Anna Klempka, Christian Fischer, Hans-Ulrich Kauczor, Marc-André Weber
PURPOSE:  To examine the relationship between superficial lesions (such as bruises, hematomas, deep abrasions, and soft tissue emphysema) and internal post-traumatic injuries, assessed using whole-body computed tomography (WBCT), and to determine if these are valid markers for internal injuries. METHODS AND MATERIALS:  250 patients who underwent WBCT emergency scans for suspected polytrauma were retrospectively analyzed after institutional review board approval of the study...
November 26, 2020: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Joel M Mor, Alexander C Rokohl, Cornelia Mauch, Ludwig M Heindl
BACKGROUND: In contrast to cutaneous melanoma, there are no uniform guidelines regarding surveillance of ocular (uveal, conjunctival) melanomas. A consented standard operating procedure (SOP) by the "Netzwerk onkologische Spitzenzentren" Germany only exists for conjunctival melanoma but not for uveal melanoma. Surveillance is partially based on German S3-guidelines for cutaneous melanoma and is carried out by oncologic centres in a multidisciplinary approach. This study aims to evaluate patients' adherence to surveillance programs and whether surveillance recommendations (examinations, intervals) can be realised...
November 26, 2020: Klinische Monatsblätter Für Augenheilkunde
Carsten Framme, Oliver Greb, Sascha Bayer, Pascal Buley, Amelie Pielen, Katerina Hufendiek, Bernd Junker, Ingo Volkmann
BACKGROUND: The treatment of macular edema with intravitreal injections has revolutionized the treatment of associated diseases in ophthalmology. However, with a few exceptions, this is a chronic treatment where patients require many injections and usually need to stay in treatment for years. Patient adherence and control of patient flow are critical to treatment success. In this manuscript, we describe the development of a patient-oriented organization management for intravitreal injections in a university hospital...
November 26, 2020: Klinische Monatsblätter Für Augenheilkunde
Francesco Donato, Elena Raffetti, Giuseppe Toninelli, Andrea Festa, Carmelo Scarcella, Maurizio Castellano
BACKGROUND: Several herbs are used for lowering high blood cholesterol levels in traditional medicines including Indian Medicine (Ayurveda). We aimed to assess the short-term effects of the combination of Guggulu (Commiphora mukul) and Triphala (Terminalia chebula, Terminalia belerica, and Phyllanthus emblica) on serum cholesterol in healthy subjects with hypercholesterolaemia. PATIENTS AND METHODS: This was a parallel randomised double-blind controlled trial that included 90 individuals at low-moderate cardiovascular risk...
November 26, 2020: Complementary Medicine Research
Wojciech Jacheć, Anna Polewczyk, Luca Segreti, Maria Grazia Bongiorni, Andrzej Kutarski
INTRODUCTION: Transvenous lead extraction (TLE) has become a frequently used tool for the management of complications related to pacemakers, implantable cardiac defibrillators and cardiac resynchronization therapy devices. However, it is still a matter of debate whether the lead extraction procedure is a safe treatment choice in the elderly. METHODS: We collected the clinical information from 3,810 patients undergoing TLE in 2 high-volume centers (Poland and Italy) between 2006 and 2017...
November 26, 2020: Gerontology
Judith Maria Brock, Adrian Billeter, Beat Peter Müller-Stich, Felix Herth
Obesity is becoming more and more prevalent especially in Western industrial nations. The understanding of adipose tissue as an endocrine organ as well as the detection of adipocytokines - hormones that are secreted from the adipose tissue - gave reason to examine the interactions between adipose tissue and target organs. These efforts have been intensified especially in the context of bariatric surgery as promising weight loss therapy. Interactions between the lung and adipose tissue have rarely been investigated and are not well understood...
November 26, 2020: Respiration; International Review of Thoracic Diseases
Masahiro Tomonari, Akimitsu Kobayashi, Izumi Yamamoto, Saeko Hatanaka, Mayuko Kawabe, Takafumi Yamakawa, Haruki Katsumata, Ai Katsuma, Aki Mafune, Yasuyuki Nakada, Yusuke Koike, Jun Miki, Takahiro Kimura, Yudo Tanno, Hiroyasu Yamamoto, Takashi Yokoo
We report a case of graft intolerance syndrome in which transplant nephrectomy was performed 11 years after kidney transplantation. A 46-year-old man was admitted to our hospital in February 2018 with a mild fever, left lower abdominal pain, and gross hematuria with enlargement of the transplanted kidney. Urinary tract infection was ruled out. Because the symptoms developed after the immunosuppressants had been stopped after kidney graft loss, graft intolerance syndrome was suspected. He had lost his graft in 2016 and had stopped all immunosuppressants since January of 2017...
November 26, 2020: Nephron
Michail Yaroustovsky, Marina Abramyan, Ekaterina Rogalskaya, Ekaterina Komardina
BACKGROUND: To date, sepsis remains one of the main challenges of intensive care in pediatrics. Newborns with low birth weight and infants with chronic diseases and congenital disorders are particularly at risk. The incidence of infectious complications in pediatric cardiac surgery is known to be approximately 15-30%. The main etiological factor of sepsis is endotoxin. AIM: To evaluate the efficiency and safety of polymyxin (PMX) B-immobilized column-direct hemoperfusion in complex intensive therapy of sepsis in children after cardiac surgery with cardiopulmonary bypass...
November 26, 2020: Blood Purification
Rosario Pivonello, Renata S Auriemma, Claudia Pivonello, Andrea M Isidori, Giovanni Corona, Annamaria Colao, Robert P Millar
The COVID-19 outbreak is a global public health issue, having profound effects on most aspects of societal well-being, including physical and mental health. A plethora of studies, globally, have suggested the existence of a sex disparity in the outcome of COVID-19 patients, that is mainly due to mechanisms of viral infection, immune response to the virus, development of a hyperinflammation, and development of systemic complications, particularly thromboembolism. These differences appear to be more pronounced in elderly COVID-19 patients...
November 26, 2020: Neuroendocrinology
Antoine Desilets, Félix Blanc-Durand, Sally Lau, Taiki Hakozaki, Rui Kitadai, Julie Malo, Wiam Belkaid, Corentin Richard, Meriem Messaoudene, Lena Cvetkovic, Suzanne Kazandjian, Mustapha Tehfe, Marie Florescu, Kevin Jao, Nathalie Daaboul, Scott Owen, Benjamin Shieh, Jason Agulnik, Victor Cohen, Chloé Charbonneau, Nicolas Marcoux, Normand Blais, Natasha B Leighl, Penelope A Bradbury, Geoffrey Liu, Frances A Shepherd, Houda Bahig, Bertrand Routy, Adrian Sacher, Arielle Elkrief
BACKGROUND: The PACIFIC trial demonstrated that durvalumab therapy following chemoradiation (CRT) was associated with improved overall survival (OS) in patients with stage III non-small cell lung cancer (NSCLC). It is unclear whether the results obtained as part of randomised controlled trials are a reflection of real-world (RW) data. Several questions remain unanswered with regard to RW durvalumab use, such as optimal time to durvalumab initiation, incidence of pneumonitis and response in PD-L1 subgroups...
November 23, 2020: European Journal of Cancer
Dilyana Todorova, Yue Zhang, Qu Chen, Jingfeng Liu, Jingjin He, Xuemei Fu, Yang Xu
BACKGROUND: With their inherent capability of unlimited self-renewal and unique potential to differentiate into functional cells of the three germ layers, human embryonic stem cells (hESCs) hold great potential in regenerative medicine. A major challenge in the application of hESC-based cell therapy is the allogeneic immune rejection of hESC-derived allografts. METHODS: We derived dendritic cell-like cells (DCLs) from wild type and CTLA4-Ig/PD-L1 knock-in hESCs, denoted WT DCLs and CP DCLs...
November 23, 2020: EBioMedicine
Troy G Seelhammer, Daniel Plack, Scott Nei, Erica Wittwer, James Nelson, Christoph Nabzdyk
Vasoplegic syndrome occurs in 8% to 12% of cases that use cardiopulmonary bypass and carries a high mortality. Although the precise cause of this shock state has yet to determined, it is postulated to be related to abnormal nitric oxide (NO)-mediated dilatation of vascular smooth muscle resulting in arterial and venous vasodilatation. Since its first report in 2014, the off-label use of hydroxocobalmin as a rescue therapy for the treatment of refractory vasodilatory shock has gained attention with a mechanism thought to be primarily mediated by the scavenge, binding to, and prevention of the formation of NO...
November 23, 2020: Heart & Lung: the Journal of Critical Care
Lianlian Lei, Feng Liu
Smoking prevalence is disproportionately high among low-income populations. To help smokers who are socioeconomically disadvantaged quit smoking, some states offer coverage of tobacco-dependence treatments, such as nicotine replacement therapy (NRT), to Medicaid beneficiaries. We used US nationally representative data (2003 and 2010/2011 Current Population Survey-Tobacco Use Supplements) and employed a difference-in-difference-in-difference approach to investigate the effects of Medicaid coverage of NRT on the usage of NRT products among Medicaid smokers...
November 4, 2020: Economics and Human Biology
Laurens F Reeskamp, Tycho R Tromp, Roeland Huijgen, Erik S G Stroes, G Kees Hovingh, Aldo Grefhorst
BACKGROUND AND AIMS: Statins suppress hepatic mRNA expression of ANGPTL3 encoding angiopoietin-like 3 in healthy subjects, but it is unknown if plasma ANGPTL3 concentrations are affected by statins prescribed to hypercholesterolemic patients in clinical practice. We therefore investigated the effect of statin treatment on plasma ANGPTL3 concentrations in hypercholesterolemic patients. In addition, we explored the underlying mechanism by which statins regulate ANGPTL3 in vitro. METHODS: Plasma ANGPTL3 concentrations were measured in 93 genetically confirmed familial hypercholesterolemia (FH) patients who were using statin therapy and 61 statin naïve FH patients...
November 18, 2020: Atherosclerosis
Yajun Cao, Hongyan Wu, Wanli Zhai, Ying Wang, Mengdi Li, Meng Li, Liu Yang, Ye Tian, Yunhao Song, Jun Li, Yinyin Wang, Qiang Ding, Linqi Zhang, Ming Cai, Zhijie Chang
Due to the multi-potential differentiation and immunomodulatory function, mesenchymal stem cells (MSCs) have been widely used in the therapy of chronic and autoimmune diseases. Recently, the novel coronavirus disease 2019 (COVID-19) has grown to be a global public health emergency but no effective drug is available to date. Several studies investigated MSCs therapy for COVID-19 patients. However, it remains unclear whether MSCs could be the host cells of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) and whether they might affect the SARS-CoV-2 entry into other cells...
October 24, 2020: Stem Cell Research
Tomohiko Ozaki, Patrick Nicholson, Joanna D Schaafsma, Ronit Agid, Timo Krings, Aleksandra Pikula, Vitor Mendes Pereira
PURPOSE: There is limited data on the effectiveness of endovascular therapy (EVT) in stroke patients with active malignancy. In this study, we investigated the outcome of EVT for acute ischemic stroke for patients with active malignancy compared to those without malignancy. METHODS: We selected patients who underwent EVT for acute ischemic stroke between January 2015 and July 2019. Patients were divided into two groups, those with active malignancy (oncology group - OG) and those without (non-oncology group, NOG)...
November 23, 2020: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Mirian Denise Stringasci, Heloísa Ciol, Renan Arnon Romano, Hilde Harb Buzza, Ilaiáli Souza Leite, Natalia Mayumi Inada, Vanderlei Salvador Bagnato
Photosensitization of all tissue in sufficient quantity to generate damage is one of the limiting factors for Photodynamic Therapy (PDT) efficiency. Methyl nicotinate (MN) is a thermogenic and vasodilating substance that facilitates the topical tissue penetration of some compounds. The topical MAL (methyl aminolevulinate) PDT is commonly used as a precursor of protoporphyrin IX (PpIX). This study investigates the safety of topical use in NM, as well as its ability to improve the efficiency of topical PDT. For this, we investigate the cytotoxicity of MN, as well as its actions in increasing cellular metabolism and vasodilation...
November 2, 2020: Journal of Photochemistry and Photobiology. B, Biology
Kuan-Ying Li, Ling-Chun Huang, Yang-Pei Chang, Yuan-Han Yang
BACKGROUND: Cognitive and psychiatric problems are common in people with epilepsy. They can have multiple causes, including structural brain lesions, the active epilepsy, and the effect of anti-epileptic therapy. Since patients' treatment compliance and quality of life are affected by cognitive and emotional status, it is crucial for clinicians to understand how anti-seizure medications (ASMs) affect cognition and mood, and to choose the proper ASM. OBJECTIVE: To conduct a literature review of the impact on cognition and mood status of lacosamide (LCM) in people with epilepsy...
November 23, 2020: Epilepsy & Behavior: E&B
Kai-Li Shi, Jun-Xiu Guo, Hui-Min Zhao, Han Hong, Chuan-Zi Yang, Yun-Hong Wu, Li-Jun Du
BACKGROUND: Long-term treatment with certain antiepileptic drugs may lead to thyroid function disturbances or alterations in bone metabolism; the data on the effects of new antiepileptic drugs on this are limited and conflicting, especially in children with epilepsy. Therefore, the aim of this study was to investigate the effects of levetiracetam and oxcarbazepine on thyroid hormone levels and bone metabolism in children with epilepsy. METHODS: A total of 51 children with new-onset partial epilepsy were selected...
November 23, 2020: Epilepsy & Behavior: E&B
Anne L Willems, Bram Vervliet
Over the past decade, increasing evidence has pointed to the importance of threat omissions and the associated violations of expectancy for long-term gains of extinction learning and exposure treatment. Yet, the identification of valid markers of these expectancy violations remains somewhat challenging, thereby complicating the translation of these scientific discoveries into viable therapeutic interventions. In order to fill this gap, we developed the expectancy violation assessment (EVA) task in which participants are presented with probability (0%, 25%, 50%, 75%, 100%) and intensity (weak, moderate, strong) information of an upcoming electrical stimulation, time-locked by a countdown clock...
November 19, 2020: Behaviour Research and Therapy
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