Siyang Cao, Xia Liu, Junwei Cui, Xiaoling Liu, Jieyu Zhong, Zijian Yang, Desheng Sun, Wei Wei
PURPOSE: Neoadjuvant chemotherapy (NACT) is increasingly adopted in the therapy of breast cancer (BC) patients with positive axillary nodes (cN+), but the reliability and feasibility of sentinel lymph node biopsy (SLNB) following NACT are still controversial. The objective of the present study is to conduct an updated meta-analysis on this issue. METHODS: A literature search was performed using PubMed, Cochrane, Embase, and Web of Science to identify papers published from January 1, 2000 to October 22, 2020 to research SLNB after NACT in BC patients...
July 22, 2021: Breast: Official Journal of the European Society of Mastology
Sinem Demir, Gulten Sezgin, Aysegul Akder Sari, Betul Bolat Kucukzeybek, Seyran Yigit, Demet Etit, Ayse Yazici, Yuksel Kucukzeybek
Invasive cribriform carcinoma (ICC) is a rare type of a primary breast carcinoma. It is subdivided into two groups as pure and mixed types. There are limited studies comparing the pure and mixed ICC at present. We aim to investigate the clinicopathological, radiological, prognostic features, and survival outcomes of two types with reviewing the published literature. 16 pure ICC and 26 mixed ICC cases were evaluated. The population consisted of 41 female and 1 male patients. The only male patient was a pure ICC case...
July 24, 2021: Annals of Diagnostic Pathology
Michael J Plaza, Jervon Wright, Sara Fernandez
No abstract text is available yet for this article.
July 24, 2021: Clinical Imaging
Nilkumar Patel, Nagavendra Kommineni, Sunil Kumar Surapaneni, Anil Kalvala, Xuegang Yaun, Aragaw Gebeyehu, Peggy Arthur, Leanne C Duke, Sara B York, David G Meckes, Mandip Singh
Extracellular Vesicles (EVs) were isolated from human umbilical cord mesenchymal stem cells (hUCMSCs) and were further encapsulated with cannabidiol (CBD) through sonication method (CBD EVs). CBD EVs displayed an average particle size of 114.1±1.02 nm, zeta potential of -30.26±0.12 mV, entrapment efficiency of 92.3±2.21% and stability for several months at 4 °C. CBD release from the EVs was observed as 50.74±2.44% and 53.99±1.4% at pH 6.8 and pH 7.4, respectively after 48 h. Ourin-vitrostudies demonstrated that CBD either alone or in EVs form significantly sensitized MDA-MB-231 cells to doxorubicin (DOX) (*P<0...
July 26, 2021: International Journal of Pharmaceutics
A Muscella, E Stefàno, N Calabriso, S A De Pascali, F P Fanizzi, S Marsigliante
Platinum complexes are currently used for breast cancer therapy, but, as with other drug classes, a series of intrinsic and acquired resistance mechanisms hinder their efficacy. To better understand the mechanisms underlying platinum complexes resistance in breast cancer, we generated a [Pt(O,O'-acac)(γ-acac)(DMS)]-resistant MCF-7, denoted as [Pt(acac)2 ]R. [Pt(O,O'-acac)(γ-acac)(DMS)] was chosen as previous works showed that it has distinct mechanisms of action from cisplatin, especially with regard to cellular targets...
July 26, 2021: Biochemical Pharmacology
Alexander M Demin, Alexandra G Pershina, Artem S Minin, Olga Ya Brikunova, Aidar M Murzakaev, Natalya A Perekucha, Alexander V Romashchenko, Oleg B Shevelev, Mikhail A Uimin, Iliya V Byzov, Dina Malkeyeva, Elena Kiseleva, Lina V Efimova, Sergey V Vtorushin, Ludmila M Ogorodova, Victor P Krasnov
Magnetic Fe3 O4 nanoparticles (MNPs) are often used to design agents enhancing contrast in magnetic resonance imaging (MRI) that can be considered as one of the efficient methods for cancer diagnostics. At present, increasing the specificity of the MRI contrast agent accumulation in tumor tissues remains an open question and attracts the attention of a wide range of researchers. One of the modern methods for enhancing the efficiency of contrast agents is the use of molecules for tumor acidic microenvironment targeting, for example, pH-low insertion peptide (pHLIP)...
July 29, 2021: ACS Applied Materials & Interfaces
Tamar Perri, Gabriel Levin, Shani Naor-Revel, Perry Eliassi-Revivo, Dror Lifshitz, Eitan Friedman, Jacob Korach
OBJECTIVE: To study the association of risk-reducing bilateral salpingo-oophorectomy (RRBSO) and breast cancer risk among BRCA pathogenic sequence variants (PSV). METHODS: Jewish Israeli BRCA-carriers who underwent RRBSO were matched with those who did not - by the mutated gene and year of birth (±1 year). Breast cancer rates were compared. RESULTS: Overall, 127 pairs met inclusion criteria, 79 (60.6%) pairs harbored BRCA1-PSV and 50 (39...
July 29, 2021: International Journal of Gynaecology and Obstetrics
Jennifer M Yeh, Kathryn P Lowry, Clyde B Schechter, Lisa R Diller, Grace O'Brien, Oguzhan Alagoz, Gregory T Armstrong, John M Hampton, Melissa M Hudson, Wendy Leisenring, Qi Liu, Jeanne S Mandelblatt, Diana L Miglioretti, Chaya S Moskowitz, Paul C Nathan, Joseph P Neglia, Kevin C Oeffinger, Amy Trentham-Dietz, Natasha K Stout
BACKGROUND: Early initiation of breast cancer screening is recommended for high-risk women, including survivors of childhood cancer treated with chest radiation. Recent studies suggest that female survivors of childhood leukemia or sarcoma treated without chest radiation are also at elevated early onset breast cancer risk. However, the potential clinical benefits and cost-effectiveness of early breast cancer screening among these women are uncertain. METHODS: Using data from the Childhood Cancer Survivor Study, we adapted two Cancer Intervention and Surveillance Modeling Network (CISNET) breast cancer simulation models to reflect the elevated risks of breast cancer and competing mortality among leukemia and sarcoma survivors...
July 29, 2021: Journal of the National Cancer Institute
Kahsu Gebrekidan, Helen Hall, Virginia Plummer, Ensieh Fooladi
BACKGROUND: Exclusive Breastfeeding (EBF) can prevent up to 13% of under-five mortality in developing countries. In Sub-Saharan Africa the rate of EBF at six months remains very low at 36%. Different types of factors such as maternal, family and work-related factors are responsible for the low rate of EBF among employed women. This study aimed to assess the prevalence of EBF continuation and associated factors among employed women in North Ethiopia. MATERIALS AND METHODS: A community-based, cross-sectional study was conducted in two towns of Tigray region, North Ethiopia...
2021: PloS One
Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
BACKGROUND: Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index (FMI), fat-free mass index (FFMI), and height with cancer risk. METHODS AND FINDINGS: Single nucleotide polymorphisms (SNPs) were used as instrumental variables for BMI (312 SNPs), FMI (577 SNPs), FFMI (577 SNPs), and height (293 SNPs). Associations of the genetic variants with 22 site-specific cancers and overall cancer were estimated in 367,561 individuals from the UK Biobank (UKBB) and with lung, breast, ovarian, uterine, and prostate cancer in large international consortia...
July 2021: PLoS Medicine
Shaolei Lu, Evgeny Yakirevich, Dongfang Yang, Ying Xiao, Li Juan Wang, Yihong Wang
Confirming the tumor origin is often a diagnostic challenge in pathology and carries significant therapeutic impacts. Cytokeratin 7, estrogen receptor, and GATA binding protein 3 (GATA3) are well-established diagnostic markers frequently used to support a tumor's breast origin. However, their specificities still have room to improve. Many nonbreast tumors express cytokeratin 7 and estrogen receptor, and urothelial tumors frequently express GATA3. There is a practical need for a new breast lineage marker that is sensitive and specific...
July 29, 2021: American Journal of Surgical Pathology
Chuan Chen, Giijs A G M Hendriks, Stein Fekkes, Ritse Mann, Jan Menssen, Carmen C N Siebers, Chris Leendert De Korte, H H G Hansen
The introduction of ultrafast ultrasound and spatiotemporal filtering has significantly improved the sensitivity of Doppler ultrasound imaging. This work describes the development of a novel 3D power Doppler imaging technique which uses a 1D-array ultrasound probe that mechanically translates at a constant speed. The continuous translation allows for a fast scan of a large 3D volume without requiring complex hardware. The technique was realized in a prototype and its feasibility illustrated using phantom and in-vivo kidney and breast lesion experiments...
July 29, 2021: IEEE Transactions on Bio-medical Engineering
Harold J Burstein, Mark R Somerfield, Debra L Barton, Ali Dorris, Lesley J Fallowfield, Dharamvir Jain, Stephen R D Johnston, Larissa A Korde, Jennifer K Litton, Erin R Macrae, Lindsay L Peterson, Praveen Vikas, Rachel L Yung, Hope S Rugo
PURPOSE: To update recommendations of the ASCO systemic therapy for hormone receptor (HR)-positive metastatic breast cancer (MBC) guideline. METHODS: An Expert Panel conducted a systematic review to identify new, potentially practice-changing data. RESULTS: Fifty-one articles met eligibility criteria and form the evidentiary basis for the recommendations. RECOMMENDATIONS: Alpelisib in combination with endocrine therapy (ET) should be offered to postmenopausal patients, and to male patients, with HR-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA -mutated, ABC, or MBC following prior endocrine therapy with or without a cyclin-dependent kinase (CDK) 4/6 inhibitor...
July 29, 2021: Journal of Clinical Oncology
Beverly Moy, R Bryan Rumble, Steven E Come, Nancy E Davidson, Angelo Di Leo, Julie R Gralow, Gabriel N Hortobagyi, Douglas Yee, Ian E Smith, Mariana Chavez-MacGregor, Rita Nanda, Heather L McArthur, Laura Spring, Katherine E Reeder-Hayes, Kathryn J Ruddy, Paul S Unger, Shaveta Vinayak, William J Irvin, Avan Armaghani, Michael A Danso, Natalie Dickson, Sophie S Turner, Cheryl L Perkins, Lisa A Carey
PURPOSE: This guideline updates recommendations of the ASCO guideline on chemotherapy and targeted therapy for patients with human epidermal growth factor receptor 2-negative metastatic breast cancer (MBC) that is either endocrine-pretreated or hormone receptor (HR)-negative. METHODS: An Expert Panel conducted a targeted systematic literature review guided by a signals approach to identify new, potentially practice-changing data that might translate into revised guideline recommendations...
July 29, 2021: Journal of Clinical Oncology
Sahar Ibrahim, Cathy Lan, Catherine Chabot, Georgia Mitsa, Marguerite Buchanan, Adriana Aguilar-Mahecha, Mounib Elchebly, Oliver Poetz, Alan Spatz, Mark Basik, Gerald Batist, René P Zahedi, Christoph H Borchers
The tumor suppressor PTEN is the main negative regulator of PI3K/AKT/mTOR signaling and is commonly found downregulated in breast cancer (BC). Conflicting data from conventional immunoassays such as immunohistochemistry (IHC) has sparked controversy about PTEN's role as a prognostic and predictive biomarker in BC, which can be largely attributed to the lack of specificity, sensitivity, and interlaboratory standardization. Here, we present a fully standardized, highly sensitive, robust microflow immuno-MRM (iMRM) assay that enables precise quantitation of PTEN concentrations in cells and fresh frozen (FF) and formalin-fixed paraffin-embedded (FFPE) tissues, down to 0...
July 29, 2021: Analytical Chemistry
Yong Zhou, Guoxi Ma, Shijun Peng, Min Tuo, Yinmou Li, Xianxiong Qin, Qiang Yu, Sijie Kuang, Hong Cheng, Jing Li
BACKGROUND: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a high incidence of local recurrence and metastasis. Circular RNAs (circRNAs) are implicated in the pathomechanism of TNBC. Here, we investigated the function of circ_0000520 in TNBC and its associated mechanism. METHODS: Reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blot assay were used to measure RNA and protein expression...
July 29, 2021: Thoracic Cancer
Mahsa Ebrahimi, Maryam Teimouri, Mehdi Pooladi
Breast cancer is among the leading causes of death due to cancers around the globe. Current therapeutic approaches towards healing of breast cancer have been associated with poor outcomes. Graphene and its derivatives have a two-dimensional flat structure, which is characterized by the ability to carry drugs and modify the surface, low cytotoxicity, and high biocompatibility. This study was performed on MCF7 and BT474 human breast cancer cells. Different concentrations of doxorubicin (DOX), graphene oxide (GO), and graphene oxide plus doxorubicin (GO-DOX) were subjected to both cell lines at specified intervals...
July 29, 2021: Applied Biochemistry and Biotechnology
Mahasti Saghatchian, Benjamin Lacas, Cécile Charles, Amal Ghouadni, Gabrielle Tergemina Clain, Diane Boinon, Suzette Delaloge, Ines Vaz-Luis, Sarah Dauchy, Philippe Amiel
PURPOSE: Beauty care (BTC) is offered at many cancer hospitals having a great uptake among patients. Nevertheless, its benefits in the Quality of life (QoL) of cancer survivors have not been assessed so far. METHODS: Our study aims to determine whether BTC improves patients' QoL related to their body image measured by the BRBI scale of the QLQ-BR23 questionnaire at the end of adjuvant chemotherapy, after breast cancer (BC) surgery. The BEAUTY study is a prospective, randomized, controlled intervention trial...
July 29, 2021: Quality of Life Research
Lan Wang, Jueheng Wu, Jie Yuan, Xun Zhu, Hongmei Wu, Mengfeng Li
No abstract text is available yet for this article.
July 19, 2021: Frontiers of Medicine
Naveen Kumar, Masoom Raza, Seema Sehrawat
Despite the existing therapies and lack of receptors such as HER-2, estrogen receptor and progesterone receptor, triple-negative breast cancer is one of the most aggressive subtypes of breast cancer. TNBCs are known for their highly aggressive metastatic behavior and typically migrate to brain and bone for secondary site propagation. Many diseases share similar molecular pathology exposing new avenues in molecular signaling for engendering innovative therapies. Generation of newer therapies and novel drugs are time consuming associated with very high resources...
July 29, 2021: Molecular and Cellular Biochemistry
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