Chao Zheng, Lixiang Yu, Linfeng Zhao, Maolin Guo, Man Feng, Hui Li, Xingchen Zhou, Yeye Fan, Liyuan Liu, Zhongbing Ma, Yining Jia, Ming Li, Ishan Barman, Zhigang Yu
The development of tools that can provide a holistic picture of the evolution of the tumor microenvironment in response to intermittent fasting on the prevention of breast cancer is highly desirable. Here, we show, for the first time, the use of label-free Raman spectroscopy to reveal biomolecular alterations induced by intermittent fasting in the tumor microenvironment of breast cancer using a dimethyl-benzanthracene induced rat model. To quantify biomolecular alterations in the tumor microenvironment, chemometric analysis of Raman spectra obtained from untreated and treated tumors was performed using multivariate curve resolution-alternative least squares and support vector machines...
May 1, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy