Hyoung June Kim, Hyuk Kim, Eun-Sil Han, Sun-Mi Park, Jae-Young Koh, Kwang-Mi Kim, Min-Soo Noh, Jung-Ju Kim, Chang-Hoon Lee
Sphingosylphosphorylcholine (SPC) is upregulated in the stratum corneum of atopic dermatitis patients by sphingomyelin deacylase. We conducted an investigation, both to confirm that intradermal injection of SPC elicits scratching in mice, and to elucidate the detailed mechanism of the SPC-induced itch-scratch response. Intradermal administration of SPC increased the incidence of scratching behavior in a dose-dependent manner. SPC-induced scratching could be suppressed, significantly, by the mu-opoid receptor antagonist, naltrexon, the vaniloid receptor agonist, capsaicin, and the histamine H1 receptor antagonist ketotifen...
March 31, 2008: European Journal of Pharmacology