Chaeyoun Oh, Sanghoon Lee, Hye Kyung Chang, Soo Min Ahn, Kyunghee Chae, Sujeong Kim, Sukil Kim, Jeong Meen Seo
BACKGROUND: In the past, general surgeons (GSs) without a pediatric surgical subspecialty often performed surgery on children and, even now, GSs are performing many pediatric surgeries. We aimed to investigate the involvement of pediatric surgeons (PSs) and GSs in pediatric surgery, compare the outcomes of surgery in the neonatal intensive care unit (NICU), and estimate the appropriate PS workforce in Korea. METHODS: We used surgical data from the National Health Insurance Service database that was collected from patients under the age of 19 years in hospitals nationwide from January 2002 to December 2017...
May 10, 2021: Journal of Korean Medical Science
Wesam Sourour, Valeria Sanchez, Michel Sourour, Jordan Burdine, Elizabeth Rodriguez Lien, Diana Nguyen, Sunil K Jain
OBJECTIVE:  This study aimed to determine if prolonged antibiotic use at birth in neonates with a negative blood culture increases the total cost of hospital stay. STUDY DESIGN:  This was a retrospective study performed at a 60-bed level IV neonatal intensive care unit. Neonates born <30 weeks of gestation or <1,500 g between 2016 and 2018 who received antibiotics were included. A multivariate linear regression analysis was conducted to determine if clinical factors contributed to increased hospital cost or length of stay...
May 11, 2021: American Journal of Perinatology
Mehmet Mutlu, Filiz Aktürk-Acar, Şebnem Kader, Yakup Aslan, Gülay Karagüzel
OBJECTIVE:  The study aimed to analyze the risk factors and clinical features of metabolic bone disease of prematurity (MBDP) in premature infants compared with infants of similar gestational age and birthweight without MBDP. STUDY DESIGN:  This retrospective case-control study was performed by comparing 81 cases of MBDP with 63 controls to identify potential risk factors. Premature infants with a gestational age ≤33 weeks and birthweight <1,500 g were included...
May 11, 2021: American Journal of Perinatology
Mohammad A Attar, Rachael A Pace, Robert E Schumacher
OBJECTIVE:  We evaluate patient characteristics, hospital course, and outcome by type discharge pulmonary support; mechanical ventilation (MV) or with tracheotomy masks (TM). STUDY DESIGN:  We reviewed records of infants admitted to the neonatal intensive care unit (NICU) that underwent tracheotomy within their first year of life between 2006 and 2017. We evaluated patient characteristics, referral pattern, destination of discharge, and outcome by type of pulmonary support at discharge (MV vs...
May 11, 2021: American Journal of Perinatology
Rima Dardik, Ophira Salomon
Intracranial hemorrhage (ICH) associated with fetal/neonatal alloimmune thrombocytopenia (FNAIT) is attributed mainly to endothelial damage caused by binding of maternal anti-HPA-1a antibodies to the αvβ3 integrin on endothelial cells (ECs). We examined the effect of anti-HPA-1a antibodies on EC function using 2 EC lines from different vascular beds, HMVEC of dermal origin and hCMEC/D3 of cerebral origin. Anti-HPA-1a sera significantly increased apoptosis in both HMVEC and hCMEC/D3 cells and permeability in hCMEC/D3 cells only...
May 11, 2021: Journal of Vascular Research
Jing Ye, Zhenghua Xiao, Lu Gao, Jing Zhang, Ling He, Han Zhang, Qi Liu, Gang Yang
Cardiomyocyte (CM) transplantation is a promising option for regenerating infarcted myocardium. However, poor cell survival and residence rates reduce the efficacy of cell transplantation. Gelatin (GA) hydrogel as a frequently-used cell carrier is a possible approach to increase the survival rate of CMs. In this study, microbial transglutaminase (mTG) and chemical crosslinkers glutaraldehyde (GTA), genipin (GP), and 1-ethyl-3-(3-dimethyl aminopropyl)-carbodiimide (EDC) were employed to prepare GA hydrogels...
May 11, 2021: Biomedical Materials
Jinhua Liao, Guihua Liu, Namei Xie, Shuo Wang, Taohong Wu, Ying Lin, Rongfang Hu, Hong-Gu He
BACKGROUND: A few positive effects of mothers' voice on physiological outcomes have been studied and limited studies have focused on the level of cortisol. In addition, white noise has recently been found to be beneficial for human sleep, but studies in premature infants were limited and no study has compared the effects of mothers' voice and white noise on premature infants. OBJECTIVE: To examine the effects of mothers' voice and white noise on sleep-wake patterns, salivary cortisol levels, weight gain, heart rate, and oxygen saturation of premature infants in a neonatal intensive care unit (NICU)...
March 26, 2021: International Journal of Nursing Studies
Siti Yuyun Rahayu Fitri, Khadidjah Siti, Nurhidayah Ikeu, Nenden Nur Asriyani Maryam
INTRODUCTION: Neonates who undergo painful medical procedures should be given analgesics to reduce future adverse risks. The evidence for massage therapy (MT) as an analgesic method still varies, both in its terminology and implementation. Only a few studies on this topic have been conducted using a standardised trial approach. This review can thus become the basis for better future research. OBJECTIVE: This review aims to identify literature on MT practices as a method to manage or control pain in neonates undergoing painful procedures...
May 8, 2021: Complementary Therapies in Medicine
Ian J Penkala, Derek C Liberti, Joshua Pankin, Aravind Sivakumar, Madison M Kremp, Sowmya Jayachandran, Jeremy Katzen, John P Leach, Rebecca Windmueller, Katharine Stolz, Michael P Morley, Apoorva Babu, Su Zhou, David B Frank, Edward E Morrisey
Regeneration of the architecturally complex alveolar niche of the lung requires precise temporal and spatial control of epithelial cell behavior. Injury can lead to a permanent reduction in gas exchange surface area and respiratory function. Using mouse models, we show that alveolar type 1 (AT1) cell plasticity is a major and unappreciated mechanism that drives regeneration, beginning in the early postnatal period during alveolar maturation. Upon acute neonatal lung injury, AT1 cells reprogram into alveolar type 2 (AT2) cells, promoting alveolar regeneration...
May 5, 2021: Cell Stem Cell
Mark Deyo-Svendsen, Sara Herrmann, Christina Andrist, Michael Phillips, Matthew Cabrera Svendsen, Rachel Oldfather Svendsen
BACKGROUND: Neonatal hypoglycemia (glucose <47) is the most common metabolic problem in newborns (incidence 5% - 15%) and can cause adverse outcomes, even in the absence of noticeable symptoms. Oral glucose gel (OGG) is safe and effective for treatment of neonatal hypoglycemia. In order to reduce interventions such as intravenous (IV) dextrose administration and neonatal intensive care unit (NICU) transfer, in October 2017, we implemented a protocol in our Level 1 rural community hospital to identify newborns with asymptomatic hypoglycemia based on risk factors and treat them with OGG...
April 2021: WMJ: Official Publication of the State Medical Society of Wisconsin
Jenna L Racine, Katie Gillespie, Kathy Hartke, Cynthia Wautlet, Kathleen M Antony
OBJECTIVE: The American College of Obstetrics and Gynecology (ACOG) has recommended every hospital disclose their level of maternal care (LOMC) to categorize the capabilities of their birthing center and regionalize perinatal care. Of the 98 birthing centers in Wisconsin, 44% have self-disclosed their LOMC. In many states, disclosing LOMC is mandated but, despite evidence and professional association recommendations, Wisconsin relies on voluntary self-reporting. We surveyed all birthing centers in Wisconsin to better understand the barriers to disclosing their LOMC...
April 2021: WMJ: Official Publication of the State Medical Society of Wisconsin
Sithyphone Khounsaknalath, Kotaro Etoh, Kaori Sakuma, Kunihiko Saito, Akira Saito, Tsuyoshi Abe, Fumio Ebara, Toshie Sugiyama, Eiji Kobayashi, Takafumi Gotoh
The study was conducted to clarify how early high plane of nutrition related to metabolic imprinting affected growth, carcass characteristics, and meat quality of grass-fed Wagyu (Japanese Black cattle). Wagyu steers were allocated randomly into two dietary groups: 1) steers fed milk replacer (crude protein 26.0%, crude fat 25.5%; maximum intake 0.6 kg/d) until 3 mo of age and then fed roughage (orchard grass hay) ad libitum from 4 to 10 mo of age (roughage group, RG; n = 11); 2) steers fed milk replacer (maximum intake of 1...
May 11, 2021: Journal of Animal Science
Joshua A Rushakoff, Alexander Polyak, Jayne Caron, Kristin Parrinella, Reza Salabat, Melissa Wong, Dominic Emerson
Coronavirus disease 2019 (COVID-19) causes the development of severe acute respiratory distress syndrome. Pregnant women may be at increased risk for the development of severe disease. We present the case of a pregnant patient who developed respiratory failure due to COVID-19 and rapidly decompensated requiring intubation. Despite mechanical ventilation, the patient's respiratory status continued to worsen. At bedside, cardiothoracic surgeons, obstetricians, intensivists, and neonatologists discussed balancing the risk of COVID-19 and respiratory failure to the patient, premature delivery to the neonate, potential coagulopathy associated with COVID-19, and the need for anticoagulation with mechanical circulatory support...
May 11, 2021: Journal of Cardiac Surgery
Gupta Puneet, Kumar Surender, Sharma Shashi Sudhan
BACKGROUND: Impact of SARS-CoV-2 infection in pregnant women and their neonates is exotic area of research now a days. Till date, there is limited knowledge about SARS-CoV-2 prevalence, maternal and perinatal outcomes of pregnant women at term in middle and low income countries. METHODS: In present retro-prospective study, medical records of pregnant women admitted for delivery were reviewed from the largest Covid-19 dedicated Shri Maharaja Gulab Singh (SMGS) maternity hospital...
May 11, 2021: Journal of Medical Virology
Youwei Bao, Xiaoli Pan, Jiewen Pan, Shuqing Pan, Danyan Zhuang, Haibo Li, Zongfu Cao
OBJECTIVE: To establish a newborn screening system for Duchenne muscular dystrophy (DMD) through assessment of MM isoenzyme of creatine kinase (CK-MM) activity. METHODS: The CK-MM level was detected using dry blood spot filter paper from 10 252 male newborns. The results were grouped based on their gestational age, sampling time and intervals between the experiments. The threshold value for CK-MM necessitating genetic testing was determined. Next-generation sequencing (NGS) was carried out for those with a CK-MM value over the threshold, and the result was verified by multiplex ligation-dependent probe amplification (MLPA)...
May 10, 2021: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Division Of Genetics And Metabolomics Child Diseases And Health Care Branch Chinese Association For Maternal And Child Health, Xiaohong Chen, Yun Sun, Yanling Yang, Lianshu Han, Xinwen Huang
Multiple acyl-CoA dehydrogenase deficiency (MADD), also known as glutaricacidemia type II, is a relatively common disorder of fatty acid oxidation metabolism. The clinical manifestations are highly heterogeneous, symptoms can develop from newborn to adulthood. Neonatal onset type is more serious with high mortality. The symptoms of late onset patients include lipid deposition myopathy and vomiting, liver disease, and encephalopathy. Analysis of blood acyl carnitine spectrum by tandem mass spectrometry can be used for the screening...
May 10, 2021: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Sahar Naeemi, Akram Eidi, Ramezan Khanbabaee, Homan Sadri-Ardekani, Abdol-Mohammad Kajbafzadeh
PURPOSE: Successful in vitro transplantation of spermatogonial stem cells (SSCs) demands effective culture systems for SSCs proliferation and differentiation. Natural extracellular matrix (ECM) creates a microenvironment suitable for culture of stem cells. In the present study, we intended to assess the capability of the porous scaffold consisting of hyaluronic acid (HA), chitosan, and decellularized testicular matrix (DTM) as a proper niche for SSCs seeding. METHODS: The testes of four NMRI mice were extracted for further detergent-based decellularization process...
May 11, 2021: International Urology and Nephrology
Marcello Napolitano, Stéphanie Franchi-Abella, Beatrice Maria Damasio, Thomas Angell Augdal, Fred Efraim Avni, Costanza Bruno, Kassa Darge, Damjana Ključevšek, Annemieke Simone Littooij, Luisa Lobo, Hans-Joachim Mentzel, Michael Riccabona, Samuel Stafrace, Seema Toso, Magdalena Maria Woźniak, Giovanni Di Leo, Francesco Sardanelli, Lil-Sofie Ording Müller, Philippe Petit
We aim to present a practical approach to imaging in suspected biliary atresia, an inflammatory cholangiopathy of infancy resulting in progressive fibrosis and obliteration of extrahepatic and intrahepatic bile ducts. Left untreated or with failure of the Kasai procedure, biliary atresia progresses to biliary cirrhosis, end-stage liver failure and death within the first years of life. Differentiating biliary atresia from other nonsurgical causes of neonatal cholestasis is difficult as there is no single method for diagnosing biliary atresia and clinical, laboratory and imaging features of this disease overlap with those of other causes of neonatal cholestasis...
May 11, 2021: Pediatric Radiology
Zhicheng Zhu, Lin Yuan, Jin Wang, Qiuping Li, Chuanzhong Yang, Xirong Gao, Shangqin Chen, Shuping Han, Jiangqin Liu, Hui Wu, Shaojie Yue, Jingyun Shi, Rui Cheng, Xiuyong Cheng, Tongyan Han, Hong Jiang, Lei Bao, Chao Chen
Importance: Extreme prematurity is associated with a substantial burden on health care systems worldwide. However, little is known about the prognosis of infants born extremely preterm in developing countries, such as China. Objective: To describe survival and major morbidity among infants born extremely preterm in China over the past decade. Design, Setting, and Participants: This retrospective cohort study was conducted from January 1, 2010, through December 31, 2019...
May 3, 2021: JAMA Network Open
Natalie Linn, Kimberly Stephens, Brenda Swanson-Biearman, Deborah Lewis, Kimberly Whiteman
Purpose: To improve outcomes of infants with neonatal abstinence syndrome (NAS) by implementing an evidence-based approach to care.Methods: An interdisciplinary team developed and implemented an educational module about the elements and principles of trauma-informed care (TIC) and standardized education on NAS for mothers with substance use disorder (SUD). The team collaborated with community behavioral health professionals to secure the services of a certified recovery specialist. Primary outcome measures of average length of stay (LOS) and admissions to special care nursery (SCN) for NAS infants were analyzed...
May 3, 2021: MCN. the American Journal of Maternal Child Nursing
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