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JOURNAL ARTICLE
Janie Degré-Pelletier, Éliane Danis, Véronique D Thérien, Boris Bernhardt, Elise B Barbeau, Isabelle Soulières
While fronto-posterior underconnectivity has often been reported in autism, it was shown that different contexts may modulate between-group differences in functional connectivity. Here, we assessed how different task paradigms modulate functional connectivity differences in a young autistic sample relative to typically developing children. Twenty-three autistic and 23 typically developing children aged 6 to 15 years underwent functional magnetic resonance imaging (fMRI) scanning while completing a reasoning task with visuospatial versus semantic content...
May 2, 2024: Cerebral Cortex
#22
JOURNAL ARTICLE
Janelle Liu, Jessica B Girault, Tomoyuki Nishino, Mark D Shen, Sun Hyung Kim, Catherine A Burrows, Jed T Elison, Natasha Marrus, Jason J Wolff, Kelly N Botteron, Annette M Estes, Stephen R Dager, Heather C Hazlett, Robert C McKinstry, Robert T Schultz, Abraham Z Snyder, Martin Styner, Lonnie Zwaigenbaum, John R Pruett, Joseph Piven, Wei Gao
The amygdala undergoes a period of overgrowth in the first year of life, resulting in enlarged volume by 12 months in infants later diagnosed with ASD. The overgrowth of the amygdala may have functional consequences during infancy. We investigated whether amygdala connectivity differs in 12-month-olds at high likelihood (HL) for ASD (defined by having an older sibling with autism), compared to those at low likelihood (LL). We examined seed-based connectivity of left and right amygdalae, hypothesizing that the HL and LL groups would differ in amygdala connectivity, especially with the visual cortex, based on our prior reports demonstrating that components of visual circuitry develop atypically and are linked to genetic liability for autism...
May 2, 2024: Cerebral Cortex
#23
JOURNAL ARTICLE
S Hossein Fatemi, Arthur Eschenlauer, Justin Aman, Timothy D Folsom, Thierry Chekouo
Autism spectrum disorder (ASD) is a developmental disorder with a rising prevalence and unknown etiology presenting with deficits in cognition and abnormal behavior. We hypothesized that the investigation of the synaptic component of prefrontal cortex may provide proteomic signatures that may identify the biological underpinnings of cognitive deficits in childhood ASD. Subcellular fractions of synaptosomes from prefrontal cortices of age-, brain area-, and postmortem-interval-matched samples from children and adults with idiopathic ASD vs...
May 2, 2024: Cerebral Cortex
#24
JOURNAL ARTICLE
Cuc Thi Kim Mai, Janne Halme, Heikki A Nurmi, Aldeliane M da Silva, Gabriela S Lorite, David Martineau, Stéphanie Narbey, Naeimeh Mozaffari, Robin H A Ras, Syed Ghufran Hashmi, Maja Vuckovac
Despite attractive cost-effectiveness, scalability, and superior stability, carbon-based printable perovskite solar cells (CPSCs) still face moisture-induced degradation that limits their lifespan and commercial potential. Here, the moisture-preventing mechanisms of thin nanostructured super-repellent coating (advancing contact angle >167° and contact angle hysteresis 7°) integrated into CPSCs are investigated for different moisture forms (falling water droplets vs water vapor vs condensed water droplets)...
May 2, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
#25
JOURNAL ARTICLE
Garrett D Santis, Yuika Okura, Keisuke Hirata, Shun-Ichi Ishiuchi, Masaaki Fujii, Sotiris S Xantheas
The binding affinity of nicotinoids to the binding residues of the α4 β2 variant of the nicotinic acetylcholine receptor (nAChR) was identified as a strong predictor of the nicotinoid's addictive character. Using ab initio calculations for model binding pockets of increasing size composed of 3, 6, and 14 amino acids (3AA, 6AA, and 14AA) that are derived from the crystal structure, the differences in binding affinity of 6 nicotinoids, namely, nicotine (NIC), nornicotine (NOR), anabasine (ANB), anatabine (ANT), myosmine (MYO), and cotinine (COT) were correlated to their previously reported doses required for increases in intracranial self-stimulation (ICSS) thresholds, a metric for their addictive function...
May 2, 2024: Journal of Physical Chemistry. B
#26
JOURNAL ARTICLE
Keng Ioi Vong, Sangmoon Lee, Kit Sing Au, T Blaine Crowley, Valeria Capra, Jeremiah Martino, Meade Haller, Camila Araújo, Hélio R Machado, Renee George, Bryn Gerding, Kiely N James, Valentina Stanley, Nan Jiang, Kameron Alu, Naomi Meave, Anna S Nidhiry, Fiza Jiwani, Isaac Tang, Ashna Nisal, Ishani Jhamb, Arzoo Patel, Aakash Patel, Jennifer McEvoy-Venneri, Chelsea Barrows, Celina Shen, Yoo-Jin Ha, Robyn Howarth, Madison Strain, Allison Elizabeth Ashley-Koch, Matloob Azam, Sara Mumtaz, Gyang Markus Bot, Richard H Finnell, Zoha Kibar, Ahmed I Marwan, Gia Melikishvili, Hal S Meltzer, Osvaldo M Mutchinick, David A Stevenson, Henry J Mroczkowski, Betsy Ostrander, Erica Schindewolf, Julie Moldenhauer, Elaine H Zackai, Beverly S Emanuel, Sixto Garcia-Minaur, Beata A Nowakowska, Roger E Stevenson, Maha S Zaki, Hope Northrup, Hanna K McNamara, Kimberly A Aldinger, Ian G Phelps, Mei Deng, Ian A Glass, Bernice Morrow, Donna M McDonald-McGinn, Simone Sanna-Cherchi, Dolores J Lamb, Joseph G Gleeson, Allison Elizabeth Ashley Koch, Hal S Meltzer, Joan Le, Kit Sing Au, Hope Northrup, Gyang Markus Bot, Valeria Capra, Richard H Finnell, Zoha Kibar, Philip J Lupo, Helio R Machado, Camila Araújo, Tony Magana, Ahmed I Marwan, Gia Melikishvili, Osvaldo M Mutchinick, Roger E Stevenson, Anna Yurrita, Maha S Zaki, Sara Mumtaz, José Ramón Medina-Bereciartu, Caroline M Kolvenbach, Shirlee Shril, Friedhelm Hildebrandt, Mahmoud M Noureldeen, Aida Ms Salem, Yukitoshi Takahashi, Hormos Salimi-Dafsari, H Westley Phillips, Brian Hanak, Bülent Kara, Ayfer Sakarya Güneş, David D Gonda, Salman Kirmani, Tinatin Tkemaladze, Joseph G Gleeson
Meningomyelocele is one of the most severe forms of neural tube defects (NTDs) and the most frequent structural birth defect of the central nervous system. We assembled the Spina Bifida Sequencing Consortium to identify causes. Exome and genome sequencing of 715 parent-offspring trios identified six patients with chromosomal 22q11.2 deletions, suggesting a 23-fold increased risk compared with the general population. Furthermore, analysis of a separate 22q11.2 deletion cohort suggested a 12- to 15-fold increased NTD risk of meningomyelocele...
May 3, 2024: Science
#27
JOURNAL ARTICLE
Chengyi Luo, Haoqing Zhang, Vanessa P W Koh, John D Wilson, Anjun Chu, Murray J Holland, Ana Maria Rey, James K Thompson
Large ensembles of laser-cooled atoms interacting through infinite-range photon-mediated interactions are powerful platforms for quantum simulation and sensing. Here we realize momentum-exchange interactions in which pairs of atoms exchange their momentum states by collective emission and absorption of photons from a common cavity mode, a process equivalent to a spin-exchange or XX collective Heisenberg interaction. The momentum-exchange interaction leads to an observed all-to-all Ising-like interaction in a matter-wave interferometer...
May 3, 2024: Science
#28
JOURNAL ARTICLE
Mansure Schafasand, Andreas Franz Resch, Ankita Nachankar, Joanna Góra, Giovanna Martino, Erik Traneus, Lars Glimelius, Dietmar Georg, Piero Fossati, Antonio Carlino, Markus Stock
BACKGROUND: Carbon ion beams are well accepted as densely ionizing radiation with a high linear energy transfer (LET). However, the current clinical practice does not fully exploit the highest possible dose-averaged LET (LETd ) and, consequently, the biological potential in the target. This aspect becomes worse in larger tumors for which inferior clinical outcomes and corresponding lower LETd was reported. PURPOSE: The vicinity to critical organs in general and the inferior overall survival reported for larger sacral chordomas treated with carbon ion radiotherapy (CIRT), makes the treatment of such tumors challenging...
May 2, 2024: Medical Physics
#29
RANDOMIZED CONTROLLED TRIAL
Sze Lin Yoong, Andrew D Brown, Gloria K W Leung, Monique Hillenaar, Jennifer L David, Josh Hayward, Claudia Strugnell, Colin Bell, Vicki Brown, Michelle Jackson, Steven Allender
BACKGROUND: Over a quarter of children aged 2-17 years living in Australia are overweight or obese, with a higher prevalence reported in regional and remote communities. Systems thinking approaches that seek to support communities to generate and implement locally appropriate solutions targeting intertwined environmental, political, sociocultural, and individual determinants of obesity have the potential to ameliorate this. There have however been reported challenges with implementation of such initiatives, which may be strengthened by incorporating implementation science methods...
2024: PloS One
#30
JOURNAL ARTICLE
Domitille Callon, Marie Glenet, Anne-Laure Lebreil, Laetitia Heng, Nicole Bouland, Caroline Fichel, Paul Fornes, Laurent Andreoletti, Fatma Berri
Major 5'-terminally deleted (5'TD) RNA forms of group-B coxsackievirus (CVB-5'TD) has been associated with myocarditis in both mice and humans. Although it is known that interferon-β (IFN-β) signaling is critical for an efficient innate immune response against CVB-induced myocarditis, the link between CVB-5'TD RNA forms and type I IFN signaling in cardiomyocytes remains to be explored. In a mouse model of CVB3/28-induced myocarditis, major early-emerging forms of CVB-5'TD RNA have been characterized as replicative viral populations that impair IFN-β production in the heart...
May 2, 2024: PLoS Pathogens
#31
JOURNAL ARTICLE
Meixin Zhang, Ashley S Tseng, Godwin Anguzu, Ruanne V Barnabas, J Lucian Davis, Andrew Mujugira, Abraham D Flaxman, Jennifer M Ross
Household-based tuberculosis (TB) contact evaluation may be an efficient strategy to reach people who could benefit from oral pre-exposure prophylaxis (PrEP) because of the epidemiological links between HIV and TB. This study estimated the number of HIV serodifferent couples in TB-affected households and potential HIV acquisitions averted through their PrEP use in 4 TB-HIV high-burden countries. We conducted a model-based analysis set in Ethiopia, Kenya, South Africa, and Uganda using parameters from population-based household surveys, systematic literature review and meta-analyses, and estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019...
2024: PLOS Glob Public Health
#32
JOURNAL ARTICLE
Elissa M Downs, James S Hodges, Guru Trikudanathan, Martin L Freeman, Srinath Chinnakotla, Varvara Kirchner, Timothy L Pruett, Gregory Beilman, Sarah Jane Schwarzenberg, Melena D Bellin
OBJECTIVES: Total pancreatectomy and islet autotransplantation (TPIAT) for pancreatitis may induce risk for essential fatty acid deficiency (EFAD) due to exocrine pancreatic insufficiency and intestinal alterations. The prevalence of EFAD post-TPIAT is currently unknown. METHODS: We abstracted essential fatty acid (EFA) profiles (n = 332 samples) for 197 TPIAT recipients (72% adult, 33% male). Statistical analyses determined the prevalence of, and associations with, EFAD post-operatively...
May 1, 2024: Pancreas
#33
JOURNAL ARTICLE
Harun K Aremu, Christianah A Dare, Idris A Adekale, Bukunmi D Adetunji, Dickson A Musa, Luqmon A Azeez, Olu I Oyewole
The incorporation of phytoactive compounds in the management of malarial vectors holds promise for the development of innovative and efficient alternatives. Nevertheless, the molecular and physiological responses that these bioactive substances induce remain underexplored. This present study investigated the toxicity of different concentrations of aqueous and methanol extracts of Ocimum tenuiflorum against larvae of Anopheles gambiae (sensu stricto) and unraveled the possible underlying molecular pathways responsible for the observed physiological effects...
2024: PloS One
#34
JOURNAL ARTICLE
Laura Barthold, Kerrington D Smith, Sushela S Chaidarun, Dawn A Fischer, Timothy B Gardner
OBJECTIVES: Total pancreatectomy with islet autotransplantation (TPIAT) is performed to improve the quality of life (QOL) of patients with chronic pancreatitis. Few reports have documented QOL following TPIAT, with none using the pancreatitis-specific Pancreatitis Quality of Life Instrument (PANQOLI). We surveyed patients at our center who underwent TPIAT to document postoperative QOL. METHODS: We collected survey data from 18 adult patients who underwent TPIAT at our medical center from 2012 to 2020...
May 1, 2024: Pancreas
#35
RANDOMIZED CONTROLLED TRIAL
Yvinna T Rodrigues, Tatiana C L A Silva, Emilė Radytė, Ervinas Bernatavičius, Alexander A Cook, Maria L A S Carvalho, Luiza E S Macedo, Joyce M P Oliveira, Talita D Martins, Maria E Fonseca, Maria T A B C Micussi, Rodrigo Pegado
This study tested the usability of a home-based self-administration transcranial direct current stimulation (tDCS) device designed specifically for women's health needs. This is a single center triple blinded clinical usability study for a new wireless, Bluetooth-controlled wearable tDCS device for women's health. The study aims to evaluate the usability and effective blinding of a home-based tDCS system. A total of forty-nine women of reproductive age were randomly allocated (1:1) to receive one session of active tDCS (n = 24) or sham tDCS (n = 25) over the motor and dorsolateral prefrontal cortex...
2024: PloS One
#36
JOURNAL ARTICLE
Kelley Arredondo, David R Renfro, Aileen Naungayan, Denise Renfro, Sharlene Burgos, Sudha Yarlagadda, Molly J Horstman, Aanand D Naik, Kyler M Godwin
This quality improvement project demonstrates that nursing leadership with Project Re-Engineered Discharge can effect change in the discharge process and improve patient outcomes.
May 2024: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
#37
EDITORIAL
Pamala D Larsen
No abstract text is available yet for this article.
May 2024: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
#38
JOURNAL ARTICLE
Bryan D Badal, Andrew Fagan, Victoria Tate, Travis Mousel, Mary Leslie Gallagher, Puneet Puri, Brian Davis, Jennifer Miller, Masoumeh Sikaroodi, Patrick Gillevet, Rolandas Gedguadas, Juozas Kupcinkas, Leroy Thacker, Jasmohan S Bajaj
INTRODUCTION: Diet can affect ammoniagenesis in cirrhosis and hepatic encephalopathy (HE) but the impact of dietary preferences on metabolomics in cirrhosis is unclear. As most Western populations follow meat-based diets, we aimed to determine the impact of substituting a single meat-based meal with an equal protein-containing vegan/vegetarian alternative on ammonia & metabolomics in outpatients with cirrhosis on a meat-based diet. METHODS: Outpatients with cirrhosis with and without prior HE on a stable Western meat-based diet were randomized 1:1:1 into 3 groups...
May 2, 2024: Clinical and Translational Gastroenterology
#39
RANDOMIZED CONTROLLED TRIAL
Benjamin R Shuman, Brad D Hendershot, David C Morgenroth, Elizabeth Russell Esposito
BACKGROUND: Ankle-foot orthoses (AFOs) are commonly used to overcome mobility limitations related to lower limb musculoskeletal injury. Despite a multitude of AFOs to choose from, there is scant evidence to guide AFO prescription and limited opportunities for AFO users to provide experiential input during the process. To address these limitations in the current prescription process, this study evaluates a novel, user-centered and personalized 'test-drive' strategy using a robotic exoskeleton ('AFO emulator') to emulate commercial AFO mechanical properties (i...
2024: PloS One
#40
JOURNAL ARTICLE
Morgan T Walcheck, Patrick B Schwartz, Noah D Carrillo, Kristina A Matkowsky, Manabu Nukaya, Christopher A Bradfield, Sean M Ronnekleiv-Kelly
OBJECTIVES: The pathogenesis of pancreas cancer (PDAC) remains poorly understood, hindering efforts to develop a more effective therapy for PDAC. Recent discoveries show the aryl hydrocarbon receptor (AHR) plays a crucial role in the development of several cancers, and can be targeted for therapeutic effect. However, its involvement in the pathogenesis of PDAC remains unclear. To address this gap, we evaluated the role of AHR in the development of PDAC pre-cancerous lesions in vivo. METHODS: We created a global AHR-null, mutant Kras-driven PDAC mouse model (A-/-KC) and evaluated the changes in PDAC precursor lesion formation (Pan-IN 1, 2, and 3) and associated fibro-inflammation between KC and A-/-KC at 5 months of age...
May 1, 2024: Pancreas
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