Victor A Verpalen, Francesca A Ververs, Martijn Slieker, Roos Nuboer, Joost F Swart, Cornelis K van der Ent, Zina Fejzic, Jos J M Westenberg, Tim Leiner, Heynric B Grotenhuis, Henk S Schipper
BACKGROUND: The recent Cardiovascular Disease in Adolescents with Chronic Disease (CDACD) study showed enhanced aortic stiffness and wall thickness in adolescents with various chronic disorders. Enhanced aortic stiffness can increase left ventricular (LV) afterload and trigger a cascade of adverse arterioventricular interaction. Here, we investigate the relation between aortic changes and LV function in the CDACD study participants. METHODS: This cross-sectional study included 114 adolescents 12-18 years old with cystic fibrosis (CF, n = 24), corrected coarctation of the aorta (CoA, n = 25), juvenile idiopathic arthritis (JIA, n = 20), obesity (n = 20), and healthy controls (n = 25)...
June 2024: IJC Heart & Vasculature