Gianfranco Vornetti, Giulio Vara, Maria Chiara Baroni, Elisabetta Mariucci, Andrea Donti, Luigi Cirillo, Stefano Ratti, Elena Cantoni, Greta Venturi, Caterina Tonon, Raffaele Lodi, Luca Spinardi
PURPOSE: Dural ectasia (DE) may significantly impact Marfan syndrome (MFS) patients' quality of life due to chronic lower back pain, postural headache and urinary disorders. We aimed to evaluate the association of quantitative measurements of DE, and their evolution over time, with demographic, clinical and genetic characteristics in a cohort of MFS patients. METHODS: We retrospectively included 88 consecutive patients (39% females, mean age 37.1 ± 14...
April 14, 2024: European Spine Journal
Per D Trobisch, Hong-Jin Kim, Stephanie Da Paz, Mahmoud Alkharsawi, Rene Castelein, Dong-Gune Chang
INTRODUCTION: Vertebral body tethering (VBT) has become an alternative option for select patients with idiopathic scoliosis. However, studies have shown a high number of tether breakages, specifically after thoracolumbar (TL) VBT, that can have a negative impact on the outcome, when the breakage occurs within the first year after surgery. In order to overcome this problem, we have started to apply an apical fusion (AF) in combination with TL VBT for select patients. This study aims to analyze the outcome after AF plus VBT...
April 13, 2024: European Spine Journal
Marina I Oliveira da Silva, Miguel Santejo, Isaac W Babcock, Ana Magalhães, Laurie S Minamide, Seok-Joon Won, Erika Castillo, Ellen Gerhardt, Christiane Fahlbusch, Raymond A Swanson, Tiago F Outeiro, Ricardo Taipa, Michael Ruff, James R Bamburg, Márcia A Liz
Cognitive dysfunction and dementia are critical symptoms of Lewy Body dementias (LBD). Specifically, alpha-synuclein (αSyn) accumulation in the hippocampus leading to synaptic dysfunction is linked to cognitive deficits in LBD. Here, we investigated the pathological impact of αSyn on hippocampal neurons. We report that either αSyn overexpression or αSyn pre-formed fibrils (PFFs) treatment triggers the formation of cofilin-actin rods, synapse disruptors, in cultured hippocampal neurons and in the hippocampus of synucleinopathy mouse models and of LBD patients...
April 13, 2024: Cell Death & Disease
Qiang Li, Jian Luan, Yong Lin, Meng Kong, Xinhu Guo, Jindong Zhao
BACKGROUND: The aim of this study was to evaluate the psychological distress pre-operatively, at 3, 6, and 12 months in patients who underwent lumbar spine fusion surgery. METHODS: A total of 440 patients received instrumented lumbar spine fusion were enrolled. Psychological distress was evaluated using the Modified Somatic Perception Questionnaire (MSPQ) and the Modified Zung Depressive Index (ZDI). The results of lumbar fusion surgery were evaluated using the Oswestry Disability Index (ODI), the Japanese Orthopedic Association (JOA-29), and the visual analog scale (VAS)...
April 13, 2024: BMC Musculoskeletal Disorders
Boby Varkey Maramattom
A 28-year-old man was brought to the emergency department with quadriparesis of acute onset after a bout of binge drinking. Evaluation revealed a mid-cervical myelopathy and magnetic resonance imaging (MRI) showed an acute compressive cervical myelopathy. He also developed rhabdomyolysis, and cervical paraspinal muscles showed MRI hyperintensities. After resolution of rhabdomyolysis and acute kidney injury, he underwent cervical spine fixation. He was found to have acute dropped head syndrome with secondary compressive myelopathy...
September 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
Andrew Lee, Ira Pande, Bruno Gran
We present a case where a 63-year-old right-handed man who presented with a 6-month history of progressive asymmetrical sensorimotor symptoms in lower limbs. This was associated with concomitant rash on the lower limbs, and mild sicca symptoms. MRI spine showed focal T2 hyperintensity in the left hemicord at C3-4 level. Skin biopsy of the rash revealed urticarial vasculitis, and lip biopsy revealed lymphocytic sialadenitis. Initial anti-Ro antibody was negative, but subsequent Ro52 antibody testing returned positive...
July 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
James P Caruso, Remi Wilson, Luke Dosselman, John Eakin, Chandrasekhar Sundarrajan, Ammar Adenwalla, Ahmed K Almekkawi, Salah G Aoun, Carlos A Bagley, Michael Van Hal, Mazin Al Tamimi
BACKGROUND: Symptomatic cervical spondylosis is often treated with anterior cervical decompression and fusion (ACDF). However, few factors can predict which cervical level will degenerate and require intervention. This analysis evaluates pre-procedural factors associated with level of first-time single-level ACDF. METHODS: We performed a retrospective analysis of patients who underwent single-level ACDF without prior history of spine surgery. Mann Whitney U-tests and Spearman rank-order correlation were performed for analyses of associations between variables of interest and ACDF level...
April 11, 2024: World Neurosurgery
Nicolas Serratrice, Aurélie Manchon, Solène Prost, Kaissar Farah, Jean-Michel Bartoli, Patrick Tropiano, Stéphane Fuentes, Benjamin Blondel
BACKGROUND: Advanced pelvic surgery is associated with potential vascular risks. The aim of this study was to complete the existing classification of the anatomical variations of the internal iliac veins encountered on a series of preoperative angio CT with a view to performing anterior lumbar spine surgery. MATERIALS AND METHODS: In this monocentric retrospective study conducted between 2010 and 2020, all preoperative angio CT performed before an anterior lumbar surgery were systematically analyzed...
April 11, 2024: Neuro-Chirurgie
Travis S CreveCoeur, Rajiv R Iyer, Hannah E Goldstein, Mychael W Delgardo, Todd C Hankinson, Mark A Erickson, Sumeet Garg, David L Skaggs, Lindsay Andras, Benjamin C Kennedy, Patrick J Cahill, Lawrence G Lenke, Peter D Angevine, Benjamin D Roye, Michael G Vitale, Anil Mendiratta, Richard C E Anderson
BACKGROUND CONTEXT: Intraoperative neurophysiological monitoring (IONM) is used to reduce the risk of spinal cord injury during pediatric spinal deformity surgery. Significant reduction and/or loss of IONM signals without immediate recovery may lead the surgeon to acutely abort the case. The timing of when monitorable signals return remains largely unknown. PURPOSE: The goal of this study was to investigate the correlation between IONM signal loss, clinical examination, and subsequent normalization of IONM signals after aborted pediatric spinal deformity surgery to help determine when it is safe to return to the operating room...
April 11, 2024: Spine Journal: Official Journal of the North American Spine Society
Siyu Zhou, Yi Zhao, Zhuoran Sun, Gengyu Han, Fei Xu, Weipeng Qiu, Tongyu Liu, Weishi Li
BACKGROUND CONTEXT: A subgroup of patients with pelvic anteversion can present with an unusually large degree of lumbar lordosis (LL), a highly sloped sacrum, and a relatively small pelvic incidence (PI). Prior to lumbar surgery, it is can be important to consider such unique sagittal alignment. However, until now, there has been a lack of a predictive model considering different pelvic alignments. Furthermore, the dynamic characteristics of an anteverted pelvis (AP) subgroup have also been unclear...
April 11, 2024: Spine Journal: Official Journal of the North American Spine Society
Emily Ashworth, David Baxter, Iain Gibb, Mark Wilson, Anthony Bull
Blast is the most common injury mechanism in conflicts of this century due to the widespread use of explosives, confirmed by recent conflicts such as in Ukraine. Data from conflicts in the last century such as Northern Ireland, the Falklands and Vietnam up to present day, show between 16 and 21% of personnel suffered a traumatic brain injury. Typical features of fatal brain injury to those outside of a vehicle (hereafter referred to as dismounted) due to blast include the presence of haemorrhagic brain injury alongside skull fractures rather than isolated penetrating injuries more typical of traditional ballistic head injuries...
April 13, 2024: Journal of Neurotrauma
Linda Baumbach, Wiebke Feddern, Benedikt Kretzler, André Hajek, Hans-Helmut König
BACKGROUND: Musculoskeletal conditions are a leading contributor to disability worldwide. The treatment of these conditions accounts for 7% of health care costs in Germany and is often provided by physiotherapists. Yet, an overview of the cost-effectiveness of treatments for musculoskeletal conditions offered by physiotherapists is missing. This review aims to provide an overview of full economic evaluations of interventions for musculoskeletal conditions offered by physiotherapists. METHODS: We systematically searched for publications in Medline, EconLit, and NHS-EED...
April 13, 2024: Sports Medicine—Open
Keegan T Conry, Lorena V Floccari, Melanie Morscher, Miraides F Brown, Todd F Ritzman
PURPOSE: The efficacy of traditional Mehta casting in the treatment of early onset scoliosis (EOS) is well-established. However, waterproof casting has not been previously described. Inherent advantages of waterproof casting include clearance for bathing/swimming, avoiding cast holidays, and improved family satisfaction. The purpose of this study was to assess the safety and efficacy of waterproof serial casting at controlling curve progression in EOS. METHODS: The current study is an IRB-approved Level IV retrospective consecutive cohort of EOS patients who underwent a serial 75% body weight traction-elongation-flexion Mehta cast protocol with waterproof cast padding...
April 13, 2024: Spine Deformity
Jiayuan Wu, Mingxing Fan, Da He, Yi Wei, Fangfang Duan, Xieyuan Jiang, Wei Tian
PURPOSE: To evaluate the accuracy and feasibility of robot-assisted cervical screw placement and factors that may affect the accuracy. METHODS: A comprehensive search was made on PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wanfang Med for the selection of potential eligible literature. The outcomes were evaluated in terms of the relative risk (RR) or standardized mean difference (MD) and corresponding 95% confidence interval (CI). Subgroup analyses of the accuracy of screw placement at different cervical segments and with different screw placement approaches were performed...
April 13, 2024: International Orthopaedics
Ziwei Ma, Yuming Yu, Ming Gao, Peng Chen, Huixia Hong, Dingle Yu, Zhenjiang Liang, Yu Bai, Qinlian Ye, Yachao Wang, Guodong Huang, Hui Tan
Depression is a common mental disorder. In recent years, more and more attention has been paid to depression and its etiology and pathogenesis. This review aims to explore the neuroprotective and antidepressant effects of hop components. By establishing an in vitro cell damage model using PC12 cells induced by corticosterone (CORT) and an in vivo depression model through the intracranial injection of lipopolysaccharide (LPS) in mice, hop ethyl acetate extract (HEA) was used to study the protective effect and mechanism of HEA on neuronal cells in vitro and the antidepression effect and mechanism in vivo...
April 13, 2024: ACS Chemical Neuroscience
Paul G Mastrokostas, Leonidas E Mastrokostas, Ahmed K Emara, Ian J Wellington, Elizabeth Ginalis, John K Houten, Amrit S Khalsa, Ahmed Saleh, Afshin E Razi, Mitchell K Ng
STUDY DESIGN: Observational Study. OBJECTIVES: This study aimed to investigate the most searched types of questions and online resources implicated in the operative and nonoperative management of scoliosis. METHODS: Six terms related to operative and nonoperative scoliosis treatment were searched on Google's People Also Ask section on October 12, 2023. The Rothwell classification was used to sort questions into fact, policy, or value categories, and associated websites were classified by type...
April 13, 2024: Global Spine Journal
Kistler-Fischbacher Melanie, Armbrecht Gabriele, Gängler Stephanie, Theiler Robert, Rizzoli Renè, Dawson-Hughes Bess, A Kanis John, C Hofbauer Lorenz, C Schimmer Ralph, Vellas Bruno, A P Da Silva José, Orav E John, W Kressig Reto, Egli Andreas, Lang Wei, A Wanner Guido, A Bischoff-Ferrari Heike
INTRODUCTION: Evidence on the effects of Vitamin D, omega-3 s and exercise on aBMD in healthy older adults is limited. We examined whether vitamin D3, omega-3 s, or a simple home-based exercise program (SHEP), alone or in combination, over three years, improve lumbar spine (LS), femoral neck (FN) or total hip (TH) aBMD assessed by DXA. METHODS: aBMD was a secondary outcome in DO-HEALTH, a 3-year, multicenter, double-blind, randomized 2 × 2 × 2 factorial design trial in generally healthy older adults age ≥ 70 years...
April 13, 2024: Journal of Bone and Mineral Research
Qinying Feng, Xiaoyu Song, Li Liu, Xinzhong Zhou, Zhihao Chen
BACKGROUND: Serotonin (5-HT) precursors regulate bone remodeling. This study aims to investigate the correlation of plasma 5-HT precursors and metabolite with bone mineral density (BMD) and bone turnover markers in postmenopausal osteoporosis (PMOP) patients. METHODS: The age, body mass index (BMI), and years since menopause (YSM) were documented for 348 postmenopausal women in normal/osteopenia/osteoporosis (OP) groups, with lumbar spine and femoral neck BMD measured...
2024: Journal of Orthopaedic Surgery
Jonathan M Hagedorn, Ryan S D'Souza, Abhishek Yadav, Tony K George, Nathan DeTemple, Erik Ovrom, Christopher M Lam, Dawood Sayed, Morgan Hall, Lauren Stephenson, Zach Rivera, Bryan Hoelzer, Timothy R Deer
OBJECTIVES: Lumbar spine surgery is a common procedure for treating disabling spine-related pain. In recent decades, both the number and cost of spine surgeries have increased despite technological advances and modification in surgical technique. For those patients that have continued uncontrolled back and/or lower extremity pain following lumbar spine surgery, spinal cord stimulation (SCS) has emerged as a viable treatment option. However, the impact of lumbar spine surgical history remains largely unstudied...
April 12, 2024: Pain Practice: the Official Journal of World Institute of Pain
Tetsutaro Abe, Masashi Miyazaki, Noriaki Sako, Shozo Kanezaki, Yuta Tsubouchi, Nobuhiro Kaku
Both bone morphogenetic protein 2 (BMP-2) and abaloparatide are used to promote bone formation. However, there is no consensus about their optimal administration. We investigated the optimal administration theory for the pairing of BMP-2 and abaloparatide in a rat spinal fusion model. Group I was only implanted in carriers and saline. Carriers with 3 µg of recombinant human BMP-2 (rhBMP-2) were implanted in other groups. Abaloparatide injections were administered three times a week for group III (for a total amount of 120 µg/kg in a week) and six times a week for group IV (for a total amount of 120 µg/kg in a week) after surgery...
March 25, 2024: International Journal of Molecular Sciences
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