keyword
https://read.qxmd.com/read/32613160/comparing-cellular-bone-matrices-for-posterolateral-spinal-fusion-in-a-rat-model
#1
Cliff Lin, Nianli Zhang, Erik I Waldorff, Paolo Punsalan, David Wang, Eric Semler, James T Ryaby, Jung Yoo, Brian Johnstone
Introduction: Cellular bone matrices (CBM) are allograft products that provide three components essential to new bone formation: an osteoconductive scaffold, extracellular growth factors for cell proliferation and differentiation, and viable cells with osteogenic potential. This is an emerging technology being applied to augment spinal fusion procedures as an alternative to autografts. Methods: We aim to compare the ability of six commercially-available human CBMs (Trinity ELITE®, ViviGen®, Cellentra®, Osteocel® Pro, Bio4® and Map3®) to form a stable spinal fusion using an athymic rat model of posterolateral fusion...
June 2020: JOR Spine
https://read.qxmd.com/read/32596764/efficacy-of-stem-cell-allograft-in-maxillary-sinus-bone-regeneration-a-randomized-controlled-clinical-and-blinded-histomorphometric-study
#2
Josh Whitt, Mohanad Al-Sabbagh, Dolphus Dawson, Ehab Shehata, Moly Housley-Smith, Alejandro Tezanos, Ahmad Kutkut
PURPOSE: This study aimed to evaluate the quality and quantity of newly generated bone in the maxillary sinus grafted with stem cell-based allograft material. METHODS: This study was a single site, prospective, blinded, randomized, and controlled clinical trial. Eleven subjects with 18 edentulous posterior maxillary sites requiring sinus augmentation for delayed implant placement using a lateral window approach were enrolled. At the time of sinus augmentation, test sinus was grafted with stem cell-based allograft (Osteocel Plus; NuVasive Therapeutics), while the control sinus was grafted with conventional cortico-cancellous allograft (alloOss; ACE Surgical)...
June 29, 2020: International Journal of Implant Dentistry
https://read.qxmd.com/read/32355628/a-comparative-evaluation-of-commercially-available-cell-based-allografts-in-a-rat-spinal-fusion-model
#3
Brian Johnstone, Nianli Zhang, Erik I Waldorff, Eric Semler, Anouska Dasgupta, Marcel Betsch, Paolo Punsalan, Holly Cho, James T Ryaby, Jung Yoo
Background: To evaluate the comparative abilities of commercially available, viable, cellular bone allografts to promote posterolateral spinal fusion. Methods: Human allografts containing live cells were implanted in the athymic rat model of posterolateral spine fusion. Three commercially available allogeneic cellular bone matrices (Trinity Evolution, Trinity ELITE and Osteocel Plus) were compared with syngeneic iliac crest bone as the control. All spines underwent radiographs, manual palpation, and micro-computed tomography (CT) analysis after excision at 6 weeks...
April 2020: International Journal of Spine Surgery
https://read.qxmd.com/read/31745449/comparative-efficacy-of-commonly-available-human-bone-graft-substitutes-as-tested-for-posterolateral-fusion-in-an-athymic-rat-model
#4
Neil Bhamb, Linda E A Kanim, Susan Drapeau, Suneeth Mohan, Erick Vasquez, Dan Shimko, William McKAY, Hyun W Bae
Background: Insufficient data exist on bone graft substitute materials efficacy; two thirds lack any clinical data.1,2 This prospective animal study identified efficacy differences among commercially available materials of several classes. Methods: Historically validated muscle pouch osteoinduction study (OIS) and posterolateral fusion (PLF) were performed in an athymic rat model. Grafting material products implanted were demineralized bone matrix (DBM)-based allografts (Accell EVO3, DBX Mix, DBX Strip, Grafton Crunch, Grafton Flex, Grafton Matrix, Grafton Putty, Magnifuse, and Progenix Plus), allografts (OsteoSponge, MinerOss), cellular allograft (Osteocel Plus), ceramics (Mozaik Strip), or activated ceramics (Actifuse ABX Putty, Vitoss BA)...
October 2019: International Journal of Spine Surgery
https://read.qxmd.com/read/29528210/inorganic-self-assembled-bioactive-artificial-proto-osteocells-inducing-bone-regeneration
#5
Miusi Shi, Ruiwen Yang, Qin Li, Kangle Lv, Richard J Miron, Jie Sun, Mei Li, Yufeng Zhang
Since the discovery of osteoinduction in the early 20th century, innovative biomaterials with osteoinductive potential have emerged as candidates for bone repair. Recently, artificial protocell models have demonstrated great potential for tissue regeneration. Herein, we developed artificial bioactive proto-osteocells by self-assembly of biodegradable biphasic-phosphate particles in the form of aqueous bone morphogenetic protein 2 (BMP2)-containing Pickering emulsions in corn oil to fulfill the release of BMP2 with controlled and local efficacy...
April 4, 2018: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/27466864/stem-cells-in-spine-surgery
#6
REVIEW
Kenneth K Hansraj
INTRODUCTION: Spine surgeons are embracing advanced biologic technologies in an attempt to help millions of people achieve a better outcome in spine surgery. These new technologies may be complicated to understand, partly because the contribution of different types of cells has not been definitively identified. This paper describes the characteristics of the stem cells used in spine surgery, including their actions and possible complications. The description necessitates an overview of all studies to date on the use of stem cells in spine surgery, as well as other cells used in cellular therapy...
October 26, 2016: Surgical Technology International
https://read.qxmd.com/read/25725368/mesenchymal-stem-cell-allograft-as-a-fusion-adjunct-in-one-and-two-level-anterior-cervical-discectomy-and-fusion-a-matched-cohort-analysis
#7
Steven J McAnany, Junyoung Ahn, Islam M Elboghdady, Alejandro Marquez-Lara, Nomaan Ashraf, Branko Svovrlj, Samuel C Overley, Kern Singh, Sheeraz A Qureshi
BACKGROUND CONTEXT: Live mesenchymal stem cell (MSC) allograft-containing allogeneic bone grafts have recently gained popularity and currently account for greater than 17% of all bone grafts and bone graft substitutes used in spinal surgery. Although the claim of cellular bone matrices containing osteogenic cells with osteoinductive properties is attractive, little is known about their clinical success when used in anterior cervical discectomy and fusion (ACDF). PURPOSE: The objective of this study was to report on the radiographic fusion rates in one- and two-level instrumented ACDF using an MSC...
February 2016: Spine Journal: Official Journal of the North American Spine Society
https://read.qxmd.com/read/25188591/osteocel-plus-cellular-allograft-in-anterior-cervical-discectomy-and-fusion-evaluation-of-clinical-and-radiographic-outcomes-from-a-prospective-multicenter-study
#8
MULTICENTER STUDY
Robert K Eastlack, Steven R Garfin, Christopher R Brown, S Craig Meyer
STUDY DESIGN: Prospective, multicenter, nonrandomized, institutional review board-approved clinical and radiographic study. OBJECTIVE: To evaluate and summarize the 2-year outcomes of patients treated with Osteocel Plus cellular allograft as part of an anterior cervical discectomy and fusion procedure. SUMMARY OF BACKGROUND DATA: Osteocel Plus is an allograft cellular bone matrix containing native mesenchymal stem cells and osteoprogenitor cells that is intended to mimic the performance of iliac crest autograft without the morbidity associated with its harvest...
October 15, 2014: Spine
https://read.qxmd.com/read/23305812/lineage-mapping-and-characterization-of-the-native-progenitor-population-in-cellular-allograft
#9
Josh Neman, Vincent Duenas, Claudia Kowolik, Amanda Hambrecht, Mike Chen, Rahul Jandial
BACKGROUND CONTEXT: The gold standard for bone grafting remains the autograft. However, the attractiveness of autograft is counterbalanced by donor site morbidity. To mimic autograft-and its fundamental properties of osteoconductivity, osteoinductivity, and osteogenicity-novel bone grafting materials such as cellular allograft (Osteocel Plus) are composed of allograft in which the progenitor cells are preserved. However, the true identity of these cells remains obscure largely due to the lack of specific bona fide antigenic markers for stem versus progenitor cells...
February 2013: Spine Journal: Official Journal of the North American Spine Society
https://read.qxmd.com/read/23251099/allograft-cellular-bone-matrix-in-extreme-lateral-interbody-fusion-preliminary-radiographic-and-clinical-outcomes
#10
Antoine G Tohmeh, Blake Watson, Mirna Tohmeh, Xavier J Zielinski
INTRODUCTION: Extreme lateral interbody fusion (XLIF) is a minimally disruptive alternative for anterior lumbar interbody fusion. Recently, synthetic and allograft materials have been increasingly used to eliminate donor-site pain and complications secondary to autogenous bone graft harvesting. The clinical use of allograft cellular bone graft has potential advantages over autograft by eliminating the need to harvest autograft while mimicking autograft's biologic function. The objective of this study was to examine 12-month radiographic and clinical outcomes in patients who underwent XLIF with Osteocel Plus, one such allograft cellular bone matrix...
2012: TheScientificWorldJournal
https://read.qxmd.com/read/23182179/the-role-of-osteocel-plus-as-a-fusion-substrate-in-minimally-invasive-instrumented-transforaminal-lumbar-interbody-fusion
#11
Joshua M Ammerman, Joseph Libricz, Matthew D Ammerman
BACKGROUND: Instrumented lumbar fusion has become an accepted and effective surgical technique used to address a wide variety of conditions of the lumbar spine. Iliac crest autograft remains the gold standard with regards to bony fusion substrate. Unfortunately there are significant potential disadvantages associated with autograft harvest, including pain, infection, iatrogenic fracture and bleeding. Osteocel Plus (OC+) is an allograft cellular bone matrix containing mesenchymal stem cells (MSCs) and osteoprogenitor cells combined with DBM and cancellous bone...
July 2013: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/22214145/the-use-of-osteo-conductive-stem-cells-allograft-in-lumbar-interbody-fusion-procedures-an-alternative-to-recombinant-human-bone-morphogenetic-protein
#12
Eubulus J Kerr, Ajay Jawahar, Terry Wooten, Stephen Kay, David A Cavanaugh, Pierce D Nunley
UNLABELLED: The use of autogenous bone graft in spinal fusion is progressively declining. Different allografts including the human bone morphogenetic protein have been proposed to facilitate fusion rates but are associated with various adverse effects. Osteocel belongs to a new class of allograft tissue material that is a re-absorbable biomaterial with allogenic mesenchymal stem cells. The purpose of the present retrospective study was to analyze the clinical effectiveness of mesenchymal stem cells allograft (Osteocel") to achieve radiological arthrodesis in adult patients undergoing lumbar interbody fusion surgery for different indications...
2011: Journal of Surgical Orthopaedic Advances
https://read.qxmd.com/read/22036146/allograft-cellular-bone-matrix-as-an-alternative-to-autograft-in-hindfoot-and-ankle-fusion-procedures
#13
Shane M Hollawell
This report summarizes the radiographic results of Osteocel Plus in 20 hindfoot and ankle fusions at a single center. The patient population was 40% female with an average age of 57.9 ± 16.1 years. Average body mass index was 33.8 ± 9.1. Risk factors included 3 smokers and 6 patients with diabetes. Primary surgical indications included trauma (50%), Charcot arthropathy (15%), foot drop with osteoarthritis (20%), primary osteoarthritis (10%), and total talar extrusion (5%). Nine patients had a history of prior hindfoot surgery in the same foot; however, only 2 of the cases reported in this series were revisions due to a failed prior surgery; the remaining 7 were treated for correction of a traumatic deformity (n = 5) or diagnosis at a new site in the same foot (n = 2)...
March 2012: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://read.qxmd.com/read/20703817/culture-and-differentiation-of-osteoblasts-on-coral-scaffold-from-human-bone-marrow-mesenchymal-stem-cells
#14
Cong Toai Tran, Ciro Gargiulo, Huynh Duy Thao, Huynh Minh Tuan, Luis Filgueira, D Michael Strong
In this paper we describe an approach that aims to provide fundamental information towards a scientific, biomechanical basis for the use of natural coral scaffolds to initiate mesenchymal stem cells into osteogenic differentiation for transplant purposes. Biomaterial, such as corals, is an osteoconductive material that can be used to home human derived stem cells for clinical regenerative purposes. In bone transplantation, the use of biomaterials may be a solution to bypass two main critical obstacles, the shortage of donor sites for autografts and the risk of rejection with allograft procedures...
November 2011: Cell and Tissue Banking
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