Tuo Deng, Jungang Zhao, Yifan Tong, Ziyan Chen, Bangjie He, Jiacheng Li, Bo Chen, Rizhao Li, Liming Deng, Haitao Yu, Baofu Zhang, Tan Zhang, Zhehao Shi, Boyang Gao, Junyan Jiang, Yunfeng Shan, Zhengping Yu, Yuepeng Jin, Yi Wang, Jinglin Xia, Gang Chen
Metastasis causes most cancer-related deaths, and the role and mechanism of periostin (POSTN) in the metastasis of hepatocellular carcinoma (HCC) remain undiscovered. In this study, DEN and HTVi HCC models were performed in hepatic-specific Postn ablation and Postn knock-in mouse to reveal the role of POSTN in HCC metastasis. Furthermore, POSTN was positively correlated with circulating EPCs level and promoted EPC mobilization and tumour infiltration. POSTN also mediated the crosstalk between HCC and EPCs, which promoted metastasis ability and upregulated CD36 expression in HCC through indirect crosstalk...
February 13, 2024: Oncogene