Priya Godara, K Sony Reddy, Welka Sahu, Biswajit Naik, Varshita Srivastava, Rusham Das, Ajay Mahor, Prateek Kumar, Rajanish Giri, Jivanage Anirudh, Harshita Tak, Hemanth Naick Banavath, Tarun Kumar Bhatt, Amit Kumar Goyal, Dhaneswar Prusty
The continuous emergence of resistance against most frontline antimalarial drugs has led to countless deaths in malaria-endemic countries, counting 619,000 deaths in 2021, with mutation in drug targets being the sole cause. As mutation is correlated frequently with fitness cost, the likelihood of mutation emergence in multiple targets at a time is extremely low. Hence, multitargeting compounds may seem promising to address drug resistance issues with additional benefits like increased efficacy, improved safety profile, and the requirement of fewer pills compared to traditional single and combinational drugs...
December 21, 2023: Molecular Diversity