Atheer Awad, Christine M Madla, Laura E McCoubrey, Fabiana Ferraro, Francesca K H Gavins, Asma Buanz, Simon Gaisford, Mine Orlu, Florence Siepmann, Juergen Siepmann, Abdul W Basit
Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local diseases, direct access to unique therapeutic targets and the potential for increasing systemic drug bioavailability and efficacy. Although a range of traditional colonic delivery technologies are available, these systems exhibit inconsistent drug release due to physiological variability between and within individuals, which may be further exacerbated by underlying disease states. In recent years, significant translational and commercial advances have been made with the introduction of new technologies that incorporate independent multi-stimuli release mechanisms (pH and/or microbiota-dependent release)...
February 2022: Advanced Drug Delivery Reviews