Weiming Yao, Guangjian Xu, Bing Bai, Hongyan Wang, Minggui Deng, Jinxin Zheng, Duoyun Li, Xiangbin Deng, Xiaojun Liu, Zhiwei Lin, Zhong Chen, Guiqiu Li, Qiwen Deng, Zhijian Yu
The aim of this study was to determine whether in vitro induced erythromycin resistance facilitates the cross-resistance to the novel fluoroketolide, solithromycin, in Staphylococcus aureus. Four strains of methicillin-susceptible S. aureus strains S2, S3, S5 and S7 were successfully induced to establish erythromycin-resistant strains by continuous in vitro culture with erythromycin. Mutations at drug binding sites were shown to increase the minimal inhibitory concentrations for ketolides, including telithromycin and the novel compound solithromycin, but did not increase for lincosamides, chloramphenicols or oxazolidinones...
June 1, 2018: FEMS Microbiology Letters