Sotirios Tsimikas, Atsushi Miyanohara, Karsten Hartvigsen, Esther Merki, Peter X Shaw, Meng-Yun Chou, Jennifer Pattison, Michael Torzewski, Janina Sollors, Theodore Friedmann, N Chin Lai, H Kirk Hammond, Godfrey S Getz, Catherine A Reardon, Andrew C Li, Carole L Banka, Joseph L Witztum
OBJECTIVES: We sought to assess the in vivo importance of scavenger receptor (SR)-mediated uptake of oxidized low-density lipoprotein (OxLDL) in atherogenesis and to test the efficacy of human antibody IK17-Fab or IK17 single-chain Fv fragment (IK17-scFv), which lacks immunologic properties of intact antibodies other than the ability to inhibit uptake of OxLDL by macrophages, to inhibit atherosclerosis. BACKGROUND: The unregulated uptake of OxLDL by macrophage SR contributes to foam cell formation, but the importance of this pathway in vivo is uncertain...
October 11, 2011: Journal of the American College of Cardiology