Adriana Trifan, Krystyna Skalicka-Woźniak, Sebastian Granica, Monika E Czerwińska, Aleksandra Kruk, Laurence Marcourt, Jean-Luc Wolfender, Evelyn Wolfram, Nils Esslinger, Andreas Grubelnik, Simon Vlad Luca
ETHNOPHARMACOLOGICAL RELEVANCE: Symphytum officinale L. (comfrey, Boraginaceae) has been traditionally used for millennia in joint distortions, myalgia, bone fractures and hematomas. However, key activity-determining constituents and molecular mechanisms underlying its use have not been completely elucidated. AIM OF THE STUDY: The objective of this study was to isolate and identify the major compounds from a hydroethanolic root extract of S. officinale and evaluate their antioxidant potential, alongside their effect on the cytokine production of ex vivo stimulated neutrophils, thus providing scientific support for the traditional use of comfrey root...
November 15, 2020: Journal of Ethnopharmacology