Ian Postuma, Chiara Magni, Barbara Marcaccio, Setareh Fatemi, Valerio Vercesi, Mario Ciocca, Giuseppe Magro, Ester Orlandi, Barbara Vischioni, Sara Ronchi, Yuan-Hao Liu, Yang Han, Changran Geng, Sara Josefina González, Silva Bortolussi
Boron Neutron Capture Therapy (BNCT) is a radiotherapy technique based on the enrichment of tumour cells with suitable 10-boron concentration and on subsequent neutron irradiation. Low-energy neutron irradiation produces a localized deposition of radiation dose caused by boron neutron capture reactions. Boron is vehiculated into tumour cells via proper borated formulations, able to accumulate in the malignancy more than in normal tissues. The neutron capture releases two high-LET charged particles (i.e., an alpha particle and a lithium ion), losing their energy in a distance comparable to the average dimension of one cell...
January 3, 2024: Scientific Reports