keyword
https://read.qxmd.com/read/38214905/a-novel-task-channel-antagonist-nasal-spray-reduces-sleep-apnea-severity-in-physiological-responders-a-randomized-blinded-trial
#21
JOURNAL ARTICLE
Amal M Osman, Barbara Toson, Ganesh Naik, Sutapa Mukherjee, Martina Delbeck, Michael Hahn, Thomas Mueller, Gerrit Weimann, Danny J Eckert
Preclinical and human physiological studies indicate that topical, selective TASK 1/3 K+ channel antagonism increases upper airway dilator muscle activity and reduces pharyngeal collapsibility during anaesthesia and nasal breathing during sleep. The primary aim of this study was to determine the effects of BAY2586116 nasal spray on OSA severity and whether individual responses vary according to differences in physiological responses and route of breathing. 10 people (5 females) with OSA (AHI=47±26events/h (mean±SD)) who completed previous sleep physiology studies with BAY2586116 were invited to return for three polysomnography studies to quantify OSA severity...
January 12, 2024: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/38182597/tail-tape-fused-virion-and-non-virion-rna-polymerases-of-a-thermophilic-virus-with-an-extremely-long-tail
#22
JOURNAL ARTICLE
Anastasiia Chaban, Leonid Minakhin, Ekaterina Goldobina, Brain Bae, Yue Hao, Sergei Borukhov, Leena Putzeys, Maarten Boon, Florian Kabinger, Rob Lavigne, Kira S Makarova, Eugene V Koonin, Satish K Nair, Shunsuke Tagami, Konstantin Severinov, Maria L Sokolova
Thermus thermophilus bacteriophage P23-45 encodes a giant 5,002-residue tail tape measure protein (TMP) that defines the length of its extraordinarily long tail. Here, we show that the N-terminal portion of P23-45 TMP is an unusual RNA polymerase (RNAP) homologous to cellular RNAPs. The TMP-fused virion RNAP transcribes pre-early phage genes, including a gene that encodes another, non-virion RNAP, that transcribes early and some middle phage genes. We report the crystal structures of both P23-45 RNAPs. The non-virion RNAP has a crab-claw-like architecture...
January 5, 2024: Nature Communications
https://read.qxmd.com/read/38117203/flexible-tape-drive-target-system-for-secondary-high-intensity-laser-driven-sources
#23
JOURNAL ARTICLE
G Zeraouli, D A Mariscal, R Hollinger, S Zahedpour Anaraki, E N Folsom, E Grace, D Rusby, M P Hill, G J Williams, G G Scott, B Sullivan, S Wang, J King, K K Swanson, R A Simpson, B Z Djordjevic, S Andrews, R Costa, B Cauble, F Albert, J J Rocca, T Ma
We present the development of a flexible tape-drive target system to generate and control secondary high-intensity laser-plasma sources. Its adjustable design permits the generation of relativistic MeV particles and x rays at high-intensity (i.e., ≥1 × 1018 W cm-2) laser facilities, at high repetition rates (>1 Hz). The compact and robust structure shows good mechanical stability and a high target placement accuracy (<4 μm RMS). Its compact and flexible design allows for mounting in both the horizontal and vertical planes, which makes it practical for use in cluttered laser-plasma experimental setups...
December 1, 2023: Review of Scientific Instruments
https://read.qxmd.com/read/38096114/antibody-response-to-covid-19-vaccine-astrazeneca-amongst-healthcare-workers-in-a-tertiary-hospital-in-nigeria
#24
JOURNAL ARTICLE
Z G Habib, V G Kwaghe, B A Ekele, A A Akor, U S Galadima, N D Baamlong, E K Olateju, P C Onyeka
BACKGROUND: With no known cure, accelerated development of vaccines became pertinent to contain the COVID-19 pandemic. OBJECTIVES: To assess the IgG antibody response to the viral spike protein and determinants of developing IgG antibodies after vaccination with two doses of the AstraZeneca vaccine. METHODS: This was a prospective cohort study amongst healthcare workers. Serum samples were obtained before vaccination and at 4 and 12 weeks after the first and second doses of the vaccine respectively...
November 30, 2023: West African Journal of Medicine
https://read.qxmd.com/read/38093431/-current-approaches-for-sampling-to-study-the-traces-of-gunshot-residue
#25
JOURNAL ARTICLE
A V Oberenko, S A Sagalakov, S V Kachin
An overview of researches, mainly by foreign specialists, on current available approaches for sampling to study the traces of gunshot residue (GSR) is presented. The comparative characteristics of traditional methods of samples (use of cotton and gauze tampons, blotting paper, textile fabrics, adhesive tapes, adhesives and vacuum samplers), as well as advanced technologies, including special devices and sorbents, are given. The characteristics of samplings from hands, scalp, nostrils, clothes of examined persons as well as procedures, that allow to increase the duration of GSR detection, are described in details...
2023: Sudebno-meditsinskaia Ekspertiza
https://read.qxmd.com/read/38081816/nearly-complete-structure-of-bacteriophage-dt57c-reveals-architecture-of-head-to-tail-interface-and-lateral-tail-fibers
#26
JOURNAL ARTICLE
Rafael Ayala, Andrey V Moiseenko, Ting-Hua Chen, Eugene E Kulikov, Alla K Golomidova, Philipp S Orekhov, Maya A Street, Olga S Sokolova, Andrey V Letarov, Matthias Wolf
The T5 family of viruses are tailed bacteriophages characterized by a long non-contractile tail. The bacteriophage DT57C is closely related to the paradigmal T5 phage, though it recognizes a different receptor (BtuB) and features highly divergent lateral tail fibers (LTF). Considerable portions of T5-like phages remain structurally uncharacterized. Here, we present the structure of DT57C determined by cryo-EM, and an atomic model of the virus, which was further explored using all-atom molecular dynamics simulations...
December 11, 2023: Nature Communications
https://read.qxmd.com/read/38061990/high-thermoelectric-performance-related-to-pvdf-ferroelectric-domains-in-p-type-flexible-pvdf-bi-0-5-sb-1-5-te-3-composite-film
#27
JOURNAL ARTICLE
Qinghui Jiang, Deng Pan, Yunfan Wang, Yong Liu, Yubo Luo, Junyou Yang, Baowen Li, Steve Dunn, Haixue Yan
There is increasing demand to power Internet of Things devices using ambient energy sources. Flexible, low-temperature, organic/inorganic thermoelectric devices are a breakthrough next-generation approach to meet this challenge. However, these systems suffer from poor performance and expensive processing preventing wide application of the technology. In this study, by combining a ferroelectric polymer (Polyvinylidene fluoride (PVDF, β phase)) with p-type Bi0.5 Sb1.5 Te3 (BST) a thermoelectric composite film with maximum is produced power factor...
December 7, 2023: Small
https://read.qxmd.com/read/38049807/efficacy-of-kinesio-taping-in-post-operative-sequalae-after-surgical-removal-of-mandibular-third-molars-a-split-mouth-randomized-control-study
#28
RANDOMIZED CONTROLLED TRIAL
Sneha Patil, Rajanikanth K, Nitin Bhola
BACKGROUND: The surgical removal of impacted lower third molars produces a significant degree of trauma to the soft tissue and bony structures of the oral cavity, which can initiate considerable inflammatory reaction. Consequently, patient experiences pain, swelling, hemorrhage, nerve paraesthesia, limited mouth opening etc. The kinesiologic tape (KT) can help with blood and lymphatic circulation and has shown acceptable outcomes in reducing pain and in managing post-operative muscle spasm...
December 4, 2023: BMC Oral Health
https://read.qxmd.com/read/38048407/osteolysis-after-augmented-scapholunate-ligament-reconstruction-a-report-of-3-cases
#29
JOURNAL ARTICLE
Ellen Y Lee, Alexander Y Shin
CASE: Augmented scapholunate ligament reconstruction using polyether ether ketone anchors and ultra-high molecular weight polyethylene synthetic tape has the theoretical advantage of improved stability, avoidance of K-wire fixation, and the potential for earlier mobilization. We present 3 cases of scaphoid and lunate osteolysis/fragmentation, operative and histologic findings at reoperation, and the sequelae of this technique. CONCLUSION: If planning to use suture anchors and synthetic tapes in small carpal bones, we recommend advising patients about the risk of osteolysis and monitoring closely patients who complain of pain with motion after surgery...
October 1, 2023: JBJS Case Connector
https://read.qxmd.com/read/38010192/high-performance-paper-based-thermoelectric-generator-from-cu-2-sns-3-nanocubes-and-bulk-traced-bismuth
#30
JOURNAL ARTICLE
Surajit Das, Bhargab P Mondal, Priya Ranjan, Anuja Datta
Flexible paper-based thermoelectric generators (PTEGs) have drawn significant interest in recent years due to their various advantages such as flexibility, adaptability, environment friendliness, low cost, and easy fabrication process. However, the reported PTEG's output performance still lags behind the performance of other flexible devices as it is not so easy to obtain a compact film on a paper-based substrate with desirable power output with the standard thermoelectric (TE) materials that have been previously utilized...
November 27, 2023: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38007872/a-facile-approach-for-oil-water-separation-using-superhydrophobic-polystyrene-silica-coated-stainless-steel-mesh-bucket
#31
JOURNAL ARTICLE
Rajaram S Sutar, Sanjay S Latthe, Akshay R Jundle, Pradip P Gaikwad, Sagar S Ingole, Saravanan Nagappan, Yong Hyun Kim, Appasaheb K Bhosale, Viswanathan S Saji, Shanhu Liu
Inspired by traditional shaduf technology in the irrigation field, we fabricated a superhydrophobic stainless steel mesh bucket by layering polystyrene and SiO2 nanoparticles through a facile dip coating technique for effective oil-water separation. The superhydrophobic steel mesh bucket could effectively lift oil as well as microplastic pollutants from the water surface. The water contact angle of a two-layered polystyrene-silica coating was 158.5° ± 2°, while the oil contact angle was nearly 0°...
November 25, 2023: Marine Pollution Bulletin
https://read.qxmd.com/read/37984876/kirigami-structured-low-impedance-and-skin-conformal-electronics-for-long-term-biopotential-monitoring-and-human-machine-interfaces
#32
JOURNAL ARTICLE
Meili Xia, Jianwen Liu, Beom Jin Kim, Yongju Gao, Yunlong Zhou, Yongjing Zhang, Duxia Cao, Songfang Zhao, Yang Li, Jong-Hyun Ahn
Epidermal dry electrodes with high skin-compliant stretchability, low bioelectric interfacial impedance, and long-term reliability are crucial for biopotential signal recording and human-machine interaction. However, incorporating these essential characteristics into dry electrodes remains a challenge. Here, a skin-conformal dry electrode is developed by encapsulating kirigami-structured poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)/polyvinyl alcohol (PVA)/silver nanowires (Ag NWs) film with ultrathin polyurethane (PU) tape...
November 20, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37973453/complications-of-synthetic-midurethral-slings-is-there-a-relevant-discrepancy-between-observational-data-and-clinical-trials
#33
REVIEW
Fawzy Farag, N I Osman, K H Pang, D Castro-Diaz, C R Chapple, F Cruz, X Gamé, H Goldman, T Greenwell, C Hampel, L M Scailteux, J P Roovers, B Welk, J Heesakkers
CONTEXT: The complications of synthetic midurethral slings (MUSs) in women with stress urinary incontinence (SUI) have become a globally debated issue. OBJECTIVE: To systematically review the short- and long-term complications of mesh slings reported in observational data compared with clinical trial data, to determine whether the complication rates from clinical trials reflects "real-world" observational data. EVIDENCE ACQUISITION: PubMed and Cochrane Library were searched...
November 14, 2023: European Urology Focus
https://read.qxmd.com/read/37967393/accuracy-of-parent-measured-weight-and-height-of-preschool-children-at-home-with-increasing-levels-of-instruction
#34
JOURNAL ARTICLE
Divya Patel, Sara K Vesely, Dipti A Dev, Emily H Guseman, Norman Hord, Kathrin Eliot, Susan B Sisson
Background: The purpose of this study was to determine how accurately parents measure their preschool child's weight and height with increasing levels of instruction. Methods: Parents measured their child's ( n  = 30 dyads) weight (own weight scale) and height (soft tape measure) using three levels of instruction: instructional guide (level 1); guide, demonstration video (level 2); and guide, video, and virtual monitoring (level 3), which were compared to researcher measurements (electronic weight scale, Stadiometer)...
November 15, 2023: Childhood Obesity
https://read.qxmd.com/read/37920643/sir-flat-cap-safety-in-radiology-flat-packed-compact-airborne-precaution-a-low-cost-portable-negative-pressure-isolation-barrier-shield-for-protecting-frontline-healthcare-workers
#35
JOURNAL ARTICLE
Shao J Ong, Ian Renfrew, Deborah X Khoo, Denise A Choong, Hui L Koh, Deborah S Ng, Lycia Teo, Joseph K Lee, Linda Yuen, Koon Liang Chia, Priscilla X Chen, Yi Ming Teo, Bertrand Ang, Swee Tian Quek
Introduction Multiple barrier shields have been described since the start of the COVID-19 pandemic. Most of these are bulky and designed for use in the main anesthetic or radiology departments. We developed a portable, negative-pressure barrier shield designed specifically for portable ultrasound examinations. A novel supine cough generation model was developed together with a reverse qualitative fit test to simulate real-world aerosol droplet generation and dispersion for evaluating the effectiveness of the barrier shield...
October 2023: Curēus
https://read.qxmd.com/read/37899427/hydrogen-sulfide-priming-enhanced-salinity-tolerance-in-sunflower-by-modulating-ion-hemostasis-cellular-redox-balance-and-gene-expression
#36
JOURNAL ARTICLE
Abeer Abdelrazk Younis, Mohamed Magdy F Mansour
BACKGROUND: The salinity threat represents an environmental challenge that drastically affects plant growth and yield. Besides salinity stress, the escalating world population will greatly influence the world's food security in the future. Therefore, searching for effective strategies to improve crop salinity resilience and sustain agricultural productivity under high salinity is a must. Seed priming is a reliable, simple, low-risk, and low-cost technique. Therefore, this work aimed to evaluate the impact of seed priming with 0...
October 30, 2023: BMC Plant Biology
https://read.qxmd.com/read/37893351/preparation-of-mgo-self-epitaxial-films-for-ybco-high-temperature-coated-conductors
#37
JOURNAL ARTICLE
Fei Yu, Yan Xue, Chaowei Zhong, Jiayi Song, Qiong Nie, Xin Hou, Baolei Wang
Ion beam-assisted deposition (IBAD) has been proposed as a promising texturing technology that uses the film epitaxy method to obtain biaxial texture on a non-textured metal or compound substrate. Magnesium oxide (MgO) is the most well explored texturing material. In order to obtain the optimal biaxial texture, the actual thickness of the IBAD-MgO film must be controlled within 12nm. Due to the bombardment of ion beams, IBAD-MgO has large lattice deformation, poor texture, and many defects in the films. In this work, the solution deposition planarization (SDP) method was used to deposit oxide amorphous Y2 O3 films on the surface of Hastelloy C276 tapes instead of the electrochemical polishing, sputtering-Al2 O3 and sputtering-Y2 O3 in the commercialized buffer layer...
October 8, 2023: Micromachines
https://read.qxmd.com/read/37865139/the-novel-faah-inhibitor-mch1-reduces-the-infarction-area-in-the-motor-cortex-related-region-but-does-not-affect-the-sensorimotor-function-or-memory-and-spatial-learning-in-rats-exposed-to-transient-middle-cerebral-artery-occlusion
#38
JOURNAL ARTICLE
K Taboada-Rosell, F A Castro-García, C Medina-Saldívar, S R Cruz-Visalaya, L F Pacheco-Otalora
Macamides, amides of fatty acids first isolated from maca (Lepidium meyenii) are potentially responsible for the reduction of ischemic injury in the stroke animal model followed by maca extract administration. This deduction comes from its ability to inhibit the fatty acid amide hydrolase activity, an enzyme related to the endocannabinoid anandamide hydrolysis. However, no study about the effects of isolated macamides on in-vivo models has been published yet. Our objective was to evaluate the effect of a 10-day 30 mg/kg i...
October 19, 2023: Brain Research
https://read.qxmd.com/read/37861430/myth-or-truth-investigation-of-the-jumping-ability-of-tunga-penetrans-siphonaptera-tungidae
#39
JOURNAL ARTICLE
Ayako Hyuga, Paul Ouma, Abneel K Matharu, Jürgen Krücken, Satoshi Kaneko, Kensuke Goto, Ulrike Fillinger
Female sand fleas (Tunga penetrans Linnaeus, 1758, Siphonaptera: Tungidae) cause a severe parasitic skin disease known as tungiasis. T. penetrans is a small flea, measuring less than 1 mm in length. The females of this species burrow into the skin of human and animal hosts and mostly affect the feet. This has led to the anecdotal assumption that T. penetrans, unlike its relatives in the Siphonaptera family, would have a limited jumping ability potentially not reaching higher body parts. However, there is no data supporting this...
October 20, 2023: Journal of Medical Entomology
https://read.qxmd.com/read/37854476/successful-rescue-ventilation-of-an-infant-with-a-laryngeal-mask-airway-after-accidental-extubation-in-the-prone-position-during-open-calvarial-reconstruction-of-a-craniosynostosis-a-case-report
#40
Androcles Lester, Matthew R Paluska, Ricardo Falcon, Timothy R Petersen, Anil K Shetty, Codruta Soneru
In this case report, we present a critical situation during an open calvarial reconstruction involving an 11-month-old infant. The patient experienced accidental extubation, requiring immediate intervention while in the prone position. Approximately two hours post-incision, ventilation became increasingly difficult due to a significant leak detected in the system. On closer inspection, it was observed that both the rubber tourniquet responsible for securing the anesthesia circuit and the tape that held the endotracheal tube in place had become loosened...
October 2023: Curēus
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