keyword
https://read.qxmd.com/read/38504250/development-of-a-new-computer-simulated-environment-to-screen-cognition-assessing-the%C3%A2-feasibility-and-acceptability-of%C3%A2-leaf-caf%C3%A3-%C3%A2-in-younger-and-older-adults
#21
JOURNAL ARTICLE
Joyce Siette, Jonathan Guion, Kiran Ijaz, Paul Strutt, Meredith Porte, Greg Savage, Deborah Richards
BACKGROUND: Existing traditional cognitive screening tools for dementia have various limitations, including overreliance on tests assessing verbal memory and, to a lesser extent, on some aspects of executive functioning. Comprehensive neuropsychological assessment is sensitive to impairment but time-intensive and expensive. Virtual reality may provide a dynamic and unique understanding of cognitive performance and increase the ecological validity of cognitive assessment...
March 19, 2024: BMC Medical Informatics and Decision Making
https://read.qxmd.com/read/38503636/a-cognitive-computational-account-of-mood-swings-in-adolescence
#22
REVIEW
Klára Gregorová, Eran Eldar, Lorenz Deserno, Andrea M F Reiter
Teenagers have a reputation for being fickle, in both their choices and their moods. This variability may help adolescents as they begin to independently navigate novel environments. Recently, however, adolescent moodiness has also been linked to psychopathology. Here, we consider adolescents' mood swings from a novel computational perspective, grounded in reinforcement learning (RL). This model proposes that mood is determined by surprises about outcomes in the environment, and how much we learn from these surprises...
March 18, 2024: Trends in Cognitive Sciences
https://read.qxmd.com/read/38499664/responsive-deep-brain-stimulation-for-the-treatment-of-tourette-syndrome
#23
JOURNAL ARTICLE
Michael S Okun, Jackson Cagle, Julieth Gomez, Dawn Bowers, Joshua Wong, Kelly D Foote, Aysegul Gunduz
To report the results of 'responsive' deep brain stimulation (DBS) for Tourette syndrome (TS) in a National Institutes of Health funded experimental cohort. The use of 'brain derived physiology' as a method to trigger DBS devices to deliver trains of electrical stimulation is a proposed approach to address the paroxysmal motor and vocal tic symptoms which appear as part of TS. Ten subjects underwent bilateral staged DBS surgery and each was implanted with bilateral centromedian thalamic (CM) region DBS leads and bilateral M1 region cortical strips...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38498674/fabrication-of-novel-3-d-nanocomposites-of-hap-tic-h-bn-zro-2-enhanced-mechanical-performances-and-in-vivo-toxicity-study-for-biomedical-applications
#24
JOURNAL ARTICLE
Sarvesh Kumar Avinashi, Shweta, Bhavna Bohra, Rajat Kumar Mishra, Savita Kumari, Zaireen Fatima, Ajaz Hussain, Bhagawati Saxena, Saurabh Kumar, Monisha Banerjee, Chandki Ram Gautam
Due to excellent biocompatibility, bioactivities, and osteoconductivity, hydroxyapatite (HAp) is considered as one of the most suitable biomaterials for numerous biomedical applications. Herein, HAp was fabricated using a bottom-up approach, i.e., a wet chemical method, and its composites with TiC, h-BN, and ZrO2 were fabricated by a solid-state reaction method with enhanced mechanical and biological performances. Structural, surface morphology, and mechanical behavior of the fabricated composites were characterized using various characterization techniques...
March 18, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38495239/clinicoradiological-features-and-long-term-cognitive-and-functional-outcome-in-patients-with-deep-cerebral-venous-thrombosis
#25
JOURNAL ARTICLE
Ameya Patwardhan, Manisha Gupta, Mariamma Philip, Anush Rangarajan, Tarachand Joshi, Suvarna Alladi, Girish B Kulkarni, Subasree Ramakrishnan
BACKGROUND: Deep cerebral venous thrombosis (DCVT) can have long-term functional and cognitive sequelae. Although literature exists on cognitive impairment after arterial stroke, cognitive sequelae after cerebral venous thrombosis (CVT) are much less studied. METHODS: Clinical records of 29 patients diagnosed with DCVT were reviewed. The Modified Telephonic Interview for Cognitive Status (TICS-M) was adapted and validated in the regional language (Kannada) and applied to 18 patients with DCVT, at a mean follow-up duration of 5...
2024: Annals of Indian Academy of Neurology
https://read.qxmd.com/read/38494948/common-pitfalls-and-how-to-avoid-them-in-child-and-adolescent-psychopharmacology-part-i
#26
REVIEW
Samuele Cortese, Frank Mc Besag, Bruce Clark, Chris Hollis, Joe Kilgariff, Carmen Moreno, Dasha Nicholls, Paul Wilkinson, Marc Woodbury-Smith, Aditya Sharma
As Faculty of the British Association for Psychopharmacology course on child and adolescent psychopharmacology, we present here what we deem are the most common pitfalls, and how to avoid them, in child and adolescent psychopharmacology. In this paper, we specifically addressed common pitfalls in the pharmacological treatment of attention-deficit/hyperactivity disorder, anxiety, bipolar disorder, depression, obsessive-compulsive disorder and related disorders, and tic disorder. Pitfalls in the treatment of other disorders are addressed in a separate paper (part II)...
March 18, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38491748/permanent-junctional-reciprocating-tachycardia-due-to-an-atypical-retrograde-slow-conducting-decremental-left-posterolateral-accessory-pathway-and-tachycardia-induced-cardiomyopathy-in-a-pregnant-adolescent
#27
Utkarsh Kohli, Sohail Hassan, Christopher Mercer, Larry Rhodes
Permanent junctional reciprocating tachycardia (PJRT) is a rare form of supraventricular tachycardia (SVT) due to a retrograde slow conducting decremental accessory pathway (AP) which is often incessant and can lead to tachycardia-induced cardiomyopathy (TIC). We report the challenging clinical course of a pregnant adolescent with PJRT due to an atypical retrograde slow conducting decremental left posterolateral AP. Pregnancy is known to exacerbate supraventricular arrhythmias and can lead to adverse maternal and fetal outcomes...
March 15, 2024: Pacing and Clinical Electrophysiology: PACE
https://read.qxmd.com/read/38488529/personalizing-rehabilitation-for-individuals-with-musculoskeletal-impairments-feasibility-of-implementation-of-the-measures-associated-to-prognostic-maps-tool
#28
JOURNAL ARTICLE
Nathalie Desmarais, Simon Décary, Catherine Houle, Christian Longtin, Thomas Gerard, Kadija Perreault, Emilie Lagueux, Pascal Tétreault, Marc-André Blanchette, Hélène Beaudry, Yannick Tousignant-Laflamme
INTRODUCTION: The M easures A ssociated to P rogno S tic (MAPS) tool is a standardized questionnaire that integrates validated prognostic tools to detect the presence of biopsychosocial prognostic factors in patients consulting for musculoskeletal disorders. PURPOSE: The objectives were to assess the: 1) feasibility of implementation of the MAPS tool, 2) clinicians' acceptability of the dashboard, and 3) patients' acceptability of the MAPS tool. METHODS: Twenty physiotherapists and two occupational therapists from seven outpatient musculoskeletal clinics were recruited to implement the MAPS tool during a 3-month timeframe, where new patients completed the questionnaire upon initial assessment...
March 15, 2024: Physiotherapy Theory and Practice
https://read.qxmd.com/read/38485576/tests-for-consciousness-in-humans-and-beyond
#29
REVIEW
Tim Bayne, Anil K Seth, Marcello Massimini, Joshua Shepherd, Axel Cleeremans, Stephen M Fleming, Rafael Malach, Jason B Mattingley, David K Menon, Adrian M Owen, Megan A K Peters, Adeel Razi, Liad Mudrik
Which systems/organisms are conscious? New tests for consciousness ('C-tests') are urgently needed. There is persisting uncertainty about when consciousness arises in human development, when it is lost due to neurological disorders and brain injury, and how it is distributed in nonhuman species. This need is amplified by recent and rapid developments in artificial intelligence (AI), neural organoids, and xenobot technology. Although a number of C-tests have been proposed in recent years, most are of limited use, and currently we have no C-tests for many of the populations for which they are most critical...
March 13, 2024: Trends in Cognitive Sciences
https://read.qxmd.com/read/38485260/update-on-the-pathophysiology-and-management-of-acute-trauma-hemorrhage-and-traumainduced-coagulopathy-tic-based-upon-viscoelastic-testing-vet
#30
JOURNAL ARTICLE
Marc Maegele
Uncontrolled hemorrhage and trauma-induced coagulopathy (TIC) remain the two predominante causes of preventable death after trauma. Early control of bleeding sources along with rapid detection, characterization and management of TIC have been associated with improved outcomes. However, recent surveys confirm vast heterogeneity in the clinical diagnosis and management of acute trauma hemorrhage and TIC even in advanced trauma centers. In addition, conventional coagulation assays, although still used frequently during the early assessment of bleeding trauma patients, have their limitations...
March 15, 2024: Clinical and Experimental Emergency Medicine
https://read.qxmd.com/read/38482064/preparation-of-co-ni-ce-tic-alloy-coatings-by-double-pulse-under-a-sulfamic-acid-system-and-a-process-mechanism-study
#31
JOURNAL ARTICLE
Jidong Li, Hongxuan Xing, Senhu Jin, Yaowu Wang, Jinlin Lu
To enhance the protective ability of copper crystallizers and extend their service life, this study explores the use of double pulse co-deposition under a sulfamic acid system to create protective coatings such as Co-Ni. The hardness test and friction wear analysis compare Co-Ni, Co-Ni-Ce, and Co-Ni-Ce/TiC coatings, revealing that the Co-Ni-Ce/TiC coating exhibits the most outstanding protective performance. SEM and XRD techniques are employed to characterize the three protective coatings, demonstrating that the incorporation of rare-earth cerium and nanoparticles improves the coating morphology and modifies their crystalline phase structure...
March 6, 2024: RSC Advances
https://read.qxmd.com/read/38479346/a-meta-analysis-of-transcranial-magnetic-stimulation-in-tourette-syndrome
#32
JOURNAL ARTICLE
Elizabeth R Steuber, Joseph F McGuire
There is growing enthusiasm for the treatment of neuropsychiatric disorders using neuromodulation. While some reports claim that transcranial magnetic stimulation (TMS) can be used to treat Tourette Syndrome (TS), little research exists to support this assertion. This meta-analysis examined the efficacy of TMS to reduce tic severity in patients with TS. Additionally, it explored the effect of TMS to reduce premonitory urge severity-the primary mechanism implicated in the frontline evidence-based treatment of TS...
March 8, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38478334/isolating-cancer-stem-cells-from-solid-tumors
#33
JOURNAL ARTICLE
Vitale Del Vecchio, Marcella La Noce, Virginia Tirino
Over the past 20 years, there has been a lot of interest in the study and investigation of cancer stem cells (CSCs) or tumor-initiating cells (TICs). CSCs are rare, dormant cells and able to self-renew and maintain tumor development and heterogeneity. A new age of basic and clinical cancer research, reclassification of human tumors, and the development of novel therapeutic approaches will undoubtedly result from a better knowledge of CSCs. In order to develop effective and therapeutic strategies to treat cancer, it is crucial to understand the basic characteristics of CSCs, their importance to cancer therapy, and methodologies to isolate, detect, and characterize them...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38476087/evaluation-of-a-psychoeducation-group-for-children-presenting-with-functional-tic-like-behaviours
#34
JOURNAL ARTICLE
Morvwen Duncan, Zoe Pearman, Katie Harrold, Amy Warren, Sacha Evans, Eve McAllister, Isobel Heyman, Sara Shavel-Jessop, Tara Murphy, Holan Liang
We describe the implementation and evaluation of an online psychoeducation group for young people experiencing functional tic-like behaviours (FTLBs) - a type of functional neurological disorder (FND). Across six groups, 50 participants completed pre- and post-group goal-based outcomes (GBOs) and 36 participants completed service-user feedback, which gathered qualitative and quantitative data about participants experiences of the group. Young people and their parents reported significant improvement in their GBOs following the group and increased knowledge and confidence in managing FTLBs...
March 13, 2024: Clinical Child Psychology and Psychiatry
https://read.qxmd.com/read/38475957/preliminary-study-on-reliability-and-validity-of-the-chinese-version-of-the-asher-mcdade-aesthetic-index
#35
JOURNAL ARTICLE
Lixian Chen, Ni Zeng, Bing Shi, Hanyao Huang
OBJECTIVES: This study aims to test the reliability and validity of the Chinese version of the Asher-McDade aesthetic index and clarify its feasibility for the postoperative outcome evaluation of cleft lip in China. METHODS: The Chinese version of the Asher-McDade aesthetic index was established through translation, back translation, debugging, and pre-survey. Eighty postoperative photographs of patients with cleft lip admitted to the West China Hospital of Stomatology, Sichuan University were included...
February 1, 2024: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://read.qxmd.com/read/38473601/strength-enhancement-of-laser-powder-bed-fusion-316l-by-addition-of-nano-tic-particles
#36
JOURNAL ARTICLE
Yanyan Liu, Deqiao Xie, Fei Lv
316L stainless steel is widely used in various industrial fields, but its strength is relatively low. The improvement of its strength has become a research hotspot. In this study, nano titanium carbide (TiC) particles are ball milled with 316L with the addition of 2 wt% and 4 wt%. The composite powder was then used for the fabrication of samples by laser powder bed fusion. The results show that the TiC is uniformly distributed in the microstructure. With the addition of TiC, the average size of the grains is significantly reduced...
February 29, 2024: Materials
https://read.qxmd.com/read/38472640/quantifying-tics-best-practices-and-design-considerations-for-video-based-tic-coding-in-research
#37
JOURNAL ARTICLE
Megan DuBois, Kerry Houlihan, Brittany Raab, Alison Pryor, Mia Kellman, Mayella Brinker, Brianna Wellen, Matthew Capriotti, Christine Conelea
Tic disorders (TD), including Tourette Syndrome, are characterized by involuntary, repetitive movements and/or vocalizations that can lead to persistent disability and impairment across the lifespan. Existing research demonstrates that video-based behavioral coding (VBBC) methods can be used to reliably quantify tics, enabling a more objective approach to tic measurement above and beyond standardly used TD questionnaires. VBBC is becoming more popular given the ease and ubiquity of obtaining patient videos...
March 12, 2024: Behavior Research Methods
https://read.qxmd.com/read/38468554/functional-tic-like-behaviors-a-common-comorbidity-in-patients-with-tourette-syndrome
#38
JOURNAL ARTICLE
Kirsten R Müller-Vahl, Anna Pisarenko, Carolin Fremer, Martina Haas, Ewgeni Jakubovski, Natalia Szejko
BACKGROUND: Comorbid functional tic-like behaviors (FTB) have been described only rarely in patients with Tourette syndrome (TS). OBJECTIVES: We present the first large sample of patients suffering from TS and FTB to raise awareness of this clinical presentation and to guide how to differentiate one from the other. METHODS: We analyzed clinical data of 71 patients (n = 27 [38.0%] female, mean age: 21.5, range: 11-55) with TS + FTB...
March 2024: Movement Disorders Clinical Practice
https://read.qxmd.com/read/38468546/premonitory-urge-in-patients-with-tics-and-functional-tic-like-behaviors
#39
JOURNAL ARTICLE
Natalia Szejko, Julian Fletcher, Davide Martino, Tamara Pringsheim
BACKGROUND: Premonitory urges (PU) are well described in primary tics, but their frequency and intensity in functional tic-like behaviors (FTLB) are unclear. OBJECTIVE: To study the experience of PU in patients with FTLB. METHODS: We compared the results of the premonitory urge for tics scale (PUTS) in adults with tics and FTLB in the University of Calgary Adult Tic Registry. RESULTS: We included 83 patients with tics and 40 with FTLB...
March 2024: Movement Disorders Clinical Practice
https://read.qxmd.com/read/38468457/time-is-ticking-for-tiktok-tics-a-retrospective-follow-up-study-in-the-post-covid-19-isolation-era
#40
JOURNAL ARTICLE
Kinga K Tomczak, Jennifer Worhach, Michael Rich, Olivia Swearingen Ludolph, Susan Eppling, Georgios Sideridis, Tamar C Katz
INTRODUCTION: During the COVID-19 pandemic, an influx of adolescents presented worldwide with acute onset of functional tic-like behaviors (FTLBs). Our goal was to evaluate psychosocial factors around onset, to elucidate outcomes after pandemic isolation protocols were lifted, and to examine therapy and medication management. METHODS: A retrospective review was performed of 56 patients ages 10-18 years with new-onset FTLBs seen at Boston Children's Hospital beginning in March 2020...
March 2024: Brain and Behavior
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