Jiri Soukup, Monika Manethova, Hana Faistova, Lukas Krbal, Barbora Vitovcova, Helena Hornychova, Jan Drugda, Tomas Cesak, David Netuka, Filip Gabalec, Ales Ryska
AIMS: Pitx2 is a transcription factor responsible for establishment of right-left axis, and development of gut and pituitary. In mouse embryos, Pitx2 is expressed in the greater curvature of the stomach and midgut. Previously, Pitx2 was studied in pituitary neuroendocrine tumours but not in other NETs. METHODS AND RESULTS: Pitx2 expression was immunohistochemically assessed in whole sections and tissue microarrays in a cohort of 224 neuroendocrine neoplasms. Pitx2 mRNA expression was analysed in 29 cases...
September 12, 2022: Histopathology