Gaston H Rueda, Natalia Causada-Calo, Rajka Borojevic, Andrea Nardelli, Maria Ines Pinto-Sanchez, Marco Constante, Josie Libertucci, Vidhyalakshmi Mohan, Philippe Langella, Linda M P Loonen, Jerry M Wells, Harry Sokol, Elena F Verdu, Premysl Bercik
Background and Aims : Tryptophan is an essential amino acid transformed by host and gut microbial enzymes into metabolites that regulate mucosal homeostasis through Aryl hydrocarbon receptor (AhR) activation. Alteration of tryptophan metabolism has been associated with chronic inflammation, however whether tryptophan supplementation affects the metabolite repertoire and AhR activation under physiologic conditions in humans, is unknown. Methods: We performed a randomized, double blind, placebo-controlled, crossover study in 20 healthy volunteers...
April 9, 2024: American Journal of Physiology. Gastrointestinal and Liver Physiology