Kwang Kiat Sim, Katie Connell, Mayank Bhandari, David Paton
Peritoneal melanosis is an uncommon benign condition, the pathophysiology of which is unclear. Macroscopically, it appears as diffuse dark brown or black pigmentation within the peritoneum, mimicking more sinister conditions such as metastatic melanoma. It has been described in a variety of contexts, but only exceedingly rarely in association with metastatic melanoma, with only two previous published case reports. We present a case of peritoneal melanosis associated with metastatic melanoma involving the spleen, previously treated with targeted and immune checkpoint inhibitor therapy...
January 11, 2021: BMJ Case Reports
Stella Baliou, Maria Goulielmaki, Petros Ioannou, Christina Cheimonidi, Ioannis P Trougakos, Markus Nagl, Anthony M Kyriakopoulos, Vassilis Zoumpourlis
BACKGROUND: Taurine (Tau) ameliorates cancer pathogenesis. Researchers have focused on the functional properties of bromamine T (BAT), a stable active bromine molecule. Both N-bromotaurine (TauNHBr) and BAT exert potent anti-inflammatory properties, but the landscape remains obscure concerning the anti-cancer effect of BAT. METHODS: We used Crystal Violet, colony formation, flow cytometry and Western blot experiments to evaluate the effect of BAT and Tau on the apoptosis and autophagy of cancer cells...
January 7, 2021: Cancers
Jianchun Zhu, Yang Li, Jinghui Liang, Jingxin Li, Kai Huang, Jing Li, Chuanyong Liu
Vincristine (VCR) is commonly used to treat a variety of hematological malignancies and solid tumors in pediatric and adult patients. However, peripheral neuropathy is a dose-limiting side effect that leaves some patients with functional disability and long-term pain. Oxytocin (OT) has demonstrated analgesic and anti-inflammatory properties, but there is no evidence regarding its effects on VCR-induced neurotoxicity. Therefore, we evaluated the potential protective effects of OT on VCR-induced neurotoxicity...
January 8, 2021: Toxicology Letters
Yangyang Zeng, Yulan Zeng, Hang Yin, Fengxia Chen, Qingqing Wang, Xiaoyan Yu, Yunfeng Zhou
Melanoma is a life-threatening form of skin cancer with an elevated risk of metastasis and high mortality rates. The prognosis and clinical outcomes of cancer immunotherapy in melanoma patients are influenced by immune cell infiltration in the tumor microenvironment (TME) and the expression of genetic factors. Despite reports suggesting that immune-classification may have a better prediction of prognosis compared to the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) TNM-classification, the definition of Immunoscore in melanoma is becoming a difficult challenge...
January 10, 2021: Aging
Tao Yuan, Ming-Long Cai, Yu-Ming Sheng, Ding Xian, Ting-Ting Shen, Wei-Ran Li, He Huang, Bo Liang, Xue-Jun Zhang, Qi-Xing Zhu
BACKGROUND: Verrucous epidermal nevi (VEN) are benign skin tumors, considered keratinocytic epidermal nevi, that appear at birth or early childhood. VEN may display a range of appearances, depending on patient age. Although the number of studies regarding VEN is increasing, the exact mechanism of VEN is still unknown. OBJECTIVES: The aim of this study was to analyze the changes in the expression of protein factors in lesions of VEN children by TMT labeling-based quantitative proteomics...
January 11, 2021: Journal of the European Academy of Dermatology and Venereology: JEADV
Cassandra M Townsend, Reena Khanna, Aze Suzanne Wilson
BACKGROUND: Limited data suggest that non-melanoma skin cancer (NMSC) risk is higher in patients with inflammatory bowel disease (IBD) particularly in those on a tumor necrosis factor-α antagonist (TNF antagonist). It remains unknown whether TNF antagonist exposure alters the clinical course of NMSC in patients with IBD or if this therapy should be discontinued. AIMS: To assess the impact of TNF antagonist exposure on NMSC severity, recurrence and need for ancillary treatments...
January 11, 2021: Digestive Diseases and Sciences
Mardeen S Karim, Courtney J Ensslin, Margaret L Dowd, Faramarz H Samie
No abstract text is available yet for this article.
January 2021: JAAD Case Reports
C Jinno, N Morimoto, A Mahara, M Sakamoto, S Ogino, T Fujisato, S Suzuki, T Yamaoka
Surgical resection of skin tumors leads to large defects in surrounding normal tissues, which should be reconstructed thereafter using the patient's own tissues taken from the other site. Our challenge is to solve this problem in dermal malignant melanoma (MM) by a novel process, named extracorporeal high pressure therapy (EHPT), in which the tissue containing tumor is resected and pressurized, and the treated tissue is re-transplant back to the same position as a tumor-free autologous dermal substitute. The key points are complete tumor death and preservation of native extra cellular matrix (ECM) by the hydrostatic pressure...
December 2020: Regenerative Therapy
Yoshitaka Wada, Hidetaka Miyazaki, Hirohisa Kusuhara, Kazuhisa Uemura, Shinichi Asamura
Venous malformations (VMs) are compressible, blue-purple tumors that are present at birth, and are treated with either surgery or sclerotherapy, or a combination of both. Patients often experience recurrent hemorrhage, swelling, pain, or difficulty in daily life. Treatment of massive VMs can, therefore, be challenging. We applied intralesional laser photocoagulation (ILP) to a 19-year-old female patient with a huge VM who had shown resistance to sclerotherapy. It spanned from the dorsal area to the lateral chest...
December 2020: Plastic and Reconstructive Surgery. Global Open
Hani Ali Shash, Sawsan Fahad Almarzouq, Abdulrahman Abdulaziz Alghamdi, Jumana Abdulwahab Alratroot
We report a very rare type of tumor in the left nasal ala in an elderly patient. An 81-year-old Saudi woman known to have hypertension, osteoporosis, and rheumatoid disease (who had been compliant to her medications) presented with a 0.5-cm fixed, firm, round well-defined nodule on the left ala of the nose (with crusting, erosion, and telangiectasia of the overlying skin), whose size had been gradually increasing for 2 years. The patient underwent excisional biopsy, and the specimen was sent for a histopathologic analysis...
December 2020: Plastic and Reconstructive Surgery. Global Open
Dua Cebeci, Şirin Yaşar, Pembegül Güneş, Sema Aytekin
Introduction: The Breast cancer is the most common malignancy in middle-aged women and that causes skin metastasis. Skin metastasis in internal cancer cases is a very rare condition and may be difficult to diagnose and have poor prognostic marker. Cutaneous metastasis of breast carcinoma is mostly seen as direct invasion and/or local infiltration. However, in addition to the well-known types, cutaneous metastases may mimic many benign skin lesions and therefore may be difficult to diagnose...
October 2020: Medical Archives
J Valtueña, D Ruiz Sánchez, G Martínez-García, M Garayar-Cantero, L Barrutia-Etxebarría, A Hadi, S Hadi, P Manchado-López, E L Garabito-Solovera
Palisaded encapsulated neuroma is a rare, benign neural tumor. The involvement of the glans penis is rare; few cases have been reported. We present a 52-year-old man with a five-month course of a solitary painless lesion of the glans penis. Full excision of the nodule was performed. Histopathological and immunohistochemical analyses and examination was consistent with a palisaded encapsulated neuroma. We describe one of a few existing cases of this kind of tumor in the glans penis.
December 15, 2020: Dermatology Online Journal
Mansha Sethi, Vaibhav Garg, Jason B Lee, Sherry Yang
The increased use of monoclonal antibodies that target the immune checkpoint T cell receptor programmed death-1 (PD1) to treat numerous solid tumors has led to several reports describing associated cutaneous adverse events. Although lichenoid reactions have been well described, we propose that PD1 inhibitor-induced inverse lichenoid eruption (PILE) is a distinct variant. We describe two patients who presented with nearly identical deeply erythematous, malodorous, eroded anogenital plaques with focal crusting...
December 15, 2020: Dermatology Online Journal
Jacob S Thomas, Anthony B El-Khoueiry, Barry J Maurer, Susan Groshen, Jacek K Pinski, Everardo Cobos, David R Gandara, Heinz J Lenz, Min H Kang, C Patrick Reynolds, Edward M Newman
BACKGROUND: Fenretinide is a synthetic retinoid that can induce cytotoxicity by several mechanisms. Achieving effective systemic exposure with oral formulations has been challenging. An intravenous lipid emulsion fenretinide formulation was developed to overcome this barrier. We conducted a study to establish the maximum tolerated dose (MTD), preliminary efficacy, and pharmacokinetics of intravenous lipid emulsion fenretinide in patients with advanced solid tumors. METHODS: Twenty-three patients with advanced solid tumors refractory to standard treatments received fenretinide as a continuous infusion for five consecutive days in 21-day cycles...
January 10, 2021: Cancer Chemotherapy and Pharmacology
Monika Bilewicz-Stebel, Beata Bergler-Czop, Robert Stebel, Maria Weryńska-Kalemba, Anna Matuszewska
Eosinophilic fasciitis is a rare disease from the group of scleroderma-like connective tissue diseases with unclear etiopathogenesis. It may be occasionally accompanied with other eosinophilic or autoimmune dysfunctions (1,2). Lack of international diagnostic criteria and treatment consensus may lead to diagnostic and therapeutic difficulties. The 61-year-old man with no significant personal or family pathological history was admitted to the Dermatology Department presenting persistent induration for several months as well as erythema and pain of the shins that gradually extended to thighs and forearms, with limited mobility of peripheral joints...
December 2020: Acta Dermatovenerologica Croatica: ADC
Valentina Audrito, Vincenzo Gianluca Messana, Enrico Moiso, Nicoletta Vitale, Francesca Arruga, Lorenzo Brandimarte, Federica Gaudino, Elisa Pellegrino, Tiziana Vaisitti, Chiara Riganti, Roberto Piva, Silvia Deaglio
Serine-threonine protein kinase B-RAF ( BRAF) -mutated metastatic melanoma (MM) is a highly aggressive type of skin cancer. Treatment of MM patients using BRAF/MEK inhibitors (BRAFi/MEKi) eventually leads to drug resistance, limiting any clinical benefit. Herein, we demonstrated that the nicotinamide adenine dinucleotide (NAD)-biosynthetic enzyme nicotinamide phosphoribosyltransferase (NAMPT) is a driving factor in BRAFi resistance development. Using stable and inducible NAMPT over-expression systems, we showed that forced NAMPT expression in MM BRAF -mutated cell lines led to increased energy production, MAPK activation, colony-formation capacity, and enhance tumorigenicity in vivo...
December 20, 2020: Cancers
Yu Sawada, Emi Mashima, Natsuko Saito-Sasaki, Motonobu Nakamura
Cell adhesion ability is one of the components to establish cell organization and shows a great contribution to human body construction consisting of various types of cells mixture to orchestrate tissue specific function. The cell adhesion molecule 1 (CADM1) is a molecule of cell adhesion with multiple functions and has been identified as a tumor suppressor gene. CADM1 has multifunctions on the pathogenesis of malignancies, and other normal cells such as immune cells. However, little is known about the function of CADM1 on cutaneous cells and cutaneous malignancies...
December 20, 2020: International Journal of Molecular Sciences
Stephan N Schön, Nicolas Skalicky, Neha Sharma, Daniel W Zumofen, Florian M Thieringer
AIMS: To develop a novel 3D-printer-assisted method to fabricate patient-specific implants for cranioplasty and to demonstrate its feasibility and it's use in 16 consecutive cases. METHODS: We report on 16 consecutive patients who have undergone cranioplasty surgery for an extensive skull defect after decompressive surgery and in which the bone flap was not available. We present the workflow for the implant production using a 3D-printer-assisted molding technique...
January 5, 2021: World Neurosurgery
Lucia Unger, Carlos Abril, Vinzenz Gerber, Vidhya Jagannathan, Christoph Koch, Eman Hamza
BACKGROUND: MicroRNAs (miRNAs) are potential biomarkers for equine sarcoids (ES). OBJECTIVES: To assess eca-miR-331, eca-miR-100, and eca-miR-1 as serum biomarkers for ES disease. ANIMALS: Sixty-eight ES cases (56 horses, 12 donkeys), 69 tumor-free controls (60 horses, 9 donkeys), and 20 horses with other skin tumors. METHODS: For this case-control study, expression of serum eca-miR-331, eca-miR-100, and eca-miR-1 in ES-affected equids was compared to tumor-free age-, sex-, and breed-matched control horses and donkeys with other skin tumors using reverse transcription quantitative PCR (polymerase chain reaction) for relative miRNA quantification...
January 7, 2021: Journal of Veterinary Internal Medicine
Shah Huzaifa Feroz, Asma Ahmed, Abilash Muralidharan, Pragatheeshwar Thirunavukarasu
Crohn's disease (CD) is a transmural inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal (GI) tract. With the disease's progression, adhesions and transmural fissuring, intra-abdominal abscesses, and fistula tracts may develop. An anal fistula (or fistula-in-ano) is a chronic abnormal epithelial lined tract communicating the anorectal lumen (internal opening) to the perineal or buttock skin (external opening). The risk of fistula development varies from 14%-38%. It can cause significant morbidity, which adversely impacts the quality of life...
December 3, 2020: Curēus
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