keyword
https://read.qxmd.com/read/38537211/68ga-dota-iba-uptake-in-breast-cancer
#1
JOURNAL ARTICLE
Feifan Xiang, Huipan Liu, Xiaoqi Tan, Yue Chen
A 77-year-old woman with recently diagnosed breast cancer underwent 68Ga-labeled DOTA-ibandronic acid (68Ga-DOTA-IBA) PET/CT scan for the evaluation of bone metastases. The examination revealed increased tracer uptake, indicating that the cervical vertebrae presented osteoblastic metastasis. Interestingly, the breast cancer also showed enhanced activity of 68Ga-DOTA-IBA.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537210/treatment-of-bone-metastases-of-breast-cancer-with-177lu-dota-iba
#2
JOURNAL ARTICLE
Jia Deng, Jian Yang, Zixuan Cheng, Yue Chen
Bone metastasis of breast cancer often presents as osteolytic. 177Lu-DOTA-ibandronic acid (177Lu-DOTA-IBA) is a new radioactive drug for bone metastasis lesion. We report a case of recurrent intermittent pain due to bone metastasis, who demonstrated a satisfactory therapy response after 2 cycles of 177Lu-DOTA-IBA. In addition, the patient did not have any observable adverse effects.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537181/comparison-between-combined-ultrasounds-and-magnetic-resonance-imaging-in-the-differentiation-of-benign-and-malignant-breast-lesions-a-cross-sectional-study
#3
JOURNAL ARTICLE
Chaoxi Li, Dehui Wen, Haiyong Lu
AIM: To explore the performance of single or combined ultrasound (US) in diagnosing malignant breast lesions, and then compare the results with a magnetic resonance imaging (MRI) aspect. MATERIAL AND METHODS: Patients' demographics, tumor markers, and imaging examination were collected. Diagnostic models based on B-mode, color Doppler ultrasounds (CDU), strain elastography (SE), MRI, B-mode US + CDU, B-mode US + SE, and B-mode US + CDU + SE were developed using logistic regression analysis...
February 13, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537158/impact-of-broadening-trial-eligibility-criteria-on-the-inclusion-of-patients-with-brain-metastases-in-cancer-clinical-trials-time-series-analyses-for-2012-2022
#4
JOURNAL ARTICLE
Hong Xiao, Riha Vaidya, Dawn L Hershman, Joseph M Unger
PURPOSE: In October 2017, an ASCO, Friends of Cancer Research (FoCR), and US Food and Drug Administration (ASCO/FoCR/FDA) task force recommended that common eligibility criteria be modified to make trials more inclusive. We examined whether patterns of exclusions regarding patients with brain metastases changed over time in relation to these recommendations. METHODS: Trial eligibility criteria were abstracted from ClinicalTrials.gov for phase I-III US-based interventional clinical trials for patients with advanced breast, colorectal, lung, or melanoma cancers from January 2012 to December 2022...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38537156/female-specific-health-care-of-military-female-designated-service-members-and-veterans-a-systematic-overview-of-reviews
#5
JOURNAL ARTICLE
Megan C McDermott, Megan G Musilli, Jill E Brown, John L Melton, Michael J Miller, Rhonda J Allard, Monica A Lutgendorf
INTRODUCTION: Since the War in Afghanistan began in 2001, service members have faced significant health effects related to service during war, with female-designated service members facing unique challenges. Numerous high-quality review articles have been published on the health and care of female-designated service members and veterans. Given the increasing volume of literature, we completed an overview of reviews on the health and health care of female-designated military populations...
March 27, 2024: Military Medicine
https://read.qxmd.com/read/38537155/giredestrant-for-estrogen-receptor-positive-her2-negative-previously-treated-advanced-breast-cancer-results-from-the-randomized-phase-ii-acelera-breast-cancer-study
#6
JOURNAL ARTICLE
Miguel Martín, Elgene Lim, Mariana Chavez-MacGregor, Aditya Bardia, Jiong Wu, Qingyuan Zhang, Zbigniew Nowecki, Felipe Melo Cruz, Rustem Safin, Sung-Bae Kim, Christian Schem, Alberto J Montero, Sarah Khan, Reeti Bandyopadhyay, Heather M Moore, Mahesh Shivhare, Monika Patre, Jorge Martinalbo, Laura Roncoroni, Pablo Diego Pérez-Moreno, Joohyuk Sohn
PURPOSE: To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor-positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455). METHODS: Post-/pre-/perimenopausal women, or men, age 18 years or older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines of systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly assigned 1:1 to giredestrant (30 mg oral once daily) or fulvestrant/aromatase inhibitor per local guidelines (+luteinizing hormone-releasing hormone agonist in pre-/perimenopausal women, and men) until disease progression/unacceptable toxicity...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38536971/quality-of-life-of-women-who-underwent-breast-cancer-treatment-relative-to-sociodemographic-behavioral-and-clinical-factors
#7
JOURNAL ARTICLE
Angélica Atala Lombelo Campos, Maria Teresa Bustamante-Teixeira, Rafaela Russi Ervilha, Vivian Assis Fayer, Jane Rocha Duarte Cintra, Renata Mendes de Freitas, Daniela Pereira de Almeida, Maximiliano Ribeiro Guerra
OBJECTIVE: Patients with cancer often undergo multiple extended treatments that decrease their quality of life. However, the quality of life of women with breast cancer after they undergo treatment remains underexplored in Brazil. Therefore, this study determined sociodemographic, behavioral, and clinical factors related to the post-treatment quality of life of women with breast cancer. METHODS: This cross-sectional study involved 101 women diagnosed with breast cancer between 2014 and 2016 and treated at a Brazilian Oncology Reference Service...
2024: Einstein
https://read.qxmd.com/read/38536949/combination-nano-delivery-systems-remodel-the-immunosuppressive-tumor-microenvironment-for-metastatic-triple-negative-breast-cancer-therapy
#8
JOURNAL ARTICLE
Liya Bai, Hui Liu, Ran You, Xiaoyu Jiang, Tao Zhang, Yunan Li, Tianhe Shan, Zhanyin Qian, Yinsong Wang, Yuanyuan Liu, Chunyu Li
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer for which effective therapies are lacking. Targeted remodeling of the immunosuppressive tumor microenvironment (TME) and activation of the body's immune system to fight tumors with well-designed nanoparticles have emerged as pivotal breakthroughs in tumor treatment. To simultaneously remodel the immunosuppressive TME and trigger immune responses, we designed two potential therapeutic nanodelivery systems to inhibit TNBC. First, the bromodomain-containing protein 4 (BRD4) inhibitor JQ1 and the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CXB) were coloaded into chondroitin sulfate (CS) to obtain CS@JQ1/CXB nanoparticles (NPs)...
March 27, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38536943/highly-accurate-profiling-of-exosome-phenotypes-using-super-resolution-tricolor-fluorescence-co-localization
#9
JOURNAL ARTICLE
Jinxiu Wei, Kai Zhu, Tingyu Wang, Tongsheng Qi, Zhuyuan Wang, Jia Li, Shenfei Zong, Yiping Cui
Exosomes contain a wealth of proteomic information, presenting promising biomarkers for the noninvasive early diagnosis of diseases, especially cancer. However, it remains a great challenge to accurately and reliably distinguish exosomes secreted from different types of cell lines. Fluorescence immunoassay is frequently used for exosome detection. Nonspecific adsorption in immunoassays is unavoidable and affects the reliability of assay results. Despite the fact that various methods have been proposed to reduce nonspecific adsorption, a more effective method that can eliminate the influence of nonspecific adsorption is still lacking...
March 27, 2024: ACS Nano
https://read.qxmd.com/read/38536933/impact-of-type-2-diabetes-on-complications-after-primary-breast-cancer-surgery-danish-population-based-cohort-study
#10
JOURNAL ARTICLE
Kasper Kjærgaard, Jannik Wheler, Looket Dihge, Peer Christiansen, Signe Borgquist, Deirdre Cronin-Fenton
BACKGROUND: Knowledge is sparse on the impact of type 2 diabetes (T2D) on surgical outcomes after breast cancer surgery. This study investigated the association between T2D and risk of complications after primary breast cancer surgery, and evaluated the biological interaction between T2D and co-morbidities. METHODS: Using the Danish Breast Cancer Group clinical database, a cohort of all Danish women diagnosed with early-stage breast cancer during 1996-2022 was created...
March 2, 2024: British Journal of Surgery
https://read.qxmd.com/read/38536816/iqgap1-and-nwasp-promote-human-cancer-cell-dissemination-and-metastasis-by-regulating-%C3%AE-1-integrin-via-fak-and-mrtf-srf
#11
JOURNAL ARTICLE
Camilla Cerutti, Serena Lucotti, Sofia T Menendez, Nicolas Reymond, Ritu Garg, Ignacio A Romero, Ruth Muschel, Anne J Ridley
Attachment of circulating tumor cells to the endothelial cells (ECs) lining blood vessels is a critical step in cancer metastatic colonization, which leads to metastatic outgrowth. Breast and prostate cancers are common malignancies in women and men, respectively. Here, we observe that β1-integrin is required for human prostate and breast cancer cell adhesion to ECs under shear-stress conditions in vitro and to lung blood vessel ECs in vivo. We identify IQGAP1 and neural Wiskott-Aldrich syndrome protein (NWASP) as regulators of β1-integrin transcription and protein expression in prostate and breast cancer cells...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38536799/pubertal-timing-a-life-course-pathway-linking-early-life-risk-to-adulthood-cardiometabolic-health
#12
JOURNAL ARTICLE
Maria E Bleil, Bradley M Appelhans, Steven E Gregorich, Robert A Hiatt, Glenn I Roisman, Cathryn Booth-LaForce
OBJECTIVE: To evaluate a series of prospective life course models testing whether the timing of pubertal development is a pathway through which prepubertal risk factors may influence adulthood cardiometabolic health. METHODS: Subjects were 655 female participants in the NICHD Study of Early Child Care and Youth Development (SECCYD) and recent SECCYD 30-year follow-up, the Study of Health in Early and Adult Life (SHINE). Prepubertal risk factors included maternal menarcheal age, child race/ethnicity, child health status indicators, and child adversity indicators...
2024: PloS One
https://read.qxmd.com/read/38536720/exploration-of-drug-resistance-mechanisms-in-triple-negative-breast-cancer-cells-using-a-microfluidic-device-and-patient-tissues
#13
JOURNAL ARTICLE
Wanyoung Lim, Inwoo Hwang, Jiande Zhang, Zhenzhong Chen, Jeonghun Han, Jaehyung Jeon, Bon-Kyoung Koo, Sangmin Kim, Jeong Eon Lee, Youngkwan Kim, Kenneth J Pienta, Sarah R Amend, Robert H Austin, Jee-Yin Ahn, Sungsu Park
Chemoresistance is a major cause of treatment failure in many cancers. However, the life cycle of cancer cells as they respond to and survive environmental and therapeutic stress is understudied. In this study, we utilized a microfluidic device to induce the development of doxorubicin-resistant (DOXR) cells from triple negative breast cancer (TNBC) cells within 11 days by generating gradients of DOX and medium. In vivo chemoresistant xenograft models, an unbiased genome-wide transcriptome analysis, and a patient data/tissue analysis all showed that chemoresistance arose from failed epigenetic control of the nuclear protein-1 (NUPR1)/histone deacetylase 11 (HDAC11) axis, and high NUPR1 expression correlated with poor clinical outcomes...
March 27, 2024: ELife
https://read.qxmd.com/read/38536613/identification-of-a-clinical-spirometra-mansoni-plerocercoid-isolate-using-molecular-and-morphological-data
#14
JOURNAL ARTICLE
Si Si Ru, Chi Cheng, Peng Jiang, Xi Zhang
Sparganosis has been a neglected parasitic zoonosis for a long time. The accurate identification of Spirometra tapeworms in clinical practice is poorly understood. A case of breast sparganosis was reported in Henan Province of central China. One plerocercoid approximately 3.5 cm in length was collected from the patient. The clinical isolate was identified as Spirometra mansoni based on the barcoding sequences of mitochondrial cytochrome c oxidase subunit 1 (cox1). Finally, the epidemiology of sparganosis in central China was reviewed...
March 27, 2024: Acta Parasitologica
https://read.qxmd.com/read/38536588/image-quality-enhancement-for-digital-breast-tomosynthesis-high-density-object-artifact-reduction
#15
JOURNAL ARTICLE
Enxiang Shen, Caozhe Li, Kanglian Zhao, Jie Yuan, Paul Carson
Breast cancer has a high incidence and mortality rate among women, early diagnosis is essential as it gives insight regarding the most appropriate therapeutic strategy for each case. Among all imaging diagnostic methods, digital breast tomosynthesis (DBT) is effective for early breast cancer detection. In DBT images, high-density object artifacts are generated when imaging objects with high X-ray absorptivity, which include metal artifacts, ripple artifacts, and deformation artifacts. In this study, we analyze the causes of these artifacts and propose a set of high-density object reconstruction methods based on iterative algorithms...
March 27, 2024: J Imaging Inform Med
https://read.qxmd.com/read/38536577/can-artificial-intelligence-detect-type-2-diabetes-in-women-by-evaluating-the-pectoral-muscle-on-tomosynthesis-diagnostic-study
#16
JOURNAL ARTICLE
Meltem M Yashar, Ilayda Begum Izci, Fatma Zeynep Gungoren, Abdulkadir A Eren, Ali A Mert, Irmak I Durur-Subasi
OBJECTIVES: This retrospective single-center analysis aimed to evaluate whether artificial intelligence can detect type 2 diabetes mellitus by evaluating the pectoral muscle on digital breast tomosynthesis (DBT). MATERIAL METHOD: An analysis of 11,594 DBT images of 287 consecutive female patients (mean age 60, range 40-77 years) was conducted using convolutional neural networks (EfficientNetB5). The inclusion criterion was left-sided screening images with unsuspicious interpretation who also had a current glycosylated hemoglobin A1c (HBA1c) % value...
March 27, 2024: Insights Into Imaging
https://read.qxmd.com/read/38536575/ethnic-inequities-in-use-of-breast-conserving-surgery-and-radiation-therapy-in-aotearoa-new-zealand-which-factors-contribute
#17
JOURNAL ARTICLE
Leah Boyle, Ross Lawrenson, Vili Nosa, Ian Campbell, Sandar Tin Tin
PURPOSE: Aotearoa/New Zealand (NZ) faces ethnic inequities with respect to breast cancer survival and treatment. This study establishes if there are ethnic differences in (i) type of surgery and (ii) receipt of radiotherapy (RT) following breast conserving surgery (BCS), among women with early-stage breast cancer in NZ. METHODS: This analysis used Te Rēhita Mata Ūtaetae (Breast Cancer Foundation National Register), a prospectively maintained database of breast cancers from 2000 to 2020...
March 27, 2024: Breast Cancer Research and Treatment
https://read.qxmd.com/read/38536544/the-suppression-of-cell-motility-through-the-reduction-of-fak-activity-and-expression-of-cell-adhesion-proteins-by-hamscs-secretome-in-mda-mb-231-breast-cancer-cells
#18
JOURNAL ARTICLE
Fatemeh Safari, Setareh Bararpour, Fatemeh Omidi Chomachaei
Breast cancer is a leading cause of death in women worldwide. Cancer therapy based on stem cells is considered as a novel and promising platform. In the present study, we explore the therapeutic effects of human amniotic mesenchymal stromal cells (hAMSCs) through the reduction of focal adhesion kinase (FAK) activity, SHP-2, and cell adhesion proteins such as Paxillin, Vinculin, Fibronectin, Talin, and integrin αvβ3 expression in MDA-MB-231 breast cancer cells. For this purpose, we employed a co-culture system using 6-well plate transwell...
March 27, 2024: Investigational New Drugs
https://read.qxmd.com/read/38536530/the-paradox-of-mri-for-breast-cancer-screening-high-risk-and-dense-breasts-available-evidence-and-current-practice
#19
REVIEW
Francesco Sardanelli, Veronica Magni, Gabriele Rossini, Fleur Kilburn-Toppin, Nuala A Healy, Fiona J Gilbert
In the mid-1990s, the identification of BRCA1/2 genes for breast cancer susceptibility led to testing breast MRI accuracy in screening women at increased risk. From 2000 onwards, ten intraindividual comparative studies showed the marked superiority of MRI: the sensitivity ranged 25-58% for mammography, 33-52% for ultrasound, 48-67% for mammography plus ultrasound, and 71-100% for MRI; specificity 93-100%, 91-98%, 89-98%, and 81-98%, respectively. Based on the available evidence, in 2006-2007, the UK National Institute for Clinical Excellence and the American Cancer Society recommended MRI screening of high-risk women, followed by other international guidelines...
March 27, 2024: Insights Into Imaging
https://read.qxmd.com/read/38536511/repeatability-of-18-f-fdg-uptake-in-metastatic-bone-lesions-of-breast-cancer-patients-and-implications-for-accrual-to-clinical-trials
#20
JOURNAL ARTICLE
Mark Muzi, Lanell M Peterson, Jennifer M Specht, Daniel S Hippe, Alena Novakova-Jiresova, Jean H Lee, Brenda F Kurland, David A Mankoff, Nancy Obuchowski, Hannah M Linden, Paul E Kinahan
BACKGROUND: Standard measures of response such as Response Evaluation Criteria in Solid Tumors are ineffective for bone lesions, often making breast cancer patients that have bone-dominant metastases ineligible for clinical trials with potentially helpful therapies. In this study we prospectively evaluated the test-retest uptake variability of 2-deoxy-2-[18F]fluoro-D-glucose (18 F-FDG) in a cohort of breast cancer patients with bone-dominant metastases to determine response criteria. The thresholds for 95% specificity of change versus no-change were then applied to a second cohort of breast cancer patients with bone-dominant metastases...
March 27, 2024: EJNMMI Research
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