Xiaobo Zhang, Jing Wang, Jingwei Xu, Wen Xu, Yin Zhang, Chenqi Luo, Shuang Ni, Haijie Han, Xingchao Shentu, Juan Ye, Jian Ji, Ke Yao
Posterior capsule opacification (PCO) is the most common long-term postoperative complication of cataract surgery, leading to secondary vision loss. Optimized intraocular lens (IOL) structure and appropriate pharmacological intervention, which provides physical barriers and biological inhibition, respectively, can block the migration, proliferation, and epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) for PCO prophylaxis. Herein, a novel indomethacin-eluting IOL (INDOM-IOL) with an optimized sharper edge and a sustained drug release behavior was developed for PCO prevention...
May 2023: Bioactive Materials