keyword
https://read.qxmd.com/read/38353365/the-prevalence-of-sentinel-central-events-scent-during-drug-induced-sleep-endoscopy
#21
JOURNAL ARTICLE
Julianna G Rodin, Manan H Parekh, Yi Cai, Brendan T Keenan, Eric R Thuler, Everett Seay, Joshua H Atkins, Alan R Schwartz, Raj C Dedhia
OBJECTIVE: With the recent addition of airflow and respiratory effort channels, our group has observed central and mixed apnea events during drug-induced sleep endoscopy (DISE). We measured the frequency and timing of sentinel central and/or mixed events (SCents), as well as assessed for differences in velum, oropharynx, tongue, and epiglottis (VOTE) classification compared to obstructive events. STUDY DESIGN: Prospective single-cohort study. SETTING: Tertiary Care Academic Medical Center...
February 14, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38342767/the-association-of-weight-loss-from-anti-obesity-medications-or-bariatric-surgery-and-apnea-hypopnea-index-in-obstructive-sleep-apnea
#22
REVIEW
Brian W Locke, Ainhoa Gomez-Lumbreras, Chia Jie Tan, Teerawat Nonthasawadsri, Sajesh K Veettil, Chanthawat Patikorn, Nathorn Chaiyakunapruk
INTRODUCTION: Weight loss is recommended for individuals with obstructive sleep apnea (OSA) and overweight or obesity, but there is limited evidence to guide the selection of weight management strategies for patients who do not lose sufficient weight with diet and lifestyle changes. We evaluated the relationship between weight loss caused by pharmacologic or surgical interventions and subsequent improvement in OSA by the apnea-hypopnea index (AHI). METHODS: PubMed, Cochrane CENTRAL, and EMBASE were searched for randomized trials comparing pharmacologic or surgical obesity interventions to usual care, placebo, or no treatment in adults with OSA...
February 11, 2024: Obesity Reviews
https://read.qxmd.com/read/38341903/pharmacological-treatment-for-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#23
REVIEW
Maria Luísa Nobre, Ayane Cristine Alves Sarmento, Priscila Farias de Oliveira, Felipe Ferreira Wanderley, José Diniz Júnior, Ana Katherine Gonçalves
OBJECTIVE: Summarize the evidence on drug therapies for obstructive sleep apnea. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. PubMed, Embase, Scopus, Web of Science, SciELO, LILACS, Scopus, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched on February 17th, 2023. A search strategy retrieved randomized clinical trials comparing the Apnea-Hypopnea Index (AHI) in pharmacotherapies...
2024: Clinics
https://read.qxmd.com/read/38338762/revisiting-the-role-of-serotonin-in-sleep-disordered-breathing
#24
REVIEW
O Aung, Mateus R Amorim, David Mendelowitz, Vsevolod Y Polotsky
Serotonin or 5-hydroxytryptamine (5-HT) is a ubiquitous neuro-modulator-transmitter that acts in the central nervous system, playing a major role in the control of breathing and other physiological functions. The midbrain, pons, and medulla regions contain several serotonergic nuclei with distinct physiological roles, including regulating the hypercapnic ventilatory response, upper airway patency, and sleep-wake states. Obesity is a major risk factor in the development of sleep-disordered breathing (SDB), such as obstructive sleep apnea (OSA), recurrent closure of the upper airway during sleep, and obesity hypoventilation syndrome (OHS), a condition characterized by daytime hypercapnia and hypoventilation during sleep...
January 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38336351/maximal-mouth-opening-in-infants-a-single-group-prospective-cohort-study
#25
JOURNAL ARTICLE
Hanie Ahmadi, Mohamed El-Rabbany, Ryan Shargo, Pat Ricalde
BACKGROUND: Detection of mandibular range of motion variations in infants may allow for early diagnosis of pathologic conditions to the temporomandibular joint. PURPOSE: The purpose of this study was to determine the normal ranges for maximal mouth opening (MMO) in healthy infants under 12 months of age. STUDY DESIGN, SETTING, SAMPLE: A single-group prospective cohort study of consecutive patients below 12 months of age was conducted in an outpatient setting at the Florida Craniofacial Institute in Tampa, Florida...
January 20, 2024: Journal of Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38334297/medication-induced-central-sleep-apnea-a-unifying-concept
#26
JOURNAL ARTICLE
Shahrokh Javaheri, W J Randerath, M Safwan Badr, Sogol Javaheri
Medication-induced central sleep apnea (CSA) is one of the 8 categories of causes of CSA but in the absence of awareness and careful history may be misclassified as primary CSA. While opioids are a well-known cause of respiratory depression and CSA, non-opioids medications including sodium oxybate, baclofen, valproic acid, gabapentin and ticagrelor are less well-recognized. Opioids-induced respiratory depression and CSA are mediated primarily by µ-opioid receptors, which are abundant in the pontomedullary centers involved in breathing...
February 9, 2024: Sleep
https://read.qxmd.com/read/38318821/the-impact-of-obstructive-sleep-apnea-treatment-on-microvascular-complications-in-patients-with-type-2-diabetes-a-feasibility-randomized-controlled-trial
#27
JOURNAL ARTICLE
Esraa A Makhdom, Alisha Maher, Ryan Ottridge, Mathew Nicholls, Asad Ali, Brendan G Cooper, Ramzi A Ajjan, Srikanth Bellary, Wasim Hanif, Fahmy Hanna, David Hughes, Vijay Jayagopal, Rajni Mahto, Mayank Patel, James Young, Ananth U Nayak, Mimi Z Chen, Julie Kyaw-Tun, Susana Gonzalez, Ravikanth Gouni, Anuradhaa Subramanian, Nicola Adderley, Smitaa Patel, Abd A Tahrani
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is associated with an increased risk of diabetes-related complications. Hence, it is plausible that Continuous Positive Airway Pressure (CPAP) could have a favorable impact on these complications. To assess the feasibility of conducting a randomized control trial (RCT) in patients with type 2 diabetes (T2D) and OSA over 2 years. METHODS: An open-label multicenter feasibility RCT of CPAP vs no CPAP in patients with T2D and OSA...
February 6, 2024: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://read.qxmd.com/read/38308750/the-prevalence-and-polysomnographic-characteristics-of-treatment-emergent-central-sleep-apnea-with-obstructive-sleep-apnea
#28
JOURNAL ARTICLE
Sinem Berik Safçi
PURPOSE: To investigate the prevalence of treatment-emergent central sleep apnea (TECSA) in individuals with obstructive sleep apnea syndrome (OSAS) during continuous positive airway pressure (CPAP) titration and assess their polysomnographic characteristics. METHODS: A total of 116 patients with OSAS who underwent full-night CPAP titration at the Sleep Laboratory of Adana City Research and Education Hospital from September 2017 to January 2018 were recruited for the study...
February 3, 2024: Sleep & Breathing
https://read.qxmd.com/read/38308748/obstructive-sleep-apnea-affects-cognition-dual-effects-of-intermittent-hypoxia-on-neurons
#29
REVIEW
Yao He, Na Dong, Xiao Wang, Ren-Jun Lv, Qin Yu, Hong-Mei Yue
Obstructive sleep apnea (OSA) is a common respiratory disorder. Multiple organs, especially the central nervous system (CNS), are damaged, and dysfunctional when intermittent hypoxia (IH) occurs during sleep for a long time. The quality of life of individuals with OSA is significantly impacted by cognitive decline, which also escalates the financial strain on their families. Consequently, the development of novel therapies becomes imperative. IH induces oxidative stress, endoplasmic reticulum stress, iron deposition, and neuroinflammation in neurons...
February 3, 2024: Sleep & Breathing
https://read.qxmd.com/read/38308558/right-versus-left-cuff-position-for-upper-airway-stimulation
#30
JOURNAL ARTICLE
Alexandra M Arambula, Antonio Bon-Nieves, Rahul Alapati, Johnny Wei, Sarah Wagoner, Amelia Lawrence, Bryan Renslo, David Rouse, Christopher Larsen
OBJECTIVE: Upper airway stimulation (UAS) is a treatment option for obstructive sleep apnea in which electrical stimulation is applied to the hypoglossal nerve. Nerve branches that control tongue protrusion are located inferiorly. Due to positioning, left-sided implants are typically placed with an inferiorly oriented electrode cuff (L-down) as opposed to superiorly on the right (R-up). In this study, we assess the impact of left- versus right-sided UAS on patient outcomes. STUDY DESIGN: Retrospective cohort study...
February 3, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38291419/nomogram-for-hospital-acquired-venous-thromboembolism-among-patients-with-cardiovascular-diseases
#31
JOURNAL ARTICLE
Qin Luo, Xin Li, Zhihui Zhao, Qing Zhao, Zhihong Liu, Weixian Yang
BACKGROUND: Identifying venous thromboembolism (VTE) is challenging for patients with cardiovascular diseases due to similar clinical presentation. Most hospital-acquired VTE events are preventable, whereas the implementation of VTE prophylaxis in clinical practice is far from sufficient. There is a lack of hospital-acquired VTE prediction models tailored specifically designed for patients with cardiovascular diseases. We aimed to develop a nomogram predicting hospital-acquired VTE specifically for patients with cardiovascular diseases...
January 30, 2024: Thrombosis Journal
https://read.qxmd.com/read/38286954/evaluation-of-condylar-and-mandibular-movements-on-the-upper-airway-during-the-use-of-mandibular-advancement-device-for-obstructive-sleep-apnea-treatment
#32
JOURNAL ARTICLE
Amanda Pereira, Marcela Gurgel, Rowdley Pereira, Cibele Dal Fabbro, Paulo de Barros Silva, Fabio Costa, Leonardo Leite, Alexandre Moro, Lucia Cevidanes, Cauby Maia Junior
OBJECTIVES: To evaluate the temporomandibular joint (TMJ), condylar and mandibular movements in obstructive sleep apnea (OSA) patients treated with mandibular advancement device (MAD) and to identify the influence of these anatomic factors on upper airway (UA) volume and polysomnographic outcomes after treatment. MATERIALS AND METHODS: Twenty OSA patients were prospectively treated with MAD. Clinical examinations, cone-beam computed tomography, and polysomnography were performed before MAD treatment and after achieving therapeutic protrusion...
January 29, 2024: Clinical Oral Investigations
https://read.qxmd.com/read/38276286/possible-molecular-mechanisms-of-hypertension-induced-by-sleep-apnea-syndrome-intermittent-hypoxia
#33
REVIEW
Yoshinori Takeda, Fuminori Kimura, Shin Takasawa
Intermittent hypoxia (IH) is a central characteristic of sleep apnea syndrome (SAS), and it subjects cells in the body to repetitive apnea, chronic hypoxia, oxygen desaturation, and hypercapnia. Since SAS is linked to various serious cardiovascular complications, especially hypertension, many studies have been conducted to elucidate the mechanism of hypertension induced by SAS/IH. Hypertension in SAS is associated with numerous cardiovascular disorders. As hypertension is the most common complication of SAS, cell and animal models to study SAS/IH have developed and provided lots of hints for elucidating the molecular mechanisms of hypertension induced by IH...
January 22, 2024: Life
https://read.qxmd.com/read/38271714/detecting-central-apneas-using-multichannel-signals-in-premature-infants
#34
JOURNAL ARTICLE
Gabriele Varisco, Zheng Peng, Deedee Kommers, Eduardus J E Cottaar, Peter Andriessen, Xi Long, Carola van Pul
Monitoring of apnea of prematurity, performed in neonatal intensive care units by detecting central apneas (CAs) in the respiratory traces, is characterized by a high number of false alarms. A two-step approach consisting of a threshold-based apneic event detection algorithm followed by a machine learning model was recently presented in literature aiming to improve CA detection. However, since this is characterized by high complexity and low precision, we developed a new direct approach that only consists of a detection model based on machine learning directly working with multichannel signals...
January 25, 2024: Physiological Measurement
https://read.qxmd.com/read/38262224/effect-of-adenotonsillectomy-on-central-sleep-apnea-a-scoping-review
#35
REVIEW
Dana Eitan, Taylor Cave, Patrick Scheffler
OBJECTIVE: The purpose of this study was to assess the effects of adenotonsillectomy (A&T) on reducing central sleep apnea (CSA) in children and adolescents with obstructive sleep apnea (OSA). METHODS: A review of the PubMed database was conducted. Two researchers independently reviewed the articles from the literature search and selected papers for further review if they met inclusion criteria. Included studies were prospective studies and case series whose patients were children 18 years or younger undergoing adenotonsillectomy for obstructive sleep apnea with reported pre and postoperative central apnea indexes (CAI)...
January 11, 2024: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/38255962/tau-protein-alterations-induced-by-hypobaric-hypoxia-exposure
#36
REVIEW
Eduardo Pena, Rocio San Martin-Salamanca, Samia El Alam, Karen Flores, Karem Arriaza
Tauopathies are a group of neurodegenerative diseases whose central feature is dysfunction of the microtubule-associated protein tau (MAPT). Although the exact etiology of tauopathies is still unknown, it has been hypothesized that their onset may occur up to twenty years before the clear emergence of symptoms, which has led to questions about whether the prognosis of these diseases can be improved by, for instance, targeting the factors that influence tauopathy development. One such factor is hypoxia, which is strongly linked to Alzheimer's disease because of its association with obstructive sleep apnea and has been reported to affect molecular pathways related to the dysfunction and aggregation of tau proteins and other biomarkers of neurological damage...
January 10, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38255259/inflammation-and-fibrosis-in-sleep-disordered-breathing-after-acute-myocardial-infarction
#37
JOURNAL ARTICLE
Jan Pec, Stefan Buchner, Henrik Fox, Olaf Oldenburg, Stefan Stadler, Lars S Maier, Michael Arzt, Stefan Wagner
BACKGROUND: After acute myocardial infarction (AMI), inflammatory processes promote tissue remodeling at the infarct site. Procollagen III amino-terminal propeptide (PIIINP) is a circulating biomarker of type III collagen synthesis that has been shown to be associated with changes in left ventricular ejection fraction (LVEF) and predicts the occurrence of heart failure after AMI. We hypothesize that sleep-disordered breathing (SDB) promotes inflammation and myocardial fibrosis, leading to reduced myocardial salvage...
January 11, 2024: Biomedicines
https://read.qxmd.com/read/38255218/perry-disease-bench-to-bedside-circulation-and-a-team-approach
#38
JOURNAL ARTICLE
Takayasu Mishima, Junichi Yuasa-Kawada, Shinsuke Fujioka, Yoshio Tsuboi
With technological applications, especially in genetic testing, new diseases have been discovered and new disease concepts have been proposed in recent years; however, the pathogenesis and treatment of these rare diseases are not as well established as those of common diseases. To demonstrate the importance of rare disease research, in this paper we focus on our research topic, Perry disease (Perry syndrome). Perry disease is a rare autosomal dominant neurodegenerative disorder clinically characterized by parkinsonism, depression/apathy, weight loss, and respiratory symptoms including central hypoventilation and central sleep apnea...
January 5, 2024: Biomedicines
https://read.qxmd.com/read/38241012/effects-of-adaptive-servo-ventilation-on-quality-of-life-the-read-asv-registry
#39
JOURNAL ARTICLE
Michael Arzt, Oliver Munt, Jean-Louis Pépin, Raphael Heinzer, Raphaela Kübeck, Ulrike von Hehn, Daniela Ehrsam-Tosi, Adam V Benjafield, Holger Woehrle
RATIONALE: Adaptive servo-ventilation (ASV) effectively treats sleep-disordered breathing (SDB), including central (CSA) and coexisting obstructive (OSA) sleep apnea. OBJECTIVES: The prospective, multicenter European READ-ASV registry investigated the effects of first-time ASV therapy on disease-specific quality of life (QoL). METHODS: The registry enrolled adults with CSA±OSA who had ASV therapy prescribed between September 2017 and March 2021...
January 19, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38237410/sleep-disordered-breathing-assessment-in-patient-with-slowly-progressive-neuromuscular-disease
#40
JOURNAL ARTICLE
Lucas Saulnier, Hélène Prigent, Sarah Hartley, Vincent Delord, Isabelle Bossard, Caroline Stalens, Frédéric Lofaso, Antoine Leotard
BACKGROUND: Sleep-disordered breathing (SDB) is common in patients with neuromuscular diseases (NMD). Focusing on hypercapnia may lead to the neglect of other SDB such as obstructive and/or central sleep apnea syndrome (SAS). Our objectives were to assess the risk of inappropriate SDB management according to different screening strategies and to evaluate the prevalence and determinants of isolated and overlapping sleep apnea in patients with slowly progressive NMD. METHODS: This monocentric, cross-sectional, retrospective study analyzed medical records of adult NMD patients referred to a sleep department...
February 2024: Sleep Medicine
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