Sonja G Schütz, Lynda D Lisabeth, Chia-Wei Hsu, Sehee Kim, Ronald D Chervin, Devin L Brown
OBJECTIVE/BACKGROUND: Stroke is often considered a risk factor for central sleep apnea (CSA). The goal of this study was to determine the prevalence and clinical correlates of CSA in patients with ischemic stroke. PATIENTS/METHODS: In this analysis, 1346 participants in the Brain Attack Surveillance in Corpus Christi (BASIC) project underwent a home sleep apnea test shortly after ischemic stroke. Respiratory events during sleep were classified as central apneas, obstructive apneas, or hypopneas...
August 28, 2020: Sleep Medicine
Shahrokh Javaheri, Scott McKane
STUDY OBJECTIVES: Idiopathic central sleep apnea (ICSA) is a rare disorder diagnosed when known causes of CSA are excluded. No established treatments exist for ICSA and long-term studies are lacking. We assessed long-term effectiveness and safety of transvenous phrenic nerve stimulation (TPNS) in patients with ICSA. METHODS: In the remedē System Pivotal Trial, 16/151 (11%) participants with CSA were diagnosed as ICSA. Patients were implanted and followed through 18 months of active therapy...
September 18, 2020: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Michele Tepedino, Gaetano Illuzzi, Michele Laurenziello, Letizia Perillo, Anna Maria Taurino, Michele Cassano, Laura Guida, Giuseppe Burlon, Domenico Ciavarella
INTRODUCTION: Obstructive sleep apnea is characterized by a reduced airflow through the upper airways during sleep. Two forms of obstructive sleep apnea are described: the central form and the obstructive form. The obstructive form is related to many factors, such as the craniofacial morphology. OBJECTIVE: To evaluate the correlation between the morphology of the cranial base, of the mandible and the maxilla, and obstructive sleep apnea severity. METHODS: Eighty-four patients, mean age of 50...
July 18, 2020: Brazilian Journal of Otorhinolaryngology
Estelle B Gauda, Silvia Conde, Mirian Bassi, Daniel B Zoccal, Debora Simoes Almeida Colombari, Eduardo Colombari, Nikola Despotovic
Obesity is a global epidemic in developed countries accounting for many of the metabolic and cardiorespiratory morbidities that occur in adults. These morbidities include type 2 diabetes, sleep-disordered breathing (SDB), obstructive sleep apnea, chronic intermittent hypoxia, and hypertension. Leptin, produced by adipocytes, is a master regulator of metabolism and of many other biological functions including central and peripheral circuits that control breathing. By binding to receptors on cells and neurons in the brainstem, hypothalamus, and carotid body, leptin links energy and metabolism to breathing...
July 8, 2020: Comprehensive Physiology
Bibi Aneesah Jaumally, Aneesa Das, Nathaniel C Cassell, G Nancy Pachecho, Ruckshanda Majid, Lara Bashoura, Diwakar D Balachandran, Saadia A Faiz
PURPOSE: Excessive daytime sleepiness (EDS) is commonly reported in patients with cancer, and it is also a cardinal feature of central disorders of hypersomnolence. Multiple sleep latency testing (MSLT) is used for objective assessment. METHODS: A retrospective review of patients with cancer history who underwent formal sleep evaluation and MSLT from 2006 to 2019 was performed. Clinical characteristics, sleep-related history, and polysomnographic data were reviewed...
September 16, 2020: Sleep & Breathing
Janannii Selvanathan, Philip W H Peng, Jean Wong, Clodagh M Ryan, Frances Chung
The past two decades has seen a substantial rise in the use of opioids for chronic pain, along with opioid-related mortality and adverse effects. A contributor to opioid-associated mortality is the high prevalence of moderate/severe sleep-disordered breathing, including central sleep apnea and obstructive sleep apnea, in patients with chronic pain. Although evidence-based treatments are available for sleep-disordered breathing, patients are not frequently assessed for sleep-disordered breathing in pain clinics...
September 14, 2020: Regional Anesthesia and Pain Medicine
Nicholas J Cutrufello, Vlad N Ianus, James A Rowley
PURPOSE OF REVIEW: Summarize the effects of opioids on sleep including sleep architecture, sleep disordered breathing (SDB) and restless legs syndrome. RECENT FINDINGS: Opioids are associated with the development of central sleep apnea (CSA) and ataxic breathing. Recent reports suggest that adaptive servo-ventilation may be an effective treatment for CSA associated with opioids. SUMMARY: Opioids have multiple effects on sleep, sleep architecture and SDB...
September 10, 2020: Current Opinion in Pulmonary Medicine
Frank Ralls, Lisa Cutchen
PURPOSE OF REVIEW: The purpose of this article is to provide a contemporary review of sleep issues affecting patients with multiple system atrophy (MSA). RECENT FINDINGS: Prodromal symptoms of MSA may occur years prior to diagnosis, including autonomic dysfunction such as orthostatic hypotension, urogenital dysfunction, rapid eye movement (REM) sleep behavior disorder (RBD), and stridor. Patients may also develop sleep-related respiratory disorders such as obstructive sleep apnea (OSA), central sleep apnea (CSA), and stridor...
September 10, 2020: Current Opinion in Pulmonary Medicine
Norman Bolden, Karen L Posner, Karen B Domino, Dennis Auckley, Jonathan L Benumof, Seth T Herway, David Hillman, Shawn L Mincer, Frank Overdyk, David J Samuels, Lindsay L Warner, Toby N Weingarten, Frances Chung
BACKGROUND: Obstructive sleep apnea (OSA) patients are at increased risk for pulmonary and cardiovascular complications; perioperative mortality risk is unclear. This report analyzes cases submitted to the OSA Death and Near Miss Registry, focusing on factors associated with poor outcomes after an OSA-related event. We hypothesized that more severe outcomes would be associated with OSA severity, less intense monitoring, and higher cumulative opioid doses. METHODS: Inclusion criteria were age ≥18 years, OSA diagnosed or suspected, event related to OSA, and event occurrence 1992 or later and <30 days postoperatively...
October 2020: Anesthesia and Analgesia
Jeffrey Voigt, Sitaramesh Emani, Sanjaya Gupta, Robin Germany, Rami Khayat
No abstract text is available yet for this article.
September 9, 2020: American Journal of Cardiology
Ester Tio, George W Culler, Elizabeth M Bachman, Stephan Schuele
OBJECTIVE: The objective of the study was to examine the frequency and characteristics of ictal central apnea (ICA) in a selective cohort of patients with mesial or neocortical temporal lobe epilepsy (TLE) undergoing surface video-electroencephalography (EEG) and multimodal recording of cardiorespiratory parameters. METHODS: We retrospectively screened 453 patients who underwent EEG in a single center including nasal airflow measurements, respiratory inductance plethysmography of thoracoabdominal excursions, peripheral capillary oxygen saturation, and electrocardiography...
September 8, 2020: Epilepsy & Behavior: E&B
Hisham ElMoaqet, Mohammad Eid, Martin Glos, Mutaz Ryalat, Thomas Penzel
Sleep apnea is a common sleep disorder that causes repeated breathing interruption during sleep. The performance of automated apnea detection methods based on respiratory signals depend on the signals considered and feature extraction methods. Moreover, feature engineering techniques are highly dependent on the experts' experience and their prior knowledge about different physiological signals and conditions of the subjects. To overcome these problems, a novel deep recurrent neural network (RNN) framework is developed for automated feature extraction and detection of apnea events from single respiratory channel inputs...
September 4, 2020: Sensors
Haley DʼSouza, Kapil G Kapoor
PURPOSE OF REVIEW: The aim of this article is to summarize up-to-date research on the effects of obstructive sleep apnea (OSA) on retinal vascular conditions. RECENT FINDINGS: OSA is associated with the development of diabetic retinopathy, retinal vein occlusion, and central serous chorioretinopathy. The severity of OSA and biomarkers such as the apnea-hypopnea index (AHI) correlate with the severity of retinal disease. Dysregulation of CLOCK genes that govern circadian rhythm is associated with development of proliferative retinal disease...
September 3, 2020: Current Opinion in Ophthalmology
Jessica Taytard, Stéphanie Valence, Chiara Sileo, Diana Rodriguez, Plamen Bokov, Guillaume Aubertin, Harriet Corvol, Nicole Beydon
We report the case of a 12-year-old girl referred to our pediatric sleep unit with a history of central sleep apnea (CSA), associated to transient episodes of tachypnea on polysomnography recordings. The patient was otherwise healthy, with no personal or family medical history, and had normal physical and neuropsychological examination. Brain magnetic resonance imaging (MRI) showed signs of cerebellar vermis dysplasia, but without the classical features of the molar tooth sign. The rest of the workup (genetic tests, blood tests, cardiac investigations) was normal, except for an increased peripheral chemosensitivity to carbon dioxide and oxygen...
September 8, 2020: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Pontus K Holmström, Jordan D Bird, Scott F Thrall, Ann Kalker, Brittney A Herrington, Jan E Soriano, Leah M Mann, Zahrah H Rampuri, Tom D Brutsaert, Øyvind Karlsson, Mingma T Sherpa, Erika K A Schagatay, Trevor A Day
NEW FINDINGS: What is the central question of this study? We investigated the effects of incremental ascent to high altitude on splenic contraction at rest and during voluntary breath holding, and the associated bradycardic diving response. We aimed to assess the relative contribution of the putative tonic splenic contraction to the hematological acclimatization process during HA ascent in native lowlanders. What is the main finding and its importance? We found that spleen volume decreased by -14...
September 7, 2020: Experimental Physiology
Weston T Powell, Christian P Schaaf, Megan E Rech, Joanna Wrede
INTRODUCTION: Schaaf-Yang Syndrome (SYS) is a genetic disorder caused by truncating variants in the MAGEL2 gene located in the maternally imprinted Prader-Willi syndrome (PWS) region at 15q11-13. The SYS phenotype shares features with PWS, a syndrome with known high incidence of sleep disorders. However, the spectrum of sleep-disorders in SYS has not been described. METHODS: We performed a retrospective analysis of polysomnograms from 22 patients in an international SYS cohort...
September 5, 2020: Pediatric Pulmonology
Leonie Kolb, Michael Arzt, Stefan Stadler, Katharina Heider, Lars S Maier, Maximilian Malfertheiner
PURPOSE: Adaptive servo-ventilation (ASV) is a therapy designed for patients with central sleep apnea (CSA) and Cheyne Stokes respiration. The aim of this study was to find predictors of ASV usage in patients with CSA in a routine sleep clinic cohort. METHODS: In this retrospective study, consecutive patients in whom ASV therapy was initiated at the University Hospital Regensburg between 2011 and 2015, were analyzed. Analysis included polysomnographies of diagnostic and ASV initiation nights, a phone questionnaire on ASV usage, readout of the ASV device 1 month after initiation ("early ASV usage," 1 month after ASV initiation), and the readout of the last month before a reappointment date set in 2015 ("late ASV usage," median 17 months after ASV initiation)...
September 3, 2020: Sleep & Breathing
Charles Saadeh, Seckin O Ulualp
OBJECTIVE: Sleep associated hypoventilation (SAH) is diagnosed when more than 25% of total sleep time (%TST) is spent with end tidal carbon dioxide (EtCO2 ) > 50 mmHg. SAH in children occurs as a single entity or combined with obstructive sleep apnea. Outcomes of surgical treatment for isolated SAH in children have not been reported. METHODS: The medical charts of children who were diagnosed with isolated SAH and did not have OSA at a tertiary children's hospital between January 2013 and December 2019 were reviewed...
September 2, 2020: Laryngoscope
Harry J Davies, Ian Williams, Nicholas S Peters, Danilo P Mandic
The non-invasive estimation of blood oxygen saturation (SpO2 ) by pulse oximetry is of vital importance clinically, from the detection of sleep apnea to the recent ambulatory monitoring of hypoxemia in the delayed post-infective phase of COVID-19. In this proof of concept study, we set out to establish the feasibility of SpO2 measurement from the ear canal as a convenient site for long term monitoring, and perform a comprehensive comparison with the right index finger-the conventional clinical measurement site...
August 28, 2020: Sensors
Tao Yuan, Wenming Yang, Lei Yang, Xueting Liu, Lie Yang, Yu Li
BACKGROUND: Whether regional anesthesia (RA) offers better long-term neurodevelopment outcomes compared to general anesthesia (GA) to infants undergoing inguinal herniorrhaphy is still under heated debate. The aim of this meta-analysis is to compare the long-term neurodevelopment impact of RA with GA on infants undergoing inguinal herniorrhaphy. METHODS: A systematic search of MEDLINE, EMBASE, PubMed, the Cochrane Central Register of Controlled Trials, clinicaltrials...
August 14, 2020: Medicine (Baltimore)
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