Zachary R Moore, Xiaojing Huang, Stephanie Lobaugh, Zhigang Zhang, Phillip Wong, Alexander Geyer, Andrew Pagano, Charles M Rudin, David R Jones, Daniel R Gomez, Joseph O Deasy, Raymond Mak, Adam M Schmitt, Paul K Paik, Andreas Rimner
BACKGROUND AND PURPOSE: Radiation pneumonitis (RP) is a common side effect of thoracic radiotherapy and often has a long course characterized by acute exacerbations and progression to permanent lung fibrosis. There are no validated biomarkers of prognosis in patients diagnosed with RP. MATERIALS AND METHODS: We analyzed a time course of serum chemokines, cytokines, and other proteins from patients with grade 2+ RP in a randomized clinical trial of a steroid taper plus nintedanib, a multiple tyrosine kinase inhibitor, versus placebo plus a steroid taper for the treatment of RP...
May 11, 2024: Radiotherapy and Oncology