Tatsushi Nagano, Sohei Kimoto, Katsuro Aso, Takashi Komori, Yasunari Yamaguchi, Kazuya Okamura, Noriya Yamamoto, Toshifumi Kishimoto
AIM: We assessed the efficacy of buprenorphine replacement taper therapy in a psychiatric hospital in Japan. METHODS: Based on the medical records, a retrospective analysis was performed to evaluate the outcomes of buprenorphine replacement taper therapy in 106 subjects with heroin dependence. RESULTS: We found that replacement and taper therapy with buprenorphine could significantly reduce withdrawal symptoms during detoxification. In addition, the completion rate of detoxification was significantly improved and the length of hospital stay was significantly reduced relative to those who received conventional treatment without buprenorphine...
October 27, 2020: Neuropsychopharmacology Reports
Li-Jun Cao, Wei Song, Lei Yue, Shao-Kun Guo, Jin-Cui Chen, Ya-Jun Gong, Ary Anthony Hoffmann, Shu-Jun Wei
The peach fruit moth (PFM), Carposina sasakii Matsumura, is a major phytophagous orchard pest widely distributed across Northeast Asia. Here, we report the chromosome-level genome for the PFM, representing the first genome for the family Carposinidae, from the lepidopteran superfamily Copromorphoidea. The genome was assembled into 404.83 Mb sequences using PacBio long-read and Illumina short-read sequences, including 275 contigs, with a contig N50 length of 2.62 Mb. All contigs were assembled into 31 linkage groups assisted by the Hi-C technique, including 30 autosomes and a Z chromosome...
October 23, 2020: Molecular Ecology Resources
Xiaohui Li, Liu Chen, Jingjing Liao, Jiechen Hui, Weihui Li, Zheng-Guo He
Reactive oxygen species (ROS) are an unavoidable host environmental cue for intracellular pathogens such as Mycobacterium tuberculosis and Mycobacterium bovis; however, the signaling pathway in mycobacteria for sensing and responding to environmental stress remains largely unclear. Here, we characterize a novel CmtR-Zur-ESX3-Zn2+ regulatory pathway in M. bovis that aids mycobacterial survival under oxidative stress. We demonstrate that CmtR functions as a novel redox sensor, and that its expression can be significantly induced under H2O2 stress...
October 8, 2020: Journal of Biological Chemistry
Shashank R Joshi
Covid-19 pandemic in India has rapidly grown though we have a low case fatality rate, high recovery rate and large population is asymptomatic or presymptomatic. Public health measures to close the tap across the country need hypervigilance and follow simple dictum of aggressive testing, tracing and isolation. The covid cases need an early diagnosis with treat and care model. Most can be managed with home isolation under telemedicine supervision with oxygen saturation screening by a simple six minute walk test...
October 2020: Journal of the Association of Physicians of India
Abby E Rudolph, Deborah J Fernau, Karin E Tobin, Carl Latkin
BACKGROUND: This analysis examined individual and network correlates of treatment enrollment for substance use disorders (SUDs) in the past 6 months and whether these factors varied by type(s) of drug(s) used and type of SUD treatment received. METHODS: Between 2014 and 2017, 330 Baltimore residents who reported using heroin, crack, and/or cocaine in the past 6 months completed a survey to assess demographics, substance use, recent SUD treatment enrollment, and information about their network members...
September 13, 2020: Drug and Alcohol Dependence
Aranka Steyaert, Pieter Audenaert, Jan Fostier
BACKGROUND: De Bruijn graphs are key data structures for the analysis of next-generation sequencing data. They efficiently represent the overlap between reads and hence, also the underlying genome sequence. However, sequencing errors and repeated subsequences render the identification of the true underlying sequence difficult. A key step in this process is the inference of the multiplicities of nodes and arcs in the graph. These multiplicities correspond to the number of times each k-mer (resp...
September 14, 2020: BMC Bioinformatics
Chang Liu, Zhigang Yin, Tingting Feng, Min Zhang, Zhi Zhou, Ying Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Lonicerae japonicae flos (LJF, the dried flower bud or newly bloomed flower of Lonicera japonica Thunb.), a typical herbal medicine, targets the lung, heart and stomach meridian with the function of clearing heat and detoxication. It ameliorated inflammatory responses and protected against acute lung inflammation in animal models. Acute lung injury (ALI) is a kind of inflammatory disease in which alveolar cells are damaged. However, a network pharmacology study to thoroughly investigate the mechanisms preventing ALI has not been performed...
September 8, 2020: Journal of Ethnopharmacology
Heejung Son, Hyun Jin Song, Hyun-Ju Seo, Heeyoung Lee, Sun Mi Choi, Sanghun Lee
BACKGROUND: As the self-administration of coffee enema is being used as a mean of self-care for detoxication in various indications, it is important that evidence-based public health information is provided for effective and safe use. However, the evidence is so far rare. This systematic review was conducted to investigate the safety and effectiveness of self-administered coffee enema in a wide range of use, and to provide evidence about its benefits and risks. METHODS: Relevant studies were retrieved from Ovid MEDLINE, Ovid Embase, the Cochrane Central Register of Controlled Trials, and the Cumulative Index to Nursing and Allied Health Literature; and also from oriental databases, KoreaMed, Korean Medical Database, Korean Studies Information Service System, National Discovery for Science Leaders, and Korea Institute of Science and Technology Information, Oriental Medicine Advanced Searching Integrated System, China National Knowledge Infrastructure, and Japan Science and Technology Information Aggregator...
September 4, 2020: Medicine (Baltimore)
Qiu-Hong Li, Wan-Ting Shan, Ai-Xia Ju, Jiao Zhao
The enzymes CYP1 A2 and CYP3 A4 were measured by building a "Cocktail" probe drug and the incubation system of liver microsomes. The compatibility of Aconiti Lateralis Radix Praeparata combined with dried Rehmanniae Radix on CYP450 enzyme protein and gene expression was explored from the level of protein and molecular biology. It explored the molecular mechanism of compatibility detoxication of Aconiti Lateralis Radix Praeparata to provide scientific support for clinical safe and effective application of Aconiti Lateralis Radix Praeparata...
August 2020: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Lei Zhang, Ting Li, Rongrong Wang, Jiaan Xu, Li Zhou, Li Yan, Zhengyan Hu, Hongwen Li, Fucun Liu, Wenxi Du, Peijian Tong, Huiling Wu, Shanxing Zhang, Letian Shan, Thomas Efferth
Background: As a degenerative joint disease with severe cartilage destruction and pain, osteoarthritis (OA) has no satisfactory therapy to date. In traditional Chinese medicine (TCM), Aconitum carmichaeli Debeaux derived Hei-shun-pian ( Hsp ) has been developed for joint pain treatment. However, it causes adverse events in OA patients. Long-time decoction has been traditionally applied to reduce the aconite toxicity of Hsp and other aconite herbs, but its detoxifying effect is uncertain...
2020: Frontiers in Pharmacology
Linna Gong, Wei Zou, Keyang Zheng, Birui Shi, Menghua Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Herba Patriniae has been used for thousands of years in China as a traditional Chinese medicine with heat-clearing and detoxicating effects. It is applied widly for the treatment of rheumatoid arthritis, diarrhea, acute hepatitis, pelvic inflammatory disease and ulcerative colitis in clinic. Two species, namely Patrinia scabiosaefolia Fisch. (PS) and Patrinia villosa Juss. (PV) from the Caprifoliaceae family, are considered as Herba Patriniae in the pharmaceutical industry...
August 23, 2020: Journal of Ethnopharmacology
Marc R Larochelle, Sarah E Wakeman, Omid Ameli, Christine E Chaisson, Jeffrey T McPheeters, William H Crown, Francisca Azocar, Darshak M Sanghavi
BACKGROUND: Relative costs of care among treatment options for opioid use disorder (OUD) are unknown. METHODS: We identified a cohort of 40,885 individuals with a new diagnosis of OUD in a large national de-identified claims database covering commercially insured and Medicare Advantage enrollees. We assigned individuals to 1 of 6 mutually exclusive initial treatment pathways: (1) Inpatient Detox/Rehabilitation Treatment Center; (2) Behavioral Health Intensive, intensive outpatient or Partial Hospitalization Services; (3) Methadone or Buprenorphine; (4) Naltrexone; (5) Behavioral Health Outpatient Services, or; (6) No Treatment...
October 2020: Medical Care
Rongrong Han, Yunmin Wei, Yonghong Xie, Lusheng Liu, Caode Jiang, Yongxiong Yu
Aluminum (Al3+) toxicity is one of the most important limitations to agricultural production worldwide. The overall response of plants to Al3+ stress has been documented, but the contribution of protein phosphorylation to Al3+ detoxicity and tolerance in plants is unclear. Using a combination of tandem mass tag (TMT) labeling, immobilized metal affinity chromatography (IMAC) enrichment and liquid chromatography-tandem mass spectrometry (LC-MS/MS), Al3+-induced phosphoproteomic changes in roots of Tamba black soybean (TBS) were investigated in this study...
2020: PloS One
Kaushal Shah, Billy Stout, Hunter Caskey
The increase in the prescription of opioid medications has resulted in a wildfire of misuse of opioids, both for medical and non-medical reasons, with over 1.7 million people in the United States (US) suffering from distinct disorders owing to opioid use. While various medications, such as methadone, buprenorphine, and naloxone, among others, have been used in treating opioid withdrawal symptoms, concerns of the potential abuse of these drugs, the cost of procurement, legislations, and prescription policies have risen...
July 11, 2020: Curēus
Yoko Yagishita, Tonibelle N Gatbonton-Schwager, Melissa L McCallum, Thomas W Kensler
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2 ) plays a critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the regulation of inflammation and cellular detoxication pathways. The contribution of the NRF2 pathway to organismal homeostasis is seen in many studies using cell lines and animal models, raising intense attention towards targeting its clinical promise. Over the last three decades, an expanding number of clinical studies have examined NRF2 inducers targeting an ever-widening range of diseases...
August 7, 2020: Antioxidants (Basel, Switzerland)
Aidong Zhang, Zongwen Zhu, Jing Shang, Shengmei Zhang, Haibin Shen, Xuexia Wu, Dingshi Zha
Global warming induces heat stress in eggplant, seriously affecting its quality and yield. The response to heat stress is a complex regulatory process; however, the exact mechanism in eggplant is unknown. We analyzed the transcriptome of eggplant under different high-temperature treatments using RNA-Seq technology. Three libraries treated at high temperatures were generated and sequenced. There were 40,733,667, 40,833,852, and 40,301,285 clean reads with 83.98%, 79.69%, and 84.42% of sequences mapped to the eggplant reference genome in groups exposed to 28°C (CK), 38°C (T38), and 43°C (T43), respectively...
2020: PloS One
Banghai Liu, Wanqian Guo, Huazhe Wang, Qishi Si, Qi Zhao, Haichao Luo, Nanqi Ren
Cobalt-mediated activation of peroxymonosulfate (PMS) has been extensively investigated for the degradation of emerging organic pollutants. In this study, PMS activation via cobalt-impregnated biochar towards atrazine (ATZ) degradation was systematically examined, and the underlying reaction mechanism was explicated. It was found that persistent free radicals (PFRs) contained in biochar play a pivotal role in PMS activation process. The PFRs enabled an efficient transfer electron to both cobalt atom and O2 , facilitating the recycle of Co(III)/Co(II), and thereby leaded to an excellent catalytic performance...
April 21, 2020: Journal of Hazardous Materials
Dong Wan, Haiyan Wang, Ivan P Pozdnyakov, Chengjun Wang, Jing Su, Yanrong Zhang, Yuegang Zuo, Dionysios D Dionysiou, Yong Chen
There are many reports on the detection and removal of emerging pollutants in the wastewater effluents, while the fate of their chlorinated derivatives generated during chlorination is not well understood. Here we investigated the photodegradation of chlorinated derivatives of bisphenol A (CDBPAs), mainly including 3-chlorobisphenol A, 3,3'-dichlorobisphenol A, 3,5-dichlorobisphenol A, 3,3',5-trichlorobisphenol A, and 3,3',5,5'-tetrachlorobisphenol A, under simulated sunlight. Distinct from BPA, CDBPAs underwent rapid direct photodegradation due to a pronounced bathochromic shift of UV absorption...
July 6, 2020: Water Research
Lan Ni, Xin-Lei Guan, Fu-Feng Chen, Peng-Fei Wu
Mitochondrial superoxide overproduction is believed to be responsible for the neurotoxicity associated with neurodegeneration. Mitochondria-targeted antioxidants, such as MitoQ, have emerged as potentially effective antioxidant therapies. Methionine sulfoxide reductase A (MsrA) is a key mitochondrial-localized endogenous antioxidative enzyme and it can scavenge oxidizing species by catalyzing the methionine (Met)-centered redox cycle (MCRC). In this study, we observed that the natural L-Met acted as a good scavenger for antimycin A-induced mitochondrial superoxide overproduction in PC12 cells...
June 2020: Current Medical Science
Alena Ryšavá, Kateřina Čížková, Jana Franková, Lenka Roubalová, Jitka Ulrichová, Jitka Vostálová, Jiří Vrba, Bohumil Zálešák, Alena Rajnochová Svobodová
The harmful effects of low energy UVA photons (315-400 nm) are associated with the massive production of reactive oxygen species resulting in oxidative stress. In response to oxidative damage, NF-E2-related factor 2 (Nrf2) is translocated to the nucleus and drives the expression of detoxication and antioxidant enzymes. UVA's effect on Nrf2 has been quite well characterised in dermal fibroblasts. However, there is a dearth of such information for keratinocytes. This study aimed to evaluate and compare the effect of UVA radiation on the Nrf2 pathway and oxidative stress related proteins in primary human dermal fibroblasts (NHDF), epidermal keratinocytes (NHEK) and human keratinocyte cell line HaCaT...
July 2, 2020: Journal of Photochemistry and Photobiology. B, Biology
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"