Isabel Blancas, Francisco J Martín-Pérez, José M Garrido, Fernando Rodríguez-Serrano
BACKGROUND: Trastuzumab is a drug used in HER2-positive breast cancer that increases patient survival. Due to cardiotoxicity is the most important side effect of trastuzumab treatment, cardiac monitoring should be a priority. The purpose of this study is to evaluate plasma NT-proBNP level and major cardiovascular risk factors as possible early predictors of trastuzumab-induced cardiotoxicity in HER2-positive breast cancer patients. METHODS: We conducted a retrospective observational study involving 66 patients with HER2-positive breast cancer treated with trastuzumab...
September 11, 2020: Breast: Official Journal of the European Society of Mastology
Min Yang, Fang Lu, Tingting Zhou, Jianjun Zhao, Chuanbo Ding, Ali Fakhri, Vinod Kumar Gupta
In this project, silver‑platinum (AgPt) nanoparticles were prepared by using the Crocus sativus L. plant ethanolic extract. The AgPt nanoparticles were characterized by applying the various method as ultraviolet-visible and infrared spectroscopy, electron microscopy, and X-ray diffraction analysis. The morphology structural indicated that the AgPt nanoparticles were spherical particles with diameter about 36.0 nm. The FTIR spectroscopy shows the efficient stabilization of the AgPt nanoparticles by phytoconstituents...
September 12, 2020: Journal of Photochemistry and Photobiology. B, Biology
Leila Kashefi-Kheyrabadi, Junmoo Kim, Sudesna Chakravarty, Sunyoung Park, Hogyeong Gwak, Seung-Il Kim, Mohsen Mohammadniaei, Min-Ho Lee, Kyung-A Hyun, Hyo-Il Jung
The quantification of cancer-derived exosomes has a strong potential for minimally invasive diagnosis of cancer during its initial stage. As cancerous exosomes form a small fraction of all the exosomes present in blood, ultra-sensitive detection is a prerequisite for the development of exosome-based cancer diagnostics. Herein, a detachable microfluidic device implemented with an electrochemical aptasensor (DeMEA) is introduced for highly sensitive and in-situ quantification of cancerous exosomes. To fabricate the aptasensor, a nanocomposite was applied on the electrode surface followed by electroplating of gold nanostructures...
September 17, 2020: Biosensors & Bioelectronics
Mehdi Mohebi, Ali Sattari, Soudeh Ghafouri-Fard, Mohammad Hossein Modarressi, Vahid Kholghi-Oskooei, Mohammad Taheri
Long non-coding RNAs (lncRNAs) have been vastly investigated for their critical roles in the pathogenesis of breast cancer. Yet, the expression pattern and clinical significance of three lncRNAs namely CTBP1AS2, LINC-ROR and SPRY4-IT1 in breast cancer are not completely clarified. In the present investigation, we assessed expression of these lncRNAs in breast cancer tissues and paired non-cancerous specimens from the same patients using quantitative real time PCR. Notably, expression of CTBP1AS2, LINC-ROR and SPRY4-IT1 were upregulated in breast cancer tissues compared with non-cancerous tissues (ER = 17...
September 22, 2020: Experimental and Molecular Pathology
Susana Ros, Alan J Wright, Paula D'Santos, De-En Hu, Richard L Hesketh, Yaniv Lubling, Dimitra Georgopoulou, Giulia Lerda, Dominique-Laurent Couturier, Pedram Razavi, Rapahel Pelossof, Ankita S Batra, Elizabeth Mannion, David Y Lewis, Alistair Martin, Richard D Baird, Mafalda Oliveira, Leonora W de Boo, Sabine C Linn, Maurizio Scaltriti, Oscar M Rueda, Alejandra Bruna, Carlos Caldas, Kevin M Brindle
PIK3CA, encoding the PI3Kα isoform, is the most frequently mutated oncogene in estrogen receptor (ER)-positive breast cancer. Isoform-selective PI3K inhibitors are used clinically but intrinsic and acquired resistance limits their utility. Improved selection of patients that will benefit from these drugs requires predictive biomarkers. We show here that persistent FOXM1 expression following drug treatment is a biomarker of resistance to PI3Kα inhibition in ER+ breast cancer. FOXM1 drives expression of lactate dehydrogenase (LDH) but not hexokinase 2 (HK-II)...
September 14, 2020: Cancer Cell
Wenli Jiang, Youlutuziayi Rixiati, Hao Huang, YiJun Shi, Caiguo Huang, Binghua Jiao
BACKGROUND: Breast cancer is the leading cause of death among women with malignant tumors worldwide. Bone metastasis is the main factor affecting the prognosis of breast cancer. Therefore, both antitumor and anti-breast-cancer-induced osteolysis agents are urgently needed. METHODS: We examined the effect of Asperolide A (AA), a marine-derived agent, on osteolysis and RANKL-induced phosphoinositide 3-kinase (PI3K)/AKT/mTOR/c-FOS/nuclear factor-activated T cell 1 (NFATc1) pathway activation, F-actin ring formation, and reactive oxygen species (ROS) generation in vitro...
September 25, 2020: Cancer Medicine
Hisano Yanagi, Takashi Watanabe, Tatsunori Nishimura, Takanori Hayashi, Seishi Kono, Hitomi Tsuchida, Munetsugu Hirata, Yuko Kijima, Shintaro Takao, Seiji Okada, Motoshi Suzuki, Kazuyoshi Imaizumi, Kenji Kawada, Hironobu Minami, Noriko Gotoh, Yohei Shimono
Metastatic progression remains the major cause of death in human breast cancer. Cancer cells with cancer stem cell (CSC) properties drive initiation and growth of metastases at distant sites. We have previously established the breast cancer patient-derived tumor xenograft (PDX) mouse model in which CSC marker CD44+ cancer cells formed spontaneous microscopic metastases in the liver. In this PDX mouse, the expression levels of S100A10 and its family proteins were much higher in the CD44+ cancer cells metastasized to the liver than those at the primary site...
September 25, 2020: Cancer Science
Jakob Weitzer, Gemma Castaño-Vinyals, Nuria Aragonés, Inés Gómez-Acebo, Marcela Guevara, Pilar Amiano, Vicente Martín, Ana Molina-Barceló, Juan Alguacil, Victor Moreno, Claudia Suarez-Calleja, José Juan Jiménez-Moleón, Rafael Marcos-Gragera, Kyriaki Papantoniou, Beatriz Pérez-Gómez, Javier Llorca, Nieves Ascunce, Leire Gil, Esther Gracia-Lavedan, Delphine Casabonne, Virginia Lope, Marina Pollán, Manolis Kogevinas
Experimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population-based case-control study (MCC-Spain) if the time-of-day when physical activity is done affects prostate and breast cancer risk. Lifetime recreational and household physical activity was assessed by in-person interviews. Information on time-of-day of activity (assessed approximately 3 years after the assessment of lifetime physical activity and confounders) was available for 781 breast cancer cases, 865 population female controls, 504 prostate cases and 645 population male controls from 10 Spanish regions, 2008-2013...
September 25, 2020: International Journal of Cancer. Journal International du Cancer
Jue-Sheng Ong, Eske M Derks, Mikael Eriksson, Jiyuan An, Liang-Dar Hwang, Douglas F Easton, Paul P Pharoah, Andrew Berchuck, Linda E Kelemen, Keitaro Matsuo, Georgia Chenevix-Trench, Per Hall, Stig E Bojesen, Penelope M Webb, Stuart MacGregor
Alcohol consumption is correlated positively with risk for breast cancer in observational studies, but observational studies are subject to reverse causation and confounding. The association with epithelial ovarian cancer (EOC) is unclear. We performed both observational Cox-regression and two-sample Mendelian randomization (MR) analyses using data from various European cohort studies (observational) and publicly available cancer consortia (MR). These estimates were compared with World Cancer Research Fund (WCRF) findings...
September 25, 2020: International Journal of Cancer. Journal International du Cancer
Pui San Tan, Maya Alsheh Ali, Mikael Eriksson, Per Hall, Keith Humphreys, Kamila Czene
Current breast cancer risk models identify mostly less aggressive tumors, although only women developing fatal breast cancer will greatly benefit from early identification. Here, we evaluated the use of mammography features (microcalcification clusters, cBIRADS density, and lack of breast density reduction) as early markers of aggressive subtypes and tumor characteristics. Mammograms were retrieved from a population-based cohort of women that were diagnosed with breast cancer from 2001-2008 in Stockholm-Gotland County, Sweden...
September 25, 2020: International Journal of Cancer. Journal International du Cancer
Derrick J Y Tan, Fernaldo Richtia Winnerdy, Kah Wai Lim, Anh Tuân Phan
The triple-negative breast cancer (TNBC), a subtype of breast cancer which lacks of targeted therapies, exhibits a poor prognosis. It was shown recently that the PIM1 oncogene is highly related to the proliferation of TNBC cells. A quadruplex-duplex hybrid (QDH) forming sequence was recently found to exist near the transcription start site of PIM1. This structure could be an attractive target for regulation of the PIM1 gene expression and thus the treatment of TNBC. Here, we present the solution structures of two QDHs that could coexist in the human PIM1 gene...
September 25, 2020: Nucleic Acids Research
Priya M Mathews, Susan A Robinson, Anisa Gire, Alan N Baer, Esen K Akpek
PURPOSE: To report the significance of extraglandular ocular involvement and long-term systemic morbidity and mortality in primary Sjögren's Syndrome (SS). METHODS: This retrospective, longitudinal cohort study included consecutive patients with primary SS evaluated at a tertiary referral center. An electronic chart review was performed and all available data were extracted from clinic visits between October 1999 and March 2019. The primary outcome measures included occurrence of extraglandular ocular manifestations of SS, serological markers, prevalence of malignancy, and incidence of death...
2020: PloS One
(no author information available yet)
No abstract text is available yet for this article.
October 2020: Nursing
Lokesh Basavarajappa, Girdhari Rijal, Kenneth Hoyt
Focused ultrasound (FUS) exposure of microbubble (MB) contrast agents can transiently increase microvascular permeability allowing anticancer drugs to extravasate into a targeted tumor tissue. Either fixed or mechanically steered in space, most studies to date have used a single element focused transducer to deliver the ultrasound (US) energy. The goal of this study was to investigate various multi-FUS strategies implemented on a programmable US scanner (Vantage 256, Verasonics Inc) equipped with a linear array for image guidance and a 128-element therapy transducer (HIFUPlex-06, Sonic Concepts)...
September 25, 2020: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Tânia Brandão
This review aims to identify, summarise and critically evaluate studies that examined moderators or mediators of the relationship between social constraints and cancer adjustment. A database search was conducted to identify eligible studies published between inception and November 2019. A narrative synthesis of the included studies was conducted. We identified 18 papers, comprising 6933 participants (Mage = 55.70) with different types of cancer (mainly breast cancer). All of the studies used the Social Constraints Scale...
September 25, 2020: Psychology, Health & Medicine
Yang Liu, Qian Du, Dan Sun, Ruiying Han, Mengmeng Teng, Siying Chen, Haisheng You, Yalin Dong
Breast cancer is one of the leading causes of cancer-related deaths in women worldwide. Unfortunately, treatments often fail because of the development of drug resistance, the underlying mechanisms of which remain unclear. Circulating tumor DNA (ctDNA) is free DNA released into the blood by necrosis, apoptosis or direct secretion by tumor cells. In contrast to repeated, highly invasive tumor biopsies, ctDNA reflects all molecular alterations of tumors dynamically and captures both spatial and temporal tumor heterogeneity...
September 25, 2020: Future Oncology
Joleen Kirsty Eden, Rita Borgen
OBJECTIVE: The study aims to explore the perceptions of Advanced Practice Radiographers (APRs) currently giving benign biopsy results to extend their role to deliver NHS Breast Screening Programme (NHSBSP) malignant outcomes. In the UK, APRs are appropriately trained to deliver results, yet traditionally have been cultured not to. Increasing pressures on NHSBSP units are a key driver for APR evolvement. A significant lack of published research provides the rationale for the study, combined with an identified service need...
September 25, 2020: British Journal of Radiology
Li-Wen Du, Hong-Li Liu, Hai-Yan Gong, Li-Jun Ling, Shui Wang, Cuiying Li, Min Zong
OBJECTIVE: To evaluate the diagnostic performance of contrast-enhanced ultrasound (CEUS) combined with conventional ultrasound (US) of axillary lymph nodes (ALNs) in predicting metastatic ALNs in patients with breast cancer. METHODS: This retrospective study included 259 patients with breast cancer who underwent conventional US and CEUS. The parameters and patterns evaluated on conventional US included short axis diameter (S), long axis/short axis (L/S) ratio, cortical thickness, resistive index (RI), lymph node (LN) morphology of grey-scale US, hilum and vascular pattern...
September 25, 2020: British Journal of Radiology
Deepti Chopra, Geoffrey Robb
No abstract text is available yet for this article.
September 25, 2020: Breast Journal
Sirkka-Liisa Lauronen, Marja-Tellervo Mäkinen, Päivi Annila, Heini Huhtala, Arvi Yli-Hankala, Maija-Liisa Kalliomäki
BACKGROUND: Inadvertent intraoperative hypothermia is a common occurrence in surgical patients. A thermal suit is an option for passive insulation. However, active warming is known to be more effective. Therefore, we hypothesised a forced-air warming unit connected to the thermal suit is superior to a commercial forced-air warming blanket and a warming mattress in breast cancer surgery. METHODS: Forty patients were randomised to this prospective, clinical trial to wear either the thermal suit or conventional hospital clothes under general anaesthesia...
September 25, 2020: Acta Anaesthesiologica Scandinavica
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