Huairui Zhao, Jia Hua, Xiaochuan Geng, Jianrong Xu, Yi Guo, Shiteng Suo, Yan Zhou, Yuanyuan Wang
BACKGROUND: High-precision detection for individual and clustered microcalcifications in mammograms is important for the early diagnosis of breast cancer. Large-scale differences between the two types and low-contrast images are major difficulties faced by radiologists when performing diagnoses. OBJECTIVE: Deep learning-based methods can provide end-to-end solutions for efficient detection. However, multicenter data bias, the low resolution of network inputs, and scale differences between microcalcifications lead to low detection rates...
November 17, 2022: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Chandan Kumar Jha, Harshit Verma, Upasna Sinha, Prashant Kumar Singh
Increased utilization of chemotherapy in breast cancer patients has led to improved survival outcomes but it has also resulted in rising incidence of adverse effects. Occurrence of new/unreported side effect poses challenge in front of clinicians. We report the case of a 53-year lady with locally advanced, hormone receptor-positive, and human epidermal growth factor-2 (HER-2) negative right breast carcinoma. She was started on neoadjuvant chemotherapy (NACT) (doxorubicin and cyclophosphamide), to facilitate breast-conserving surgery...
2022: Breast Disease
Zahra Ghaemi, Bahram M Soltani, Seyed Javad Mowla
BACKGROUND: ErbB/PI3K signaling is widely recognized as a critical modulator of malignancy and miRNAs have been found to play a crucial role in the regulation of this pathway. OBJECTIVE: This study aimed to identify novel miRNAs related to the ErbBs loci and investigate the functional effects of these miRNAs on ErbB/PI3K signaling in cancer progression. MATERIALS AND METHODS: Bioinformatics tools and RNA-seq data were used to discover novel miRNAs in breast and colon cancer cells...
2022: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Katja C W van Dongen, Athanasia Ioannou, Sebastiaan Wesseling, Karsten Beekmann, Clara Belzer
The Amadori product fructoselysine is formed upon heating of food products and is abundantly present in infant formula while being almost absent in breast milk. The human gut microbiota can degrade fructoselysine for which interindividual differences have been described for adults. The aim of this study is to compare functional differences in microbial fructoselysine degradation between breast-fed and formula-fed infants, in view of their different diets and resulting different fructoselysine exposures. First, a publicly available metagenomic dataset with metagenome assembled genomes (MAGs) from infant fecal samples was analyzed and showed that query genes involved in fructoselysine degradation (frlD/yhfQ) were abundantly present in multiple bacterial taxa in the fecal samples, with a higher prevalence in the formula-fed infants...
November 28, 2022: FEMS Microbiology Ecology
Sarah Hesse, Kim Williamson, Deborah Bonney, Marie Finley, Tom Meehan
BACKGROUND: Lifestyle factors place those who experience incarceration at increased risk of morbidity and mortality from a range of preventable diseases, including cancer. METHODS: Two nurses were employed for a period of 6months to facilitate bowel and breast cancer screening of prisoners across four correctional centres in Queensland. We identify factors impacting on cancer screening in prisons and document the outcomes for those screened. RESULTS: Both screening programs produced a positivity rate of ∼17% in those screened, with 23 individuals returning a positive faecal occult blood test and five women requiring further investigations following breast screening...
November 29, 2022: Australian Journal of Primary Health
Fabio Santanelli Di Pompeo, Demosthenes Panagiotakos, Guido Firmani, Michail Sorotos
BACKGROUND: The epidemiologic picture of Breast Implant Associated-Anaplastic Large Cell Lymphoma (BIA-ALCL) is unclear, with no high-level evidence, as only case reports and series are available. OBJECTIVES: We aimed at updating the BIA-ALCL epidemiology by using all available data through a systematic review of scientific literature. METHODS: A search on PubMed, Scopus, and Web of Science was conducted between October 2021 and April 2022...
November 29, 2022: Aesthetic Surgery Journal
Monika Graeser, Oleg Gluz, Claudia Biehl, Daniel Ulbrich-Gebauer, Matthias Christgen, Jenci Palatty, Sherko Kuemmel, Eva-Maria Grischke, Doris Augustin, Michael Braun, Jochem Potenberg, Rachel Wuerstlein, Katja Krauss, Claudia Schumacher, Helmut Forstbauer, Toralf Reimer, Andrea Stefek, Hans Holger Fischer, Enrico Pelz, Christine Zu Eulenburg, Ronald Kates, Hua Ni, Cornelia Kolberg-Liedtke, Friedrich Feuerhake, Hans Heinrich Kreipe, Ulrike Nitz, Nadia Harbeck
PURPOSE: TTo identify associations of biological signatures and stromal tumor infiltrating lymphocytes (sTILs) with pathological complete response (pCR, ypT0 ypN0) and survival in the phase II WSG-ADAPT HER2+/HR- trial (NCT01817452). EXPERIMENTAL DESIGN: Patients with cT1-cT4c, cN0-3 HER2+/HR- early breast cancer (EBC) were randomized to pertuzumab+trastuzumab (P+T, n=92) or P+T+paclitaxel (n=42). Gene expression signatures were analyzed in baseline (BL) biopsies using NanoString Breast Cancer 360 panel (n=117); BL and on-treatment (week 3) sTIL levels were available in 119 and 76 patients, respectively...
November 28, 2022: Clinical Cancer Research
Zhi Hua Ren, Jason Stockmann, Andrew Dewdney, Ray F Lee
PURPOSE: An MRI scanner is equipped with global shim systems for shimming one region of interest (ROI) only. However, it often fails to reach state-of-the-art when shimming two isolated regions of interest simultaneously, even though the two-area shimming can be essential in scan scenarios, such as bilateral breasts or dyadic brains. To address these challenges, a hybrid active and passive local shimming technique is proposed to simultaneously shim two isolated region-of-interest areas within the whole FOV...
November 28, 2022: Magnetic Resonance in Medicine
Allison M Porman, Justin T Roberts, Emily D Duncan, Madeline L Chrupcala, Ariel A Levine, Michelle A Kennedy, Michelle M Williams, Jennifer K Richer, Aaron M Johnson
N6-methyladenosine (m6A) modification of RNA regulates normal and cancer biology, but knowledge of its function on long noncoding RNAs (lncRNAs) remains limited. Here, we reveal that m6A regulates the breast cancer-associated human lncRNA HOTAIR. Mapping m6A in breast cancer cell lines, we identify multiple m6A sites on HOTAIR, with 1 single consistently methylated site (A783) that is critical for HOTAIR-driven proliferation and invasion of triple-negative breast cancer (TNBC) cells. Methylated A783 interacts with the m6A "reader" YTHDC1, promoting chromatin association of HOTAIR, proliferation and invasion of TNBC cells, and gene repression...
November 28, 2022: PLoS Biology
Fuad Ameen, Saleh AlNAdhari, Ali A Al-Homaidan
Multifunctional drugs have shown great promise in biomedicine. Organisms with antimicrobial and anticancer activity in combination with antioxidant activity need further research. The Red Sea and the Arabian Gulf coasts were randomly sampled to find fungi with multifunctional activity. One hundred strains (98 fungi and 2 lichenized forms) were isolated from 15 locations. One-third of the isolates inhibited clinical bacterial (Staphylococcus aureus, Bacillus subtilis, Vibrio cholerae, Salmonella typhi, S. paratyphi) and fungal pathogens (Talaromycets marneffei, Malassezia globose, Cryptococcus neoformans, Candida albicans, Aspergillus fumigatus) and four cancer cell lines (Hep G2 liver, A-549 lung, A-431skin, MCF 7 breast cancer)...
2022: PloS One
Gwendolyn J McGinnis, Sarah Holden, Betty Yu, Charlton Ransom, Carolyn Guidarelli, Brian De, Kevin Diao, David Boyce, Charles R Thomas, Kerri Winters-Stone, Jacob Raber
PURPOSE/OBJECTIVES: Cancer treatment survivors often report impaired functioning and increased falls. Not all survivors experience the same symptom burden, suggesting individual susceptibilities. APOE genotype is a potential genetic risk factor for cancer treatment related side effects. Lifestyle factors such as physical activity can mitigate the effect of APOE genotype on measures of clinical interest in individuals without a history of cancer. We tested the hypothesis that APOE genotype influences cancer treatment related side effects and symptoms as well as response to exercise intervention...
November 17, 2022: Oncotarget
Jason Gurney, James Stanley, Andrea Teng, Jeremy Krebs, Jonathan Koea, Chunhuan Lao, Ross Lawrenson, Ineke Meredith, Dianne Sika-Paotonu, Diana Sarfati
The number of new cases of cancer is increasing each year, and rates of diabetes mellitus are also increasing dramatically over time. It is not an unusual occurrence for an individual to have both cancer and diabetes at the same time, given they are both individually common, and that one condition can increase the risk of the other. In this manuscript, we use national-level diabetes (Virtual Diabetes Register) and cancer (New Zealand Cancer Registry) data on nearly five million individuals over 44 million person-years of follow-up to examine the occurrence of cancer amongst a national prevalent cohort of patients with diabetes...
2022: PloS One
Yanjia Zhuang, Xiaogang Pang, Yuchen Qi, Tianshu Zhang, Guimao Cao, Heming Xue, Yifan Xu, Shuoxin Xie, Yifan Liu, Yinuo Wang, Yunxiao Li, Ying Xiong, Yuanyuan Li, Hui Shen
[This corrects the article DOI: 10.3389/fonc.2022.939636.].
2022: Frontiers in Oncology
Janghee Lee, Hakyoung Kim, Soong June Bae, Jung Hwan Ji, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn, Joon Jeong, Sae Byul Lee, Sung Gwe Ahn
IMPORTANCE: Body mass index (BMI) may affect the 21-gene recurrence score (RS) in patients with ER-positive, ERBB2-negative breast cancer. If high BMI increases genomic risk in ER-positive, ERBB2-negative breast cancer, weight control will become more important. OBJECTIVE: To assess the association between RS and BMI according to age groups and address BMI as a factor associated with high RS. DESIGN, SETTING, AND PARTICIPANTS: This cohort study included 2295 patients with ER-positive, ERBB2-negative breast cancer who had undergone a multigene assay between March 29, 2010, and December 31, 2020, in 2 hospitals...
November 1, 2022: JAMA Network Open
Ki-Jin Ryu, Min Sun Kim, Ji Yoon Lee, Seunghyun Nam, Hye Gyeong Jeong, Tak Kim, Hyuntae Park
IMPORTANCE: The association of tamoxifen use with the risk of uterine diseases, such as endometrial cancer, in premenopausal women with breast cancer remains controversial. However, many studies have reported an increased risk of uterine disease among postmenopausal tamoxifen users. OBJECTIVE: To investigate the association of tamoxifen use with the risk of endometrial cancer and other uterine diseases in premenopausal women with breast cancer. DESIGN, SETTING, AND PARTICIPANTS: A nationwide, population-based, retrospective longitudinal cohort study with an 18-year study period was conducted using data obtained from the Korean National Health Insurance Service...
November 1, 2022: JAMA Network Open
Mingzhou Gao, Hao Zhang, Zhan Gao, Ya Sun, Guanghao Xu, Fengqin Wei, Jieqiong Wang, Dongmei Gao
BACKGROUND: Premenstrual dysphoric disorder (PMDD) is high in women of childbearing age with obvious premenstrual irritability. However, reliable animal models are still lacking. MATERIALS AND METHODS: PMDD rat model of premenstrual irritability was induced by the resident-intruder paradigm (RIP). Behavioral characteristics were determined by the aggressive behavior test, elevated plus maze, open-field test, and breast width measurement. The estrous cycle in rats was artificially manipulated by bilateral ovariectomy and exogenous hormone injection to verify the model phenotype's dependence on the estrous cycle...
November 27, 2022: Aging
Yahiya Y Syed
Futibatinib (Lytgobi® ) is an oral, covalently binding, irreversible inhibitor of fibroblast growth factor receptor (FGFR)1-4 that is being developed by Taiho Oncology and Taiho Pharmaceutical for the treatment of cancers, including cholangiocarcinoma, breast cancer, gastric cancer, urothelial cancer, oesophageal cancer and non-small cell lung cancer. Futibatinib was approved in the USA on 30 September 2022 for the treatment of adult patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma harbouring FGFR2 gene fusions or other rearrangements...
November 28, 2022: Drugs
S Swathi Krishna, Beena Briget Kuriakose, P K Lakshmi
Phytoestrogens are non-steroidal, polyphenolic compounds that are derived from plants and have biological properties similar to those of human estrogens. Their bioactivity, which is based on the core ring system, is caused by their structural resemblance to estrogen. Flavonoids, coumestans, lignans, and stilbenes are the four major categories into which they can be divided. They are structurally and functionally related to ovarian and placental estrogens, which are essential in female reproductive processes...
November 28, 2022: Archives of Pharmacal Research
Elizabeth Sainsbury, Lara Costard, Fergal J O'Brien, Caroline M Curtin
Assessment of cell cytotoxicity following transfection of cells with microRNA (miRNA) is an essential step in the evaluation of basic miRNA functional effects within cells in both 2D and 3D microenvironments. The lactate dehydrogenase (LDH) assay is a colorimetric assay that provides a basic, dependable method for determining cellular cytotoxicity through assessment of the level of plasma membrane damage in a cell population. Here, we describe the overexpression of miRNA in breast cancer cells when cultured in 3D collagen-based biomaterial scaffolds, achieved by Lipofectamine transfection, with subsequent examination of cell cytotoxicity using the LDH assay...
2023: Methods in Molecular Biology
Jayanthi Vijayakumar, Tufia Haddad, Kalpna Gupta, Janet Sauers, Douglas Yee
The opioid receptor (OR) antagonist naltrexone inhibits estrogen receptor-α (ER) function in model systems. The goal of this study was to determine the clinical activity of naltrexone in patients with ER-positive metastatic breast cancer. Patients with hormone receptor positive metastatic breast cancer were enrolled on a phase II study of naltrexone. An escalating dose scheme was used to reach the planned dose of 50 mg daily. The primary objective of the study was to evaluate response to therapy as measured by stabilization or reduction of the tumor Maximum Standardized Uptake Value (SUVmax) at 4 weeks by PET-CT scan...
November 28, 2022: Investigational New Drugs
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