keyword
https://read.qxmd.com/read/37734127/can-newborn-infants-with-positive-hiv-soon-after-birth-be-diagnosed-with-intrauterine-infection
#1
REVIEW
Yuqian Luo, Yi-Hua Zhou, Hong Zhao
BACKGROUND: Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) can occur intrauterine, intrapartum, and postpartum. Currently, infants with confirmed positive results in virological tests before 48 h of age are defined as having intrauterine infection. AIM: We herein review the literature that identifies emerging challenges in diagnosing intrauterine HIV infection to rethink the current diagnostic criteria. FINDINGS: A number of reports have shown that some infants who were diagnosed with intrauterine HIV infection after birth became negative for HIV in the subsequent follow-ups, including negative HIV antibodies at the age of 12-18 months...
August 25, 2023: Journal of Infection and Public Health
https://read.qxmd.com/read/37734110/intra-operative-evaluation-of-textured-anatomic-implant-rotation-a-prospective-study
#2
JOURNAL ARTICLE
Cyril S Gary, Kunal M Kirloskar, Min Jung Koh, Andrew I Abadeer, Jessica S Wang, Gabriel Del Corral, Kenneth L Fan, David H Song
BACKGROUND: Textured implants were developed with the goal of reducing rates of capsular contracture and preventing implant malposition (eg., malrotation). Recent evidence has questioned whether textured implants are as resistant to malrotation as previously reported. METHODS: Women presenting to a single healthcare system for removal of textured implants were prospectively enrolled in the study from September 2019 to July of 2022. Patients who underwent removal of an anatomic, textured implant in the operating room were included in the study, while those who did not undergo implant removal, or were found to have a smooth implant, or a round, textured implant were excluded...
September 19, 2023: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/37733984/feasibility-of-symptom-monitoring-during-the-first-year-of-endocrine-therapy-for-early-breast-cancer-using-patient-reported-outcomes-collected-via-smartphone-app
#3
JOURNAL ARTICLE
Karen Lisa Smith, Hua-Ling Tsai, David Lim, Chenguang Wang, Raquel Nunes, Mary J Wilkinson, Jennifer Y Sheng, Rima Couzi, John Fetting, Carol Riley, Antonio C Wolff, Cesar A Santa-Maria, Katie Papathakis, Lauren Collins-Chase, Christie Hilton, Elissa Thorner, Amanda Montanari, Dara Ikejiani, Claire Snyder, Vered Stearns
PURPOSE: Treatment-associated symptoms drive early discontinuation of adjuvant endocrine therapy (ET) for breast cancer. We hypothesized that symptom monitoring with electronic patient-reported outcomes (ePROs) during adjuvant ET will enhance symptom detection, symptom management, and persistence. METHODS: Eligible patients were initiating ET for stage 0-III breast cancer. Participants completed ePRO surveys via smartphone at baseline and 1, 3, 6, and 12 months...
September 21, 2023: JCO oncology practice
https://read.qxmd.com/read/37733975/enhancing-efficiency-and-reach-using-facebook-to-recruit-breast-cancer-survivors-for-a-telephone-based-supportive-care-randomized-trial-during-the-covid-19-pandemic
#4
JOURNAL ARTICLE
Deborah B Ejem, Stephen Wechsler, Sarah Gallups, Sarah Khalidi, Jazmine Coffee-Dunning, Aoyjay P Montgomery, Courtney J Stevens, Kimberly Keene, Gabrielle B Rocque, Mary Chamberlin, Mark T Hegel, Andres Azuero, Maria Pisu, Daphne Ellis, Stacey A Ingram, Valerie M Lawhon, Tiffany Gilbert, Kali Morrissette, Jamme Morency, Karen Thorp, Megan Codini, Robin Newman, Jennifer Echols, Danielle Cloyd, Sarah Dos Anjos, Colleen Muse, Susan Goedeken, Kristen Elizabeth Laws, Jennae Herbert, Marie Bakitas, Kathleen D Lyons
PURPOSE: Evidence supporting social media-based recruitment of cancer survivors is limited. This paper describes how we used Facebook during the COVID-19 pandemic to augment our recruitment of breast cancer survivors for our two-site telephone-based randomized clinical trial (RCT) at Dartmouth-Hitchcock Medical Center and the University of Alabama at Birmingham. METHODS: Originally a two-site RCT of a telephone-delivered breast cancer survivorship intervention, we extended our clinic-based recruitment to Facebook...
September 21, 2023: JCO oncology practice
https://read.qxmd.com/read/37733921/azi2-mediates-tbk1-activation-at-unresolved-selective-autophagy-cargo-receptor-complexes-with-implications-for-cd8-t-cell-infiltration-in-breast-cancer
#5
JOURNAL ARTICLE
Syn Kok Yeo, Michael Haas, Kanakaraju Manupati, Mingang Hao, Fuchun Yang, Song Chen, Jun-Lin Guan
Most breast cancers do not respond to immune checkpoint inhibitors and there is an urgent need to identify novel sensitization strategies. Herein, we uncovered that activation of the TBK-IFN pathway that is mediated by the TBK1 adapter protein AZI2 is a potent strategy for this purpose. Our initial observations showed that RB1CC1 depletion leads to accumulation of AZI2, in puncta along with selective macroautophagy/autophagy cargo receptors, which are both required for TBK1 activation. Specifically, disrupting the selective autophagy function of RB1CC1 was sufficient to sustain AZI2 puncta accumulation and TBK1 activation...
September 21, 2023: Autophagy
https://read.qxmd.com/read/37733904/evaluation-of-intraoperative-breast-radiotherapy-on-local-recurrence-a-brazilian-cohort
#6
JOURNAL ARTICLE
Cintia Melo Sousa, Izabella Nobre Queiroz, Ana Paula Drummond-Lage
PURPOSE: Assess the local recurrence rate and global survival rate among women diagnosed with breast cancer who underwent intraoperative electron radiotherapy (IOERT) between 2007 and 2017, in a single private healthcare setting in Belo Horizonte, Brazil. MATERIAL AND METHODS: This is a retrospective study based on medical records about the outcomes of patients submitted to breast-conserving surgery followed by IOERT. The collected variables included the patient's profile and tumor features, IOERT isodose, and outcomes...
September 21, 2023: International Journal of Radiation Biology
https://read.qxmd.com/read/37733800/differential-benefit-of-metronomic-chemotherapy-among-triple-negative-breast-cancer-subtypes-treated-in-the-ibcsg-trial-22-00
#7
JOURNAL ARTICLE
Andrea Joaquin Garcia, Mattia Rediti, David Venet, Samira Majjaj, Roswitha Kammler, Elisabetta Munzone, Lorenzo Gianni, Beat Thürlimann, István Láng, Marco Colleoni, Sherene Loi, Giuseppe Viale, Meredith M Regan, Laurence Buisseret, Françoise Rothé, Christos Sotiriou
PURPOSE: To explore whether specific triple-negative breast cancer (TNBC) molecular subtypes are predictive for a benefit from maintenance low-dose cyclophosphamide and methotrexate (CM) in the adjuvant IBCSG 22-00 phase III clinical trial. EXPERIMENTAL DESIGN: RNA sequencing was performed on a selection of 347 TNBC FFPE tumor samples following a case-cohort-like sampling. TNBC subtypes were computed on gene expression data. The association between TNBC subtypes and treatment outcome was assessed using a Cox proportional-hazard interaction test...
September 21, 2023: Clinical Cancer Research
https://read.qxmd.com/read/37733788/near-infrared-spectral-tomography-for-predicting-residual-cancer-burden-during-early-stage-neoadjuvant-chemotherapy-for-breast-cancer
#8
JOURNAL ARTICLE
Xu Cao, Kristen E Muller, Mary D Chamberlin, Jiang Gui, Peter A Kaufman, Gary N Schwartz, Roberta M DiFlorio-Alexander, Brian W Pogue, Keith D Paulsen, Shudong Jiang
PURPOSE: The aim of this study is to investigate whether Near-Infrared Spectral Tomography (NIRST) might serve as a reliable prognostic tool to predict Residual Cancer Burden (RCB) in breast cancer patients undergoing neoadjuvant chemotherapy (NAC) based upon early treatment response measurements. EXPERIMENTAL DESIGN: A total of thirty-five breast cancer patients receiving NAC were included in this study. NIRST imaging was performed at multiple time points, including: before treatment, at end of the first cycle, at the mid-point, and post-NAC treatments...
September 21, 2023: Clinical Cancer Research
https://read.qxmd.com/read/37733621/challenges-in-interpretation-of-us-breast-findings-in-the-emergency-setting
#9
JOURNAL ARTICLE
Anastasiia Morozova, Claudia Cotes, Shima Aran, Harnoor Singh
Emergencies in breast imaging are infrequent but not rare. Although infectious conditions such as mastitis and breast abscess are the most common breast diseases encountered in acute care settings, other entities that may require additional imaging or different treatment approaches are also seen and include traumatic injury and breast cancer. While mammography is widely available for breast evaluation in outpatient facilities, most emergency departments do not have mammography units. This makes evaluation of patients with breast disease incomplete in the acute care setting and emphasizes the role of appropriate US techniques for interpretation...
October 2023: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://read.qxmd.com/read/37733620/imaging-and-management-of-radial-scars-and-complex-sclerosing-lesions
#10
JOURNAL ARTICLE
Bushra Z Manzar, Jordana Phillips, Elizabeth H Dibble, Liza M Quintana, Ana P Lourenco
Radial scars and complex sclerosing lesions, often collectively referred to as radial sclerosing lesions (RSLs), are breast lesions characterized by sclerotic stroma with entrapped epithelial elements. RSLs have imaging features that overlap with those of breast malignancy and often become the target of imaging-guided biopsy given their suspicious imaging appearance. These can be identified in isolation or can also be associated with atypia or other high-risk lesions that have intrinsic malignant potential, increasing the risk of carcinoma and affecting prognosis and management of RSLs...
October 2023: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://read.qxmd.com/read/37733619/metastatic-invasive-lobular-carcinoma-of-the-breast
#11
JOURNAL ARTICLE
Heba Albasha, Pegah Khoshpouri, Melina Hosseiny, Moozhan Nikpanah
No abstract text is available yet for this article.
October 2023: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://read.qxmd.com/read/37733618/problem-solving-breast-mri
#12
JOURNAL ARTICLE
Beatriu Reig, Eric Kim, Chloe M Chhor, Linda Moy, Alana A Lewin, Laura Heacock
Breast MRI has high sensitivity and negative predictive value, making it well suited to problem solving when other imaging modalities or physical examinations yield results that are inconclusive for the presence of breast cancer. Indications for problem-solving MRI include equivocal or uncertain imaging findings at mammography and/or US; suspicious nipple discharge or skin changes suspected to represent an abnormality when conventional imaging results are negative for cancer; lesions categorized as Breast Imaging Reporting and Data System 4, which are not amenable to biopsy; and discordant radiologic-pathologic findings after biopsy...
October 2023: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://read.qxmd.com/read/37733416/celebrity-identification-and-reasoned-action-an-integrative-model-of-the-relationship-between-media-use-and-breast-cancer-screening-intention
#13
JOURNAL ARTICLE
Suahn Jang Cho, Yan Tian
This study investigates the relationship between media use and breast cancer screening intentions by integrating the celebrity identification model and the theory of reasoned action. It tests an integrative model with survey data from 315 U.S. adult women. The study found that media use for breast cancer information was positively associated with parasocial interaction (PSI) and identification with celebrities who have or have had breast cancer; PSI was positively associated with attitudes, descriptive and injunctive norms in breast cancer screening, while identification with celebrities was positively associated with descriptive norms; attitudes, injunctive norms and descriptive norms were positively associated with breast cancer screening intentions...
September 21, 2023: Health Communication
https://read.qxmd.com/read/37733364/sentinel-lymph-node-biopsy-vs-no-axillary-surgery-in-patients-with-small-breast-cancer-and-negative-results-on-ultrasonography-of-axillary-lymph-nodes-the-sound-randomized-clinical-trial
#14
JOURNAL ARTICLE
Oreste Davide Gentilini, Edoardo Botteri, Claudia Sangalli, Viviana Galimberti, Mauro Porpiglia, Roberto Agresti, Alberto Luini, Giuseppe Viale, Enrico Cassano, Nickolas Peradze, Antonio Toesca, Giulia Massari, Virgilio Sacchini, Elisabetta Munzone, Maria Cristina Leonardi, Francesca Cattadori, Rosa Di Micco, Emanuela Esposito, Adele Sgarella, Silvia Cattaneo, Massimo Busani, Massimo Dessena, Anna Bianchi, Elisabetta Cretella, Francisco Ripoll Orts, Michael Mueller, Corrado Tinterri, Badir Jorge Chahuan Manzur, Chiara Benedetto, Paolo Veronesi
IMPORTANCE: Sentinel lymph node biopsy (SLNB) is the standard of care for axillary node staging of patients with early breast cancer (BC), but its necessity can be questioned since surgery for examination of axillary nodes is not performed with curative intent. OBJECTIVE: To determine whether the omission of axillary surgery is noninferior to SLNB in patients with small BC and a negative result on preoperative axillary lymph node ultrasonography. DESIGN, SETTING, AND PARTICIPANTS: The SOUND (Sentinel Node vs Observation After Axillary Ultra-Sound) trial was a prospective noninferiority phase 3 randomized clinical trial conducted in Italy, Switzerland, Spain, and Chile...
September 21, 2023: JAMA Oncology
https://read.qxmd.com/read/37733358/sentinel-node-biopsy-for-early-breast-cancer-a-sound-for-de-escalation
#15
JOURNAL ARTICLE
Seema A Khan
No abstract text is available yet for this article.
September 21, 2023: JAMA Oncology
https://read.qxmd.com/read/37733340/cancer-incidence-and-mortality-estimates-in-arab-countries-in-2018-a-globocan-data-analysis
#16
JOURNAL ARTICLE
Mariam Al-Muftah, Fares Al-Ejeh
BACKGROUND: Arab countries are projecting increase in cancer incidence and mortality, however, there are limited studies that compare the epidemiology of cancer in Arab countries compared to other parts of the world. METHODS: We used the 2018 Global Cancer Observatory data to compare the age-standardized incidence and mortality estimates in Arab-speaking countries to the rest of the world. RESULTS: Rates for incidence and mortality for all cancers in Arab countries were lower than the world's rates but the incidence rates of non-Hodgkin and Hodgkin lymphoma, bladder, breast, and liver cancers were higher...
September 21, 2023: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/37733286/brain-computer-interface-relieves-chronic-chemotherapy-induced-peripheral-neuropathy-a-randomized-double-blind-placebo-controlled-trial
#17
JOURNAL ARTICLE
Sarah Prinsloo, Ted J Kaptchuk, Dirk De Ridder, Randall Lyle, Eduardo Bruera, Diane Novy, Carlos H Barcenas, Lorenzo G Cohen
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) includes negative sensations that remain a major chronic problem for cancer survivors. Previous research demonstrated that neurofeedback (a closed-loop brain-computer interface [BCI]) was effective at treating CIPN versus a waitlist control (WLC). The authors' a priori hypothesis was that BCI would be superior to placebo feedback (placebo control [PLC]) and to WLC in alleviating CIPN and that changes in brain activity would predict symptom report...
September 21, 2023: Cancer
https://read.qxmd.com/read/37733281/research-on-black-women-and-breastfeeding-assessing-publication-trends-1980-2020
#18
JOURNAL ARTICLE
Katherine M Johnson, Sarah Kington
Background: Research on race/ethnicity and breastfeeding has consistently found lower rates for Black mothers compared with other U.S. women, due to various social, cultural, and historical factors. Aggregate analyses illuminate racial/ethnic differences, but they only provide partial insight into the factors contextualizing breastfeeding decisions and rates. We examined articles addressing Black women and breastfeeding (1980-2020) to assess publication trends. Materials and Methods: A targeted literature search in PubMed for research on Black women and breastfeeding (1980-2020)...
September 21, 2023: Breastfeeding Medicine
https://read.qxmd.com/read/37733277/a-quality-improvement-initiative-to-increase-the-milk-donation-to-the-human-milk-bank-post-coronavirus-disease-19-pandemic
#19
JOURNAL ARTICLE
Vamsi Krishna Vaddi, Dwayne Mascarenhas, Kirthana S B, Nitu Mundhra, Ruchi Nanavati
Background and Objective : Donor human milk (DHM) from the human milk bank (HMB) is the next best alterative in circumstances when mother's own milk is not available. There was a steep decline in the volume of DHM collected during the coronavirus disease-19 (COVID-19) pandemic due to various factors, while DHM demand increased. Hence, a quality improvement (QI) study was conducted to increase the volume of milk donation to HMB from postpandemic baseline of 300-400 to 1,000 mL/day over 8 weeks. Materials and Methods: Fish bone analysis was used to identify the potential barriers, and four Plan-Do-Study-Act (PDSA) cycles were conducted from January 2021 to March 2021 to address the key barriers...
September 21, 2023: Breastfeeding Medicine
https://read.qxmd.com/read/37733262/validating-tools-to-detect-and-inactivate-monkeypox-virus-in-human-milk
#20
JOURNAL ARTICLE
Alex E Clark, Annalee Furst, Kristija Sejane, Lisa Stellwagen, Marissa Proost, David Pride, Davey M Smith, Aaron F Carlin, Lars Bode
Objectives: Breastfeeding and human milk (HM) improve maternal and infant morbidities and mortality. Therefore, monitoring the safety of breastfeeding and access to HM is of critical importance. In this study, we assessed tools to monitor the presence of monkeypox virus (MPXV) in HM and whether standard Holder pasteurization inactivates MPXV. Materials and Methods: Heat-inactivated MPXV was added to HM or viral transport media (VTM) and analyzed using both research and clinical MPXV quantitative polymerase chain reaction (qPCR) tests...
September 21, 2023: Breastfeeding Medicine
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