Mohsen Rokni, Elham Farhadi, Hoda Kavosi, Maryam Akhtari, Elham Madreseh, Samaneh Enayati, Mina Sadeghi Shaker, Shayan Mostafaei, Farhad Gharibdoost, Mahdi Mahmoudi, Mohammad Vodjgani
Systemic sclerosis (SSc) is an autoimmune systemic disease that is characterized by immune dysregulation, inflammation, vasculopathy, and fibrosis. Tissue fibrosis plays an important role in SSc and can affect several organs such as the dermis, lungs, and heart. Dysregulation of interferon (IFN) signaling contributes to the SSc pathogenesis and interferon regulatory factor 1 (IRF1) has been indicated as the main regulator of type I IFN. This study aimed to clarify the effect of IFN-gamma (-γ) and dexamethasone (DEX) on the IRF1, extracellular signal-regulated kinase 1/2 (ERK1/2), and the expression of alpha-smooth muscle actin (α-SMA) in myofibroblasts and genes involved in the inflammation and fibrosis processes in early diffuse cutaneous systemic sclerosis (dcSSc)...
April 7, 2024: Iranian Journal of Allergy, Asthma, and Immunology