Chet Moritz, Edelle C Field-Fote, Candace Tefertiller, Ilse van Nes, Randy Trumbower, Sukhvinder Kalsi-Ryan, Mariel Purcell, Thomas W J Janssen, Andrei Krassioukov, Leslie R Morse, Kristin D Zhao, James Guest, Ralph J Marino, Lynda M Murray, Jill M Wecht, Markus Rieger, Jared Pradarelli, Amanda Turner, Jessica D'Amico, Jordan W Squair, Gregoire Courtine
Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions. Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk trial that evaluated the safety and efficacy of ARCEX Therapy to improve arm and hand functions in people with chronic SCI. ARCEX Therapy involves the delivery of externally applied electrical stimulation over the cervical spinal cord during structured rehabilitation. The primary endpoints were safety and efficacy as measured by whether the majority of participants exhibited significant improvement in both strength and functional performance in response to ARCEX Therapy compared to the end of an equivalent period of rehabilitation alone...
May 2024: Nature Medicine