Krishnendu Mondal, Rupali Mandal, Indranil Chakrabarti
Context: Eyelids by virtue of its unique histomorphology give rise to multitudes of different pathological conditions. Appropriate preoperative cytological diagnoses of these cases are necessary to determine their optimal therapy. Aims: The aims of this study were to evaluate the utility of various cytological techniques in diagnosing the definite pathology for palpebral lesions and thereby to highlight the drawbacks associated with cytology in this context. Materials and Methods: Fine-needle cytology with or without applying the aspiration was the preferable method...
January 2021: Journal of Microscopy and Ultrastructure
Guilherme Canho Bittner, Felipe Bochnia Cerci, Elisa Mayumi Kubo, Stanislav N Tolkachjov
Mohs micrographic surgery is a specialized form of skin cancer surgery that has the highest cure rates for several cutaneous malignancies. Certain skin cancers can have small extensions or "roots" that may be missed if an excised tumor is serially cross-sectioned in a "bread-loaf" fashion, commonly performed on excision specimens. The method of Mohs micrographic surgery is unique in that the dermatologist (Mohs surgeon) acts as both surgeon and pathologist, from the preoperative considerations until the reconstruction...
March 24, 2021: Anais Brasileiros de Dermatologia
Anna Hwee Sing Heng, Yee-How Say, Yang Yie Sio, Yu Ting Ng, Fook Tim Chew
BACKGROUND: Multiple factors have been attributed to acne vulgaris predisposition and individual variations in the severity of skin symptoms, and genetics stood out as one of the major factors. METHODS: We performed a systematic review on the genes and their variants that have been investigated for association with acne presentation and severity. A random-effect meta-analysis using the allele model (minor allele vs. major allele) was also conducted to provide an overall estimation of risk effects of frequently reported gene variants...
April 13, 2021: BMC Medical Genomics
Bilal Fawaz, Carlos Vieira, Ashley Decker, Naomi Lawrence
BACKGROUND: Verrucous carcinoma is a rare mucocutaneous malignancy characterized by slow, relentless growth and a low metastasis rate. OBJECTIVE: Herein we summarize surgical success rates and review newer approaches to the treatment of verrucous carcinomas. Methods & Materials: PubMed electronic searches were performed by B.F. and C.V. using combinations of the following terms: ''verrucous carcinoma,'' ''Ackerman tumor,'' ''Buschke Lowenstein,'' ''epithelioma cuniculatum,'' ''carcinoma cuniculatum,'' ''papillomatosis cutis,'' ''treatment,'' ''therapeutics,'' ''management,'' ''mohs surgery,'' and ''excision...
April 14, 2021: Journal of Dermatological Treatment
Melodi Javid Whitley, Jutamas Suwanpradid, Chester Lai, Simon Jiang, Jonathan L Cook, Daniel E Zelac, Ross Rudolph, David L Corcoran, Simone Degan, Ivan Spasojevic, Howard Levinson, Detlev Erdmann, Claire Reid, Jennifer Y Zhang, Simon C Robson, Eugene Healy, Wendy L Havran, Amanda S MacLeod
Ultraviolet radiation (UVR) and immunosuppression are major risk factors for cutaneous squamous cell carcinoma (cSCC). Regulatory T cells (Tregs) promote cSCC carcinogenesis and in other solid tumors, infiltrating Tregs and CD8+ T cells express ENTPD1 (also known as CD39), an ecto-enzyme that catalyzes the rate-limiting step in converting extracellular ATP to extracellular adenosine. We previously demonstrated that extracellular purine nucleotides influence DNA Damage Repair (DDR). Here we investigate whether DDR is modulated via purinergic signaling in cSCC...
April 10, 2021: Journal of Investigative Dermatology
Özgür Baysal, Fevzi Sağlam, Ömer Sofulu, Okan Yiğit, Evrim Şirin, Bülent Erol
OBJECTIVE: This study aimed to investigate amputation-related factors after limb-salvage surgery (LSS) in patients with extremity-located bone and soft-tissue sarcomas and determine the relationship between these factors and patient survival. METHODS: In this retrospective study at our institution, patients in whom LSS was first performed because of an extremity-located musculoskeletal sarcoma, and subsequently amputation was carried out for various indications were included...
March 2021: Acta Orthopaedica et Traumatologica Turcica
Richa Tiwari, Nirmalya Ganguli, Hunain Alam, Indrajit Sahu, Chella Krishna Vadivel, Shruti Sinha, Shweta Patel, Sayli Nitin Jamghare, Sanjay Bane, Rahul Thorat, Subeer S Manjumdar, Milind M Vaidya
Keratin 8/18, the predominant keratin pair of simple epithelia, is known to be aberrantly expressed in several squamous cell carcinomas, where its expression is often correlated with increased invasion, neoplastic progression, and poor prognosis. The majority of keratin 8/18 structural and regulatory functions are governed by post-translational modifications, particularly phosphorylation. Apart from filament reorganization, cellular processes including cell cycle, cell growth, cellular stress, and apoptosis are known to be orchestrated by K8 phosphorylation at specific residues in the head and tail domains...
April 13, 2021: Cell Biology International
Rosalaura V Villarreal González, Sandra N González Díaz, Rodrigo A de la Cruz Cruz, Oscar Vidal Gutiérrez, Cindy E de Lira Quezada
BACKGROUND: Taxanes adjuvant therapy is recommended in certain high risk or metastatic tumors, particularly in lung and breast cancer, but also in other types of cancer like ovarian. The incidence of severe adverse drug reactions to paclitaxel is of approximately 10%. OBJECTIVES: Analyze type I hypersensitivity reactions to paclitaxel and their management in the Mexican population. METHOD: It is a retrospective, observational and descriptive study that included type I hypersensitivity reactions to paclitaxel reported from our database...
April 13, 2021: Journal of Oncology Pharmacy Practice
Taro Shinogi, Kotaro Nagase, Takuya Inoue, Keiko Sato, Ayako Onita, Ayako Takamori, Yutaka Narisawa
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine carcinoma of the skin associated with Merkel cell polyomavirus and immunosuppression. Although MCC incidence is rising worldwide, MCC has not been sufficiently investigated in Japan. This study aimed to determine MCC demographics in Japan, including incidence, age, sex, location, spontaneous regression, and pure/combined MCC. Using PubMed and Igaku Chuo Zasshi, 847 MCC cases between 1985 and 2015 were extracted, and the main epidemiological characteristics were described...
April 13, 2021: Journal of Dermatology
Yan-Hong Cui, Seungwon Yang, Jiangbo Wei, Christopher R Shea, Wen Zhong, Fang Wang, Palak Shah, Muhammad G Kibriya, Xiaolong Cui, Habibul Ahsan, Chuan He, Yu-Ying He
Here we show that FTO as an N6 -methyladenosine (m6 A) RNA demethylase is degraded by selective autophagy, which is impaired by low-level arsenic exposure to promote tumorigenesis. We found that in arsenic-associated human skin lesions, FTO is upregulated, while m6 A RNA methylation is downregulated. In keratinocytes, chronic relevant low-level arsenic exposure upregulated FTO, downregulated m6 A RNA methylation, and induced malignant transformation and tumorigenesis. FTO deletion inhibited arsenic-induced tumorigenesis...
April 12, 2021: Nature Communications
David Y Chen, Ian M Ferguson, Krista A Braun, Leslie A Sutton, Nichole M Helton, Sai Mukund Ramakrishnan, Amanda M Smith, Christopher A Miller, Timothy J Ley
DNA hypomethylation is a feature of epidermal cells from aged and sun-exposed skin, but the mechanisms responsible for this methylation loss are not known. Dnmt3a is the dominant de novo DNA methyltransferase in the skin; while epidermal Dnmt3a deficiency creates a premalignant state in which keratinocytes are more easily transformed by topical mutagens, the conditions responsible for this increased susceptibility to transformation are not well understood. Using whole genome bisulfite sequencing, we identified a focal, canonical DNA hypomethylation phenotype in the epidermal cells of Dnmt3a-deficient mice...
April 20, 2021: Proceedings of the National Academy of Sciences of the United States of America
Kai Lu, Madhavi Bhat, Sara Peters, Rita Mitra, Xiaokui Mo, Tatiana M Oberyszyn, Partha S Dasgupta, Sujit Basu
Although the role of dopamine (DA) in malignant tumors has been reported, its function in premalignant lesions is unknown. Herein we report that the stimulation of DA D2 receptors in endothelial cells in ultraviolet B (UVB)-induced cutaneous lesions in mice significantly reduced the tumor number, tumor burden, and malignant squamous cell carcinoma in these animals. DA D2 receptor agonist inhibited vascular-endothelial growth factor-A (VEGF)-dependent proangiogenic genes in vitro and in vivo. However, the mice pretreated with selective DA D2 receptor antagonist inhibited the actions of the agonist, thereby suggesting that the action of DA was through its D2 receptors in the endothelial cells...
April 12, 2021: Cancer Prevention Research
Robert H Hester, Gabriel N Hortobagyi, Bora Lim
Inflammatory breast cancer (IBC) is a rare and aggressive malignancy that is often initially misdiagnosed due to its similar presentation to more benign breast pathology such as mastitis, resulting in treatment delays. Presenting symptoms of IBC include erythema, skin changes such as peau d' orange or nipple inversion, edema, and warmth of the affected breast. The average age at diagnosis is younger than in non-IBC. Known risk factors include African-American race and obesity. Diagnostic criteria include erythema occupying at least one-third of the breast, edema, peau d' orange, and/or warmth, with or without an underlying mass; rapid onset of fewer than three months; and pathologic confirmation of invasive carcinoma...
April 9, 2021: American Journal of Obstetrics and Gynecology
Sean K Lau, David S Cassarino, Stephen S Koh
Cellular neurothekeoma is a cutaneous tumor with a distinctive histopathologic appearance characterized by a dermal based multinodular proliferation of epithelioid to spindled cells. Although the tumor may show varying amounts of myxoid stroma, extensive myxoid change is uncommon. The tumor typically presents as a solitary nodule with a predilection for the head and neck and upper limbs; examples of multiple cellular neurothekeomas are decidedly rare. The present report describes a unique case of multiple myxoid cellular neurothekeomas arising in a 60 year old female with systemic lupus erythematosus...
April 12, 2021: Journal of Cutaneous Pathology
Philip J Mease, Iain B McInnes, Lai-Shan Tam, Kiefer Eaton, Steve Peterson, Agata Schubert, Soumya D Chakravarty, Anna Parackal, Chetan S Karyekar, Sandhya Nair, Wolf-Henning Boehncke, Christopher Ritchlin
OBJECTIVE: The efficacy of the novel interleukin (IL)-23p19 inhibitor guselkumab for psoriatic arthritis (PsA) has recently been demonstrated in two phase 3 trials (DISCOVER-1 & -2) but has not been evaluated vs other targeted therapies for PsA. The objective was to compare guselkumab to targeted therapies for PsA for safety and joint and skin efficacy through network meta-analysis (NMA). METHODS: A systematic literature review was conducted in January 2020 to identify randomized controlled trials...
March 24, 2021: Rheumatology
Xiaorong Fu, Ran Zhao, Goo Yoon, Jung-Hyun Shim, Bu Young Choi, Fanxiang Yin, Beibei Xu, Kyle Vaughn Laster, Kangdong Liu, Zigang Dong, Mee-Hyun Lee
Background: Skin cancer is one of the most commonly diagnosed cancers worldwide. The 5-year survival rate of the most aggressive late-stage skin cancer ranges between 20 and 30%. Thus, the discovery and investigation of novel target therapeutic agents that can effectively treat skin cancer is of the utmost importance. The T-lymphokine-activated killer cell-originated protein kinase (TOPK), which belongs to the serine-threonine kinase class of the mitogen-activated protein kinase kinase (MAPKK) family, is highly expressed and activated in skin cancer...
2021: Frontiers in Cell and Developmental Biology
Zhen Zhu, Hao Song, Juan Xu
T-cell-mediated immune response is the prerequisite for T-cell-based immunotherapy. However, the limitation of T-cell infiltration in solid tumors restricted the therapeutic effect of T-cell-based immunotherapy. The present study screened the molecular and genetic features of The Cancer Genome Atlas (TCGA)-skin cutaneous melanoma (SKCM) cohort, revealing that T-cell infiltration negatively correlated with genome copy number alteration. The analysis of the TCGA-SKCM cohort indicated that the copy number of CDKN2A was significantly decreased in patients with low T-cell infiltration...
2021: Frontiers in Oncology
Umar Zeb Khan, Matiullah Masroor, Wenlong Yang, Muhammad Riaz, Hai Liu
Solitary extramedullary plasmacytoma, an extremely rare case which accounts for about 3% of all plasma cell neoplasms, often occurs in the head and neck region such as para nasal sinuses, nasal cavity and oral cavity, it also occurs in the lymph nodes, lungs, thyroid, intestine, liver, pancreas, testis, breast, or skin. Isolated primary plasmacytoma of adrenal is extremely rare and only nine documented cases have been reported in the literature. We are presenting the 10th case which is the youngest patient until now with symptoms of fever and hepatosplenomegaly...
March 2021: Gland Surgery
Benlong Yang, Shuyue Zheng, Xiaoyan Huang, Jiajian Chen, Zhebin Liu, Guangyu Liu, Shujun Wang, Zhimin Shao, Jiong Wu
Background: Mitoxantrone hydrochloride injection for lymph tracing (MHI) is a novel lymphatic tracer for sentinel lymph node (SLN) in patients with early breast cancer but exhibited remarkable liver, kidney, and hematologic toxicities in previous studies. Here, the pharmacokinetics and pharmacodynamics profiles of MHI were evaluated to surmise safety and tolerability. Methods: Phase 1 open-label, single center, and dose escalation study was performed. Ten patients with invasive breast cancer received 0...
March 2021: Gland Surgery
Junying Chen, Yuxiong Ding, Fei Huang, Ruilong Lan, Zeng Wang, Weikang Huang, Ruiqing Chen, Bing Wu, Lengxi Fu, Yunhua Yang, Jun Liu, Jinsheng Hong, Weijian Zhang, Lurong Zhang
Liver cancer is one of the most common malignant tumors with no available satisfactory treatment. The aim of the present study was to investigate the anti-tumor effect of an irradiated hepatocellular carcinoma (HCC) whole-cell vaccine and its underlying mechanisms. Hepa1-6 and H22 HCC cell lines were irradiated in preparation for whole-cell vaccine production. Subsequently, two HCC tumor-bearing mouse models were created by injecting these Hepa1-6 and H22 cells into the abdominal skin of C57BL/6 and ICR mice, respectively...
May 2021: Oncology Letters
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