Qiuchen Rao, Haidong Li, Qian Zhou, Ming Zhang, Xiuchao Zhao, Lei Shi, Junshuai Xie, Li Fan, Yeqing Han, Fumin Guo, Shiyuan Liu, Xin Zhou
OBJECTIVE: To comprehensively assess the impact of aging, cigarette smoking, and chronic obstructive pulmonary disease (COPD) on pulmonary physiology using 129 Xe MR. METHODS: A total of 90 subjects were categorized into four groups, including healthy young (HY, n = 20), age-matched control (AMC, n = 20), asymptomatic smokers (AS, n = 28), and COPD patients (n = 22). 129 Xe MR was utilized to obtain pulmonary physiological parameters, including ventilation defect percent (VDP), alveolar sleeve depth (h), apparent diffusion coefficient (ADC), total septal wall thickness (d), and ratio of xenon signal from red blood cells and interstitial tissue/plasma (RBC/TP)...
May 15, 2024: European Radiology