Ali A Rabaan, Maha Fahad Alenazy, Ahmad A Alshehri, Mohammed Abdulrahman Alshahrani, Maha F Al-Subaie, Hayam A Alrasheed, Nawal A Al Kaabi, Nanamika Thakur, Nabiha A Bouafia, Mohammed Alissa, Abdulrahman M Alsulaiman, Abeer M AlBaadani, Hatem M Alhani, Ali H Alhaddad, Wadha A Alfouzan, Batool Mohammed Abu Ali, Khadija H Al-Abdulali, Faryal Khamis, Ali Bayahya, Mona A Al Fares, Manish Sharma, Manish Dhawan
SARS-CoV-2, responsible for COVID-19, shares 79% and 50% of its identity with SARS-CoV-1 and MERS-CoV, respectively. It uses the same main cell attachment and entry receptor as SARS-CoV-1, which is the ACE-2 receptor. However, key residues in the receptor-binding domain of its S-protein seem to give it a stronger affinity for the receptor and a better ability to hide from the host immune system. Like SARS-CoV-1 and MERS-CoV, cytokine storms in critically ill COVID-19 patients cause ARDS, neurological pathology, multiorgan failure, and increased death...
September 9, 2023: Journal of Infection and Public Health