Leanne M Redman, Kimberly L Drews, Samuel Klein, Linda Van Horn, Rena R Wing, Xavier Pi-Sunyer, Mary Evans, Kaumudi Joshipura, S Sonia Arteaga, Alison G Cahill, Rebecca G Clifton, Kimberly A Couch, Paul W Franks, Dympna Gallagher, Debra Haire-Joshu, Corby K Martin, Alan M Peaceman, Suzanne Phelan, Elizabeth A Thom, Susan Z Yanovski, William C Knowler
AIMS: To examine the effect of lifestyle (diet and physical activity) interventions on the prevalence of GDM, considering the method of GDM ascertainment and its association with early pregnancy characteristics and maternal and neonatal outcomes in the LIFE-Moms consortium. METHODS: LIFE-Moms evaluated the effects of lifestyle interventions to optimize gestational weight gain in 1,148 pregnant women with BMI ≥25 kg/m2 and without known diabetes at enrollment, compared with standard care...
November 22, 2020: Diabetes Research and Clinical Practice
Marina Brailova, Damien Bouvier, Adeline Regnier, Marie Szymanowski, Vincent Sapin, Régine Minet-Quinard
In order to propose a course of action to be taken in the face of any hyperhomocysteinemia, we have reported for the first time in a French journal the recommendations made within the framework of the European E-HOD project for the diagnosis and treatment of remethylation disorders. The remethylation route ensures homocysteine-methionine conversion. It is linked to the folate cycle and the intracellular metabolism of cobalamins. Remethylation disorders can be classified into three groups: 1) isolated disorders (cblD-HC, cblE, cblG) corresponding to an isolated deficit in the production of methylcobalamin, cofactor of methionine synthase; 2) combined disorders (cblC, cblD-MMA/HC, cblF, cblJ) corresponding to an alteration of the transport and intracellular metabolism of cobalamins, which causes a defect in the synthesis of the two functional forms of cobalamin: methylcobalamin and adenosylcobalamin, a cofactor for methyl malonylCoA mutase; 3) MTHFR deficit, an abnormality of the folate cycle...
November 24, 2020: Annales de Biologie Clinique
Aya Mohr-Sasson, Idan Timor, Raanan Meyer, David Stockheim, Raoul Orvieto, Roy Mashiach
PURPOSE: To compare the prevalence of placental abnormalities in pregnancy following different modes of operative myomectomy. METHODS: A retrospective cohort study, including all women after myomectomy that gave birth in a single tertiary care center from February 2011 to January 2019. Data was collected from the patients' medical files and completed by telephone questionnaire. Patients were stratified to 3 groups, according to the mode of operative myomectomy (laparotomy, laparoscopy, hysteroscopy)...
November 25, 2020: Journal of Maternal-fetal & Neonatal Medicine
Carlos Perez, Lisa Felix, Simone Durry, Christine R Rose, Ghanim Ullah
Spontaneous neuronal and astrocytic activity in the neonate forebrain is believed to drive the maturation of individual cells and their integration into complex brain-region-specific networks. The previously reported forms include bursts of electrical activity and oscillations in intracellular Ca2+ concentration. Here, we use ratiometric Na+ imaging to demonstrate spontaneous fluctuations in the intracellular Na+ concentration of CA1 pyramidal neurons and astrocytes in tissue slices obtained from the hippocampus of mice at postnatal days 2-4 (P2-4)...
November 25, 2020: Journal of Neurophysiology
Anne T Berg, Hannah Palac, Greta Wilkening, Frank Zelko, Leah Schust Meyer
OBJECTIVE: SCN2A-associated developmental and epileptic encephalopathies (DEEs) present with seizures, developmental impairments, and often both. We sought to characterize the level and pattern of development in children with SCN2A variants, and to address the sensitivity of the Vineland Adaptive Behavior Scales (VABS) in measuring changes over time in children with SCN2A-DEEs. METHODS: Clinical histories for participants with pathogenic SCN2A variants in the Simons SearchLight project were analyzed for descriptive purposes...
November 25, 2020: Epilepsia
Meredith E Mowitz, Alexandra Mangili, Linda Han, Rajeev Ayyagari, Wei Gao, Jessie Wang, Jing Zhao, Sujata P Sarda
OBJECTIVE: To evaluate the prevalence of chronic respiratory morbidity (CRM) in preterm infants (born ≤28 weeks gestational age (GA)) and compare healthcare resource utilization and costs among infants with/without CRM, and with/without bronchopulmonary dysplasia (BPD). METHODS: Commercial claims data from the Truven MarketScan database were retrospectively analyzed. Included infants were born ≤28 weeks GA and admitted to a neonatal intensive care unit (January 2009-June 2016)...
November 25, 2020: Expert Review of Pharmacoeconomics & Outcomes Research
Arieh Riskin, Omer Itzchaki, David Bader, Adir Iofe, Arina Toropine, Shlomit Riskin-Mashiah
BACKGROUND: The incidence of gestational diabetes mellitus (GDM) is increasing in parallel to the worldwide obesity and type 2 diabetes pandemic. Both GDM and pre-gestational diabetes mellitus (PGDM) are associated with short- and long-term consequences in the offspring. There are few recent studies addressing outcomes of newborns born to women diagnosed with GDM and PGDM in Israel. OBJECTIVES: To assess perinatal complications in offspring of women with GDM and PGDM...
September 2020: Israel Medical Association Journal: IMAJ
Ella Schwarzmann Aley-Raz, Gil Talmon, Marina Peniakov, Jamal Hasanein, Clari Felszer-Fisch, Scott A Weiner
BACKGROUND: Neonatal hypothermia (< 36°C) has been associated with both neonatal morbidity and mortality. OBJECTIVES: To develop a multifactorial approach to reduce the incidence of neonatal hypothermia at admission to the neonatal intensive care unit. METHODS: The approach involved a detailed quality improvement (QI) plan, which included the use of occlusive wrapping and exothermic mattresses as well as higher delivery and operating room environmental temperatures...
September 2020: Israel Medical Association Journal: IMAJ
Naftali Justman, Gilad Shahak, Ola Gutzeit, Dikla Ben Zvi, Yuval Ginsberg, Ido Solt, Dana Vitner, Ron Beloosesky, Zeev Weiner, Yaniv Zipori
BACKGROUND: The World Health Organization classified coronavirus disease-19 (COVID-19) as a pandemic and recommends strict restrictions regarding most aspects of daily activities. OBJECTIVES: To evaluate whether the pandemic has changed the prenatal care and pregnancy outcome in pregnant women without COVID-19. METHODS: The authors conducted a cross-sectional study to describe changes in outpatient clinic visits and to compare the rates of cesarean and instrumental deliveries between two periods of time: March-April 2020 (during the COVID-19 outbreak) with March-April of the preceding year, 2019...
September 2020: Israel Medical Association Journal: IMAJ
Domenico Minasi, Sara Manti, Fernanda Chiera, Amelia Licari, Gian Luigi Marseglia
Urticaria is a mast cell-driven disease presenting with wheals, angioedema, or both. Acute urticaria (AU) lasts < 6 weeks. AU is a not common condition in newborns and infants since they are showing an immune system functionally insufficient. In newborns and infants, AU is typically generalized and featured by large, annular, or geographic plaques, often slightly raised. The clinical features of the disease depend on the peculiar structure of neonatal and infant skin. A careful morphological examination of the lesions is essential to differentiate AU from other skin eruptions that may have overlapping features and to treat it adequately...
November 2020: Pediatric Allergy and Immunology
Carlo Pietrasanta, Andrea Ronchi, Federico Schena, Claudia Ballerini, Lea Testa, Giacomo Artieri, Domenica Mercadante, Fabio Mosca, Lorenza Pugni
SARS-CoV-2 infection in the neonatal period poses previously unmet challenges to obstetricians and neonatologists, but several key questions are yet to be answered. Few cases of presumed in utero vertical transmission of the virus from infected mothers to fetuses have been reported, but stronger evidence is needed, from larger datasets with multiple biospecimens rigorously analyzed. Whether acquired before or after birth, SARS-CoV-2 infection in neonates can be symptomatic, but our comprehension of neonatal immune response and the subsequent clinical characteristics of COVID-19 in early life are incomplete...
November 2020: Pediatric Allergy and Immunology
Qingnian Goh, Sia Nikolaou, Kritton Shay-Winkler, Marianne E Emmert, Roger Cornwall
Neonatal brachial plexus injury (NBPI) causes disabling and incurable contractures, or limb stiffness, which result from proteasome-mediated protein degradation impairing the longitudinal growth of neonatally denervated muscles. We recently showed in a mouse model that the 20S proteasome inhibitor, bortezomib, prevents contractures after NBPI. Given that contractures uniquely follow neonatal denervation, the current study tests the hypothesis that proteasome inhibition during a finite window of neonatal development can prevent long-term contracture development...
November 25, 2020: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Raziye Celen, Fatma Tas Arslan, Hanifi Soylu
BACKGROUND: The present study aims to test the effect of Safe Individualized Nipple-Feeding Competence (SINC) protocol on the preterm infants' weight gain, transition to oral feeding, and duration of hospitalization. METHODS: The procedure was designed as a single-blind, parallel-group randomized controlled trial. The trial was conducted in a neonatal intensive care unit in Konya. The data were collected from 80 preterm infants between February 2018 and March 2019...
November 24, 2020: JPEN. Journal of Parenteral and Enteral Nutrition
Xianxian Jia, Bo Wu, Jinhui Huang, Lin Fan, Miao Yang, Wei Xu
Arrested alveolar development is the main pathological characteristic of neonatal bronchopulmonary dysplasia (BPD); however, a number of studies aiming to improve alveolarization have focused on alveolar epithelial cell damage and impairment. Previously, the authors reported that the Wnt signaling plays a key role in alveolar injury and repair by regulating alveolar epithelial type II cell (AECII) proliferation and differentiation. In the present study, the authors wished to investigate whether Yes‑associated protein (YAP), a transcriptional coactivator in the Hippo signaling pathway, affects AECII proliferation and differentiation via the Wnt/β‑catenin pathway in BPD...
November 18, 2020: International Journal of Molecular Medicine
Morgan L Sherer, Jun Lei, Patrick Creisher, Minyoung Jang, Ramya Reddy, Kristin Voegtline, Sarah Olson, Kirsten Littlefield, Han-Sol Park, Rebecca L Ursin, Abhinaya Ganesan, Theresa Boyer, Diane M Brown, Samantha N Walch, Annukka A R Antar, Yukari C Manabe, Kimberly Jones-Beatty, William Christopher Golden, Andrew J Satin, Jeanne S Sheffield, Andrew Pekosz, Sabra L Klein, Irina Burd
Importance: The effects of SARS-CoV-2 infection on immune responses during pregnancy have not been systematically evaluated. Objective: To assess the impact of SARS-CoV-2 infection during pregnancy on inflammatory and humoral responses in maternal and fetal samples and compare antibody responses to SARS-CoV-2 among pregnant and non-pregnant women. Design: Immune responses to SARS-CoV-2 were analyzed using samples from pregnant and non-pregnant women who had either tested positive or negative for SARS-CoV-2...
November 16, 2020: medRxiv: the preprint server for health sciences
Ronald Okidi, Vanusa Da Consolação Sambo, Jacob Eyul
Umbilical stump sepsis in a nonpassively immunized neonate poses a high risk to neonatal tetanus. Management of neonatal tetanus is still a great challenge in resource-limited settings where some health facilities lack tetanus toxoid containing vaccines, ventilator support, and inaccessibility of tetanus immunoglobulin.
November 2020: Clinical Case Reports
Giovanna Marchini, Daniel Martín Muñoz, Ylva Vladic Stjernholm
A neonatal parietal bone fracture was complicated by subgaleal and subdural hematomas after a vacuum extraction delivery. Low-dose computer tomography visualized a comminuted skull fracture. Close observation of infants delivered by vacuum extraction, conservative management after a skull fracture, and further studies on vacuum traction monitoring are warranted.
November 2020: Clinical Case Reports
Wajeeha Syed, Nazia Liaqat, Qudsia Qazi, Sumaira Yasmeen
Objectives: To determine relationship between immediate postpartum umbilical cord pH, fetal distress and neonatal outcome. Methods: This descriptive cross-sectional study was conducted in the department of Gynaecology, Lady Reading Hospital Peshawar, Pakistan, from January 2019 to July 2019. This study included 27 full-term pregnant women who had abnormal CTG during the active or latent phase of labour. Data were analyzed by IBM SPSS Statistics for Windows, Version 23...
November 2020: Pakistan Journal of Medical Sciences Quarterly
Seine A Shintani, Takumi Washio, Hideo Higuchi
The heart rhythm is maintained by oscillatory changes in [Ca2+ ]. However, it has been suggested that the rapid drop in blood pressure that occurs with a slow decrease in [Ca2+ ] preceding early diastolic filling is related to the mechanism of rapid sarcomere lengthening associated with spontaneous tension oscillation at constant intermediate [Ca2+ ]. Here, we analyzed a new type of oscillation called hyperthermal sarcomeric oscillation. Sarcomeres in rat neonatal cardiomyocytes that were warmed at 38-42 °C oscillated at both slow (~ 1...
November 24, 2020: Scientific Reports
Mandy E Spoorenberg, Renate E Wachters-Hagedoorn, Richard van Wijk, Jacques B de Kok
Infantile pyknocytosis is a rare and self-limiting cause of hemolytic anemia in neonates. It can result in severe anemia and hyperbilirubinemia. The pathogenesis is unknown: a genetic origin has been discussed; however, based on the current literature it is not clear which genetic mutations should be considered. We present a case of a premature twin, in whom genetic screening was performed. Genetic mutations in 46 genes associated with hereditary hemolytic anemia and dyserythropoietic anemia were tested. No mutations were found...
November 23, 2020: Journal of Pediatric Hematology/oncology
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