keyword
https://read.qxmd.com/read/38535420/functional-recovery-and-regenerative-effects-of-direct-transcutaneous-electrical-nerve-stimulation-in-treatment-of-post-covid-19-guillain-barr%C3%A3-and-acute-transverse-myelitis-overlap-syndrome-a-clinical-case
#1
Mustafa Al-Zamil, Natalia G Kulikova, Inessa A Minenko, Numman Mansur, Denis M Zalozhnev, Marat B Uzdenov, Alina A Dzhanibekova, Alikhan A Gochiyayev, Natalia A Shnayder
Transcutaneous electrical nerve stimulation (TENS) has proven effective in treating pain in many experimental and clinical studies. In addition to the analgesic effect, direct TENS of peripheral nerves had anti-inflammatory and regenerative effects in the treatment of distal polyneuropathy and spinal cord injury. This work demonstrates the experience of using direct TENS in the treatment of a 52-year-old patient with post-COVID-19 Guillain-Barré (GBS) and acute transverse myelitis (ATM) overlap syndrome...
February 26, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38534437/post-traumatic-trigeminal-neuropathy-neurobiology-and-pathophysiology
#2
REVIEW
Tal Eliav, Rafael Benoliel, Olga A Korczeniewska
Painful traumatic trigeminal neuropathy (PTTN) is a chronic neuropathic pain that may develop following injury to the trigeminal nerve. Etiologies include cranio-orofacial trauma that may result from dental, surgical, or anesthetic procedures or physical trauma, such as a motor vehicle accident. Following nerve injury, there are various mechanisms, including peripheral and central, as well as phenotypic changes and genetic predispositions that may contribute to the development of neuropathic pain. In this article, we review current literature pertaining to the cellular processes that occur following traumatic damage to the trigeminal nerve, also called cranial nerve V, that results in chronic neuropathic pain...
March 4, 2024: Biology
https://read.qxmd.com/read/38534336/progressive-irreversible-proprioceptive-piezo2-channelopathy-induced-lost-forced-peripheral-oscillatory-synchronization-to-the-hippocampal-oscillator-may-explain-the-onset-of-amyotrophic-lateral-sclerosis-pathomechanism
#3
JOURNAL ARTICLE
Balázs Sonkodi
Amyotrophic lateral sclerosis (ALS) is a mysterious lethal multisystem neurodegenerative disease that gradually leads to the progressive loss of motor neurons. A recent non-contact dying-back injury mechanism theory for ALS proposed that the primary damage is an acquired irreversible intrafusal proprioceptive terminal Piezo2 channelopathy with underlying genetic and environmental risk factors. Underpinning this is the theory that excessively prolonged proprioceptive mechanotransduction under allostasis may induce dysfunctionality in mitochondria, leading to Piezo2 channelopathy...
March 12, 2024: Cells
https://read.qxmd.com/read/38532992/peripheral-nerve-stimulation-for-the-treatment-of-superior-cluneal-neuralgia-a-cadaver-demonstration-of-a-novel-technique-for-lead-placement
#4
JOURNAL ARTICLE
Alaa Abd-Elsayed, Michael J Gyorfi
Superior cluneal neuralgia (SCN) is a distinct cause of lower back and/or leg pain related to pathology of the superior cluneal nerve. When assessing a patient with low back pain (LBP), superior cluneal neuralgia is frequently misdiagnosed. The pathophysiology of SCN ranges from myofascial compression brought on by aberrant muscle tone to direct iatrogenic injury or trauma. In this technical report we will discuss the anatomy of superior cluneal nerve, superior cluneal neuralgia, current treatment modalities, and a novel approach to peripheral nerve stimulation (PNS) lead placement via a cadaver demonstration for SCN...
2024: Journal of Pain Research
https://read.qxmd.com/read/38527351/a-systematic-review-of-registered-clinical-trials-for-peripheral-nerve-injuries
#5
JOURNAL ARTICLE
Ala Elhelali, Sami Tuffaha
Upper extremity peripheral nerve injuries (PNIs) significantly impact daily functionality and necessitate effective treatment strategies. Clinical trials play a crucial role in developing these strategies. However, challenges like retrospective data collection, reporting biases, inconsistent outcome measures, and inadequate data sharing practices hinder effective research and treatment advancements. This review aims to analyze the landscape of reporting, methodological design, outcome measures, and data sharing practices in registered clinical trials concerning upper extremity PNIs...
April 1, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38523615/advancements-in-autologous-peripheral-nerve-transplantation-care-a-review-of-strategies-and-practices-to-facilitate-recovery
#6
REVIEW
Guoying Xu, Xiaodi Zou, Yanzhao Dong, Ahmad Alhaskawi, Haiying Zhou, Sohaib Hasan Abdullah Ezzi, Vishnu Goutham Kota, Mohamed Hasan Abdulla Hasan Abdulla, Olga Alenikova, Sahar Ahmed Abdalbary, Hui Lu
Autologous peripheral nerve transplantation, a pioneering technique in nerve injury treatment, has demonstrated remarkable progress. We examine recent nursing strategies and methodologies tailored to various anatomical sites, highlighting their role in postoperative recovery enhancement. Encompassing brachial plexus, upper limb, and lower limb nerve transplantation care, this discussion underscores the importance of personalized rehabilitation plans, interdisciplinary collaboration, and innovative approaches like nerve electrical stimulation and nerve growth factor therapy...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38519978/a-novel-microglia-targeting-strategy-based-on-nanoparticle-mediated-delivery-of-mir-26a-5p-for-long-lasting-analgesia-in-chronic-pain
#7
JOURNAL ARTICLE
Yitian Lu, Shuai Liu, Peng Wang, Xiangna Guo, Zaisheng Qin, Honghao Hou, Tao Tao
Accumulating evidence supports the notion that microglia play versatile roles in different chronic pain conditions. However, therapeutic strategies of chronic pain by targeting microglia remain largely overlooked. This study seeks to develop a miRNA-loaded nano-delivery system by targeting microglia, which could provide a decent and long-lasting analgesia for chronic pain. Surface aminated mesoporous silica nanoparticles were adopted to load miR-26a-5p, a potent analgesic miRNA, by electrostatic adsorption, which can avoid miR-26a-5p is rapidly released and degraded...
March 23, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38519856/a-hybrid-approach-that-may-facilitate-the-repair-of-traumatic-popliteal-artery-pseudoaneurysms
#8
JOURNAL ARTICLE
Areti Vassiliou, Michail Peroulis, Vassilios Tatsis, Vangelis G Alexiou
PURPOSE: Traumatic popliteal pseudoaneurysms may occur in accidents or as an iatrogenic complication of a total knee arthroplasty. Complications often arise in open repair because of distorted anatomy. Up to 22% of the patients may suffer above-knee amputation. Endovascular treatment has proven to be an effective solution. However, the long-term performance of stents at the hinge point of the popliteal artery is questionable. We present a hybrid technique that was used successfully in 2 cases...
March 22, 2024: Journal of Endovascular Therapy
https://read.qxmd.com/read/38518607/genipin-crosslinking-promotes-biomechanical-reinforcement-and-pro-regenerative-macrophage-polarization-in-bioartificial-tubular-substitutes
#9
JOURNAL ARTICLE
Jone Berasain, Paula Ávila-Fernández, Rocío Cárdenas-Pérez, Antoni Ignasi Cànaves-Llabrés, Miguel Etayo-Escanilla, Miguel Alaminos, Víctor Carriel, Óscar Darío García-García, Jesús Chato-Astrain, Fernando Campos
Traumatic nerve injuries are nowadays a significant clinical challenge and new substitutes with adequate biological and mechanical properties are in need. In this context, fibrin-agarose hydrogels (FA) have shown the possibility to generate tubular scaffolds with promising results for nerve repair. However, to be clinically viable, these scaffolds need to possess enhanced mechanical properties. In this line, genipin (GP) crosslinking has demonstrated to improve biomechanical properties with good biological properties compared to other crosslinkers...
March 20, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38517315/research-advancements-on-nerve-guide-conduits-for-nerve-injury-repair
#10
REVIEW
Shoushuai Wang, Xinggui Wen, Zheyuan Fan, Xiangdong Ding, Qianqian Wang, Zhongling Liu, Wei Yu
Peripheral nerve injury (PNI) is one of the most serious causes of disability and loss of work capacity of younger individuals. Although PNS has a certain degree of regeneration, there are still challenges like disordered growth, neuroma formation, and incomplete regeneration. Regarding the management of PNI, conventional methods such as surgery, pharmacotherapy, and rehabilitative therapy. Treatment strategies vary depending on the severity of the injury. While for the long nerve defect, autologous nerve grafting is commonly recognized as the preferred surgical approach...
March 25, 2024: Reviews in the Neurosciences
https://read.qxmd.com/read/38512321/adjunctive-effect-of-photobiomodulation-therapy-with-nd-yag-laser-in-the-treatment-of-inferior-alveolar-nerve-paresthesia
#11
JOURNAL ARTICLE
Javad Yazdani, Hosein Eslami, MohamadAli Ghavimi, Meghdad Eslami
Background : Disruption of peripheral branches of the trigeminal nerve in the field of maxillofacial surgery is a known risk due to the close connection of these branches with the bony structures of the maxilla and mandible. As a result, injuries of the lingual nerve and inferior alveolar nerve take place within routine maxillofacial surgery procedures, including local anesthetic injection, wisdom tooth surgery, and dental implant placement, resulting in paresthesia and dysesthesia. During the last three decades, low-level lasers (LLL) have been frequently used in various medical fields...
March 2024: Photobiomodulation, photomedicine, and laser surgery
https://read.qxmd.com/read/38511527/objective-evidence-that-nerve-decompression-surgery-reduces-neuropathic-dfu-recurrence-risk-to-less-than-5
#12
JOURNAL ARTICLE
Scott Nickerson, Dwayne S Yamasaki
SCOPE AND SIGNIFICANCE Care for the diabetic foot ulcer (DFU) continues to be a frustrating challenge. Standard of care (SOC) methods are plagued by regrettable levels of delayed healing, failures to heal, recurrence risk, and association with amputations and early mortality.1 We hope to bring attention to the clinical reports observing that diabetes is frequently accompanied by nerve trunk enlargement. Local sites of compression can then occur that cause neural dysfunction and pain, but respond to surgical nerve decompression (ND) and recover a degree of normal function...
March 21, 2024: Advances in Wound Care
https://read.qxmd.com/read/38510377/the-role-of-micrornas-in-axon-regeneration-after-peripheral-nerve-injury-a-bibliometric-analysis
#13
Kutiluke Shoukeer, Shalayiding Aierxiding, Aikebaierjiang Aisaiti, Abuduwupuer Haibier, Chunhua Liu, Zhiwei Jia, Abudunaibi Aili, Li Shu, Kan Jiang, Aikeremujiang Muheremu
OBJECTIVE: This study analyzed the current research hotspots and future development trends of the therapeutic effects of microRNA on PNI axonal regeneration through bibliometric methods. Moreover, the current advantages and disadvantages of this field as well as future development prospects are discussed in depth. METHODS: CiteSpace V and VOSviewer were used as bibliometric tools to complete the analysis of the research focus and direction of the published articles...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38509741/electroacupuncture-suppresses-neuronal-ferroptosis-to-relieve-chronic-neuropathic-pain
#14
JOURNAL ARTICLE
Chunchun Xue, Wenyun Kui, Aiping Huang, Yanan Li, Lingxing Li, Zhen Gu, Lei Xie, Shuyi Kong, Jun Yu, Hongfeng Ruan, Kaiqiang Wang
Growing evidence supports the analgesic efficacy of electroacupuncture (EA) in managing chronic neuropathic pain (NP) in both patients and NP models induced by peripheral nerve injury. However, the underlying mechanisms remain incompletely understood. Ferroptosis, a novel form of programmed cell death, has been found to be activated during NP development, while EA has shown potential in promoting neurological recovery following acute cerebral injury by targeting ferroptosis. In this study, to investigate the detailed mechanism underlying EA intervention on NP, male Sprague-Dawley rats with chronic constriction injury (CCI)-induced NP model received EA treatment at acupoints ST36 and GV20 for 14 days...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38509493/analysis-of-the-incidence-and-risk-factors-of-blood-transfusion-in-total-knee-revision-a-retrospective-nationwide-inpatient-sample-database-study
#15
JOURNAL ARTICLE
Xiaoyin Li, Hao Xie, Shuxia Liu, Jian Wang, Zhanjun Shi, Qiaobing Yao, Qinfeng Yang, Qiuhong Li, Liangxiao Bao
OBJECTIVE: This study sought to determine the incidence and risk factors of blood transfusion among patients undergoing total knee revision (TKR) using a nationwide database. METHODS: A retrospective data analysis was conducted based on the Nationwide Inpatient Sample (NIS), enrolling patients who underwent TKR from 2010 to 2019 with complete information. The patients were divided into two groups based on whether they received blood transfusion or not. The demographic characteristics (race, sex, and age), length of stay (LOS), total charge of hospitalization, hospital characteristics (admission type, insurance type, bed size, teaching status, location, and region of hospital), hospital mortality, comorbidities, and perioperative complications were analyzed...
March 20, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38508208/-commentary-on-the-article-of-s-deininger-et-al-functional-outcome-of-peripheral-nerve-injury-after-pediatric-supracondylar-humerus-fracture-comparison-of-surgical-and-conservative-treatment
#16
JOURNAL ARTICLE
Wiebke Hülsemann
No abstract text is available yet for this article.
February 2024: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://read.qxmd.com/read/38508207/-functional-outcome-of-peripheral-nerve-injury-after-pediatric-supracondylar-humerus-fracture-comparison-of-surgical-and-conservative-treatment
#17
JOURNAL ARTICLE
Stefanie Deininger, Gregor Antoniadis, Maria Teresa Pedro
Supracondylar humerus fractures are the most common elbow fractures in children up to 10 years of age. The incidence of associated nerve injuries varies up to 15% depending on the data. Traumatic and iatrogenic lesions mainly affect the ulnar nerve. The regeneration of peripheral nerves is comparatively better in childhood. In the present study, the functional results after surgical and conservative treatment of nerve injuries in children after supracondylar fractures were compared and analyzed for influencing factors...
February 2024: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://read.qxmd.com/read/38507417/post-treatment-with-maropitant-reduces-oxidative-stress-endoplasmic-reticulum-stress-and-neuroinflammation-on-peripheral-nerve-injury-in-rats
#18
JOURNAL ARTICLE
Raquel Vieira Niella, Janaína Maria Xavier Corrêa, João Felipe Ribeiro Dos Santos, Larissa Ferreira Lima, Claire Souza da Costa Marques, Luciano Cardoso Santos, Larissa Rodrigues Santana, Álvaro José Chávez Silva, Keilane Silva Farias, Carlos Priminho Pirovani, Juneo Freitas Silva, Mário Sérgio Lima de Lavor
OBJECTIVE: To determine the effective dose and therapeutic potential of maropitant using through expression of mediators of oxidative stress, inflammatory and of the unfolded protein response (UPR) (bio) markers on spinal cord using a model of neuropathic pain induced through chronic constriction injury (CCI) in rats. STUDY DESIGN: Randomized, blinded, prospective experimental study. ANIMALS: 98 male Wistar rats. METHODS: Rats were anesthetized with sevoflurane and after CCI, they were randomly assigned to the following groups that received: vehicle, 3, 6, 15, 30 e 50 mg/kg/24q of maropitant...
2024: PloS One
https://read.qxmd.com/read/38506688/comparison-of-radiofrequency-ablation-and-craniotomy-microvascular-decompression-for-treatment-of-hemifacial-spasm
#19
JOURNAL ARTICLE
Huidan Lin, Shun Zhang, Xiang Gao, Lei Wu, Gang Cao, Lina Xuan, Yuyue Xun, Yongqing Liu, Changshun Huang, Bing Huang
BACKGROUND: Hemifacial spasm (HFS) is distinguished by sudden and involuntary spasms of the facial muscles, predominantly on one side of the face. Microvascular decompression (MVD) is an efficacious surgical technique for treating HFS; however, MVD may occasionally lead to noteworthy postoperative complications. Previously, we reported the successful utilization of an innovative awake computed tomography-guided percutaneous puncture of the stylomastoid foramen for administering radiofrequency ablation (RFA) therapy in the treatment of HFS...
March 2024: Pain Physician
https://read.qxmd.com/read/38506390/anesthetic-approach-to-trauma-patients-in-the-city-hospital-after-the-2023-mara%C3%A5-earthquake
#20
JOURNAL ARTICLE
Aylin Kılınçarslan, Ceyda Özhan Caparlar, Müge Çakırca, Fatma Özkan Sipahioğlu, Funda Atar, Selma Ölmez, Nur Yılmaz, Merve Karaşahin, Derya Özkan
BACKGROUND: The February 6, 2023, Kahramanmaraş earthquake caused significant destruction across our country. More than 50,000 people lost their lives, thousands were injured, and health facilities were damaged. Victims were transferred to hospitals in other provinces for treatment. This study evaluates the anesthesia approach applied to the injured who were transferred to our tertiary hospital. METHODS: We retrospectively reviewed the data of patients who underwent surgery between February 6 and February 20, 2023...
March 2024: Turkish Journal of Trauma & Emergency Surgery: TJTES
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