B Reyn, E Van Eycken, M Louwman, K Henau, K Schreuder, L Brochez, M Garmyn, N A Kukutsch
BACKGROUND: Cutaneous melanoma (CM) is a multifactorial disease, with both environmental and genetic factors involved. The incidence of CM has risen rapidly during the last decades, making it a growing public health problem. OBJECTIVES: The purpose of this retrospective study was to compare incidence and survival data of CM between two neighboring countries, Belgium (BE) and The Netherlands (NL). METHODS: Data were collected by the Belgian Cancer Registry (BCR) and the Netherlands Cancer Registry (NCR) from 1 January 2004 until 31 December 2016...
March 3, 2021: Journal of the European Academy of Dermatology and Venereology: JEADV
Mike C M van Zon, José D van der Waa, Mitko Veta, Gertruud A M Krekels
BACKGROUND: Basal cell carcinoma (BCC) is the most common type of skin cancer with incidence rates rising each year. Mohs micrographic surgery (MMS) is most often chosen as treatment for BCC on the face for which each frozen section has to be histologically analysed to ensure complete tumor removal. This causes a heavy burden on health economics. OBJECTIVES: To develop and evaluate a deep learning model for the automated detection of BCC-negative slides and classification of BCC in histopathology slides of MMS based on whole-slide image (WSI)...
March 3, 2021: Experimental Dermatology
Manjusha Annaji, Ishwor Poudel, Sai H S Boddu, Robert D Arnold, Amit K Tiwari, R Jayachandra Babu
BACKGROUND: Resveratrol (3, 5, 4' -trihydroxystilbene), a natural polyphenol and phytoalexin, has drawn considerable attention in the past decade due to its wide variety of therapeutic activities such as anticancer, anti-inflammatory, and antioxidant properties. However, its poor water solubility, low chemical stability, and short biological half-life limit its clinical utility. RECENT FINDINGS: Nanoparticles overcome the limitations associated with conventional chemotherapeutic drugs, such as limited availability of drugs to the tumor tissues, high systemic exposures, and consequent toxicity to healthy tissues...
March 2, 2021: Cancer reports
Ania Henning, Mackenzie Banks, Abraham M Korman, I Hans Iwenofu, Catherine G Chung
De-differentiated chondrosarcoma (DDCS) is an extremely aggressive tumor of the bone characterized by a high-grade, non-chondroid sarcoma adjacent to a low- or intermediate-grade chondrosarcoma. Adequate tumor sampling demonstrating the biphasic features is necessary to make an accurate diagnosis. The diagnosis may be challanging as histopathology may mimic other neoplasms. We present a case of 76-year-old woman with a history of breast cancer who presented with a pathologic non-displaced fracture. A bone biopsy demonstrated a high-grade neoplasm composed of pleomorphic spindled and epithelioid cells with focal expression of AE1/3 and GATA3, most likely consistent with metastatic breast carcinoma...
March 2, 2021: Journal of Cutaneous Pathology
Vivek Moorthy, Koushik Sanku, Harjinder P Singh, Ratesh Khillan, Pathik P Patel
Lynch syndrome is an autosomal dominant disorder caused by germline mutation affecting mismatch-repair genes. Genetic testing is performed selectively. Diagnosed individuals are to undergo surveillance to detect and manage Lynch syndrome-related cancers early in the course. Muir-Torre syndrome is a phenotypic variant of Lynch syndrome characterized by sebaceous neoplasms, keratoacanthoma, or both in addition to other Lynch syndrome-related cancers. Other neoplasms of the skin, such as squamous cell carcinoma, are not recognized as part of the Lynch syndrome tumor-spectrum...
February 25, 2021: Curēus
Abdulrahman F Alluhaybi, Nael M Hatatah
Kaposi's sarcoma (KS) is a vascular tumor that originates from the endothelial and immune cells. Lesions usually appear on the skin and oral mucosa, but they may also extend to involve lymph nodes and visceral organs. Patients typically present with multiple painless purplish spots on the face, oral mucosa, and genitalia. We report a case of cutaneous KS in a 31-year-old male with an unknown positive HIV status. Clinical presentation and investigations were both toward KS. Therefore, our patient was treated immediately after diagnosis but could not tolerate the antiretroviral therapy and had unfortunate consequences...
February 24, 2021: Curēus
Sara Custodio-Cabello, Luis Cabezón-Gutiérrez, Magda Palka-Kotlowska, Eduardo Oliveros Acebes, Parham Khosravi-Shahi
Merkel cell carcinoma (MCC) is a rare neuroendocrine cutaneous malignancy. During early stages, surgery is the primary treatment followed by radiotherapy in patients at high risk of recurrence. Definitive radiation therapy is an alternative for patients who are not surgical candidates, reserving chemotherapy for metastatic disease. We present a case of a male patient diagnosed with MCC and stage IV colorectal cancer and we focus on the skin tumor shrinkage after specific colorectal cancer treatment.
January 26, 2021: Curēus
Qing-Shan Liang, Jian-Gang Xie, ChaoPing Yu, ZhuSheng Feng, JingChang Ma, Yuan Zhang, Dong Wang, JianGuo Lu, Ran Zhuang, Jikai Yin
Splenectomy has been reported to improve liver fibrosis in patients with cirrhosis and hypersplenism. However, the mechanisms remain unclear. Tumor necrosis factor superfamily 14 (TNFSF14; also known as LIGHT) is highly expressed in the context of fibrosis and promotes disease progression in patients with fibrotic diseases such as pulmonary and skin fibrosis. Here, we determined whether splenectomy controls the production of LIGHT to improve liver fibrosis. Splenectomy reduced serum LIGHT levels in cirrhotic patients with hypersplenism and a ConA-induced liver fibrosis mouse model...
March 3, 2021: Experimental & Molecular Medicine
Huanbo Xu, Yangliang Huang, Yi Zhong, Guowang Lu
In recurrent posterior cervical intradural tumour resections, serious complications can be developed. The dural can become affected by inflammatory factors or removed during tumor resection; if cerebrospinal fluid (CSF) leakage cannot be stopped by duraplasty, artificial meninges or fascia repair, large pseudomeningocele can develop posteriorly within the soft tissue of the neck. When the pressure of the CSF cannot be maintained steadily, persistent clinical symptoms can occur, such as postural headache or central fever...
March 2, 2021: Scientific Reports
Jae Ho Choi, Gi Ho Lee, Sun Woo Jin, Ji Yeon Kim, Yong Pil Hwang, Eun Hee Han, Young Ho Kim, Hye Gwang Jeong
Impressic acid (IPA), a lupane-type triterpenoid from Acanthopanax koreanum , has many pharmacological activities, including the attenuation of vascular endothelium dysfunction, cartilage destruction, and inflammatory diseases, but its influence on atopic dermatitis (AD)-like skin lesions is unknown. Therefore, we investigated the suppressive effect of IPA on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin symptoms in mice and the underlying mechanisms in cells. IPA attenuated the DNCB-induced increase in the serum concentrations of IgE and thymic stromal lymphopoietin (TSLP), and in the mRNA levels of thymus and activation regulated chemokine(TARC), macrophage derived chemokine (MDC), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13), tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in mice...
February 26, 2021: International Journal of Molecular Sciences
Amanda F Nahhas, Andrew T Scales, Julie Pfeifle, Sean R Stephenson
Breast cancer is the most common malignancy to metastasize to the skin in women. Cutaneous breast carcinoma may arise as cutaneous metastasis or secondary to direct tumor extension to the skin. This report describes an unusual presentation of cutaneous metastatic lobular breast carcinoma that involved diffuse cutaneous lesions and rapid progression from onset of breast mass to development of clinically apparent metastatic skin lesions.
January 2021: Cutis; Cutaneous Medicine for the Practitioner
He Li, Congpin Wang, Xiaoqing Li, Yinghui Kong, Weiguo Sun
Melanocyte-specific CD8+ T cells enrichment correlates with the severity of vitiligo, and the role of A20 derived from myeloid cells in the enrichment of pathogenic T cells is unknown. Premelanosome (PMEL)-specific transgenic CD8+ T cells were adoptive transferred into Krt14- Kitl* mice to construct the vitiligo model, which was further mated with A20MKO mice and IKK2fl/fl mice. Bone marrow cells were stimulated with 30% L929 cell-conditioned medium, Fc-human tumor necrosis factor, and lipopolysaccharides to induce bone marrow-derived macrophages (BMDMs)...
March 2, 2021: Dermatologic Therapy
Matteo Fallico, Giuseppina Raciti, Antonio Longo, Michele Reibaldi, Vincenza Bonfiglio, Andrea Russo, Rosario Caltabiano, Giuseppe Gattuso, Luca Falzone, Teresio Avitabile
Uveal melanoma (UM) represents the most prominent primary eye cancer in adults. With an incidence of approximately 5 cases per million individuals annually in the United States, UM could be considered a relatively rare cancer. The 90‑95% of UM cases arise from the choroid. Diagnosis is based mainly on a clinical examination and ancillary tests, with ocular ultrasonography being of greatest value. Differential diagnosis can prove challenging in the case of indeterminate choroidal lesions and, sometimes, monitoring for documented growth may be the proper approach...
April 2021: International Journal of Oncology
Hui-Jen Tsai, Her-Shyong Shiah, Jang-Yang Chang, Wu-Chou Su, Nai-Jung Chiang, Li-Tzong Chen
S-1, an oral pyrimidine fluoride-derived agent, is effective against various cancers. Sorafenib, an oral multikinase inhibitor, was found to prolong the survival of various cancers and enhance the cytotoxicity of chemotherapeutic agents. We conducted a phase I dose escalation study to determine dose-limiting toxicity (DLT) and maximal tolerated dose (MTD) of S-1 when combined with sorafenib for refractory solid tumors. Eligible patients received escalating doses (30, 35, and 40 mg/m2 bid) of S-1 Day 1 (D1)-D14 and continuous sorafenib 400 mg bid from cycle 1 D8 every 21 days in a standard 3 + 3 study design...
March 1, 2021: Scientific Reports
Isak W Tengesdal, Dinoop R Menon, Douglas G Osborne, Charles P Neff, Nicholas E Powers, Fabia Gamboni, Adolfo G Mauro, Angelo D'Alessandro, Davide Stefanoni, Morkos A Henen, Taylor S Mills, Dennis M De Graaf, Tania Azam, Beat Vogeli, Brent E Palmer, Eric M Pietras, James DeGregori, Aik-Choon Tan, Leo A B Joosten, Mayumi Fujita, Charles A Dinarello, Carlo Marchetti
Interleukin-1β (IL-1β)-mediated inflammation suppresses antitumor immunity, leading to the generation of a tumor-permissive environment, tumor growth, and progression. Here, we demonstrate that nucleotide-binding domain, leucine-rich containing family, pyrin domain-containing-3 (NLRP3) inflammasome activation in melanoma is linked to IL-1β production, inflammation, and immunosuppression. Analysis of cancer genome datasets (TCGA and GTEx) revealed greater NLRP3 and IL-1β expression in cutaneous melanoma samples ( n = 469) compared to normal skin ( n = 324), with a highly significant correlation between NLRP3 and IL-1β ( P < 0...
March 9, 2021: Proceedings of the National Academy of Sciences of the United States of America
Feifei Zhao, Zhifeng Jia, Yingfa Feng, Zenghuai Li, Jiangang Feng
BACKGROUND: Malignant melanoma is the most fatal type of skin tumor. Circular RNAs (circRNAs) have been implicated in the malignant progression of melanoma. OBJECTIVE: The main purpose of this paper was to identify the precise parts of circ_0079593 in the malignant progression of melanoma. METHODS: The levels of circ_0079593, miR-573 and abhydrolase domain containing 2 (ABHD2) were determined by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot...
February 4, 2021: Journal of Dermatological Science
Angelos Mantelakis, Argiris Kostantinos, Alwyn D'Souza, Anil Joshi
Reconstructive options in nonmelanomatous skin tumors of the head and neck region are limited in the frail, elderly patient group, where split skin thickness or full thickness grafts may not be a viable option. This study examines the use decellularized cadaveric dermis (DCELL), an acellular dermis product produced in the United Kingdom for the reconstruction of these skin defects. This was a single-center, prospective study of patients undergoing single stage wide local excision of nonmelanomatous skin cancer and reconstruction with decellularized dermis...
March 1, 2021: Facial Plastic Surgery: FPS
Hamilton Kakwere, Hua Zhang, Elizabeth S Ingham, Marina Nura-Raie, Spencer K Tumbale, Riley Allen, Sarah M Tam, Bo Wu, Cheng Liu, Azadeh Kheirolomoom, Brett Z Fite, Asaf Ilovitsh, Jamal S Lewis, Katherine W Ferrara
Resiquimod is an immunopotent toll-like receptor 7/8 agonist with antitumor activity. Despite being potent against skin cancers, it is poorly tolerated systemically due to toxicity. Integrating resiquimod into nanoparticles presents an avenue to circumvent the toxicity problem. Herein, the preparation of degradable nanoparticles with covalently bound resiquimod and their systemic application in cancer immunotherapy is reported. Dispersion in water of amphiphilic constructs integrating resiquimod covalently bound via degradable amide or ester linkages yields immune-activating nanoparticles...
March 1, 2021: Advanced Healthcare Materials
Alejandra Reolid, E Muñoz-Aceituno, F Abad-Santos, M C Ovejero-Benito, E Daudén
Epigenetics is the study of the mechanisms that regulate gene expression without modifying DNA sequences. Knowledge of and evidence about how epigenetics plays a causative role in the pathogenesis of many skin diseases is increasing. Since the epigenetic changes present in tumor diseases have been thoroughly reviewed, we believe that knowledge of the new epigenetic findings in non-tumor immune-mediated dermatological diseases should be of interest to the general dermatologist. Hence, the purpose of this review is to summarize the recent literature on epigenetics in most non-tumor dermatological pathologies, focusing on psoriasis...
March 1, 2021: Molecular Diagnosis & Therapy
Mary Jane Lim-Fat, Kun Wei Song, J Bryan Iorgulescu, Brian M Andersen, Deborah A Forst, Justin T Jordan, Elizabeth R Gerstner, David A Reardon, Patrick Y Wen, Isabel Arrillaga-Romany
PURPOSE: Although uncommon, detection of BRAF V600E mutations in adult patients with glioblastoma has become increasingly relevant given the widespread application of molecular diagnostics and encouraging therapeutic activity of BRAF/MEK inhibitors. METHODS: We performed a retrospective study of adult glioblastoma patients treated at Dana-Farber Cancer Institute/Brigham and Women's Hospital or Massachusetts General Hospital from January 2011 to July 2019 with an identified BRAF V600E mutation by either immunohistochemistry or molecular testing...
March 1, 2021: Journal of Neuro-oncology
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