Jean Stafford, Serhiy Dekhtyar, Anna-Karin Welmer, Davide L Vetrano, Giulia Grande, Erika J Laukka, Anna Marseglia, Vanessa Moulton, Rosie Mansfield, Yiwen Liu, Ke Ning, Karin Wolf-Ostermann, Henry Brodaty, Suraj Samtani, Mohammad Arfan Ikram, René Melis, Joanna Rymaszewska, Dorota Szcześniak, Giorgio Di Gessa, Marcus Richards, Daniel Davis, Praveetha Patalay, Jane Maddock
BACKGROUND: Social health markers, including marital status, contact frequency, network size, and social support, have been shown to be associated with cognition. However, the mechanisms underlying these associations remain poorly understood. We investigated whether depressive symptoms and inflammation mediated associations between social health and subsequent cognition. METHODS: In the English Longitudinal Study of Ageing (ELSA), a nationally representative longitudinal study in England, UK, we sampled 7136 individuals aged 50 years or older living in private households without dementia at baseline or at the intermediate mediator assessment timepoint, who had recorded information on at least one social health marker and potential mediator...
May 2024: The Lancet. Healthy longevity