Khurram Nasir, Reed Mszar, Miguel Cainzos-Achirica, Gowtham R Grandhi, Tycho R Tromp, Rodrigo Alonso, Márcio S Bittencourt, Eric Bruckert, José Luis Díaz-Díaz, Antonio Gallo, G Kees Hovingh, Marcio H Miname, Ovidio Muñiz-Grijalvo, Jing Pang, Leopoldo Perez de Isla, Eric J G Sijbrands, Gerald F Watts, Pedro Mata, Raul D Santos
OBJECTIVES: Individuals with familial hypercholesterolemia (FH) are at an increased risk for coronary artery disease (CAD). While prior research has shown variability in coronary artery calcification (CAC) among those with FH, studies with small sample sizes and single-center recruitment have been limited in their ability to characterize CAC and plaque burden in subgroups based on age and sex. Understanding the spectrum of atherosclerosis may result in personalized risk assessment and tailored allocation of costly add-on, non-statin lipid-lowering therapies...
March 2024: American journal of preventive cardiology