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JOURNAL ARTICLE
Shouyue Zhang, Ao Sun, Jing-Mei Qian, Shuo Lin, Wenjing Xing, Yun Yang, Han-Zhou Zhu, Xin-Yi Zhou, Yan-Shuo Guo, Yun Liu, Yu Meng, Shu-Lin Jin, Wenhao Song, Cheng-Ping Li, Zhaofu Li, Shuai Jin, Jian-Hua Wang, Meng-Qiu Dong, Caixia Gao, Chunlai Chen, Yang Bai, Jun-Jie Gogo Liu
The CRISPR system is an adaptive immune system found in prokaryotes that defends host cells against the invasion of foreign DNA1 . As part of the ongoing struggle between phages and the bacterial immune system, the CRISPR system has evolved into various types, each with distinct functionalities2 . Type II Cas9 is the most extensively studied of these systems and has diverse subtypes. It remains uncertain whether members of this family can evolve additional mechanisms to counter viral invasions3,4 ...
May 29, 2024: Nature
#2
JOURNAL ARTICLE
Nian-Zhuang Qiu, Hui-Mei Hou, Tian-Yang Guo, Yu-Li Lv, Yao Zhou, Fang-Fang Zhang, Feng Zhang, Xiao-Dan Wang, Wei Chen, Yong-Feng Gao, Mei-Hua Chen, Xue-Hui Zhang, Han-Ting Zhang, Hao Wang
Phosphodiesterase 8 (PDE8), as a member of PDE superfamily, specifically promotes the hydrolysis and degradation of intracellular cyclic adenosine monophosphate (cAMP), which may be associated with pathogenesis of Alzheimer's disease (AD). However, little is currently known about potential role in the central nervous system (CNS). Here we investigated the distribution and expression of PDE8 in brain of mouse, which we believe can provide evidence for studying the role of PDE8 in CNS and the relationship between PDE8 and AD...
May 23, 2024: Neurochemical Research
#3
JOURNAL ARTICLE
Chu-Xu Zhu, Kai Yan, Liang Chen, Rong-Rong Huang, Zhen-Hua Bian, Hao-Ran Wei, Xue-Mei Gu, Yang-Yang Zhao, Meng-Chu Liu, Cai-Xia Suo, Zhi-Kun Li, Zhi-Yi Yang, Min-Qiang Lu, Xue-Feng Hua, Liang Li, Zhi-Bin Zhao, Lin-Chong Sun, Hua-Feng Zhang, Ping Gao, Zhe-Xiong Lian
BACKGROUND & AIMS: The liver is the main organ of ketogenesis, while ketones are mainly metabolized in peripheral tissues via the critical enzyme OXCT1. We previously found that ketolysis is reactivated in hepatocellular carcinoma (HCC) cells through OXCT1 expression to promote tumor progression; however, whether OXCT1 regulates antitumor immunity remains unclear. METHODS: To investigate the expression pattern of OXCT1 in hepatocellular carcinoma in vivo, we conducted multiplex immunohistochemistry (mIHC) experiments on human HCC specimens...
May 15, 2024: Journal of Hepatology
#4
JOURNAL ARTICLE
Mei-Huan Wang, Yue-Hua Gao, Zhen-Dan Zhao, Hua-Wei Zhang
Breast cancer (BC) is a heterogeneous malignancy with a dismal prognosis. Disulfidptosis is a novel type of regulated cell death that happens in the presence of glucose deficiency and is linked to the metabolic process of glycolysis. However, the mechanism of action of disulfidptosis and glycolysis-related genes (DGRG) in BC, as well as their prognostic value in BC patients, remain unknown. After identifying the differentially expressed DGRG in normal and BC tissues, a number of machine learning algorithms were utilized to select essential prognostic genes to develop a model, including SLC7A11, CACNA1H, SDC1, CHST1, and TFF3...
May 15, 2024: Environmental Toxicology
#5
JOURNAL ARTICLE
Dan Li, Mei-Yan Gao, Cheng-Hua Deng, Guo-Bi Li, Shao-Jie Qin, Qing-Yuan Yang, Bai-Qiao Song
A 44 .610 .8 topology hybrid ultramicroporous material (HUM), {[Cu1.5 F(SiF6 )(L)2.5 ]·G}n , (L = 4,4'-bisimidazolylbiphenyl, G = guest molecules), 1, formed by cross-linking interpenetrated 3D four-connected CdSO4 -type nets with hexafluorosilicate anions is synthesized and evaluated in the context of gas sorption and separation herein. 1 is the first HUM functionalized with two different types of fluorinated sites (SiF6 2- and F- anions) lining along the pore surface. The optimal pore size (≈5 Å) combining mixed and high-density electronegative fluorinated sites enable 1 to preferentially adsorb C2 H2 over CO2 and C2 H4 by hydrogen bonding interactions with a high C2 H2 isosteric heat of adsorption (Qst ) of ≈42...
May 15, 2024: Small
#6
JOURNAL ARTICLE
Ying-Qin Gao, Jun Jie Seah, Mei-Lan Wang, Qing-Ping Tang, De-Yun Wang, Xian-Yun Bi, Hua-Wei Han, Tie-Song Zhang, Jing Ma
OBJECTIVES: To compare the epidemiology and disease patterns of allergic rhinitis (AR) at 2 different altitudes in children aged 6-7 years, and subsequently to compare with and augment data from international studies. MATERIALS AND METHODS: This is a multistage, clustered and stratified random sample study. The study area comprises 2 distinct areas within Yunnan Province, China. Low altitude was represented by Xishuangbanna Prefecture (XB), while high altitude was represented by Diqing Prefecture (DiQ)...
May 2024: World Allergy Organization Journal
#7
JOURNAL ARTICLE
Kong-Wen Ouyang, Tian-Tian Wang, Hua Wang, Ye-Xin Luo, Yi-Fan Hu, Xin-Mei Zheng, Qing Ling, Kai-Wen Wang, Yong-Wei Xiong, Jin Zhang, Wei Chang, Yu-Feng Zhang, Zhi Yuan, Hao Li, Lan Gao, De-Xiang Xu, Hua-Long Zhu, Lan Yang, Hua Wang
Cadmium (Cd) is a widely distributed typical environmental pollutant and one of the most toxic heavy metals. It is well-known that environmental cadmium causes testicular damage by inducing classic types of cell death such as cell apoptosis and necrosis. However, as a new type of cell death, the role and mechanism of pyroptosis in cadmium-induced testicular injury remain unclear. In the current study, we used environmental cadmium to generate a murine model with testicular injury and AIM2-dependent pyroptosis...
May 2, 2024: Science of the Total Environment
#8
JOURNAL ARTICLE
Lei Gao, Yan-Jun Xiong, Ya-Xue Liang, Peng-Fei Huang, Shuang Liu, Yu Xiao, Qian Huang, Hua Wang, Hui-Mei Wu
Inflammatory cytokines have crucial roles in the pathogenesis of tuberculosis (TB), and interleukin (IL)-27 and IL-35 have a pro-inflammatory and anti-inflammatory effect on many diseases, including infectious diseases. Therefore, we evaluated the relationship between IL-27 and IL-35 gene polymorphism, expression levels, and pulmonary TB (PTB) susceptibility. Nine single-nucleotide polymorphisms (SNPs) in the IL-27 gene (rs181206, rs153109, and rs17855750) and the IL-35 gene (rs4740, rs428253, rs9807813, rs2243123, rs2243135, and rs568408) were genotyped by the SNPscan technique in 497 patients with PTB and 501 controls...
2024: Frontiers in Immunology
#9
JOURNAL ARTICLE
Zhi-Qin Cao, Gao-Qian Wang, Rui Luo, Yao-Hui Gao, Jian-Ming Lv, Sheng-Ying Qin, Guo-Dong Chen, Takayoshi Awakawa, Xue-Feng Bao, Qing-Hua Mei, Xin-Sheng Yao, Dan Hu, Ikuro Abe, Hao Gao
Enfumafungin-type antibiotics, represented by enfumafungin and fuscoatroside, belong to a distinct group of triterpenoids derived from fungi. These compounds exhibit significant antifungal properties with ibrexafungerp, a semisynthetic derivative of enfumafungin, recently gaining FDA's approval as the first oral antifungal drug for treating invasive vulvar candidiasis. Enfumafungin-type antibiotics possess a cleaved E-ring with an oxidized carboxyl group and a reduced methyl group at the break site, suggesting unprecedented C-C bond cleavage chemistry involved in their biosynthesis...
April 23, 2024: Journal of the American Chemical Society
#10
JOURNAL ARTICLE
Ming-Ming Bian, Yao-Mei Xu, Lin Zhang, Hua-Zheng Yan, Jian-Xiong Gao, Gui-Qiang Fu, Yang-Yang Wang, He-Zuo Lü
BACKGROUND: Oxidative stress is a crucial factor contributing to the occurrence and development of secondary damage in spinal cord injuries (SCI), ultimately impacting the recovery process. α-lipoic acid (ALA) exhibits potent antioxidant properties, effectively reducing secondary damage and providing neuroprotective benefits. However, the precise mechanism by which ALA plays its antioxidant role remains unknown. METHODS: We established a model of moderate spinal cord contusion in rats...
April 22, 2024: Journal of Spinal Cord Medicine
#11
JOURNAL ARTICLE
Yu Zhang, Ying-Bin Wang, Gui-Hua Yao, Hong Tang, Li-Xin Chen, Li-Xue Yin, Tian-Gang Zhu, Jian-Jun Yuan, Wei Han, Jun Yang, Xian-Hong Shu, Ya Yang, Yu-Lin Wei, Yan-Li Guo, Wei-Dong Ren, Dong-Mei Gao, Gui-Lin Lu, Ji Wu, Hong-Ning Yin, Yu-Ming Mu, Jia-Wei Tian, Li-Jun Yuan, Xiao-Jing Ma, Hong-Yan Dai, Yun-Chuan Ding, Ming-Yan Ding, Qing Zhou, Hao Wang, Di Xu, Mei Zhang, Yun Zhang
Three-dimensional (3D) echocardiography is an emerging technique for assessing right ventricular (RV) volume and function, but 3D-RV normal values from a large Chinese population are still lacking. The aim of the present study was to establish normal values of 3D-RV volume and function in healthy Chinese volunteers. A total of 1117 Han Chinese volunteers from 28 laboratories in 20 provinces of China were enrolled, and 3D-RV images of 747 volunteers with optimal image quality were ultimately analyzed by a core laboratory...
May 2024: MedComm
#12
JOURNAL ARTICLE
Gui-Qiang Fu, Yang-Yang Wang, Yao-Mei Xu, Ming-Ming Bian, Lin Zhang, Hua-Zheng Yan, Jian-Xiong Gao, Jing-Lu Li, Yu-Qing Chen, Nan Zhang, Shu-Qin Ding, Rui Wang, Jiang-Yan Li, Jian-Guo Hu, He-Zuo Lü
Inflammation is one of the key injury factors for spinal cord injury (SCI). Exosomes (Exos) derived from M2 macrophages have been shown to inhibit inflammation and be beneficial in SCI animal models. However, lacking targetability restricts their application prospects. Considering that chemokine receptors increase dramatically after SCI, viral macrophage inflammatory protein II (vMIP-II) is a broad-spectrum chemokine receptor binding peptide, and lysosomal associated membrane protein 2b (Lamp2b) is the key membrane component of Exos, we speculated that vMIP-II-Lamp2b gene-modified M2 macrophage-derived Exos (vMIP-II-Lamp2b-M2-Exo) not only have anti-inflammatory properties, but also can target the injured area by vMIP-II...
April 18, 2024: Experimental Neurology
#13
JOURNAL ARTICLE
Yue Cao, Shengyan Wang, Huan Li, Yan-Yan Gao, Mei Li, Hua Wang, Wenlei Zhu, Yang Zhou
Anisotropic growth of nanomaterials enables advances in building diverse and complex architectures, which exhibit unique properties and enrich the choice of nano-building modules for electrochemical sensor devices. Herein, an anisotropic growth method was proposed to anchor gold nanoparticles (AuNPs) onto both ends of quasi-two-dimensional CdSe semiconductor quantum nanoplatelets (NPLs), appearing with a monodisperse and uniform nano-dumbbell shape. Then, these AuNPs were exploited as natural anchor points and further initiated self-assembly to create complex architectures via dithiol bridges...
April 19, 2024: Analyst
#14
JOURNAL ARTICLE
Wan-Ping Yang, Mei-Qi Li, Jie Ding, Jia-Yan Li, Gang Wu, Bao Liu, Yu-Qi Gao, Guo-Hua Wang, Qian-Qian Luo
High-altitude polycythemia (HAPC) affects individuals living at high altitudes, characterized by increased red blood cells (RBCs) production in response to hypoxic conditions. The exact mechanisms behind HAPC are not fully understood. We utilized a mouse model exposed to hypobaric hypoxia (HH), replicating the environmental conditions experienced at 6000 m above sea level, coupled with in vitro analysis of primary splenic macrophages under 1% O2 to investigate these mechanisms. Our findings indicate that HH significantly boosts erythropoiesis, leading to erythrocytosis and splenic changes, including initial contraction to splenomegaly over 14 days...
April 17, 2024: ELife
#15
JOURNAL ARTICLE
Jun Han, Jie Gao, Demei Chen, Mou Du, Yuxin Wu, Xidong Ma, Mei Xie, Hua Han, Chongchong Wu, Xinying Xue
BACKGROUND: Pulmonary mucinous adenocarcinoma is a special type of lung cancer. Its imaging manifestations are diverse, which brings challenges to clinical diagnosis. However, its formation mechanism is unclear. OBJECTIVE: The objective of this study is to analyse the relevant mechanisms of the formation of pulmonary mucinous adenocarcinoma by observing its different imaging and pathological manifestations. DATA AND METHODS: Retrospective analysis was conducted on imaging manifestations and pathological data of 103 patients with pulmonary mucinous adenocarcinoma confirmed intraoperatively or pathologically...
April 2024: Clinical Respiratory Journal
#16
RANDOMIZED CONTROLLED TRIAL
Jie Tian, Yong-Ping Song, Gao-Chong Zhang, Shu-Fang Wang, Xiao-Xiang Chu, Ye Chai, Chun-Ling Wang, Ai-Li He, Feng Zhang, Xu-Liang Shen, Wei-Hua Zhang, Lin-Hua Yang, Da-Nian Nie, Dong-Mei Wang, Huan-Ling Zhu, Da Gao, Shi-Feng Lou, Ze-Ping Zhou, Guo-Hong Su, Yan Li, Jin-Ying Lin, Qing-Zhi Shi, Gui-Fang Ouyang, Hong-Mei Jing, Sai-Juan Chen, Jian Li, Jian-Qing Mi
PURPOSE: The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy of the arsenic realgar-indigo naturalis formula (RIF) plus imatinib with that of imatinib monotherapy in patients with newly diagnosed chronic phase CML (CP-CML). METHODS: In this multicenter, randomized, double-blind, phase 3 trial, 191 outpatients with newly diagnosed CP-CML were randomly assigned to receive oral RIF plus imatinib (n = 96) or placebo plus imatinib (n = 95)...
April 11, 2024: Journal of Cancer Research and Clinical Oncology
#17
JOURNAL ARTICLE
Correlation between health literacy and life quality in elderly patients with chronic periodontitis.
Jianhong Jiang, Xinglian Shi, Quanmin He, Li Gao, Kun Yang, Taiping Wang, Zhezhen Li, Mei Liu
OBJECTIVES: This study aims to explore the status quo of health literacy and quality of life in elderly patients with chronic periodontitis and determine their correlation to understand the influencing factors of health literacy and quality of life. METHODS: A total of 150 elderly patients with chronic periodontitis were investigated using the general information questionnaire, Oral Health Literacy-Adult Questionnaire, and Oral Health Impact Profile for Chronic Periodontitis...
December 1, 2023: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
#18
JOURNAL ARTICLE
Yao-Sheng Wei, Jian-Ying Zhao, Talha Javed, Ahmad Ali, Mei-Ting Huang, Hua-Ying Fu, Hui-Li Zhang, San-Ji Gao
Plants must adapt to the complex effects of several stressors brought on by global warming, which may result in interaction and superposition effects between diverse stressors. Few reports are available on how drought stress affects Xanthomonas albilineans ( Xa ) infection in sugarcane ( Saccharum spp. hybrids). Drought and leaf scald resistance were identified on 16 sugarcane cultivars using Xa inoculation and soil drought treatments, respectively. Subsequently, four cultivars contrasting to drought and leaf scald resistance were used to explore the mechanisms of drought affecting Xa -sugarcane interaction...
March 17, 2024: Plants (Basel, Switzerland)
#19
JOURNAL ARTICLE
Kefang Lai, Dejun Sun, Ranran Dai, Ronnie Samoro, Hae-Sim Park, Annika Åstrand, David Cohen, Maria Jison, Vivian H Shih, Viktoria Werkström, Yuhui Yao, Yajuan Zhang, Wenying Zheng, Nanshan Zhong, Albay Albert, Bo Jianping, Chen Bi, Chen Lijun, Chen Mei, Chen Min, Chen Ping, Chen Zhimin, Chian Chih-Feng, Cho You Sook, Fu Xiuhua, Gao Xiwen, Gu Wei, Han Wei, Han Zhihai, Hu Xi Wei, Huang Kewu, Huang Mao, Isidro Marie Grace Dawn, Jeong Inbeom, Jiang Luning, Jiang Mingyan, Jiang Shanping, Jin Meiling, Kang Jian, Kim Jin Woo, Kim Sang-Ha, Kuang Jiulong, Kuo Ping-Hung, Li Jie, Li Manxiang, Li Minjing, Li Ruoran, Li Wen, Li Xianhua, Li Yanming, Lim Seong Yong, Liu Chuanhe, Liu Chuntao, Liu Jing, Liu Xiaoxia, Lu Huiyu, Luo Zhuang, Ma Shengxi, Mao Liangping, Min Kyung Hoon, Mu Lin, Park Choon-Sik, Park Hae Sim, Park Hye-Kyung, Park Jung-Won, Perng Diahn-Warng, Samoro Ronnie, Shi Guochao, Sun Debin, Sun Dejun, Wang Chun-Hua, Wang Guangfa, Wang Limin, Wang Xuefen, Wang Yan, Wei Liping, Wu Haihong, Xiao Yi, Xiao Zuke, Xie Canmao, Xu Jin-Fu, Xu Xingxiang, Xu Xiyuan, Yan Jianping, Yang Hongzhong, Yoon Ho Joo, Yu Wencheng, Zhang Jin, Zhang Longju, Zhang Min, Zhang Wei, Zhao Jianping, Zhao Ziwen, Zhu Xiaoli, Zhu Yingqun
BACKGROUND: Benralizumab is indicated as add-on therapy in patients with uncontrolled, severe eosinophilic asthma; it has not yet been evaluated in a large Asian population with asthma in a clinical trial. OBJECTIVE: To evaluate the efficacy and safety of benralizumab in patients with severe asthma in Asia. METHODS: MIRACLE (NCT03186209) was a randomized, Phase 3 study in China, South Korea, and the Philippines. Patients aged 12-75 years with severe asthma receiving medium-to-high-dose inhaled corticosteroid/long-acting β2 -agonists, stratified (2:1) by baseline blood eosinophil count (bEOS) (≥300/μL; <300/μL), were randomized (1:1) to benralizumab 30 mg or placebo...
April 1, 2024: Respiratory Medicine
#20
JOURNAL ARTICLE
Sheng-Ren Sun, Xiao-Bin Wu, Jian-Sheng Chen, Mei-Ting Huang, Hua-Ying Fu, Qin-Nan Wang, Philippe Rott, San-Ji Gao
Sugarcane (Saccharum spp.) is an important sugar and biofuel crop in the world. It is frequently subjected to drought stress, thus causing considerable economic losses. Transgenic technology is an effective breeding approach to improve sugarcane tolerance to drought using drought-inducible promoter(s) to activate drought-resistance gene(s). In this study, six different promoters were cloned from sugarcane bacilliform virus (SCBV) genotypes exhibiting high genetic diversity. In β-glucuronidase (GUS) assays, expression of one of these promoters (PSCBV-YZ2060 ) is similar to the one driven by the CaMV 35S promoter and >90% higher compared to the other cloned promoters and Ubi1...
March 26, 2024: Communications Biology
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