Ying He, Yunyuan Nong, Junliang Qin, Linlin Feng, Jinghua Qin, Qianyi Wang, Lijun Deng, Siqi Tang, Meiling Zhang, Xiaofeng Fan, Min Dong, Jinbin Wei, Shihan Pan, Zhiheng Su
BACKGROUND: Oyster polypeptide (OP) is a mixture of oligopeptides extracted from oysters through enzyme lysis, separation and purification. OP is associated with immunomodulatory effects, but the underlying mechanisms are not known. Therefore, this study combined 1 H-NMR urinary metabolomics and 16S rRNA gene sequencing of the gut microbiome to determine the immunoprotective mechanisms of OP in rats subjected to cyclophosphamide-induced immunosuppression. RESULTS: OP can restored the body weight and the structure of spleen and thymus in cyclophosphamide-induced immunosuppression rats...
April 17, 2024: Journal of the Science of Food and Agriculture