Marius Trøseid, Tuva B Dahl, Jan C Holter, Anders B Kildal, Sarah L Murphy, Kuan Yang, Ana Quiles-Jiménez, Lars Heggelund, Karl Erik Müller, Anders Tveita, Annika E Michelsen, Simen Bøe, Aleksander R Holten, Hedda Hoel, Alexander Mathiessen, Trond M Aaløkken, Børre Fevang, Beathe K Granerud, Kristian Tonby, Katerina N Henriksen, Tøri V Lerum, Fredrik Müller, Ole H Skjønsberg, Andreas Barratt-Due, Anne M Dyrhol-Riise, Pål Aukrust, Bente Halvorsen, Thor Ueland
BACKGROUND: T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown. OBJECTIVES: To investigate whether T-cell activation and exhaustion persist and are associated with prolonged respiratory dysfunction and death after hospitalization for COVID-19. METHODS: Plasma and serum from two Norwegian cohorts of hospitalized patients with COVID-19 (n = 414) were analyzed for soluble (s) markers of T-cell activation (sCD25) and exhaustion (sTim-3) during hospitalization and follow-up...
August 18, 2022: Journal of Internal Medicine