Peter Rossing
No abstract text is available yet for this article.
November 25, 2020: Clinical Journal of the American Society of Nephrology: CJASN
Flory T Muanda, Matthew A Weir, Lavanya Bathini, Kristin K Clemens, Vlado Perkovic, Manish M Sood, Eric McArthur, Jessica M Sontrop, Richard B Kim, Amit X Garg
BACKGROUND AND OBJECTIVES: Sitagliptin, a dipeptidyl peptidase-4 inhibitor, is commonly prescribed to patients with type 2 diabetes. As this drug is primarily eliminated by the kidney, a reduced dose is recommended for patients with CKD. Some evidence suggests that sitagliptin is associated with a higher risk of congestive heart failure, particularly at higher doses. We compare the 1-year risk of death or hospitalization with congestive heart failure in patients with CKD newly prescribed sitagliptin at >50 versus ≤50 mg/d...
November 25, 2020: Clinical Journal of the American Society of Nephrology: CJASN
Sadayoshi Ito, Naoki Kashihara, Kenichi Shikata, Masaomi Nangaku, Takashi Wada, Yasuyuki Okuda, Tomoko Sawanobori
BACKGROUND AND OBJECTIVES: Diabetic kidney disease is an important complication of type 2 diabetes. In a phase 2b study, adding esaxerenone to renin-angiotensin system inhibitors dose dependently reduced the urinary albumin-to-creatinine ratio in patients with type 2 diabetes and microalbuminuria. This 52-week phase 3 study further investigated the effects of esaxerenone on the urinary albumin-to-creatinine ratio in this patient group. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this multicenter, randomized, double-blind study, patients with type 2 diabetes and a urinary albumin-to-creatinine ratio of 45 to <300 mg/g creatinine treated with renin-angiotensin system inhibitors were randomized to esaxerenone or placebo for 52 weeks ( n =455)...
November 25, 2020: Clinical Journal of the American Society of Nephrology: CJASN
J Emilio Sanchez-Alvarez, Elena Astudillo Cortes, Miguel Seras Mozas, Raúl García Castro, Carlos Miguel Hidalgo Ordoñez, Ana Cristina Andrade López, Catalina Ulloa Clavijo, Anna Gallardo Pérez, Carmen Rodríguez Suárez
INTRODUCTION: Alterations in bone and mineral metabolism are very common in chronic kidney disease (CKD). The increase in phosphate levels leads to bone disease, risk of calcification and greater mortality, so any strategy aimed at reducing them should be welcomed. The latest drug incorporated into the therapeutic arsenal to treat hyperphosphataemia in CKD is sucroferric oxyhydroxide (SFO). OBJECTIVE: To analyse the efficacy and safety of SFO in 3 cohorts of patients, one with advanced CKD not on dialysis, another on peritoneal dialysis and the last on haemodialysis, followed for 6 months...
November 22, 2020: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Salvatore Di Paolo, Marco Fiorentino, Luca De Nicola, Gianpaolo Reboldi, Loreto Gesualdo, Federica Barutta, Andrea Natali, Giuseppe Penno, Paola Fioretto, Giuseppe Pugliese
AIMS: This joint document of the Italian Society of Nephrology and the Italian Diabetes Society reviews the main indications to perform a renal biopsy in diabetic patients, according to the recommendations of a panel of experts based on all available scientific evidence. DATA SYNTHESIS: Renal biopsy has a pivotal role in assessing the nature and severity of renal injury in patients with diabetic kidney disease (DKD). The procedure is mandatory in the presence of one of more of the following features: rapid onset or progression of albuminuria or sudden onset of nephrotic syndrome, rapid GFR decline with or without albuminuria, hematuria, active urine sediment, clinical and/or laboratory suspicion of other systemic diseases, and, in patients with type 1 diabetes, short diabetes duration and absence of retinopathy...
November 27, 2020: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Misghina Weldegiorgis, Mark Woodward
BACKGROUND: Hypertension (HTN) is an established risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). Whether sex differences in the effect of HTN on CKD and ESRD incidence exist remains unclear. This systematic review and meta-analysis was conducted to evaluate the relative impact of HTN on CKD and ESRD risk in women compared with men. METHODS: We systematically searched Embase and PubMed for cohort studies until 24 July 2020. Studies were selected if they reported a sex-specific association between systolic blood pressure (SBP) and CKD or ESRD...
November 25, 2020: BMC Nephrology
Michael Girsberger, Christopher T Chan
BACKGROUND: Increased right ventricular systolic pressure (RVSP), a surrogate marker for pulmonary hypertension, is common in patients with end-stage kidney disease. Limited data suggest improvement of RVSP with intensive dialysis, but it is unknown whether these improvements translate to better clinical outcomes. METHODS: We conducted a retrospective single center cohort study at the Toronto General Hospital. All patients who performed intensive home hemodialysis (IHHD) for at least a year between 1999 and 2017, and who had a baseline as well as a follow-up echocardiogram more than a year after IHHD, were included...
November 25, 2020: BMC Nephrology
Masaaki Inaba, Yasuro Kumeda, Shinsuke Yamada, Norikazu Toi, Chie Hamai, Koichi Noguchi, Eikichi Yasuda, Yutaka Furumitsu, Masanori Emoto, Yoshiteru Ohno
BACKGROUND: An association of higher levels of β-hydroxybutyrate (β-HB) in serum with greater mortality in hemodialysis (HD) patients has been reported. This study examined the significance of arterial ketone body ratio (AcAc/β-HB), a relevant marker of energy state, in HD patients. METHODS: The levels of arterial AcAc and β-HB, and AcAc/β-HB ratio were determined in 49 HD patients just before undergoing an HD session. Additionally, changes in those levels during the session were examined to investigate their associations with clinical nutritional markers...
November 25, 2020: BMC Nephrology
Kalaivani Gobalarajah, Prabagar Subramaniam, Uthpala Apekshani Jayawardena, Gobalarajah Rasiah, Sittampalam Rajendra, Jasotha Prabagar
BACKGROUND: Increase in the number of cases in Chronic Kidney Disease of Unknown etiology (CKDu) in Sri Lanka has become a health issue of national concern. Even though, Northern Province is not identified as a high-risk province, there is an increasing trend of CKDu after the end of civil war in the Northern Province. METHODS: The present study was conducted in Thunukkai Division in Mullaitivu District to investigate the socio demographic and clinical pattern of CKDu patients and to evaluate the quality of their water sources...
November 25, 2020: BMC Nephrology
Shasha Yu, Xiaofan Guo, Guang Xiao Li, Hongmei Yang, Liqiang Zheng, Yingxian Sun
BACKGROUND: Metabolic healthy obesity (MHO), a phenotype of obesity, seems to be associated with a lower risk of cardiovascular disease. However, MHO has a close relationship with a higher incidence of metabolic syndrome and diabetes. This study aimed to investigate the prevalence of MHO at baseline, the changes in the obese metabolic phenotype at follow-up and the relationship of this phenotype with the incidence of mildly reduced estimated glomerular filtration rate (eGFR) in rural Northeast Chinese...
November 24, 2020: BMC Nephrology
Yuxin Yang, Kexin Shi, Devang M Patel, Fang Liu, Tieqiao Wu, Zhonglin Chai
PURPOSE OF REVIEW: Diabetic kidney disease (DKD) is a leading cause of mortality and morbidity in diabetes. This review aims to discuss the major features of DKD, to identify the difficult barrier encountered in developing a therapeutic strategy and to provide a potentially superior novel approach to retard DKD. RECENT FINDINGS: Renal inflammation and fibrosis are prominent features of DKD. Transforming growth factor beta (TGFβ) with its activity enhanced in DKD plays a key pathological profibrotic role in promoting renal fibrosis...
November 20, 2020: Current Opinion in Nephrology and Hypertension
Wanning Wang, Jia Li, Lu Cai
PURPOSE OF REVIEW: Sirtuins are a family of nicotinamide adenine dinucleotide+-dependent enzymes catalyzing target protein deacetylation to modulate cellular metabolism, response to oxidative stress and inflammation, senescence, autophagy and apoptosis. In this review, we provide an overview of recent studies regarding the alterations and roles of sirtuins in a variety of renal and cardiovascular diseases. We are also going to highlight activators and inhibitors of sirtuins in the prevention of these diseases...
November 20, 2020: Current Opinion in Nephrology and Hypertension
Radica Z Alicic, Emily J Cox, Joshua J Neumiller, Katherine R Tuttle
As the prevalence of diabetes continues to climb, the number of individuals living with diabetic complications will reach an unprecedented magnitude. The emergence of new glucose-lowering agents - sodium-glucose cotransporter 2 inhibitors and incretin therapies - has markedly changed the treatment landscape of type 2 diabetes mellitus. In addition to effectively lowering glucose, incretin drugs, which include glucagon-like peptide 1 receptor (GLP1R) agonists and dipeptidyl peptidase 4 (DPP4) inhibitors, can also reduce blood pressure, body weight, the risk of developing or worsening chronic kidney disease and/or atherosclerotic cardiovascular events, and the risk of death...
November 20, 2020: Nature Reviews. Nephrology
Sophia Zoungas, Kevan R Polkinghorne
No abstract text is available yet for this article.
November 19, 2020: Clinical Journal of the American Society of Nephrology: CJASN
George Bakris, Megumi Oshima, Kenneth W Mahaffey, Rajiv Agarwal, Christopher P Cannon, George Capuano, David M Charytan, Dick de Zeeuw, Robert Edwards, Tom Greene, Hiddo J L Heerspink, Adeera Levin, Bruce Neal, Richard Oh, Carol Pollock, Norman Rosenthal, David C Wheeler, Hong Zhang, Bernard Zinman, Meg J Jardine, Vlado Perkovic
BACKGROUND AND OBJECTIVES: The Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial demonstrated that the sodium glucose cotransporter 2 (SGLT2) inhibitor canagliflozin reduced the risk of kidney failure and cardiovascular events in participants with type 2 diabetes mellitus and CKD. Little is known about the use of SGLT2 inhibitors in patients with eGFR <30 ml/min per 1.73 m2 . The participants in the CREDENCE study had type 2 diabetes mellitus, a urinary albumin-creatinine ratio >300-5000 mg/g, and an eGFR of 30 to <90 ml/min per 1...
November 19, 2020: Clinical Journal of the American Society of Nephrology: CJASN
Meseret Derbew Molla, Maria Degef, Abebe Bekele, Zeleke Geto, Feyissa Challa, Tadesse Lejisa, Tigist Getahun, Meron Sileshi, Yosef Tolcha, Genet Ashebir, Daniel Seifu
BACKGROUND: Chronic kidney disease (CKD), which is characterized by its asymptomatic nature until an end stage, is one of the most common public health problems in the world. Thus, a regular checkup, especially for those individuals with high risk groups is inevitably important, and the screening has been done with laboratory findings. However, in developing countries, including Ethiopia screening for CKD are rarely done, and it is becoming common to hear sudden death from the kidney failure...
November 18, 2020: BMC Nephrology
Parth M Patel, Alexander M Kandabarow, Eseosa Aiwerioghene, Enrique Blanco-Martinez, Spencer Hart, David J Leehey, Ahmer Farooq, Kristin G Baldea, Thomas M T Turk
INTRODUCTION: Proton-pump inhibitors (PPIs) may increase the risk of kidney stone formation, but the mechanism has not been elucidated. There is a paucity of literature evaluating the effects of PPIs on urinary metabolites and urine pH. METHODS: We performed a retrospective review of nephrolithiasis patients treated at our institution and compared patients who were taking PPIs to those who were not at the time of their 24-h urine collections. Hierarchical multivariate linear regression was used to evaluate the independent relationship between PPI use and urinary mineral composition...
November 18, 2020: International Urology and Nephrology
Ayumu Kimura, Marenao Tanaka, Norihito Moniwa, Arata Osanami, Koki Abe, Daisuke Miyamori, Yufu Gocho, Satoru Shibata, Makoto Terasawa, Yusuke Okazaki, Tomohisa Yamashita, Masayuki Koyama, Masato Furuhashi, Hirofumi Ohnishi, Tetsuji Miura
BACKGROUND: Atrial fibrillation (AF) is an established risk factor for ischemic stroke in a general population. However, its impact in patients on hemodialysis (HD), a group with a high risk for stroke, is still controversial. Here we examined this issue in a Japanese cohort. METHODS: This study was designed as a multicenter cohort study. HD patients (n = 1,067) were enrolled from 22 institutes in January 2009 and followed up for 3 years. Patients with missing data (n = 196) or kidney transplantation (n = 4) were excluded, and 867 patients contributed to the analysis of the risk of new-onset of ischemic stroke...
November 18, 2020: Clinical and Experimental Nephrology
Sevda Alvirdizadeh, Emad Yuzbashian, Parvin Mirmiran, Shahryar Eghtesadi, Fereidoun Azizi
BACKGROUND: The link between dietary protein intake and the risk of kidney dysfunction is always a challenging issue. This study aimed to investigate the relationship between total protein, plant protein, and animal protein intake with the risk of incident chronic kidney disease (CKD). METHODS: This study was performed on 1639 adults aged ≥27 years who participated in the Tehran Lipid and Glucose Study. Dietary data were evaluated using a valid and reliable semi-quantitative food frequency questionnaire (FFQ)...
November 17, 2020: BMC Nephrology
Simonetta Bacci, Maria Giulia Tinti, Anna Rauseo, Valentina Massa, Gianluigi Vendemiale, Salvatore De Cosmo
No abstract text is available yet for this article.
November 16, 2020: Nephrology, Dialysis, Transplantation
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