Scr observations in 1,181 neonates in the first week of life with birth weight, gestational age (GA), and postnatal age as covariates was conducted...
September 22, 2020: Neonatology
Udit U Saraf, Ajay Asranna, Ramshekhar N Menon, Manju Mohan P, Vipina Vp, Ashalatha Radhakrishnan, Ajith Cherian, Sanjeev V Thomas
PURPOSE: Epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS), with its associated impact on language, is an important cause of morbidity with epilepsy in children. The effects of various treatment-approaches and the aetiological/electrophysiological factors affecting therapeutic response are not fully understood. METHOD: A retrospective study of patients admitted to the institute and diagnosed to have CSWS pattern on EEG was conducted. Spike and Wave Frequency/100 s(SWF) was calculated from sleep-EEG records...
August 28, 2020: Seizure: the Journal of the British Epilepsy Association
Cristian Coarfa, Sandra L Grimm, Tiffany Katz, Yuhao Zhang, Rahul K Jangid, Cheryl L Walker, Bhagavatula Moorthy, Krithika Lingappan
Sex as a biological variable plays a critical role both during lung development and in modulating postnatal hyperoxic lung injury and repair. The molecular mechanisms behind these sex-specific differences need to be elucidated. Our objective was to determine if the neonatal lung epigenomic landscape reconfiguration has profound effects on gene expression and could underlie sex-biased differences in protection from or susceptibility to diseases. Neonatal male and female mice (C57BL/6) were exposed to hyperoxia (95% FiO, PND 1-5: saccular stage) or room air and euthanized on PND 7 and 21...
September 11, 2020: Redox Biology
Hedieh Khalatbari, Francisco A Perez, Amy Lee, Dennis Ww Shaw
BACKGROUND: The use of non-sedated T2-weighted Half-Fourier Acquisition Single-shot Turbo spin Echo (T2 HASTE) magnetic resonance imaging (MRI) sequences in screening for spinal cord syrinx in neonates with spinal dysraphism has not been reported in the literature. OBJECTIVE: To review our experience using T2 HASTE imaging of the spine (i.e., rapid spine MRI) in non-sedated neonates for detecting spinal cord syrinx in neonates with spinal dysraphism. MATERIALS AND METHODS: We performed a retrospective search of our radiology database for neonates with spinal dysraphism who had rapid spine MRIs between May 2017 to February 2020...
September 19, 2020: World Neurosurgery
Yan-Peng Li, Zhong Tai, Zhi-Pang Huang, Ru-Liang Pan, Paul A Garber, Feng-Qin Yu, Wen Xiao
Birth attendance, or midwifery service, is an important characteristic in human evolution, and has been argued to separate our lineage from other taxa in the animal kingdom. Recent studies, however, indicate that similar or analogous behaviors also may occur in a small number of nonhuman primate species. Here, we report the first case of both male and female attendance and female birth assistance in a wild species of nonhuman primate, the black-and-white snub-nosed monkey (Rhinopithecus bieti). At our field site in Yunnan, China we observed a diurnal birth event in which the leader male of a one-male unit (OMU) remained in close- proximity (0-2 meters) to the parturient, groomed her, and remained vigilant over a five hour pre- and postpartum period...
September 19, 2020: Behavioural Processes
Keiko Sato, Genta Kakiyama, Mitsuyoshi Suzuki, Nakayuki Naritaka, Hajime Takei, Hiroaki Sato, Akihiko Kimura, Tsuyoshi Murai, Takao Kurosawa, William M Pandak, Hiroshi Nittono, Toshiaki Shimizu
Bile acid compositions are known to change dramatically after birth with aging. However, no reports have described the transition of conjugated urinary bile acids from the neonatal period to adulthood, and such findings would noninvasively offer insights into hepatic function. The aim of this study was to investigate differences in bile acid species, conjugation rates, and patterns, and to pool characteristics for age groups. We measured urinary bile acids in spot urine samples from 92 healthy individuals ranging from birth to 58 years old using liquid chromatography tandem mass spectrometry (LC/ESI-MS/MS)...
September 19, 2020: Steroids
A F Macchione, V Trujillo, F Anunziata, M Sahonero, A Anastasia, P Abate, J C Molina
Early ethanol exposure alters neonatal breathing plasticity. Respiratory EtOH's effects are attributed to central respiratory network disruptions, particularly in the medullary serotonin (5 H T) system. In this study we evaluated the effects of neonatal pre-exposure to low/moderate doses upon breathing rates, activation patterns of brainstem's nuclei and expression of 5 H T2A and 2C receptors. At PD9, breathing frequencies, tidal volumes and apneas were examined in pups pre-exposed to vehicle or ethanol (2...
September 19, 2020: Behavioural Brain Research
Céline Thibault, Shavonne L Massey, Nicholas S Abend, Maryam Y Naim, Alexandra Zoraian, Athena F Zuppa
The objective of this study was to describe the pharmacokinetics (PK) of intravenous phenobarbital in neonates and infants on extracorporeal membrane oxygenation (ECMO) and to provide dosing recommendations in this population. We performed a retrospective single-center PK study of phenobarbital in neonates and infants on ECMO between January 1, 2014, and December 31, 2018. We developed a population PK model using nonlinear mixed-effects modeling, performed simulations using the final PK parameters, and determined optimal dosing based on attainment of peak and trough concentrations between 20 and 40 mg/L...
September 22, 2020: Journal of Clinical Pharmacology
Sedef Duran, Rıdvan Duran, Betül Acunaş, Gülay Cesur, Nükhet Aladağ Çiftdemir
OBJECTIVES: Preterm infants are at high risk for nutritional difficulties during the neonatal period and early childhood. Long-term nutritional difficulties contribute to unbalanced food intake and growth disorders and are the source of major emotional stress for the family. The aim of this study is to investigate the eating problems of late and moderately preterm (LMPT) infants at the age of two, and to examine the association of these problems with the mental status of their mothers...
September 21, 2020: Journal of Pediatric Gastroenterology and Nutrition
Mette Vingborg Eklund, Christina Prinds, Sofie Mørk, Maiken Damm, Sören Möller, Dorte Hvidtjørn
This study describes religious/spiritual beliefs, practices, changes, and needs among parents bereaved by pregnancy or neonatal loss, and assess gender differences in religiosity/spirituality, in this population. A cross-sectional study using data from the Danish cohort Life After the Loss was conducted. Data were gathered from a questionnaire survey collected between January 2016 and December 2019. Among 713 respondents, several answered in the affirmative to items related to religious/spiritual beliefs and practices...
September 22, 2020: Death Studies
Nuria Martín Ruiz, Segundo Rite Gracia, Juan Pablo García Íñiguez, María Pilar Samper Villagrasa
INTRODUCTION AND OBJECTIVE: neonatal hypoglycemia persistently offers multiple diagnostic controversies. This study aims to present the current situation regarding neonatal hypoglycaemia detection, and to gain insiht into the most widely used portable glucometers in neonatal units today. METHODS: an online questionnaire was prepared and sent to the members of the Spanish Society of Neonatology; a total of 75 hospitals participated. RESULTS: portable glucometers continue to be widely used in the neonatal population...
September 22, 2020: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Yongman Guo, Paul A Garber, Jundong Tian, Jiqi Lu
Lateralized behavior is considered an observable phenotype of cerebral functional asymmetry and has been documented in many mammalian species. In the present study, we examined evidence of lateralization in neonatal nipple contact, maternal cradling, and the relationship between these two behaviors during the first 12 weeks of life in wild Taihangshan macaques (Macaca mulatta tcheliensis). The results showed that across our sample of nine mother-infant dyads: (1) Seven of nine neonates exhibited a significant left-side nipple preference during the first 12 weeks of life, whereas eight of nine mothers displayed a significant right-side cradling preference; (2) at the population level, there was a significant preference for left nipple contact by neonatal Taihangshan macaques and a significant right-hand maternal cradling preference; (3) at the population level, there was a nonsignificant negative correlation between neonatal nipple preference and maternal cradling bias; and (4) the strength of individual neonatal nipple preference and maternal cradling laterality were not correlated...
September 22, 2020: American Journal of Primatology
Yaniv Zipori, Ragda Zidan, Roy Lauterbach, Arin Hagag, Yuval Ginsberg, Ido Solt, Zeev Weiner, Amir Kugelman, Ron Beloosesky
INTRODUCTION: Our objective was to evaluate whether there is a relationship between the "time during the day" of maternal betamethasone administration between 24 and 34 weeks' gestation and the risk for neonatal hypoglycemia. MATERIAL AND METHODS: A retrospective study included cases between 2008 and 2018. Eligible cases were pregnant women with singleton pregnancies who received a single course of betamethasone between 24 and 34 weeks' gestation. Each woman was allocated into one of four pre-defined groups based on the time when intramuscular betamethasone was administered...
September 22, 2020: Archives of Gynecology and Obstetrics
Ivett Dorina Szeredi, Gábor Jancsó, Orsolya Oszlács, Péter Sántha
Peripheral nerve injury is associated with spinal microgliosis which plays a pivotal role in the development of neuropathic pain behavior. Several agents of primary afferent origin causing the microglial reaction have been identified, but the type(s) of primary afferents that release these mediators are still unclear. In this study, specific labeling of C-fiber spinal afferents by lectin histochemistry and selective chemodenervation by capsaicin were applied to identify the type(s) of primary afferents involved in the microglial response...
September 22, 2020: Cell and Tissue Research
Kathleen M Baggett, Betsy Davis, Susan H Landry, Edward G Feil, Anna Whaley, Alana Schnitz, Craig Leve
BACKGROUND: Neonatal intensive care unit (NICU) history, combined with systemic inequities for mothers of nondominant cultures and mothers who are socioeconomically disadvantaged, places infants at an extraordinary risk for poor developmental outcomes throughout life. Although receipt of early intervention (EI) is the best single predictor of developmental outcomes among children with and at risk for early developmental delays, mothers and infants with the greatest needs are least likely to receive EI...
September 22, 2020: Journal of Medical Internet Research
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September 22, 2020: Journal of Paediatrics and Child Health
C J J Cuijpers, J van 't Hooft, C Schneeberger, J H van der Lee, N E Simons, M A van Os, J van der Ven, C J M de Groot, B W J Mol, A G van Wassenaer-Leemhuis
OBJECTIVE: To evaluate, in children born to women with a short cervix, and otherwise low-risk , the long-term outcomes after antenatal vaginal progesterone versus placebo (follow-up of the Triple P trial). METHODS: The Triple P trial randomized low risk women (n=80) with a short cervix at screening (≤30mm), to progesterone (n=41) or placebo (n=39). At 2'years corrected age children were invited for a neurodevelopmental assessment using the Bayley Scales of Infant and Toddler Development-third edition (BSID-III) and a neurological and physical examination by a blinded assessor...
September 22, 2020: Ultrasound in Obstetrics & Gynecology
Raffaele Falsaperla, Simona Zaami, Maria Giovanna Aguglia, Catia Romano, Agnese Suppiej, Luigi Memo
INTRODUCTION: Neonatal abstinence syndrome (NAS) in a newborn is a result of the sudden discontinuation of exposure to psychotropic drugs abused by the mother during pregnancy. Since forty decades, the standardized Finnegan Neonatal Abstinence Scoring Tool (FNAST) documents the infant withdrawal, and initiate the appropriate treatment regimen, when elevated scored are reported. Whereas FNAST is successfully applied for opioids NAS, in case of other psychotropic drugs and especially cocaine, the tool is not always efficacious or predictive...
July 2020: Annali Dell'Istituto Superiore di Sanità
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