Lucie Friedauer, Beata Rezny-Kasprzak, Helmuth Steinmetz, Richard du Mesnil de Rochemont, Christian Foerch
BACKGROUND: Superficial siderosis of the central nervous system is a sporadic finding in magnetic resonance imaging, resulting from recurrent bleedings into the subarachnoid space. This study aimed to determine the frequency of spinal dural cerebrospinal fluid (CSF)-leaks among patients with a symmetric infratentorial siderosis pattern. METHODS: We screened 97.733 magnetic resonance images performed between 2007 and 2018 in our neurocenter by a keyword search for "hemosiderosis" and "superficial siderosis"...
October 24, 2020: European Journal of Neurology
Brian Fiani, Juliana Runnels, Ashley Taylor, Manraj Sekhon, Daniel Chacon, Michael McLarnon, Rebecca Houston, Sasha Vereecken
Spinal injury is among the most severe and feared injuries an athlete may face. We present an up-to-date review of the recent literature, stratifying recommendations based on injury location (cervical, thoracic, and lumbar spine) and type, as well as, the level of competitive play (high school, collegiate, professional). A literature search was completed to identify all publications reporting return to play guidelines for athletic injuries or injury-related surgery irrespective of the study design. Publication dates were not restricted by year...
October 26, 2020: Reviews in the Neurosciences
Wenhui Qu, Kiall F Suazo, Wenfeng Liu, Shaowu Cheng, Angela Jeong, David Hottman, Li-Lian Yuan, Mark D Distefano, Ling Li
Protein prenylation is a post-translational lipid modification that governs a variety of important cellular signaling pathways, including those regulating synaptic functions and cognition in the nervous system. Two enzymes, farnesyltransferase (FT) and geranylgeranyltransferase type I (GGT), are essential for the prenylation process. Genetic reduction of FT or GGT ameliorates neuropathology but only FT haplodeficiency rescues cognitive function in transgenic mice of Alzheimer's disease. A follow-up study showed that systemic or forebrain neuron-specific deficiency of GGT leads to synaptic and cognitive deficits under physiological conditions...
October 24, 2020: Molecular Neurobiology
Alexandra Krez, Sanchita Agarwal, Mariana Bucovsky, Donald J McMahon, Yizhong Hu, Marc Bessler, Beth Schrope, Angela Carrelli, Shannon Clare, Xiang-Dong Edward Guo, Shonni J Silverberg, Emily M Stein
CONTEXT: The prevalence of obesity is burgeoning among African American and Latina women; however, few studies investigating the skeletal effects of bariatric surgery have focused on these groups. OBJECTIVE: To investigate long-term skeletal changes following Roux-en-Y gastric bypass (RYGB) in African American and Latina women. DESIGN: Four-year prospective cohort study. PATIENTS: African American and Latina women presenting for RYGB (n = 17, mean age 44, body mass index 44 kg/m2) were followed annually for 4 years postoperatively...
September 16, 2020: Journal of Clinical Endocrinology and Metabolism
Manhal Izzy, Benyam D Addissie, Juan Pablo Arab, Moira B Hilscher, Amanda Cartee, David C Lee, Yong Lee, Joel G Fletcher, Tony M Keaveny, William Sanchez
BACKGROUND: Assessment of bone density is an important part of liver transplant (LT) evaluation for early identification and treatment of osteoporosis (OP). Dual-energy X-ray absorptiometry (DXA) is currently the standard clinical test for osteoporosis; however, it may contribute to the appointment burden on LT candidates during the cumbersome evaluation process and there are limitations affecting its accuracy. In this study, we evaluate the utility of biomechanical analysis of vertebral images obtained during triple phase dual-energy abdominal CT (TPCT) in diagnosing osteoporosis among LT candidates...
October 23, 2020: Liver Transplantation
Omar M Al Jammal, Arvin R Wali, Courtney S Lewis, Michelle V Zaldana, Ahmed S Suliman, Martin H Pham
BACKGROUND: Giant pseudomeningoceles are an uncommon complication of spine surgery. Surgical management and extirpation can be difficult, and guidelines remain unclear. METHODS: Here, we present a 56-year-old female patient with a history of grade III L5-S1 spondylolisthesis who was treated with 2 prior spine surgeries. The patient was treated with bone grafting for pseudarthrosis and instrumentation from L4 to ilium. After unsuccessful intraoperative and postoperative cerebrospinal fluid drainage and dural repair, the patient presented to the emergency room with debilitating positional headaches...
October 23, 2020: International Journal of Spine Surgery
Milavec Helena, Ravikumar Nivetha, Syn Li-Xun Nicholas, Soekojo Cinnie Yentia, Chng Wee Joo, Kumar Naresh
INTRODUCTION: Multiple myeloma (MM) is the most frequent primary malignancy of the spine. We aimed to investigate the clinical presentation, surgical indications and outcomes, complications, survival, and its influencing factors in surgically treated MM patients with symptomatic involvement of the spine (SIS). METHODS: Retrospective analysis of prospectively collected data. Out of 350 MM patients treated at our institution over a period of 12 years (2006-2018), we identified 24 patients who were surgically treated for SIS...
October 23, 2020: International Journal of Spine Surgery
Jason M Cuéllar, Willis Wagner, Alexandre Rasouli
BACKGROUND: As healthcare costs rise, attempts are being made to perform an increasing proportion of spine surgery in ambulatory surgery centers (ASCs). ASCs are more efficient, both economically and functionally. There remains uncertainty regarding the safety of performing anterior lumbar procedures requiring vascular access, as little has been published on this subset of patients. METHODS: This is a consecutive case series analysis of anterior lumbar spine surgeries that were performed in a free-standing ASC in a private-practice setting over a 1-year period, including anterior lumbar interbody fusion, artificial disc replacement, and hybrid procedures...
October 23, 2020: International Journal of Spine Surgery
Luis Alvarez-Galovich, Felix Tome-Bermejo, Ana B Moya, Ignacio Mahillo-Fernandez, Angel R Piñera, Charles L Mengis, Jesus M Gallego, Francisco M Garzón, Maria G Rodriguez, Sylvia Sanz, Alejandro Peiro-Garcia
BACKGROUND: Degenerative spine disease is a common cause of low back pain in people age 65 years or older. Nonsurgical treatment is tried first, but if it is unsuccessful, surgery is advocated. This has special connotations for both underlying disease and the biomechanical characteristics of osteoporotic bone. We conducted an observational study to investigate the clinical and radiological outcome in patients in this age group with poor bone quality and degenerative lumbar instability treated with fusion using perforated pedicle screws augmented with polymethylmethacrylate (PMMA)...
October 23, 2020: International Journal of Spine Surgery
Luca Colucci-D'Amato, Luisa Speranza, Floriana Volpicelli
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin receptor kinase B (TrkB) and the low affinity p75 neurotrophin receptor (p75NTR). BDNF plays an important role in proper growth, development, and plasticity of glutamatergic and GABAergic synapses and through modulation of neuronal differentiation, it influences serotonergic and dopaminergic neurotransmission. BDNF acts as paracrine and autocrine factor, on both pre-synaptic and post-synaptic target sites...
October 21, 2020: International Journal of Molecular Sciences
Roberto Bomprezzi, Andrew P Chen, Christopher C Hemond
OBJECTIVES: To answer the question whether cervical spondylosis would increase the incidence of cord lesions in MS patients, we investigated the statistical association between the two pathologies. METHODS: We extracted demographics, basic disease characteristics and MRI data of a cohort of 304 consecutive MS patients. For a subset of 176 patients, a detailed analysis independently assessed for each cervical level the co-existence of spinal canal narrowing from spondylosis and corresponding cord signal abnormalities...
October 15, 2020: Clinical Neurology and Neurosurgery
Renaud Lafage, Bryan Ang, Basel Sheikh Alshabab, Jonathan Elysee, Francis Lovecchio, Karen Weissman, Han Jo Kim, Frank Schwab, Virginie Lafage
OBJECTIVES: To train and validate an algorithm mimicking experienced surgeons' decision making regarding upper instrumented vertebra (UIV) selection in the surgical correction of thoracolumbar adult spinal deformity (ASD). METHODS: A retrospective review was conducted of a single center database of ASD patients who underwent fusion of at least the lumbar spine (UIV>L1 to pelvis) from 2013-2018. Data collection included demographic and radiographic information...
October 19, 2020: World Neurosurgery
François Dantas, Antônio Carlos Vieira Caires, Gustavo Agra Cariri, Fernando Luiz Rolemberg Dantas
BACKGROUND: Stroke is a potentially life-threatening condition that can lead to disability and prolonged hospital stay. Perioperative stroke is a rare complication of spine surgery, especially in elective procedures. The prevalence of this complication varies in the literature, and the physiopathology is uncertain in many cases. OBJECTIVES: To describe five cases of patients who underwent spine surgery complicated by perioperative stroke and to analyze their characteristics and clinical outcomes...
October 19, 2020: World Neurosurgery
Pouilles Jean-Michel, Gosset Anna, Breteau Alice, Trémollieres Florence Anne
INTRODUCTION/BACKGROUND: Severe vertebral osteoporosis is a rare condition in early postmenopausal women. We seek to determine whether Trabecular Bone Score (TBS), which is a new bone texture measurement, could be of additional value in evaluating trabecular bone properties in this population. METHODOLOGY: Lumbar spine (LS) and femoral neck (FN) bone mineral densities (BMDs) and TBS were measured in 105 early postmenopausal women (group 1: "cases", mean age: 53...
October 19, 2020: Bone
Guijuan Deng, Lu Yin, Kai Li, Bo Hu, Xiaoru Cheng, Ling Wang, Yong Zhang, Li Xu, Shaoqi Xu, Lei Zhu, Jiman Shao, Xiaoguang Hao, Jun Zhou, Jinhua Tang, Wei Li, Yu Jiang, Xiaoguang Cheng
BACKGROUND CONTEXT: Previous studies have reported conflicting results for the relationships between anthropometric adiposity indexes and bone mineral density, based on dual-energy X-ray absorptiometry (DXA). However, few studies were published based on quantitative computed tomography (QCT), especially for Chinese population. PURPOSE: To evaluate the associations of spine bone mineral density (BMD) with body mass index (BMI), waist circumstance (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR) and a body shape index (ABSI) using QCT...
October 19, 2020: Spine Journal: Official Journal of the North American Spine Society
Chirag A Berry, Dinesh Thawrani, Fadi Makhoul
BACKGROUND CONTEXT: The oblique prepsoas retroperitoneal approach to the lumbar spine for interbody fusion or OLIF provides safe access to nearly all lumbar levels. A wide interval between the psoas and aorta allows for a safe and straightforward left-sided oblique approach to the discs above L5. Inclusion of L5-S1 in this approach, however, requires modifications in the technique to navigate the complex and variable vascular anatomy distal to the bifurcation of the great vessels. While different oblique approaches to L5-S1 have been described in the literature, to our knowledge, no previous study has provided guidance for the choice of technique...
October 19, 2020: Spine Journal: Official Journal of the North American Spine Society
Adam J Michalik, Rajeev K Patel
BACKGROUND CONTEXT: Discogenic lumbosacral back pain continues to present a challenging clinical entity with limited, controversial therapeutic options. No study to date has evaluated the efficacy of fluoroscopically guided transforaminal epidural steroid injections (TFESI) in a homogenous patient population with axial lumbosacral back pain from discogenic pathology utilizing strict, explicitly clinical and radiographic criteria. Additionally, there is a paucity of published data utilizing Patient Reported Outcome Measurement Information System (PROMIS) scores as an outcome measure for interventional spine procedures...
October 19, 2020: Spine Journal: Official Journal of the North American Spine Society
Bracken G Smith, Allen M Pratt, Julie A Anderson, Jarom J Ray
INTRODUCTION: Targeted Endodontic Microsurgery (TEMS) combines trephine burs and 3D-printed guides to make flapless maxillary palatal root-end surgery possible. This study assessed the location of the greater palatine artery (GPA), the relationship of the GPA to maxillary molar root ends, and the feasibility of flapless palatal-approach TEMS. METHODS: Three endodontists analyzed 250 CBCT images of maxillary molars for: 1) transition morphology between the hard palate and the alveolar process adjacent to first and second molars as an indication of the most likely location of the GPA, 2) the superior-inferior relationship between the GPA and root ends, and 3) the feasibility of palatal-approach TEMS...
October 19, 2020: Journal of Endodontics
Nicolai Maldaner, Martin Nikolaus Stienen
No abstract text is available yet for this article.
October 2020: Arthritis Care & Research
Juan Antonio Valera-Calero, Jesús Guodemar-Pérez, Joshua A Cleland, Cristina Ojedo-Martín, Gracia María Gallego-Sendarrubias
OBJECTIVE: A correct examination is essential during a differential diagnosis of neck pain patients. Therefore, the objective of this study was to provide an update on the properties considered most important by PTs when conducting accessory and physiological movement tests during the cervical spine physical examination. METHODS: A total of 84 private physiotherapy centres participated in this online cross-sectional survey including 415 active physiotherapists and members of one autonomous Spanish Physiotherapists School...
October 22, 2020: International Journal of Clinical Practice
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