Jose Javier Fernández, Arturo Marín, Romel Rosales, Rebekah Penrice-Randal, Petra Mlcochova, Yolanda Alvarez, Fernando Villalón-Letelier, Soner Yildiz, Enrique Pérez, Raveen Rathnasinghe, Anastasija Cupic, Thomas Kehrer, Melissa B Uccellini, Sara Alonso, Fernando Martínez, Briana Lynn McGovern, Jordan J Clark, Parul Sharma, Yolanda Bayón, Andrés Alonso, Randy A Albrecht, Kris M White, Michael Schotsaert, Lisa Miorin, James P Stewart, Julian A Hiscox, Ravindra K Gupta, Nerea Irigoyen, Adolfo García-Sastre, Mariano Sánchez Crespo, Nieves Fernández
SARS-CoV-2 infection can cause severe pneumonia, wherein exacerbated inflammation plays a major role. This is reminiscent of the process commonly termed cytokine storm, a condition dependent on a disproportionated production of cytokines. This state involves the activation of the innate immune response by viral patterns and coincides with the biosynthesis of the biomass required for viral replication, which may overwhelm the capacity of the endoplasmic reticulum and drive the unfolded protein response (UPR)...
April 20, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease