Selahattin Ayas, Gülçin Benbir Şenel, Derya Karadeniz
Arnold Chiari malformation (ACM) is herniation of brain stem structures, especially cerebellar tonsils, from the foramen magnum into the cervical spinal canal. Sleep-related respiratory disorders are reported at a higher rate in this patient group than the general population, at about 60-75%. A 43-year-old male patient was diagnosed with ACM type 1.5 at the center where he applied with complaints of weakness in the extremities, speech disorder and syncope triggered by coughing, and a decompression of posterior fossa (PFD) was applied to the patient...
July 2020: Tüberküloz Ve Toraks
Hamed Amirifard, Khosro Sadeghniiat-Haghighi, Arezu Najafi
Patients with Chiari type I malformation may also present with sleep disordered breathing mainly central sleep apnea. Here, we report a patient with Chiari I malformation referred to our clinic because of snoring and sleep disordered breathing. He was a 28-year-old man referred to us for evaluation of snoring. An overnight polysomnography revealed central sleep apnea. On further evaluation of central sleep apnea, the patient found to have Chiari malformation type I on brain MRI. The patient developed obstructive sleep apnea after surgery for Chiari malformation...
April 2020: Sleep Science
Alvaro Emilio Ortiz-Naretto, Miriam Patricia Pereiro, Glenda Ernst, Juan Manuel Aramburo, Ana María Tovo, Andres Vázquez-Fernández, Eduardo Borsini
Objective: to compare mountaineers with and without asymptomatic sleep apnea (OSA) before the ascent and to study high altitude-related sleep disorders, its interaction with metabolic, neuroendocrine and immunological components. Material and Methods: During an expedition to Mount Aconcagua, researchers assessed the respiratory polygraphy (RP), clinical condition and inflammatory parameters, and rhythm of cortisol secretion in mountaineers sleeping at different altitude camps...
April 2020: Sleep Science
Rui-Ni Wu, Wei-Chen Hung, Ching-Tsuey Chen, Li-Ping Tsai, Wen-Sung Lai, Ming-Yuan Min, Shi-Bing Wong
BACKGROUND: Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by multiple respiratory, cognitive, endocrine, and behavioral symptoms, such as central apnea, intellectual disabilities, exaggerated stress responses, and temper tantrums. The locus coeruleus noradrenergic system (LC-NE) modulates a diverse range of behaviors, including arousal, learning, pain modulation, and stress-induced negative affective states, which are possibly correlated with the pathogenesis of PWS phenotypes...
July 29, 2020: Journal of Neurodevelopmental Disorders
Dang-Khoa Nguyen, Jonathan Liang, Megan Durr
BACKGROUND: Nasal obstruction is a common complaint in patients with sleep-disordered breathing and obstructive sleep apnea (OSA). Although topical nasal treatments (TNTs) have been shown to reduce nasal resistance and improve nasal obstruction, there is conflicting evidence regarding the role of TNTs in adult OSA. In this systematic review and meta-analysis we aim to evaluate the role of TNTs in adults with OSA. Data sources used included PubMed, Ovid MEDLINE, and Cochrane Central, from January 2001 to July 2019...
July 26, 2020: International Forum of Allergy & Rhinology
Jens Spiesshoefer, Nora Hegerfeld, Malte Frank Gerdes, Sören Klemm, Martha Gorbachevski, Robert Radke, Izabela Tuleta, Claudio Passino, Xiaoyi Jiang, Paolo Sciarrone, Winfried Randerath, Michael Dreher, Matthias Boentert, Alberto Giannoni
BACKGROUND: Increased sympathetic drive is the key determinant of systolic heart failure progression, being associated with worse functional status, arrhythmias, and increased mortality. Central sleep apnea is highly prevalent in systolic heart failure, and its effects on sympathovagal balance (SVB) and hemodynamics might depend on relative phase duration and background pathophysiology. OBJECTIVE: This study compared the effects of central apneas in patients with and without systolic heart failure on SVB and hemodynamics during sleep...
July 22, 2020: Sleep & Breathing
Victoria S Sprung, Graham J Kemp, John Ph Wilding, Valerie Adams, Kieran Murphy, Malcolm Burgess, Stephen Emegbo, Matthew Thomas, Alexander J Needham, Andrew Weimken, Richard J Schwab, Ari Manuel, Sonya E Craig, Daniel J Cuthbertson
INTRODUCTION: Obstructive sleep apnoea (OSA) and type 2 diabetes mellitus (T2DM) often occur concurrently, and untreated OSA may potentially amplify the high risk of cardiovascular disease in T2DM. Compliance with continuous positive airway pressure (CPAP), the conventional treatment for OSA, can be poor and considering weight loss is the most effective treatment for OSA. This trial examines whether the glucagon-like peptide-1 receptor agonist liraglutide, a glucose-lowering therapy associated with significant weight loss used in T2DM, can improve the severity and symptoms of OSA...
July 22, 2020: BMJ Open
Ross A Barman, Amanda R Fields, Austin J Eells, Ioanna Kouri, Meghna P Mansukhani, Bhargavi Gali, Juraj Sprung, Toby N Weingarten
PURPOSE: Treatment-emergent central sleep apnea (TECSA) is a central sleep-related breathing disorder, characterized by either the persistence or emergence of central sleep apnea during the initiation of positive airway pressure therapy for obstructive sleep apnea. The purpose of this study was to review the perioperative course of patients diagnosed with TECSA. METHODS: We reviewed medical records of patients with TECSA who had a procedure or surgery with general anesthesia between January 1, 2009 and May 1, 2018...
July 21, 2020: Journal of Anesthesia
Arild Hetland, Maria Vistnes, Kristina H Haugaa, Kristian Hovde Liland, Margareth Olseng, Thor Edvardsen
Background: In chronic heart failure (CHF), obstructive sleep apnea (OSA) and Cheyne-Stokes respiration (CSR) are associated with increased mortality. The present study aimed to evaluate the prognostic effect of CSR compared to OSA, in otherwise similar groups of CHF patients. Methods: Screening for sleep-disordered breathing (SDB) was conducted among patients with CHF of New York Heart Association (NYHA) class II-IV, and left ventricular ejection fraction (LVEF) of ≤45%...
June 2020: Cardiovascular Diagnosis and Therapy
L X Zhang, G Q Zhao, G Wang, X Wang, J Y Fan, S P Nie, Y X Wei
Objective: To investigate the relationship between different waist-hip ratios and sleep-disordered breathing (SDB) in patients with acute coronary syndrome (ACS) and its effect on patients' long-term prognosis. Methods: A total of 725 patients who were diagnosed with ACS in the emergency ward of Beijing An Zhen Hospital from June 2015 to May 2017 were included, and all the patients were monitored for sleep and breathing. Patients were divided into four groups according to their waist-hip ratios. The differences of SDB-related indicators among the four groups were compared, and the correlation between different waist-hip ratios and SDB was analyzed using multiple logistic regression...
July 21, 2020: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Maija Seppä-Moilanen, Sture Andersson, Turkka Kirjavainen
BACKGROUND: The significance of arousal in apnea termination in preterm infants is not known. METHODS: We investigated the appearance of arousals from sleep with polysomnography for 21 preterm infants at a median age of 36 gestational weeks. RESULTS: The polysomnographic appearance of sleep was fragmented by frequent arousals. The number of spontaneous arousals unrelated to apneas was 18 per h in sleep; higher in rapid eye movement (REM) sleep than in non-REM sleep (p < 0...
July 18, 2020: Pediatric Research
Kevin Vézina, Jennifer Mariasine, Rochelle Young, Myrtha Reyna, Zihang Lu, Padmaja Subbarao, Theo J Moraes, Allan B Becker, Stuart E Turvey, Malcolm R Sears, Diana L Lefebvre, Meghan B Azad, Carmen Rasmussen, Jacqueline Pei, Indra Narang, Piush J Mandhane
RATIONALE: Sleep study interpretation in children needs to be based on age-specific normal values. While several studies have reported normal cardiorespiratory parameters during sleep in children and adolescents, few have included younger children. OBJECTIVES: To describe cardiopulmonary indices specifically oxygen saturation, heart rate, as well as frequency of obstructive and central apneas in healthy one-year-old Canadian infants during sleep. METHODS: Home sleep cardiorespiratory monitoring (HSCM) was performed among infants participating in the Edmonton sub-cohort of the Canadian Healthy Infant Longitudinal Development (CHILD) Study at their one-year follow-up visit...
July 17, 2020: Annals of the American Thoracic Society
Norman Bolden, Karen L Posner, Karen B Domino, Dennis Auckley, Jonathan L Benumof, Seth T Herway, David Hillman, Shawn L Mincer, Frank Overdyk, David J Samuels, Lindsay L Warner, Toby N Weingarten, Frances Chung
BACKGROUND: Obstructive sleep apnea (OSA) patients are at increased risk for pulmonary and cardiovascular complications; perioperative mortality risk is unclear. This report analyzes cases submitted to the OSA Death and Near Miss Registry, focusing on factors associated with poor outcomes after an OSA-related event. We hypothesized that more severe outcomes would be associated with OSA severity, less intense monitoring, and higher cumulative opioid doses. METHODS: Inclusion criteria were age ≥18 years, OSA diagnosed or suspected, event related to OSA, and event occurrence 1992 or later and <30 days postoperatively...
July 14, 2020: Anesthesia and Analgesia
Stephanie Enner, Sanaya Hormozdyaran, Robin Varughese, Jennifer Milillo, Ivan Pavkovic, Emma Laureta, James Schneider, Sanjeev Kothare
No abstract text is available yet for this article.
June 5, 2020: Pediatric Neurology
Tiffany W Dong, David B MacLeod, Antoinette Santoro, Zachary Augustine, Stratton Barth, Mary Cooter, Richard E Moon
PURPOSE: Reported incidence of postoperative opioid-induced respiratory depression (OIRD) range from 0.5 to 41% and is not reliably predicted by traditional risk factors. This study tests a new methodology to investigate ventilatory chemosensitivity as a new potential risk factor and explore OIRD distribution across sleep and wakefulness. METHODS: Preoperative patient ventilatory chemosensitivity was quantified by hypercapnic ventilatory responses with (HCVRREMI , effect site concentration 0...
July 16, 2020: Journal of Applied Physiology
Baha Al-Shawwa, Zarmina Ehsan, David G Ingram
STUDY OBJECTIVES: The impact of vitamin D on human health including sleep has been well described in adults. Its deficiency has been associated with multiple sleep disorders such as decrease in sleep duration, worsening of sleep quality, and even OSA. Such correlation is less evident in the pediatric population. In the current study, we examined the relationship between sleep architecture and vitamin D status in children referred to a sleep clinic. METHODS: This was a retrospective-cohort study in a tertiary care children's hospital over a 1-year period...
July 15, 2020: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Jason A Hayes, Talal Aljuhani, Kyle De Oliveira, Bradley C Johnston
BACKGROUND: Drugs such as propofol and ketamine are used alone or in combination to provide sedation for medical procedures in children. The purpose of this systematic review was to compare the safety and effectiveness of propofol and ketamine to other drug regimens. METHODS: We searched Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews (CDSR), Web of Science, and the grey literature (meta-Register of Controlled Trials, ClinicalTrials...
July 7, 2020: Anesthesia and Analgesia
Frédéric Lofaso, Karl Leroux, Ghilas Boussaid, Hélène Prigent, Bruno Louis
BACKGROUND: Adaptive servoventilation (ASV) is a recently developed ventilation mode designed to stabilize ventilation in patients with central sleep apnea and Cheyne-Stokes respiration. Alternatively, modes aiming to maintain average ventilation over several breaths, such as average volume-assured pressure support (AVAPS) and intelligent volume-assured pressure support (iVAPS), could be efficient during ventilation instability by reducing central events. These modes are available on a variety of devices...
July 14, 2020: Respiratory Care
Hannah V Fletcher, Peter Siu Pan Cho, Stewart Lee Loong, Luis Estrada-Petrocelli, Amit S Patel, Surinder S Birring, Kai K Lee
STUDY OBJECTIVES: Exercise capacity is impaired in obstructive sleep apnea (OSA). There are conflicting reports on the effect of CPAP on maximal exercise capacity. The objective of this review was to determine if there is a change in exercise capacity and anaerobic threshold following continuous positive airway pressure (CPAP) treatment in OSA patients. METHODS: We conducted a systematic review and meta-analyses to summarize the changes in peak rate of oxygen uptake (V̇O₂peak) or maximum rate of oxygen uptake (V̇O₂max) and anaerobic threshold (AT) during cardiopulmonary exercise testing following CPAP intervention in patients with OSA...
July 14, 2020: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Tomomi Ogata, Kazuhiro Muramatsu, Kaori Miyana, Hiroshi Ozawa, Motoki Iwasaki, Hirokazu Arakawa
BACKGROUND: Congenital central hypoventilation syndrome (CCHS) is a rare disease characterized by sleep apnea. Anoxia often occurs soon after birth, and it is important to prevent anoxia-mediated central nervous system complications; however, data on the relationship between respiratory management and the prognosis for intellectual development of patients with CCHS is not well yet investigate. METHODS: We performed a retrospective chart review cohort study of patients with CCHS in Japan...
July 13, 2020: BMC Pediatrics
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