keyword
https://read.qxmd.com/read/36088544/mog-and-aqp4-antibodies-among-children-with-multiple-sclerosis-and-controls
#21
JOURNAL ARTICLE
Cristina M Gaudioso, Soe Mar, T Charles Casper, Rachel Codden, Adam Nguyen, Gregory Aaen, Leslie Benson, Tanuja Chitnis, Carla Francisco, Mark P Gorman, Manu S Goyal, Jennifer Graves, Benjamin M Greenberg, Janace Hart, Lauren Krupp, Timothy Lotze, Sona Narula, Sean J Pittock, Mary Rensel, Moses Rodriguez, John Rose, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Bianca Weinstock-Guttman, Yolanda Wheeler, Emmanuelle Waubant, Eoin P Flanagan
OBJECTIVE: The purpose of this study was to determine the frequency of myelin oligodendrocyte glycoprotein (MOG)-IgG and aquaporin-4 (AQP4)-IgG among patients with pediatric-onset multiple sclerosis (POMS) and healthy controls, to determine whether seropositive cases fulfilled their respective diagnostic criteria, to compare characteristics and outcomes in children with POMS versus MOG-IgG-associated disease (MOGAD), and identify clinical features associated with final diagnosis. METHODS: Patients with POMS and healthy controls were enrolled at 14 US sites through a prospective case-control study on POMS risk factors...
February 2023: Annals of Neurology
https://read.qxmd.com/read/36053710/erratum-first-search-for-bosonic-superweakly-interacting-massive-particles-with-masses-up-to-1-mev-c-2-with-gerda-phys-rev-lett-125-011801-2020
#22
M Agostini, A M Bakalyarov, M Balata, I Barabanov, L Baudis, C Bauer, E Bellotti, S Belogurov, A Bettini, L Bezrukov, D Borowicz, E Bossio, V Bothe, V Brudanin, R Brugnera, A Caldwell, C Cattadori, A Chernogorov, T Comellato, V D'Andrea, E V Demidova, N Di Marco, E Doroshkevich, V Egorov, F Fischer, M Fomina, A Gangapshev, A Garfagnini, C Gooch, P Grabmayr, V Gurentsov, K Gusev, J Hakenmüller, S Hemmer, R Hiller, W Hofmann, M Hult, L V Inzhechik, J Janicskó Csáthy, J Jochum, M Junker, V Kazalov, Y Kermaïdic, H Khushbakht, T Kihm, I V Kirpichnikov, A Klimenko, R Kneißl, K T Knöpfle, O Kochetov, V N Kornoukhov, P Krause, V V Kuzminov, M Laubenstein, A Lazzaro, M Lindner, I Lippi, A Lubashevskiy, B Lubsandorzhiev, G Lutter, C Macolino, B Majorovits, W Maneschg, M Miloradovic, R Mingazheva, M Misiaszek, P Moseev, I Nemchenok, K Panas, L Pandola, K Pelczar, L Pertoldi, P Piseri, A Pullia, C Ransom, L Rauscher, S Riboldi, N Rumyantseva, C Sada, F Salamida, S Schönert, J Schreiner, M Schütt, A-K Schütz, O Schulz, M Schwarz, B Schwingenheuer, O Selivanenko, E Shevchik, M Shirchenko, H Simgen, A Smolnikov, D Stukov, A A Vasenko, A Veresnikova, C Vignoli, K von Sturm, T Wester, C Wiesinger, M Wojcik, E Yanovich, B Zatschler, I Zhitnikov, S V Zhukov, D Zinatulina, A Zschocke, A J Zsigmond, K Zuber, G Zuzel
This corrects the article DOI: 10.1103/PhysRevLett.125.011801.
August 19, 2022: Physical Review Letters
https://read.qxmd.com/read/35971224/diagnostic-delay-in-patients-with-eosinophilic-esophagitis-has-not-changed-since-the-first-description-30-years-ago-diagnostic-delay-in-eosinophilic-esophagitis
#23
JOURNAL ARTICLE
Fritz R Murray, Andrea S Kreienbuehl, Thomas Greuter, Simon Nennstiel, Ekaterina Safroneeva, Catherine Saner, Valeria Schindler, Christoph Schlag, Alain M Schoepfer, Philipp Schreiner, Alex Straumann, Luc Biedermann
INTRODUCTION: Eosinophilic esophagitis (EoE) is a chronic progressive disease. Diagnostic delay (DD) is associated with increased risk of esophageal strictures and food impactions. We aimed to assess the evolution of DD since the first description of EoE in 1993 until 2021. METHODS: We analyzed data from patients prospectively included in the Swiss EoE database. DD was calculated as the time interval between the first occurrence of EoE symptoms and the confirmed diagnosis...
November 1, 2022: American Journal of Gastroenterology
https://read.qxmd.com/read/35969495/long-term-changes-in-plasma-proteomic-profiles-in-premenopausal-and-postmenopausal-black-and-white-women-the-atherosclerosis-risk-in-communities-study
#24
JOURNAL ARTICLE
Duke Appiah, Pamela J Schreiner, James S Pankow, Guy Brock, Weihong Tang, Faye L Norby, Erin D Michos, Christie M Ballantyne, Aaron R Folsom
OBJECTIVE: The activity, localization, and turnover of proteins within cells and plasma may contribute to physiologic changes during menopause and may influence disease occurrence. We examined cross-sectional differences and long-term changes in plasma proteins between premenopausal and naturally postmenopausal women. METHODS: We used data from 4,508 (19% Black) women enrolled in the Atherosclerosis Risk in Communities study. SOMAscan multiplexed aptamer technology was used to measure 4,697 plasma proteins...
August 16, 2022: Menopause: the Journal of the North American Menopause Society
https://read.qxmd.com/read/35821975/material-radiopurity-control-in-the-xenonnt-experiment
#25
JOURNAL ARTICLE
E Aprile, K Abe, F Agostini, S Ahmed Maouloud, M Alfonsi, L Althueser, E Angelino, J R Angevaare, V C Antochi, D Antón Martin, F Arneodo, L Baudis, A L Baxter, L Bellagamba, R Biondi, A Bismark, A Brown, S Bruenner, G Bruno, R Budnik, C Capelli, J M R Cardoso, D Cichon, B Cimmino, M Clark, A P Colijn, J Conrad, J J Cuenca-García, J P Cussonneau, V D'Andrea, M P Decowski, P Di Gangi, S Di Pede, A Di Giovanni, R Di Stefano, S Diglio, A Elykov, S Farrell, A D Ferella, H Fischer, W Fulgione, P Gaemers, R Gaior, M Galloway, F Gao, R Glade-Beucke, L Grandi, J Grigat, A Higuera, C Hils, K Hiraide, L Hoetzsch, J Howlett, M Iacovacci, Y Itow, J Jakob, F Joerg, N Kato, P Kavrigin, S Kazama, M Kobayashi, G Koltman, A Kopec, H Landsman, R F Lang, L Levinson, I Li, S Liang, S Lindemann, M Lindner, K Liu, F Lombardi, J Long, J A M Lopes, Y Ma, C Macolino, J Mahlstedt, A Mancuso, L Manenti, A Manfredini, F Marignetti, T Marrodán Undagoitia, K Martens, J Masbou, D Masson, E Masson, S Mastroianni, M Messina, K Miuchi, K Mizukoshi, A Molinario, S Moriyama, K Morå, Y Mosbacher, M Murra, K Ni, U Oberlack, J Palacio, R Peres, J Pienaar, M Pierre, V Pizzella, G Plante, J Qi, J Qin, D Ramírez García, S Reichard, A Rocchetti, N Rupp, L Sanchez, J M F Dos Santos, G Sartorelli, J Schreiner, D Schulte, H Schulze Eißing, M Schumann, L Scotto Lavina, M Selvi, F Semeria, P Shagin, E Shockley, M Silva, H Simgen, A Takeda, P L Tan, A Terliuk, C Therreau, D Thers, F Toschi, G Trinchero, C Tunnell, F Tönnies, K Valerius, G Volta, Y Wei, C Weinheimer, M Weiss, D Wenz, J Westermann, C Wittweg, T Wolf, Z Xu, M Yamashita, L Yang, J Ye, L Yuan, G Zavattini, Y Zhang, M Zhong, T Zhu, J P Zopounidis, M Laubenstein, S Nisi
The selection of low-radioactive construction materials is of the utmost importance for rare-event searches and thus critical to the XENONnT experiment. Results of an extensive radioassay program are reported, in which material samples have been screened with gamma-ray spectroscopy, mass spectrometry, and <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow/> <mml:mn>222</mml:mn></mml:msup> </mml:math> Rn emanation measurements. Furthermore, the cleanliness procedures applied to remove or mitigate surface contamination of detector materials are described...
2022: European Physical Journal. C, Particles and Fields
https://read.qxmd.com/read/35704440/factors-associated-with-age-related-declines-in-cardiorespiratory-fitness-from-early-adulthood-through-midlife-cardia
#26
JOURNAL ARTICLE
Kelley Pettee Gabriel, Byron C Jaeger, Barbara Sternfeld, Erin E Dooley, Mercedes R Carnethon, David R Jacobs, Cora E Lewis, Bjoern Hornikel, Jared P Reis, Pamela J Schreiner, James M Shikany, Kara M Whitaker, Stephen Sidney
PURPOSE: This study aimed to describe maximal and submaximal cardiorespiratory fitness from early adulthood to midlife and examine differences in maximal fitness at age 20 yr and changes in fitness overtime by subcategories of sociodemographic, behavioral, and health-related factors. METHODS: Data include 5018 Coronary Artery Risk Development in Young Adults participants (mean (SD) age, 24.8 (3.7) yr; 53.3% female; and 51.4% Black participants) who completed at least one maximal graded exercise test at baseline and/or the year 7 and 20 exams...
July 1, 2022: Medicine and Science in Sports and Exercise
https://read.qxmd.com/read/35675673/oxidative-stress-and-menopausal-status-the-coronary-artery-risk-development-in-young-adults-cohort-study
#27
JOURNAL ARTICLE
Amir S Heravi, Erin D Michos, Di Zhao, Bharath Ambale-Venkatesh, Henrique Doria De Vasconcellos, Donald Lloyd-Jones, Pamela J Schreiner, Jared P Reis, Colin Wu, Cora E Lewis, James M Shikany, Stephen Sidney, Eliseo Guallar, Chiadi E Ndumele, Pamela Ouyang, Ron C Hoogeveen, Joao A C Lima, Dhananjay Vaidya, Wendy S Post
Background: Low endogenous estrogen concentrations after menopause may contribute to higher oxidative stress and greater cardiovascular disease (CVD) risk. However, differences in oxidative stress between similarly aged premenopausal and postmenopausal women are not well-characterized on a population level. We hypothesized that urinary isoprostane concentrations, a standard measure of systemic oxidative stress, are higher in women who have undergone menopause compared to premenopausal women. Methods and Results: We examined differences in urinary 8-isoprostane (iPF2α -III) and 2,3-dinor-8-isoprostane (iPF2α -III-M) indexed to urinary creatinine between 279 postmenopausal and 196 premenopausal women in the Coronary Artery Risk Development in Young Adults (CARDIA) study, using linear regression with progressive adjustment for sociodemographic factors and traditional CVD risk factors...
July 2022: Journal of Women's Health
https://read.qxmd.com/read/35559604/synthetic-doping-of-diamondoids-through-skeletal-editing
#28
JOURNAL ARTICLE
Andrey A Fokin, Olga K Reshetylova, Vladyslav V Bakhonsky, Alexander E Pashenko, Alena Kivernik, Tatyana S Zhuk, Jonathan Becker, Jeremy E P Dahl, Robert M K Carlson, Peter R Schreiner
We present a strategy for the skeletal editing of diamondoid structures to selectively displace methylene for heteroatom moieties in the carbon framework. This constitutes a synthetic approach to doping diamond-like structures with electron donor dopants (O, N, and S). The key steps involve two subsequent retro-Barbier fragmentations followed by cage reconstruction in the presence of a dopant. Remarkably, the incorporation of n-dopants reduces the strain of the diamondoid cage as shown through homodesmotic equations...
May 13, 2022: Organic Letters
https://read.qxmd.com/read/35464994/pulse-shape-analysis-in-gerda-phase-ii
#29
JOURNAL ARTICLE
M Agostini, G Araujo, A M Bakalyarov, M Balata, I Barabanov, L Baudis, C Bauer, E Bellotti, S Belogurov, A Bettini, L Bezrukov, V Biancacci, E Bossio, V Bothe, V Brudanin, R Brugnera, A Caldwell, C Cattadori, A Chernogorov, T Comellato, V D'Andrea, E V Demidova, N Di Marco, E Doroshkevich, F Fischer, M Fomina, A Gangapshev, A Garfagnini, C Gooch, P Grabmayr, V Gurentsov, K Gusev, J Hakenmüller, S Hemmer, R Hiller, W Hofmann, J Huang, M Hult, L V Inzhechik, J Janicskó Csáthy, J Jochum, M Junker, V Kazalov, Y Kermaïdic, H Khushbakht, T Kihm, K Kilgus, A Kirsch, I V Kirpichnikov, A Klimenko, K T Knöpfle, O Kochetov, V N Kornoukhov, P Krause, V V Kuzminov, M Laubenstein, A Lazzaro, M Lindner, I Lippi, A Lubashevskiy, B Lubsandorzhiev, G Lutter, C Macolino, B Majorovits, W Maneschg, L Manzanillas, M Miloradovic, R Mingazheva, M Misiaszek, Y Müller, I Nemchenok, K Panas, L Pandola, K Pelczar, L Pertoldi, P Piseri, A Pullia, C Ransom, L Rauscher, M Redchuk, S Riboldi, N Rumyantseva, C Sada, F Salamida, S Schönert, J Schreiner, M Schütt, A-K Schütz, O Schulz, M Schwarz, B Schwingenheuer, O Selivanenko, E Shevchik, M Shirchenko, L Shtembari, H Simgen, A Smolnikov, D Stukov, A A Vasenko, A Veresnikova, C Vignoli, K von Sturm, V Wagner, T Wester, C Wiesinger, M Wojcik, E Yanovich, B Zatschler, I Zhitnikov, S V Zhukov, D Zinatulina, A Zschocke, A J Zsigmond, K Zuber, G Zuzel
The GERmanium Detector Array (Gerda) collaboration searched for neutrinoless double- <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mi>β</mml:mi></mml:math> decay in <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow/> <mml:mn>76</mml:mn></mml:msup> </mml:math> Ge using isotopically enriched high purity germanium detectors at the Laboratori Nazionali del Gran Sasso of INFN. After Phase I (2011-2013), the experiment benefited from several upgrades, including an additional active veto based on LAr instrumentation and a significant increase of mass by point-contact germanium detectors that improved the half-life sensitivity of Phase II (2015-2019) by an order of magnitude...
2022: European Physical Journal. C, Particles and Fields
https://read.qxmd.com/read/35122454/transverse-relaxation-anisotropy-of-the-achilles-and-patellar-tendon-studied-by-mr-microscopy
#30
JOURNAL ARTICLE
Benedikt Hager, Markus M Schreiner, Sonja M Walzer, Lena Hirtler, Vladimir Mlynarik, Andreas Berg, Xeni Deligianni, Oliver Bieri, Reinhard Windhager, Siegfried Trattnig, Vladimir Juras
BACKGROUND: T2 * anisotropy affects the clinical assessment of tendons (magic-angle artifact) and may be a source of T2 *-misinterpretation. PURPOSE: To analyze T2 *-anisotropy and T2 *-decay of Achilles and patellar tendons in vitro at microscopic resolution using a variable-echo-time (vTE) sequence. STUDY TYPE: Prospective. SPECIMEN: Four human Achilles and four patellar tendons. FIELD STRENGTH/SEQUENCE: A 7 T MR-microscopy; 3D-vTE spoiled-gradient-echo-sequence (T2 *-mapping)...
October 2022: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/34776783/calibration-of-the-gerda-experiment
#31
JOURNAL ARTICLE
M Agostini, G Araujo, A M Bakalyarov, M Balata, I Barabanov, L Baudis, C Bauer, E Bellotti, S Belogurov, A Bettini, L Bezrukov, V Biancacci, E Bossio, V Bothe, V Brudanin, R Brugnera, A Caldwell, C Cattadori, A Chernogorov, T Comellato, V D'Andrea, E V Demidova, N Di Marco, E Doroshkevich, F Fischer, M Fomina, A Gangapshev, A Garfagnini, C Gooch, P Grabmayr, V Gurentsov, K Gusev, J Hakenmüller, S Hemmer, R Hiller, W Hofmann, J Huang, M Hult, L V Inzhechik, J Janicskó Csáthy, J Jochum, M Junker, V Kazalov, Y Kermaïdic, H Khushbakht, T Kihm, I V Kirpichnikov, A Klimenko, R Kneißl, K T Knöpfle, O Kochetov, V N Kornoukhov, P Krause, V V Kuzminov, M Laubenstein, M Lindner, I Lippi, A Lubashevskiy, B Lubsandorzhiev, G Lutter, C Macolino, B Majorovits, W Maneschg, L Manzanillas, M Miloradovic, R Mingazheva, M Misiaszek, P Moseev, Y Müller, I Nemchenok, L Pandola, K Pelczar, L Pertoldi, P Piseri, A Pullia, C Ransom, L Rauscher, S Riboldi, N Rumyantseva, C Sada, F Salamida, S Schönert, J Schreiner, M Schütt, A-K Schütz, O Schulz, M Schwarz, B Schwingenheuer, O Selivanenko, E Shevchik, M Shirchenko, L Shtembari, H Simgen, A Smolnikov, D Stukov, A A Vasenko, A Veresnikova, C Vignoli, K von Sturm, T Wester, C Wiesinger, M Wojcik, E Yanovich, B Zatschler, I Zhitnikov, S V Zhukov, D Zinatulina, A Zschocke, A J Zsigmond, K Zuber, G Zuzel
The GERmanium Detector Array (Gerda) collaboration searched for neutrinoless double- <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mi>β</mml:mi></mml:math> decay in <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow/> <mml:mn>76</mml:mn></mml:msup> </mml:math> Ge with an array of about 40 high-purity isotopically-enriched germanium detectors. The experimental signature of the decay is a monoenergetic signal at <mml:math xmlns:mml="https://www...
2021: European Physical Journal. C, Particles and Fields
https://read.qxmd.com/read/34734193/multi-ancestry-genome-wide-association-study-accounting-for-gene-psychosocial-factor-interactions-identifies-novel-loci-for-blood-pressure-traits
#32
JOURNAL ARTICLE
Daokun Sun, Melissa Richard, Solomon K Musani, Yun Ju Sung, Thomas W Winkler, Karen Schwander, Jin Fang Chai, Xiuqing Guo, Tuomas O Kilpeläinen, Dina Vojinovic, Hugues Aschard, Traci M Bartz, Lawrence F Bielak, Michael R Brown, Kumaraswamy Chitrala, Fernando P Hartwig, Andrea R V R Horimoto, Yongmei Liu, Alisa K Manning, Raymond Noordam, Albert V Smith, Sarah E Harris, Brigitte Kühnel, Leo-Pekka Lyytikäinen, Ilja M Nolte, Rainer Rauramaa, Peter J van der Most, Rujia Wang, Erin B Ware, Stefan Weiss, Wanqing Wen, Lisa R Yanek, Dan E Arking, Donna K Arnett, Ana Barac, Eric Boerwinkle, Ulrich Broeckel, Aravinda Chakravarti, Yii-Der Ida Chen, L Adrienne Cupples, Martha L Davigulus, Lisa de Las Fuentes, Renée de Mutsert, Paul S de Vries, Joseph A C Delaney, Ana V Diez Roux, Marcus Dörr, Jessica D Faul, Amanda M Fretts, Linda C Gallo, Hans Jörgen Grabe, C Charles Gu, Tamara B Harris, Catharina C A Hartman, Sami Heikkinen, M Arfan Ikram, Carmen Isasi, W Craig Johnson, Jost Bruno Jonas, Robert C Kaplan, Pirjo Komulainen, Jose E Krieger, Daniel Levy, Jianjun Liu, Kurt Lohman, Annemarie I Luik, Lisa W Martin, Thomas Meitinger, Yuri Milaneschi, Jeff R O'Connell, Walter R Palmas, Annette Peters, Patricia A Peyser, Laura Pulkki-Råback, Leslie J Raffel, Alex P Reiner, Kenneth Rice, Jennifer G Robinson, Frits R Rosendaal, Carsten Oliver Schmidt, Pamela J Schreiner, Lars Schwettmann, James M Shikany, Xiao-Ou Shu, Stephen Sidney, Mario Sims, Jennifer A Smith, Nona Sotoodehnia, Konstantin Strauch, E Shyong Tai, Kent Taylor, André G Uitterlinden, Cornelia M van Duijn, Melanie Waldenberger, Hwee-Lin Wee, Wen-Bin Wei, Gregory Wilson, Deng Xuan, Jie Yao, Donglin Zeng, Wei Zhao, Xiaofeng Zhu, Alan B Zonderman, Diane M Becker, Ian J Deary, Christian Gieger, Timo A Lakka, Terho Lehtimäki, Kari E North, Albertine J Oldehinkel, Brenda W J H Penninx, Harold Snieder, Ya-Xing Wang, David R Weir, Wei Zheng, Michele K Evans, W James Gauderman, Vilmundur Gudnason, Bernardo L Horta, Ching-Ti Liu, Dennis O Mook-Kanamori, Alanna C Morrison, Alexandre C Pereira, Bruce M Psaty, Najaf Amin, Ervin R Fox, Charles Kooperberg, Xueling Sim, Laura Bierut, Jerome I Rotter, Sharon L R Kardia, Nora Franceschini, Dabeeru C Rao, Myriam Fornage
Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from 5 ancestry groups...
January 14, 2021: HGG advances
https://read.qxmd.com/read/34720720/characterization-of-inverted-coaxial-76-ge-detectors-in-gerda-for-future-double-%C3%AE-decay-experiments
#33
JOURNAL ARTICLE
M Agostini, G Araujo, A M Bakalyarov, M Balata, I Barabanov, L Baudis, C Bauer, E Bellotti, S Belogurov, A Bettini, L Bezrukov, V Biancacci, E Bossio, V Bothe, V Brudanin, R Brugnera, A Caldwell, C Cattadori, A Chernogorov, T Comellato, V D'Andrea, E V Demidova, N Di Marco, E Doroshkevich, F Fischer, M Fomina, A Gangapshev, A Garfagnini, C Gooch, P Grabmayr, V Gurentsov, K Gusev, J Hakenmüller, S Hemmer, W Hofmann, J Huang, M Hult, L V Inzhechik, J Janicskó Csáthy, J Jochum, M Junker, V Kazalov, Y Kermaïdic, H Khushbakht, T Kihm, I V Kirpichnikov, A Klimenko, R Kneißl, K T Knöpfle, O Kochetov, V N Kornoukhov, P Krause, V V Kuzminov, M Laubenstein, M Lindner, I Lippi, A Lubashevskiy, B Lubsandorzhiev, G Lutter, C Macolino, B Majorovits, W Maneschg, L Manzanillas, M Miloradovic, R Mingazheva, M Misiaszek, P Moseev, Y Müller, I Nemchenok, L Pandola, K Pelczar, L Pertoldi, P Piseri, A Pullia, C Ransom, L Rauscher, S Riboldi, N Rumyantseva, C Sada, F Salamida, S Schönert, J Schreiner, M Schütt, A-K Schütz, O Schulz, M Schwarz, B Schwingenheuer, O Selivanenko, E Shevchik, M Shirchenko, L Shtembari, H Simgen, A Smolnikov, D Stukov, A A Vasenko, A Veresnikova, C Vignoli, K von Sturm, T Wester, C Wiesinger, M Wojcik, E Yanovich, B Zatschler, I Zhitnikov, S V Zhukov, D Zinatulina, A Zschocke, A J Zsigmond, K Zuber, G Zuzel
Neutrinoless double- <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mi>β</mml:mi></mml:math> decay of <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow/> <mml:mn>76</mml:mn></mml:msup> </mml:math> Ge is searched for with germanium detectors where source and detector of the decay are identical. For the success of future experiments it is important to increase the mass of the detectors. We report here on the characterization and testing of five prototype detectors manufactured in inverted coaxial (IC) geometry from material enriched to 88% in <mml:math xmlns:mml="https://www...
2021: European Physical Journal. C, Particles and Fields
https://read.qxmd.com/read/34720714/-222-rn-emanation-measurements-for-the-xenon1t-experiment
#34
JOURNAL ARTICLE
E Aprile, J Aalbers, F Agostini, M Alfonsi, L Althueser, F D Amaro, V C Antochi, E Angelino, J R Angevaare, F Arneodo, D Barge, L Baudis, B Bauermeister, L Bellagamba, M L Benabderrahmane, T Berger, P A Breur, A Brown, E Brown, S Bruenner, G Bruno, R Budnik, C Capelli, J M R Cardoso, D Cichon, B Cimmino, M Clark, D Coderre, A P Colijn, J Conrad, J P Cussonneau, M P Decowski, A Depoian, P Di Gangi, A Di Giovanni, R Di Stefano, S Diglio, A Elykov, G Eurin, A D Ferella, W Fulgione, P Gaemers, R Gaior, A Gallo Rosso, M Galloway, F Gao, L Grandi, M Garbini, C Hasterok, C Hils, K Hiraide, L Hoetzsch, E Hogenbirk, J Howlett, M Iacovacci, Y Itow, F Joerg, N Kato, S Kazama, M Kobayashi, G Koltman, A Kopec, H Landsman, R F Lang, L Levinson, Q Lin, S Lindemann, M Lindner, F Lombardi, J A M Lopes, E López Fune, C Macolino, J Mahlstedt, L Manenti, A Manfredini, F Marignetti, T Marrodán Undagoitia, K Martens, J Masbou, D Masson, S Mastroianni, M Messina, K Miuchi, A Molinario, K Morå, S Moriyama, Y Mosbacher, M Murra, J Naganoma, K Ni, U Oberlack, K Odgers, J Palacio, B Pelssers, R Peres, J Pienaar, V Pizzella, G Plante, J Qin, H Qiu, D Ramírez García, S Reichard, A Rocchetti, N Rupp, J M F Dos Santos, G Sartorelli, N Šarčević, M Scheibelhut, S Schindler, J Schreiner, D Schulte, M Schumann, L Scotto Lavina, M Selvi, F Semeria, P Shagin, E Shockley, M Silva, H Simgen, A Takeda, C Therreau, D Thers, F Toschi, G Trinchero, C Tunnell, M Vargas, G Volta, O Wack, H Wang, Y Wei, C Weinheimer, M Weiss, D Wenz, J Westermann, C Wittweg, J Wulf, Z Xu, M Yamashita, J Ye, G Zavattini, Y Zhang, T Zhu, J P Zopounidis
The selection of low-radioactive construction materials is of utmost importance for the success of low-energy rare event search experiments. Besides radioactive contaminants in the bulk, the emanation of radioactive radon atoms from material surfaces attains increasing relevance in the effort to further reduce the background of such experiments. In this work, we present the <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow/> <mml:mn>222</mml:mn></mml:msup> </mml:math> Rn emanation measurements performed for the XENON1T dark matter experiment...
2021: European Physical Journal. C, Particles and Fields
https://read.qxmd.com/read/34695218/long-term-cumulative-blood-pressure-in-young-adults-and-incident-heart-failure-coronary-heart-disease-stroke-and-cardiovascular-disease-the-cardia-study
#35
JOURNAL ARTICLE
Chike C Nwabuo, Duke Appiah, Henrique T Moreira, Henrique D Vasconcellos, Yuichiro Yano, Jared P Reis, Ravi V Shah, Venkatesh L Murthy, Norrina B Allen, Stephen Sidney, Paul Muntner, Cora E Lewis, Donald M Lloyd-Jones, Pamela J Schreiner, Samuel S Gidding, João A C Lima
AIMS: Cumulative blood pressure (BP) is a measure that incorporates the severity and duration of BP exposure. The prognostic significance of cumulative BP in young adults for cardiovascular diseases (CVDs) in comparison to BP severity alone is, however, unclear. METHODS AND RESULTS: We investigated 3667 Coronary Artery Risk Development in Young Adults participants who attended six visits over 15 years (year-0 (1985-1986), year-2, year-5, year-7, year-l0, and year-15 exams)...
October 25, 2021: European Journal of Preventive Cardiology
https://read.qxmd.com/read/34667079/proser1-mediates-tet2-o-glcnacylation-to-regulate-dna-demethylation-on-utx-dependent-enhancers-and-cpg-islands
#36
JOURNAL ARTICLE
Xiaokang Wang, Wojciech Rosikiewicz, Yurii Sedkov, Tanner Martinez, Baranda S Hansen, Patrick Schreiner, Jesper Christensen, Beisi Xu, Shondra M Pruett-Miller, Kristian Helin, Hans-Martin Herz
DNA methylation at enhancers and CpG islands usually leads to gene repression, which is counteracted by DNA demethylation through the TET protein family. However, how TET enzymes are recruited and regulated at these genomic loci is not fully understood. Here, we identify TET2, the glycosyltransferase OGT and a previously undescribed proline and serine rich protein, PROSER1 as interactors of UTX, a component of the enhancer-associated MLL3/4 complexes. We find that PROSER1 mediates the interaction between OGT and TET2, thus promoting TET2 O-GlcNAcylation and protein stability...
January 2022: Life Science Alliance
https://read.qxmd.com/read/34642648/software-training-in-hep
#37
JOURNAL ARTICLE
Sudhir Malik, Samuel Meehan, Kilian Lieret, Meirin Oan Evans, Michel H Villanueva, Daniel S Katz, Graeme A Stewart, Peter Elmer, Sizar Aziz, Matthew Bellis, Riccardo Maria Bianchi, Gianluca Bianco, Johan Sebastian Bonilla, Angela Burger, Jackson Burzynski, David Chamont, Matthew Feickert, Philipp Gadow, Bernhard Manfred Gruber, Daniel Guest, Stephan Hageboeck, Lukas Heinrich, Maximilian M Horzela, Marc Huwiler, Clemens Lange, Konstantin Lehmann, Ke Li, Devdatta Majumder, Judita Mamužić, Kevin Nelson, Robin Newhouse, Emery Nibigira, Scarlet Norberg, Arturo Sánchez Pineda, Mason Proffitt, Brendan Regnery, Amber Roepe, Stefan Roiser, Henry Schreiner, Oksana Shadura, Giordon Stark, Stephen Nicholas Swatman, Savannah Thais, Andrea Valassi, Stefan Wunsch, David Yakobovitch, Siqi Yuan
The long-term sustainability of the high-energy physics (HEP) research software ecosystem is essential to the field. With new facilities and upgrades coming online throughout the 2020s, this will only become increasingly important. Meeting the sustainability challenge requires a workforce with a combination of HEP domain knowledge and advanced software skills. The required software skills fall into three broad groups. The first is fundamental and generic software engineering (e.g., Unix, version control, C++, and continuous integration)...
2021: Computing and software for big science
https://read.qxmd.com/read/34544078/systematic-review-of-outcome-measures-used-in-observational-studies-of-adults-with-eosinophilic-esophagitis
#38
Alain M Schoepfer, Camilla Schürmann, Sven Trelle, Marcel Zwahlen, Christopher Ma, Mirna Chehade, Evan S Dellon, Vipul Jairath, Brian G Feagan, Albert J Bredenoord, Luc Biedermann, Thomas Greuter, Philipp Schreiner, Alex Straumann, Ekaterina Safroneeva
BACKGROUND: Over the last 20 years, diverse outcome measures have been used to evaluate the effectiveness of therapies for eosinophilic esophagitis (EoE). This systematic review aims to identify the readouts used in observational studies of topical corticosteroids, diet, and dilation in adult EoE patients. METHODS: We searched MEDLINE and Embase for prospective and retrospective studies (cohorts/case series, randomized open-label, and case-control) evaluating the use of diets, dilation, and topical corticosteroids in adults with EoE...
2021: International Archives of Allergy and Immunology
https://read.qxmd.com/read/34538422/hyperexcitable-phenotypes-in-induced-pluripotent-stem-cell-derived-neurons-from-patients-with-15q11-q13-duplication-syndrome-a-genetic-form-of-autism
#39
JOURNAL ARTICLE
James J Fink, Jeremy D Schreiner, Judy E Bloom, Jadin James, Dylan S Baker, Tiwanna M Robinson, Richard Lieberman, Leslie M Loew, Stormy J Chamberlain, Eric S Levine
BACKGROUND: Chromosome 15q11-q13 duplication syndrome (Dup15q) is a neurogenetic disorder caused by duplications of the maternal copy of this region. In addition to hypotonia, motor deficits, and language impairments, patients with Dup15q commonly meet the criteria for autism spectrum disorder and have a high prevalence of seizures. It is known from mouse models that synaptic impairments are a strong component of Dup15q pathophysiology; however, cellular phenotypes that relate to seizures are less clear...
December 1, 2021: Biological Psychiatry
https://read.qxmd.com/read/34453205/single-stage-total-hip-arthroplasty-after-failed-fixation-of-proximal-femoral-fractures-an-increased-risk-for-periprosthetic-joint-infections
#40
JOURNAL ARTICLE
P Hemmann, F Schmidutz, M D Ahrend, S G Yan, U Stöckle, A J Schreiner
BACKGROUND: Higher complication rates have been reported for total hip arthroplasty (THA) after osteosynthesis of proximal femur fractures (PFF). This study evaluated the infection risk for conversion of internal fixation of PFF to THA by a single-staged procedure in the absence of clear infection signs. METHODS: Patients undergoing a one-staged conversion to THA (2013-2018) after prior internal fixation of the proximal femur were included. Preoperative diagnostics with laboratory results, hip aspirations as well as intraoperative microbiology and sonication were assessed...
August 28, 2021: Archives of Orthopaedic and Trauma Surgery
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