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JOURNAL ARTICLE
Marzia Rossi, Andrea Vecchi, Camilla Tiezzi, Valeria Barili, Paola Fisicaro, Amalia Penna, Ilaria Montali, Stephane Daffis, Simon P Fletcher, Anuj Gaggar, Jonathan Medley, Michael Graupe, Latesh Lad, Alessandro Loglio, Roberta Soffredini, Marta Borghi, Teresa Pollicino, Cristina Musolino, Arianna Alfieri, Federica Brillo, Diletta Laccabue, Marco Massari, Chiara Boarini, Gianluca Abbati, Giuseppe Pedrazzi, Gabriele Missale, Pietro Lampertico, Carlo Ferrari, Carolina Boni
OBJECTIVE: Exhausted hepatitis B virus (HBV)-specific CD8 T cells in chronic HBV infection are broadly heterogeneous. Characterisation of their functional impairment may allow to distinguish patients with different capacity to control infection and reconstitute antiviral function. DESIGN: HBV dextramer+CD8 T cells were analysed ex vivo for coexpression of checkpoint/differentiation markers, transcription factors and cytokines in 35 patients with HLA-A2+chronic hepatitis B (CHB) and in 29 control HBsAg negative CHB patients who seroconverted after NUC treatment or spontaneously...
January 30, 2023: Gut
#42
JOURNAL ARTICLE
Sara Monteiro Moraes, Teresa Cristina Abreu Ferrari, Alline Beleigoli
BACKGROUND: Global Trigger Tool (GTT) of the Institute for Healthcare Improvement (IHI) has been used as a measurement strategy for patient safety by several institutions and national programs. Although the greater ability of the GTT to identify adverse events (AEs) compared to other methods has already been demonstrated, there are few data on its accuracy and studies suggest lower sensitivity for minor AEs. This study aimed to assess the accuracy of the GTT for identifying AEs in adult inpatients for all AEs and for the subgroup of AEs with greater harm to the patient, classified as F-I on the IHI-GTT adapted version of the National Coordinating Council for Medication Error Reporting and Prevention (NCC MERP) Index for Categorizing Errors...
January 27, 2023: International Journal for Quality in Health Care
#43
JOURNAL ARTICLE
Cd34 Immunostaining Adds Specificity To Microvascular invasion Analysis in Hepatocellular Carcinoma.
Henrique Gama, Ronniel Albuquerque, David Campos Wanderley, Marcelo Antônio Pascoal Xavier, Fernanda Maria Farage Osório, Cláudia Alves Couto, Teresa Cristina de Abreu Ferrari, Agnaldo S Lima, Paulo Henrique Costa Diniz, Paula Vieira Teixeira Vidigal
INTRODUCTION: Hepatocellular carcinoma is the most common primary neoplasia of the liver. Microvascular invasion predicts outcome and defines tumor staging. However, its diagnosis is still a challenge. The present study aims to evaluate inter and intraobserver agreement in identifying the presence of microvascular invasion using conventional and immunohistochemistry histology. METHODS: Three pathologists performed the analysis of 76 hepatocellular carcinoma explants to characterize the presence of microvascular invasion using the hematoxylin/eosin stain and immunohistochemistry for CD34...
2023: Journal of Hepatocellular Carcinoma
#44
JOURNAL ARTICLE
Oronzo Catalano, Giulia Bendotti, Teresa L Aloi, Alberto Ferrari Bardile, Mirella Memmi, Patrick Gambelli, Daniela Zanaboni, Alessandra Gualco, Emanuela Cattaneo, Antonio Mazza, Mauro Frascaroli, Esmeralda Eshja, Riccardo Bellazzi, Paolo Poggi, Giovanni Forni, Maria Teresa La Rovere
Background Atherosclerosis vulnerability regression has been evidenced mostly in randomized clinical trials with intensive lipid-lowering therapy. We aimed to demonstrate vulnerability regression in real life, with a comprehensive quantitative method, in patients with asymptomatic mild to moderate carotid atherosclerosis on a secondary prevention program. Methods and Results We conducted a single-center prospective observational study (MAGNETIC [Magnetic Resonance Imaging as a Gold Standard for Noninvasive Evaluation of Atherosclerotic Involvement of Carotid Arteries]): 260 patients enrolled at a cardiac rehabilitation center were followed for 3 years with serial magnetic resonance imaging...
January 11, 2023: Journal of the American Heart Association
#45
JOURNAL ARTICLE
Mattia Cominacini, Silvia Suardi, Giulia Ferrari, Roberto Ciresa, Federica Tosi, Sergio De Marchi, Maria Teresa Valenti, Luca Dalle Carbonare
BACKGROUND: The emerging use of direct oral anticoagulants (DOAC) in the management of cancer-associated venous thromboembolism (CAT) is significantly improving therapeutic adherence and quality of life. Despite this, many conditions can restrict the therapeutic index of these drugs. For all these reasons the latest guidelines recommend the use of heparins in the treatment of CAT as the preferred treatment in some clinical settings. OBJECTIVES: We evaluated the efficacy and the safety of DOAC, in terms of recurrent venous thromboembolism (VTE) and major bleeding (MB), as a composite primary outcome...
December 28, 2022: Journal of Cancer Research and Clinical Oncology
#46
JOURNAL ARTICLE
Marta Colaneri, Teresa Chiara Pieri, Silvia Roda, Alessandra Ricciardi, Manuel Gotti, Jacqueline Ferrari, Luca Arcaini, Sara Rattotti, Antonio Piralla, Federica Giardina, Guglielmo Ferrari, Paolo Sacchi, Valentina Zuccaro, Fausto Baldanti, Raffaele Bruno
Early therapies to prevent severe COVID-19 have an unclear impact on patients with hematological malignancies. The aim of this study was to assess their efficacy in this group of high-risk patients with COVID-19 in preventing hospitalizations and reducing the SARS-CoV-2 shedding. This was a single-center, retrospective, observational study conducted in the Fondazione IRCSS Policlinico San Matteo of Pavia, Northern Italy. We extracted the data of patients with hematologic malignancies and COVID-19 who received and did not receive early COVID-19 treatment between 23 December 2021, and May 2022...
December 15, 2022: Journal of Clinical Medicine
#47
JOURNAL ARTICLE
Chiara Zecca, Rosanna Tortelli, Paola Carrera, Maria Teresa Dell'Abate, Giancarlo Logroscino, Maurizio Ferrari
The term frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative disorders characterized mainly by atrophy of the frontal and anterior temporal lobes. Based on clinical presentation, three main clinical syndromes have traditionally been described: behavioral variant frontotemporal dementia (bvFTD), non-fluent/agrammatic primary progressive aphasia (nfPPA), and semantic variant PPA (svPPA). However, over the last 20 years, it has been recognized that cognitive phenotypes often overlap with motor phenotypes, either motor neuron diseases or parkinsonian signs and/or syndromes like progressive supranuclear palsy (PSP) and cortico-basal syndrome (CBS)...
December 12, 2022: Critical Reviews in Clinical Laboratory Sciences
#48
JOURNAL ARTICLE
Christina Erbe, Teresa Temming, Daniela Ohlendorf, Irene Schmidtmann, Ambili Mundethu, Priscila Ferrari-Peron, Heinrich Wehrbein
To compare four plaque indices used in orthodontics. An objective, quantitative plaque index and three subjective conventional plaque indices were analyzed. The study included n = 50 photographs of n = 50 subjects with a multibracket appliance (MB) in the maxilla and mandible. Photographs were taken using Digital Plaque Imaging Analysis (DPIA) and the Percentage Plaque Index (PPI) was calculated. The conventional plaque indices, a modified version of the Turesky-modification of the Quigley & Hein Index (TQH index), Attin index, and modified bonded bracket index (mBB index) were collected from n = 14 evaluators using the DPIA photographs...
December 5, 2022: Scientific Reports
#49
RANDOMIZED CONTROLLED TRIAL
Samantha Sperduti, Elia Paradiso, Claudia Anzivino, Clara Lazzaretti, Silvia Limoncella, Sara D'Alessandro, Neena Roy, Francesca Reggianini, Tommaso Ferrari, Beatrice Melli, Giovanni Battista La Sala, Alessia Nicoli, Jessica Daolio, Maria Teresa Villani, Simonetta Tagliavini, Tommaso Trenti, Francesco Potì, Reinhild Sandhowe, Chiara Centonze, Monica Lispi, Manuela Simoni, Livio Casarini
STUDY QUESTION: Does LH addition to FSH in vitro recover the human primary granulosa lutein cell (hGLC) sub/poor-response? SUMMARY ANSWER: A picomolar concentration of LH may recover the FSH-induced cAMP and progesterone production of hGLC from sub/poor-responder women. WHAT IS KNOWN ALREADY: Clinical studies suggested that FSH and LH co-treatment may be beneficial for the ovarian response of sub/poor-responders undergoing ovarian stimulation during ART...
January 5, 2023: Human Reproduction
#50
MULTICENTER STUDY
João Pedro Marto, Davide Strambo, George Ntaios, Thanh N Nguyen, Roman Herzig, Anna Czlonkowska, Jelle Demeestere, Ossama Yassin Mansour, Alexander Salerno, Susanne Wegener, Philipp Baumgartner, Carlo W Cereda, Giovanni Bianco, Morin Beyeler, Marcel Arnold, Emmanuel Carrera, Paolo Machi, Valerian Altersberger, Leo Bonati, Henrik Gensicke, Manuel Bolognese, Nils Peters, Stephan Wetzel, Marta Magriço, João Nuno Ramos, João Sargento-Freitas, Rita Machado, Carolina Maia, Egídio Machado, Ana Paiva Nunes, Patricia Ferreira, Teresa Pinho E Melo, Mariana Carvalho Dias, André Paula, Manuel Alberto Correia, Pedro Castro, Elsa Azevedo, Luís Albuquerque, José Nuno Alves, Joana Ferreira-Pinto, Torcato Meira, Liliana Pereira, Miguel Rodrigues, Andre Pinho Araujo, Marta Rodrigues, Mariana Rocha, Ângelo Pereira-Fonseca, Luís Ribeiro, Ricardo Varela, Sofia Malheiro, Manuel Cappellari, Cecilia Zivelonghi, Giulia Sajeva, Andrea Zini, Mauro Gentile, Stefano Forlivesi, Ludovica Migliaccio, Maria Sessa, Sara La Gioia, Alessandro Pezzini, Davide Sangalli, Marialuisa Zedde, Rosario Pascarella, Carlo Ferrarese, Simone Beretta, Susanna Diamanti, Ghil Schwarz, Giovanni Frisullo, Simona Marcheselli, Pierre Seners, Candice Sabben, Simon Escalard, Michel Piotin, Benjamin Maïer, Guillaume Charbonnier, Fabrice Vuillier, Loïc Legris, Pauline Cuisenier, Francesca R Vodret, Gaultier Marnat, Jean-Sebastien Liegey, Igor Sibon, Fabian Flottmann, Gabriel Broocks, Nils-Ole Gloyer, Ferdinand O Bohmann, Jan Hendrik Schaefer, Christian Nolte, Heinrich J Audebert, Eberhard Siebert, Marek Sykora, Wilfried Lang, Julia Ferrari, Lukas Mayer-Suess, Michael Knoflach, Elke Ruth Gizewski, Jeffrey Stolp, Lotte J Stolze, Jonathan M Coutinho, Paul Nederkoorn, Ido van den Wijngaard, Joke De Meris, Robin Lemmens, Sylvie De Raedt, Fenne Vandervorst, Matthieu Pierre Rutgers, Antoine Guilmot, Anne Dusart, Flavio Bellante, Patricia Calleja-Castaño, Fernando Ostos, Guillermo González-Ortega, Paloma Martín-Jiménez, Sebastian García-Madrona, Antonio Cruz-Culebras, Rocio Vera, Maria Consuelo Matute, Blanca Fuentes, María Alonso-de-Leciñana, Ricardo Rigual, Exuperio Díez-Tejedor, Soledad Perez-Sanchez, Joan Montaner, Fernando Díaz-Otero, Natalia Pérez-de-la-Ossa, Belén Flores-Pina, Lucia Muñoz-Narbona, Angel Chamorro, Alejandro Rodríguez-Vázquez, Arturo Renú, Oscar Ayo-Martin, Francisco Hernández-Fernández, Tomas Segura, Herbert Tejada-Meza, Daniel Sagarra-Mur, Marta Serrano-Ponz, Thant Hlaing, Isaiah See, Robert Simister, David Werring, Espen Saxhaug Kristoffersen, Annika Nordanstig, Katarina Jood, Alexandros Rentzos, Libor Šimůnek, Dagmar Krajíčková, Antonín Krajina, Robert Mikulik, Martina Cviková, Jan Vinklárek, David Školoudík, Martin Roubec, Eva Hurtikova, Rostislav Hrubý, Svatopluk Ostry, Ondrej Skoda, Marek Pernicka, Lubomir Jurak, Zuzana Eichlová, Martin Jíra, Martin Kovar, Michal Panský, Pavel Mencl, Hana Palouskova, Aleš Tomek, Petr Janský, Anna Olšerová, Martin Sramek, Roman Havlicek, Petr Malý, Lukáš Trakal, Jan Fiksa, Matěj Slovák, Michal Adam Karlinski, Maciej Nowak, Halina Sienkiewicz-Jarosz, Anna Bochynska, Pawel Wrona, Tomasz Homa, Katarzyna Sawczynska, Agnieszka Slowik, Ewa Wlodarczyk, Marcin Wiacek, Izabella Tomaszewska-Lampart, Bartosz Sieczkowski, Halina Bartosik-Psujek, Marta Bilik, Anna Bandzarewicz, Malgorzata Dorobek, Justyna Zielinska-Turek, Marta Nowakowska-Kotas, Krystian Obara, Paweł Urbanowski, Slawomir Budrewicz, Maciej Guziński, Milena Świtońska, Iwona Rutkowska, Paulina Sobieszak-Skura, Beata M Labuz-Roszak, Aleksander Debiec, Jacek Staszewski, Adam Stępień, Jacek Zwiernik, Grzegorz Wasilewski, Cristina Tiu, Elena Oana Terecoasă, Razvan Alexandru Radu, Anca Negrila, Bogdan Dorobat, Cristina Panea, Vlad Tiu, Simona Petrescu, Atilla Ozdemir, Mostafa Mahmoud, Hussam El-Samahy, Hazem Abdelkhalek, Jasem Al-Hashel, Ismail Ibrahim Ismail, Athari Salmeen, Abdoreza Ghoreishi, Sergiu Ionut Sabetay, Hana Gross, Piers Klein, Mohamad Abdalkader, Pascal Jabbour, Kareem El Naamani, Stavropoula Tjoumakaris, Rawad Abbas, Ghada A Mohamed, Alex Chebl, Jiangyong Min, Majesta Hovingh, Jenney P Tsai, Muhib Khan, Krishna Nalleballe, Sanjeeva Onteddu, Hesham Masoud, Mina Michael, Navreet Kaur, Laith Maali, Michael G Abraham, Priyank Khandelwal, Ivo Bach, Melody Ong, Denis Babici, Ayaz M Khawaja, Maryam Hakemi, Kumar Rajamani, Vanessa Cano-Nigenda, Antonio Arauz, Pablo Amaya, Natalia Llanos, Akemi Arango, Miguel Ángel Vences, Jose Dominguo Barrientos Guerra, Rayllene Caetano, Rodrigo Targa Martins, Sergio Daniel Scollo, Patrick Matic Yalung, Shashank Nagendra, Abhijit Gaikwad, Kwon-Duk Seo, Georgios Georgiopoulos, Raul G Nogueira, Patrik Michel
BACKGROUND AND OBJECTIVES: COVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19. METHODS: This was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection...
February 14, 2023: Neurology
#51
Flavio Andresciani, Daniele Vertulli, Giuseppina Pacella, Carlo Altomare, Caterina Bernetti, Maria Teresa Bitonti, Andrea Buoso, Ugo Ferrari, Bruno Beomonte Zobel, Rosario Francesco Grasso
We present the case of a 50-year-old woman affected by a rectal gastrointestinal stromal tumor (GIST), with a recurrence in pre-sacral and pre-coccygeal space after surgery and Imatinib therapy. GISTs are the most common mesenchymal tumors of the gastrointestinal tract and rectal GISTs are rare (only 2% of cases); magnetic resonance and computed tomography are the main imaging techniques for diagnosis and follow-up, while ultrasound and contrast-enhanced ultrasound may be useful to perform a percutaneous biopsy, as in the case presented: the imaging features of the lesion in all these imaging methods are displayed...
January 2023: Radiology Case Reports
#52
JOURNAL ARTICLE
Alessandra Macciotta, Alberto Catalano, Maria Teresa Giraudo, Elisabete Weiderpass, Pietro Ferrari, Heinz Freisling, Sandra M Colorado-Yohar, Carmen Santiuste, Pilar Amiano, Alicia K Heath, Heather A Ward, Sofia Christakoudi, Paolo Vineis, Deependra Singh, Salvatore Vaccarella, Matthias B Schulze, Anouk E Hiensch, Evelyn M Monninkhof, Verena Katzke, Rudolf Kaaks, Rosario Tumino, Fulvio Lazzarato, Lorenzo Milani, Antonio Agudo, Christina C Dahm, Laura Baglietto, Vittorio Perduca, Gianluca Severi, Sara Grioni, Salvatore Panico, Eva Ardanaz, Kristin Benjaminsen Borch, Faith O Benebo, Tonje Braaten, Maria-Jose Sánchez, Claudia Giachino, Carlotta Sacerdote, Fulvio Ricceri
BACKGROUND: Many studies have shown that socioeconomic position (SEP) is associated with the incidence of malignant tumors at different sites. This study aims to estimate the association between educational level (as proxy for SEP) and cancer incidence and to understand if the observed associations might be partially explained by lifestyle behaviors. METHODS: The analyses were performed on data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, globally and by sex...
October 28, 2022: Cancer Epidemiology, Biomarkers & Prevention
#53
JOURNAL ARTICLE
Danilo Buonsenso, Davide Pata, Barbara Fiori, Maurizio Sanguinetti, Anna Acampora, Vittoria Ferrari, Rossana Albano, Teresa Spanu, Piero Valentini
BACKGROUND AND AIM: Antibiotic resistance represents one of the major public health issues, due to the potential future ineffectiveness of available antibiotics. However, epidemiological studies on E. coli antibiotic resistance patterns in the pediatric population are limited. METHODS: We conducted a retrospective analysis on children younger than 18 years of age admitted to the Department of Pediatrics from April 2016 to April 2018 with E. coli isolation on biological materials...
October 26, 2022: Acta Bio-medica: Atenei Parmensis
#54
JOURNAL ARTICLE
Giovanni de Girolamo, Clarissa Ferrari, Valentina Candini, Chiara Buizza, Gemma Calamandrei, Marta Caserotti, Teresa Gavaruzzi, Paolo Girardi, Katrine Bach Habersaat, Lorella Lotto, Martha Scherzer, Fabrizio Starace, Alessandra Tasso, Manuel Zamparini, Cristina Zarbo
COVID-19 pandemic had a negative impact on the mental health and well-being (WB) of citizens. This cross-sectional study included 4 waves of data collection aimed at identifying profiles of individuals with different levels of WB. The study included a representative stratified sample of 10,013 respondents in Italy. The WHO 5-item well-being scale (WHO-5) was used for the assessment of WB. Different supervised machine learning approaches (multinomial logistic regression, partial least-square discriminant analysis-PLS-DA-, classification tree-CT-) were applied to identify individual characteristics with different WB scores, first in waves 1-2 and, subsequently, in waves 3 and 4...
October 26, 2022: Scientific Reports
#55
JOURNAL ARTICLE
Fiorenza Ferrari, Miriam Manera, Gianluca Villa, Annalisa De Silvestri, Nicholas Simone Manuel Bianchi Bosisio, Angelo Guglielmi, Giovanni Mazza, Costanza Colombo, Luigi D'Auria, Rampino Teresa, Mirko Belliato
Patients receiving extracorporeal membrane oxygenation (ECMO) often suffer from acute kidney injury (AKI), requiring continuous renal replacement therapy (CRRT). In our clinical practice, we connected the inlet line of a CRRT machine to the postoxygenator Luer port and the outlet line to the inlet Luer port of the oxygenator. In this case series, we analyzed the interaction between the two machines. Between December 31, 2017, and December 31, 2019, we enrolled 15 patients from the ICU of the San Matteo Hospital, Pavia, Italy...
October 14, 2022: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#56
JOURNAL ARTICLE
Lilian Martins Oliveira Diniz, Jesiana Ferreira Pedrosa, Pedro Pires Pimenta, Luynne Lana Monteiro, Rafael Arantes Oliveira, André Vinícius Soares Barbosa, Joziele de Souza Lima, Bruna Campos Cardoso Vilela, Livya Isabella Teles de Oliveira Lima, Ana Laura Moreira Teixeira, Teresa Cristina de Abreu Ferrari
No abstract text is available yet for this article.
October 1, 2022: Pediatric Infectious Disease Journal
#57
JOURNAL ARTICLE
Alessandra Coutinho de Faria, Bernardo Henrique Mendes Correa, Luciana Costa Faria, Paula Vieira Teixeira Vidigal, Marcelo Antônio Pascoal Xavier, Teresa Cristina Abreu Ferrari
BACKGROUND: Occult hepatitis B virus infection (OBI) is defined as the presence of hepatitis B virus (HBV) deoxyribonucleic acid (DNA) in the liver of individuals with undetectable hepatitis B virus surface antigen (HBsAg) in the serum. The actual prevalence of OBI and its clinical relevance are not yet fully understood. OBJECTIVE: To evaluate the prevalence of HBV DNA in liver biopsies of HBsAg-negative patients with chronic liver disease of different etiologies in a referral center in Brazil and compare two different HBV DNA amplification protocols to detect HBV...
September 23, 2022: São Paulo Medical Journal
#58
REVIEW
Laura Bonvicini, Ilaria Pingani, Francesco Venturelli, Nicoletta Patrignani, Maria Chiara Bassi, Serena Broccoli, Francesca Ferrari, Teresa Gallelli, Costantino Panza, Massimo Vicentini, Paolo Giorgi Rossi
Childhood obesity is a high prevalence condition that causes a high burden of disease in adulthood. Mobile phone app are increasingly used to prevent it. We summarized the evidence on the effectiveness of mobile apps for devices used by parents to prevent and treat childhood and adolescent obesity. An update of a systematic review of the literature (De Lepeleere et al., 2017) was carried out. PubMed, Embase, Cochrane, CINAHL, PsycINFO, Scopus, and ERIC were searched up to 2020. The included studies should target children 1-18 years, compare an app aimed at preventing or treating overweight and obesity, as stand-alone intervention or as part of a complex program, installed on parents' mobile devices, to no intervention or an intervention without the app...
October 2022: Preventive Medicine Reports
#59
JOURNAL ARTICLE
Majdi Imterat, Nicolò Bizzarri, Robert Fruscio, Anna Myriam Perrone, Alexander Traut, Andreas du Bois, Andrea Rosati, Debora Ferrari, Pierandrea De Iaco, Beyhan Ataseven, Raffaella Ergasti, Silvia Volontè, Marco Tesei, Florian Heitz, Maria Teresa Perri, Nicole Concin, Francesco Fanfani, Giovanni Scambia, Anna Fagotti, Philipp Harter
OBJECTIVE: This international study aimed to investigate the impact of substage, histological type and other prognostic factors on long-term survival for stage I ovarian carcinoma. METHODS: Our study was a retrospective multicenter cohort study that included patients with the International Federation of Gynecology and Obstetrics (FIGO) stage I (IA-IC3) ovarian carcinoma treated at four European referral centers in Germany and Italy. Using Kaplan-Meier survival curves we compared overall and disease-free survival between the different stage I groups...
September 14, 2022: International Journal of Gynecological Cancer
#60
JOURNAL ARTICLE
Riccardo Marconcini, Paolo Fava, Amedeo Nuzzo, Simona Manacorda, Marco Ferrari, Francesco De Rosa, Michele De Tursi, Enrica Teresa Tanda, Francesca Consoli, Alessandro Minisini, Nicola Pimpinelli, Francesca Morgese, Melissa Bersanelli, Marco Tucci, Maristella Saponara, Alessandro Parisi, Marcella Ocelli, Serena Bazzurri, Giulia Massaro, Riccardo Morganti, Isabella Ciardetti, Ignazio Stanganelli
Background: BRAF and MEK inhibitors target therapies (TT) and AntiPD1 immunotherapies (IT) are available first-line treatments for BRAF v600 mutant metastatic melanoma patients. ECOG PS (E), baseline LDH (L), and baseline number of metastatic sites (N) are well-known clinical prognostic markers that identify different prognostic categories of patients. Direct comparison between first-line TT and IT in different prognostic categories could help in first line treatment decision. Methods: This is a retrospective analysis conducted in 14 Italian centers on about 454 metastatic melanoma patients, divided in 3 groups: group A-patients with E = 0, L within normal range, and N less than 3; group B-patients not included in group A or C; group C-patients with E > 0, L over the normal range, and N more than 3...
2022: Frontiers in Oncology
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