Danielle I Aronowitz, Tracy R Geoffrion, Sarah Piel, Sarah R Morton, Jonathan Starr, Richard W Melchior, Hunter A Gaudio, Rinat Degani, Nicholas J Widmann, M Katie Weeks, Nicolina R Ranieri, Emilie Benson, Tiffany S Ko, Daniel J Licht, Marco Hefti, J William Gaynor, Todd J Kilbaugh, Constantine D Mavroudis
Optimal oxygen management during pediatric cardiopulmonary bypass (CPB) is unknown. We previously demonstrated an increase in cortical mitochondrial reactive oxygen species and decreased mitochondrial function after CPB using hyperoxic oxygen management. This study investigates whether controlled oxygenation (normoxia) during CPB reduces cortical mitochondrial dysfunction and oxidative injury. Ten neonatal swine underwent three hours of continuous CPB at 34 °C (flow > 100 mL/kg/min) via cervical cannulation targeting a partial pressure of arterial oxygen (PaO2 ) goal < 150 mmHg (normoxia, n = 5) or >300 mmHg (hyperoxia, n = 5)...
May 17, 2024: International Journal of Molecular Sciences