Lorenzo Zamboni, Igor Portoghese, Alessio Congiu, Silvia Carli, Ruggero Munari, Angela Federico, Francesco Centoni, Adelelmo Lodi Rizzini, Fabio Lugoboni
The considerable prominence of internet addiction (IA) in adolescence is at least partly explained by the limited knowledge thus far available on this complex phenomenon. In discussing IA, it is necessary to be aware that this is a construct for which there is still no clear definition in the literature. Nonetheless, its important clinical implications, as emerging in recent years, justify the lively interest of researchers in this new form of behavioral addiction. Over the years, studies have associated IA with numerous clinical problems...
2020: Frontiers in Psychology
Kathrin Viol, Günter Schiepek, Martin Kronbichler, Arnulf Hartl, Carina Grafetstätter, Peter Strasser, Anna Kastinger, Helmut Schöller, Eva-Maria Reiter, Sarah Said-Yürekli, Lisa Kronbichler, Brigitte Kravanja-Spannberger, Barbara Stöger-Schmidinger, Marc-Thorsten Hütt, Wolfgang Aichhorn, Benjamin Aas
BACKGROUND: While considerable progress has been made in exploring the psychological, the neural, and the neurochemical dimensions of OCD separately, their interplay is still an open question, especially their changes during psychotherapy. METHODS: Seventeen patients were assessed at these three levels by psychological questionnaires, fMRI, and venipuncture before and after inpatient psychotherapy. Seventeen controls were scanned at comparable time intervals. First, pre/post treatment changes were investigated for all three levels separately: symptom severity, whole-brain and regional activity, and the concentrations of cortisol, serotonin, dopamine, brain-derived neurotrophic factor (BDNF), and immunological parameters (IL-6, IL-10, TNFα)...
November 25, 2020: BMC Psychiatry
Edward Kwabena Ameyaw, John Elvis Hagan, Bright Opoku Ahinkorah, Abdul-Aziz Seidu, Thomas Schack
The novel coronavirus pandemic has undoubtedly emerged as a serious public health threat in many societies across the world. Due to the sporadic and unpredictable nature of the pandemic, it is important to admit that the virus can cause psychological distress and emotional instability that might impact on people in diverse ways at the individual, community and national levels, with serious mental health implications (e.g. depression, mood disorders, obsessive-compulsive disorder, other anxiety disorders). Due to the weak healthcare challenges inherent in Africa, these mental health challenges require urgent redress to ensure mental health well-being for all, especially COVID-19-positive patients who have recovered (i...
2020: Pan African Medical Journal
Yi Tong Tan, Imogen C Rehm, Judith L Stevenson, Alexander De Foe
INTRODUCTION: As social media platforms become commonplace in daily life, online peer support groups have become an increasingly popular resource for people living with physical and mental health issues. Although the benefits of using online peer support groups have been well documented, there can be also be significant risks associated with groups hosted on social media platforms. People living with obsessive-compulsive related disorders may be particularly vulnerable to negative experiences in such groups...
November 11, 2020: Journal of Affective Disorders
Maike Salazar Kämpf, Steffen Nestler, Jana Hansmeier, Julia Glombiewski, Cornelia Exner
Objective: The alliance between patient and therapist is central for therapeutic progress. Social mimicry, the automatic imitation of another person, has been linked to building relationships. This is the first preregistered study to systematically investigate mimicry and its effects on the working alliance in real psychotherapy sessions. Method: Sixty-four different patient-therapist dyads were filmed during a cognitive behavioral therapy (CBT) treatment for obsessive-compulsive disorder (OCD). By using actor-partner interdependence models, we analyzed the extent to which therapists' and patients' earlier mimicry predicted their own mimicry ( actor effect ), how they influenced each other in their mimicry ( partner effect ) and the effects of mimicry on the patients' alliance...
November 24, 2020: Psychotherapy Research: Journal of the Society for Psychotherapy Research
David Castle, Francesca Beilharz, Katharine A Phillips, Vlasios Brakoulias, Lynne M Drummond, Eric Hollander, Konstantinos Ioannidis, Stefano Pallanti, Samuel R Chamberlain, Susan L Rossell, David Veale, Sabine Wilhelm, Michael Van Ameringen, Bernardo Dell'Osso, Jose M Menchon, Naomi A Fineberg
Body dysmorphic disorder (BDD) is characterized by a preoccupation with a perceived appearance flaw or flaws that are not observable to others. BDD is associated with distress and impairment of functioning. Psychiatric comorbidities, including depression, social anxiety, and obsessive-compulsive disorder are common and impact treatment. Treatment should encompass psychoeducation, particularly addressing the dangers associated with cosmetic procedures, and may require high doses of selective serotonin reuptake inhibitors* (SSRI*) and protracted periods to establish full benefit...
November 20, 2020: International Clinical Psychopharmacology
Swarna Pandian, Jian-Ping Zhao, Fernando J Bustos, Cansu Tunca, Ramiro D Almeida, Martha Constantine-Paton, Yasunobu Murata
Myosin Va (MyoVa) is a plus-end filamentous-actin motor protein that is highly and broadly expressed in the vertebrate body, including in the nervous system. In excitatory neurons MyoVa transports cargo toward the tip of the dendritic spine, where the post-synaptic density (PSD) is formed and maintained. MyoVa mutations in humans cause neurological dysfunction, intellectual disability, hypomelanation and death in infancy or childhood. Here we characterize the Flailer (Flr) mutant mouse, which is homozygous for a myo5a mutation that drives high levels of mutant MyoVa (Flr protein) specifically in the CNS...
November 23, 2020: ENeuro
Tingting Xu, Qiumeng Gu, Qing Zhao, Pei Wang, Qiang Liu, Qing Fan, Jue Chen, Zhen Wang
OBJECTIVES: Convergent evidence has demonstrated that trait impulsivity, a key feature in obsessive-compulsive disorder (OCD), involves dysregulated frontal-striatal circuits. The present study aims to explore relationships between frontal-striatal circuits, trait impulsivity, and obsessive-compulsive symptoms. METHODS: Thirty-six unmedicated patients with OCD and 50 healthy controls (HCs) matched for age, sex, and years of education underwent a magnetic resonance imaging (MRI) procedure...
November 13, 2020: Journal of Affective Disorders
Shokhrukh Sultanov, Nazira Khodzhaeva, Zarifjon Ashurov, Yekaterina Lyan, Lola Shadmanova
Background: The continuous research on minor depressive disorder is one of the pressing issues in the context of the COVID-19 pandemic. We studied the features of minor depressive disorder subtypes in conditions of the COVID-19 pandemic. Materials and Methods: Sixty-two patients were observed with the administration of clinical follow-up research method. Results: The following major subtypes of minor depressive disorder were identified: Asthenic, hysterical, hypochondriacal, apathetic, and minor depressive disorder with obsessive-compulsive symptoms...
September 2020: Indian Journal of Psychiatry
Agustin Lugo-Radillo, Jorge Luis Cortes-Lopez
Obsessive Compulsive Disorder (OCD) is a chronic neuropsychiatric condition, characterized by obsessions and compulsions, which is usually disabling for the suffering individual. The first-line treatment is not effective in all patients. There is evidence showing the effectiveness of psilocybin and psilocybin-containing mushrooms in the treatment of OCD symptoms. We present the case of a male adult with OCD who showed a clinically meaningful reduction of his OCD symptomatology after the consumption of psilocybin-containing mushrooms...
November 22, 2020: Journal of Psychoactive Drugs
Matthew R Burns, Shannon Y Chiu, Bhavana Patel, Sotiris G Mitropanopoulos, Joshua K Wong, Adolfo Ramirez-Zamora
"Deep brain stimulation is a safe and effective therapy for the management of a variety of neurologic conditions with Food and Drug Administration or humanitarian exception approval for Parkinson disease, dystonia, tremor, and obsessive-compulsive disorder. Advances in neurophysiology, neuroimaging, and technology have driven increasing interest in the potential benefits of neurostimulation in other neuropsychiatric conditions including dementia, depression, pain, Tourette syndrome, and epilepsy, among others...
February 2021: Neurologic Clinics
Laura F Bringmann, Date C van der Veen, Marieke Wichers, Harriëtte Riese, Gert Stulp
PURPOSE: The experience sampling method (ESM) is used for intensive longitudinal time-series data collection during normal daily life. ESM data give information on momentary affect, activities and (social) context of, for example, patients suffering from mental disorders, and allows for person-specific feedback reports. However, current personalized feedback reports only display a selection of measured variables, and typically involve only summary statistics, thus not reflecting the dynamic fluctuations in affect and its influencing factors...
November 22, 2020: Quality of Life Research
H Javelot, L Weiner
Although the "panic" word has been abundantly linked to the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic in the press, in the scientific literature very few studies have considered whether the current epidemic could predispose to the onset or the aggravation of panic attacks or panic disorder. Indeed, most studies thus far have focused on the risk of increase and aggravation of other psychiatric disorders as a consequence of the SARS-CoV-2 epidemic, such as obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and generalized anxiety disorder (GAD)...
August 10, 2020: L'Encéphale
Brenna M Williams, Cheri A Levinson
OBJECTIVE: Eating disorders (EDs) are highly comorbid with obsessive-compulsive disorder (OCD). In order to develop treatments which better address commonly comorbid ED and OCD symptoms, it is important to identify potential shared mechanisms. Two potential shared mechanisms are maladaptive perfectionism and intolerance of uncertainty (IU). We aimed to assess how maladaptive perfectionism and IU may contribute to the maintenance of ED and OCD symptoms in individuals with EDs. METHODS: In the current study (N = 168 individuals with an ED), we analysed cross-sectional and prospective path models of maladaptive perfectionism and IU as maintenance factors of ED and OCD symptoms...
November 21, 2020: European Eating Disorders Review: the Journal of the Eating Disorders Association
Eric A Storch, Aron Tendler, Sophie C Schneider, Andrew G Guzick, Valerie La Buissonniere-Ariza, Wayne K Goodman
Deep transcranial magnetic stimulation (dTMS) has emerged as a treatment option for adults with obsessive-compulsive disorder (OCD) who continue to exhibit impairing symptoms following an adequate response to first line interventions. Currently, little is known about the predictors or moderators of dTMS outcome for OCD. This paper examined if several theoretically relevant variables may predict and moderate treatment effects including OCD symptom severity, functional impairment, co-occurring depressive symptoms, age, gender, age of OCD onset, and family history of OCD...
November 11, 2020: Journal of Psychiatric Research
Paweł Holas, Małgorzata Draps, Ewelina Kowalewska, Karol Lewczuk, Mateusz Gola
Compulsive sexual behaviour disorder (CSBD) is a medical condition that can impair social and occupational functioning and lead to severe distress. To date, treatment effectiveness studies of CSBD are under-developed; typically, treatment for CSBD is based on guidelines for substance or other behavioural addictions. Mindfulness-based relapse prevention (MBRP) is an evidence-based treatment for substance addiction aimed at, among other things, reducing craving and negative affect-i.e. processes that are implicated in the maintenance of problematic sexual behaviours...
November 17, 2020: Journal of Behavioral Addictions
Jinyoung Lee, Ji Hyun Baek, Dongbin Lee, Sung Woo Ahn, So-Yung Yang, Yujin Choi, Yong Chun Bahk, Kyung Sue Hong
BACKGROUND: When evaluating the long-term treatment response to mood stabilizers using the Alda scale, mood stabilizer combination therapy is typically considered a confounding factor, and patients receiving combination therapy are excluded from the analysis. However, this may result in bias if those under combination therapy are worse treatment responders. This study aims to explore whether the Alda scale is applicable to patients taking lithium and valproate combination therapy. We compared long-term treatment response in patients receiving monotherapy and combination therapy of the two drugs, and investigated clinical correlates of the responses to each drug...
November 20, 2020: International Journal of Bipolar Disorders
Fabio Bellia, Matteo Vismara, Eugenia Annunzi, Carlo Cifani, Beatrice Benatti, Bernardo Dell'Osso, Claudio D'Addario
Obsessive-Compulsive Disorder (OCD) is a prevalent and severe clinical condition whose hallmarks are excessive, unwanted thoughts (obsessions) and repetitive behaviors (compulsions). The onset of symptoms generally occurs during pre-adult life and typically affects subjects in different aspects of their life's, compromising social and professional relationships. Although robust evidence suggests a genetic component in the etiopathogenesis of OCD, the causes of the disorder are still not completely understood...
November 6, 2020: Journal of Psychiatric Research
Minyi Chu, Tingting Xu, Yi Wang, Pei Wang, Qiumeng Gu, Qiang Liu, Eric F C Cheung, Raymond C K Chan, Zhen Wang
BACKGROUND: Childhood trauma is a vulnerability factor for the development of obsessive-compulsive disorder (OCD). Empirical findings suggest that trauma-related alterations in brain networks, especially in thalamus-related regions, have been observed in OCD patients. However, the relationship between childhood trauma and thalamic connectivity in patients with OCD remains unclear. The present study aimed to examine the impact of childhood trauma on thalamic functional connectivity in OCD patients...
November 20, 2020: Psychological Medicine
Wenying Xu, Xiaoxiao Zhang, Yuhan Wang, Hengfen Gong, Yiwen Wu, Bomin Sun, ChenCheng Zhang, Dianyou Li
INTRODUCTION: Globus pallidus internus (GPi) deep brain stimulation (DBS) combined with anterior capsulotomy offers a promising treatment option for severe medication-refractory cases of Tourette's syndrome (TS) with psychiatric comorbidities. Several patients treated with this combined surgery experienced sustained relief after discontinuation of stimulation over the course of treatment. METHODS: Retrospectively, the medical records and clinical outcomes were reviewed of 8 patients (6 men; 2 women with mean age of 20...
November 18, 2020: Stereotactic and Functional Neurosurgery
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