keyword
https://read.qxmd.com/read/32951304/application-of-vermillion-myocutaneous-flap-in-restoration-after-lip-cancer-resection
#1
Xue Li, Zhuoxuan Li, Lin Qi, Shu Wang, Chunli Yao
OBJECTIVE: To investigate the application of the vermillion myocutaneous flap in restoration after lip cancer resection. METHOD: From July 2012 to December 2019, six patients with lip cancer admitted in our department were included in this study. Total defect of the whole layer of the lip, accounted for 1/3-1/2 of the total length of the lip after tumor resection, were repaired by vermillion myocutaneous flap. For the case defect presenting >1/2 of the total length of the lip, a local rotational flap was designed with vermillion myocutaneous flap compound to repair the defect...
September 19, 2020: Dermatologic Therapy
https://read.qxmd.com/read/32950725/aminolevulinate-photodynamic-therapy-ala-pdt-for-giant-seborrheic-keratosis-of-the-head-a-case-report
#2
Huanhuan Zhang, Guo Wei, Chunmin Zhang, Qingqing Xu, Chunhong Zhang
Although Seborrheic keratosis of the head is very common, giant seborrheic keratosis is rare. This condition should be distinguished from many skin malignant tumors by skin histopathological and immunohistochemistry. We will report a case of a 61-year-old woman who presented with a large, dark-brown, well-demarcated plaque on the top of her head for seven years which progressed rapidly for one year. Dermoscopy, histopathological examination and immunohistochemical examination were performed successively. The patient was diagnosed with seborrheic keratosis, for which she was treated with aminolevulinate photodynamic therapy (ALA-PDT)...
September 17, 2020: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/32949805/congenital-midline-spinal-hamartoma-in-a-5-month-old-infant
#3
Elric Brahm Malelak, Christopher Lauren, Donny Argie, Tri Nugraheni
BACKGROUND: Congenital midline spinal hamartoma is a very rare tumor-like proliferation that mostly occurred during childhood. It consists of mature, well-differentiated ectodermal and mesodermal elements that present in an abnormal location and mostly associated with neurofibromatosis type 1 and spinal dysraphism. CASE DESCRIPTION: A 5-month-old male patient presented with a complaint of a bump over the lower back. The bump is already presented since birth with the size is approximately 3 cm in diameter and growth slowly...
September 16, 2020: World Neurosurgery
https://read.qxmd.com/read/32948783/expression-profiles-of-proton-sensing-g-protein-coupled-receptors-in-common-skin-tumors
#4
Wybke Klatt, Susanne Wallner, Christoph Brochhausen, Judith A Stolwijk, Stephan Schreml
The proton-sensing GPCRs (pH-GPCRs) GPR4 (GPR19), TDAG8 (GPR65, T-cell death associated gene 8), OGR1 (GPR68, ovarian cancer GPCR1), and G2A (GPR132, G2 accumulation protein) are involved in sensing and transducing changes in extracellular pH (pHe ). Extracellular acidification is a central hallmark of solid cancer. pH-GPCR function has been associated with cancer cell proliferation, adhesion, migration and metastasis, as well as with modulation of the immune system. Little is known about the expression levels and role of pH-GPCRs in skin cancer...
September 18, 2020: Scientific Reports
https://read.qxmd.com/read/32947348/intraoperative-indocyanine-green-fluorescence-angiography-is-sensitive-for-predicting-postoperative-wound-complications-in-soft-tissue-sarcoma-surgery
#5
Benjamin K Wilke, Douglas S Schultz, Maria T Huayllani, Daniel Boczar, Aaron C Spaulding, Courtney E Sherman, Peter M Murray, Antonio J Forte
INTRODUCTION: Indocyanine green (ICG) angiography is a novel technology that has been predictive of postoperative wound complications. It is unknown whether this technology can successfully predict complications after sarcoma resection. In this study, we aimed to evaluate the sensitivity and specificity of ICG angiography in predicting postoperative wound complications after soft-tissue sarcoma resection. METHODS: A prospective cohort study of 23 patients was performed beginning October 2017 at our institution...
September 17, 2020: Journal of the American Academy of Orthopaedic Surgeons
https://read.qxmd.com/read/32947334/esthetic-repair-of-facial-skin-defect-after-resection-of-malignant-tumor-with-lateral-maxillocervical-island-fasciocutaneous-flap
#6
Zhongliang Lang, Liping Zhao, Yanjun Chu
The face is a high-incidence area for malignant skin tumors, which often need surgically extended resectioning, and the secondary defects generally need esthetic repair. This report introduces a type of flap (lateral maxillocervical-island fasciocutaneous flap)-repair method that can not only repair the defect accurately but also result in skin texture comparable with the surroundings. Moreover, the incision in the flap area is concealed, so as to not cause facial-organ deformity and to achieve an esthetic repair effect...
September 17, 2020: Journal of Craniofacial Surgery
https://read.qxmd.com/read/32947155/cancer-risk-in-patients-with-primary-immune-thrombocytopenia-a-swedish-nationwide-register-study
#7
Charlotta Ekstrand, Shahram Bahmanyar, Honar Cherif, Helle Kieler, Marie Linder
BACKGROUND: Immune thrombocytopenia (ITP) is an autoimmune disease treated with immunosuppressive agents, thrombopoietin receptor agonists, immunomodulation drugs and/or splenectomy. Patients with ITP have been found to have increased risk ofhematological malignancies. Studies investigating stomach/liver cancer are contradictory and the risk of developing other solid tumors is largely unknown. We aimed at estimating risk of overall and organ-specific cancers in patients with primary ITP...
September 15, 2020: Cancer Epidemiology
https://read.qxmd.com/read/32946880/lack-of-distinct-molecular-profile-of-primary-dermal-melanoma
#8
Sheila Shaigany, Basile Tessier-Cloutier, Klaus J Busam, Basil Horst
BACKGROUND: Primary dermal melanoma (PDM) is a rare variant of melanoma which simulates metastatic melanoma to the skin. Diagnosis of PDM cannot be established on histologic grounds alone, but requires absence of evidence of melanoma elsewhere by clinical history and/or imaging studies. Despite this entity being clinically well documented, limited data on molecular characterization is available. We performed comprehensive mutation and copy number variation analysis in a series of primary dermal melanomas in search for distinctive molecular features...
September 15, 2020: Human Pathology
https://read.qxmd.com/read/32946877/qr-313-an-antisense-oligonucleotide-shows-therapeutic-efficacy-for-treatment-of-dominant-and-recessive-dystrophic-epidermolysis-bullosa-a-preclinical-study
#9
Olivier Bornert, Marieke Hogervorst, Pauline Nauroy, Johannes Bischof, Jim Swildens, Ioannis Athanasiou, Sara F Tufa, Douglas R Keene, Dimitra Kiritsi, Stefan Hainzl, Eva M Murauer, M Peter Marinkovich, Gerard Platenburg, Ingrid Hausser, Verena Wally, Tita Ritsema, Ulrich Koller, Elisabeth M Haisma, Alexander Nyström
Dystrophic epidermolysis bullosa (DEB) is a blistering skin disease caused by mutations in the gene COL7A1 encoding collagen VII. DEB can be inherited in a recessive (RDEB) or dominant (DDEB) manner and is associated with a high wound burden. Perpetual cycles of wounding and healing drive fibrosis in DDEB and RDEB, as well as the formation of a tumor-permissive microenvironment. Prolonging wound free episodes by improving the quality of wound healing would therefore confer substantial benefit for individuals with DEB...
September 15, 2020: Journal of Investigative Dermatology
https://read.qxmd.com/read/32945301/dissolving-microneedles-integrated-with-ph-responsive-micelles-containing-aiegen-with-ultra-photostability-for-enhancing-melanoma-photothermal-therapy
#10
Sihui Wei, Guilan Quan, Chao Lu, Xin Pan, Chuanbin Wu
Photothermal therapy (PTT) based on aggregation-induced emission luminogen (AIEgen) is very promising for superficial tumor therapy due to the superior photostability and photothermal conversion efficiency of AIEgens. However, the systemic administration of AIEgen remains challenging, mainly because of solubility dissatisfaction and biodistribution. Here, a dissolving microneedle (MN) system loaded with AIEgen (NIR950) was developed for topical administration to treat malignant skin tumor melanoma. Firstly, NIR950-loaded polymeric micelles (NIR950@PMs) were prepared via a nanoprecipitation method to increase the drug solubility...
September 18, 2020: Biomaterials Science
https://read.qxmd.com/read/32944466/estrogen-and-progesterone-receptor-expression-in-breast-carcinoma-and-its-association-with-clinicopathological-variables-among-the-pakistani-population
#11
Shahzada K Sohail, Rahat Sarfraz, Muhammad Imran, Muhammad Kamran, Samina Qamar
Introduction The prognosis of breast cancer depends on the histological type, size of the tumor, tumor necrosis, skin, nipple and chest wall invasion, lymphovascular invasion, grade, stage, the status of estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2), cell proliferation marker (ki-67), and type of therapy. Estrogen receptor and progesterone receptor expression in breast cancer is, so far, the most useful predictive marker. We have undertaken this study to find the expression of ER and PgR in breast carcinoma and its association with other prognostically important clinicopathological variables...
August 14, 2020: Curēus
https://read.qxmd.com/read/32944222/exosomes-from-oral-tissue-stem-cells-biological-effects-and-applications
#12
REVIEW
Quan Shi, Na Huo, Xing Wang, Shuo Yang, Juncheng Wang, Tong Zhang
As natural nanoparticles, exosomes are a type of extracellular vesicles that are enclosed by a lipid bilayer and contain various cargos, including miRNA, mRNA, DNA and proteins. Exosomes have rapidly gained attention as a highly promising cell-free therapy. Because the cargo of exosomes changes with the changes in parent cells and status, exosomes from different types of cells may exhibit different biological effects. Considering the particularity of oral tissue stem cells, their exosomes were isolated and used to examine their related biological functions and the possibility of replacing stem cells...
2020: Cell & Bioscience
https://read.qxmd.com/read/32944060/basal-cell-carcinoma-risk-and-solar-uv-exposure-in-occupationally-relevant-anatomic-sites-do-histological-subtype-tumor-localization-and-fitzpatrick-phototype-play-a-role-a-population-based-case-control-study
#13
A Bauer, E Haufe, L Heinrich, A Seidler, H J Schulze, P Elsner, H Drexler, S Letzel, S M John, M Fartasch, T Brüning, S Dugas-Breit, M Gina, W Weistenhöfer, K Bachmann, I Bruhn, B M Lang, R Brans, J P Allam, W Grobe, S Westerhausen, P Knuschke, M Wittlich, T L Diepgen, J Schmitt
Background: A two-fold risk increase to develop basal cell carcinoma was seen in outdoor workers exposed to high solar UV radiation compared to controls. However, there is an ongoing discussion whether histopathological subtype, tumor localization and Fitzpatrick phototype may influence the risk estimates. Objectives: To evaluate the influence of histological subtype, tumor localization and Fitzpatrick phototype on the risk to develop basal cell carcinoma in highly UV-exposed cases and controls compared to those with moderate or low solar UV exposure...
2020: Journal of Occupational Medicine and Toxicology
https://read.qxmd.com/read/32944050/intravascular-large-b-cell-lymphoma-a-report-of-two-cases
#14
Fereshteh Ameli, Fatemeh Nili Ahmad Abadi, Hana Saffar
One of the rare variants of extranodal large B-cell lymphoma is intravascular large B-cell lymphoma (IVLBCL). Characteristics of IVLBCL include intraluminal selective proliferation of atypical lymphoid cells in small to medium-sized vessels. The etiologic of IVLBCL is unknown, but due to the growth pattern of this tumor, it is speculated that IVLBCL is caused by a defect in homing receptor of tumor cells. IVLBCL can involve any organ but central nervous system, lungs, and skin are the most involved sites. IVLBCL does not usually involve lymph nodes...
2020: Iranian Journal of Pathology
https://read.qxmd.com/read/32943867/a-ph-sensitive-prodrug-nanocarrier-based-on-diosgenin-for-doxorubicin-delivery-to-efficiently-inhibit-tumor-metastasis
#15
Zeliang Wei, Haibo Wang, Guang Xin, Zhi Zeng, Shiyi Li, Yue Ming, Xiaoyu Zhang, Zhihua Xing, Li Li, Youping Li, Boli Zhang, Junhua Zhang, Hai Niu, Wen Huang
Background: The metastasis, one of the biggest barriers in cancer therapy, is the leading cause of tumor deterioration and recurrence. The anti.-metastasis has been considered as a feasible strategy for clinical cancer management. It is well known that diosgenin could inhibit tumor metastasis and doxorubicin (DOX) could induce tumor apoptosis. However, their efficient delivery remains challenging. Purpose: To address these issues, a novel pH-sensitive polymer-prodrug based on diosgenin nanoparticles (NPs) platform was developed to enhance the efficiency of DOX delivery (DOX/NPs) for synergistic therapy of cutaneous melanoma, the most lethal form of skin cancer with high malignancy, early metastasis and high mortality...
2020: International Journal of Nanomedicine
https://read.qxmd.com/read/32943457/phase-1b-study-of-chemoprevention-with-green-tea-polyphenon-e-and-erlotinib-in-patients-with-advanced-premalignant-lesions-apl-of-the-head-and-neck
#16
Dong M Shin, Sreenivas Nannapaneni, Mihir R Patel, Qiuying Shi, Yuan Liu, Zhengjia Chen, Amy Chen, Mark W El-Deiry, Jonathan J Beitler, Conor E Steuer, Steven M Roser, Adam M Klein, Taofeek K Owonikoko, Suresh S Ramalingam, Fadlo Raja Khuri, Zhuo G Chen, Nabil F Saba
PURPOSE: Based on synergistic effects between green tea polyphenon E (PPE) and epidermal growth factor receptor-tyrosine kinase inhibitor in preclinical studies, we conducted a phase 1b study of the PPE and erlotinib combination in patients with advanced premalignant lesions (APL) of the oral cavity and larynx. PATIENTS AND METHODS: Patients were treated with a fixed dose of PPE (200mg 3x day) and dose escalation of erlotinib (50, 75, 100 mg daily) for 6-months (6-M) with tissue biopsy at baseline and 6-M...
September 17, 2020: Clinical Cancer Research
https://read.qxmd.com/read/32943050/a-novel-skin-stretching-device-for-closing-large-skin-soft-tissue-defects-after-soft-tissue-sarcoma-resection
#17
Qiang Wu, Zengwu Shao, Yubin Li, Saroj Rai, Min Cui, Ying Yang, Baichuan Wang
BACKGROUND: Closure of large skin-soft tissue defects following soft tissue sarcoma (STS) resection has been a great challenge. The objective of this study was to evaluate the effectiveness of a novel, simple, and cheap skin-stretching device (bidirectional regulation-hook skin closure system, BHS) for closing large skin-soft tissue defects resulting from the removal of STS and the complications associated with the use of the BHS. METHODS: From January 2017 to September 2018, 25 patients with STS underwent BHS therapy after tumor resection...
September 17, 2020: World Journal of Surgical Oncology
https://read.qxmd.com/read/32942876/an-incidental-finding-of-pheochromocytoma-in-a-33-year-old-patient-with-lynch-syndrome
#18
Emília Mojtová, Jana Hanajíková, Olívia Hamidová, Gabriel Bognár, Daniel Dyttert, Marianna Grigerová, Štefan Kečkéš, Ján Podoba
Pheochromocytoma is a catecholamine-producing neuroendocrine tumor arising from chromaffin cells of the adrenal medulla. The detection of these tumors is extremely important because they are associated with high cardiovascular morbidity and mortality. Progress in molecular genetics has revealed that up to 35% of pheochromocytomas are inhereted. Lynch syndrome (hereditary nonpolypous colorectal cancer - HNPCC) is an autosomal dominant genetic condition that is associated with a high risk of colorectal cancer or other extracolonic tumors (adenocarcinoma of endometrium, stomach, ovarian carcinoma, carcinoma of urinary tract, small intestine, brain tumors and skin cancer)...
2020: Vnitr̆ní Lékar̆ství
https://read.qxmd.com/read/32939793/prame-expression-in-155-cases-of-metastatic-melanoma
#19
Sarah E Gradecki, Craig L Slingluff, Alejandro A Gru
BACKGROUND: PRAME is a promising immunohistochemical marker in distinguishing benign from malignant primary cutaneous melanocytic lesions and lymph node deposits. We hypothesize that PRAME may also reliably identify melanoma metastases that are clinically detected in skin, lymph nodes, or small intestine. METHODS: A total of 155 cases of metastatic melanoma to lymph node (N = 54) and non-lymph node (N = 101) sites were stained with an antibody against PRAME...
September 16, 2020: Journal of Cutaneous Pathology
https://read.qxmd.com/read/32939611/antinociception-induced-by-artemisinin-nanocapsule-in-a-model-of-postoperative-pain-via-spinal-tlr4-inhibition
#20
L M S Elisei, T R Moraes, I H Malta, I Charlie-Silva, I M O Sousa, F P Veras, M A Foglio, L F Fraceto, G Galdino
Artemisinin (ART) was initially described for the control of inflammation and pain. However, the mechanisms involved with its antinociceptive effect are still poorly understood. Thus, this present study aimed to investigate the effect of ART in both free and nanocapsulated form on postoperative pain, as well as the participation of the spinal Toll-like receptor 4 (TLR4) in this process. Postoperative pain was induced using the skin/muscle incision retraction (SMIR) model in male Swiss mice. After 3 and 28 days of SMIR, the animals received an intrathecal injection of free or nanocapsulated ART, and the nociceptive threshold was evaluated by von Frey filament test...
September 16, 2020: Inflammopharmacology
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