Sebastián Zagmutt, Paula Mera, Ismael González-García, Kevin Ibeas, María Del Mar Romero, Arnaud Obri, Beatriz Martin, Anna Esteve-Codina, M Carmen Soler-Vázquez, Marianela Bastias-Pérez, Laia Cañes, Elisabeth Augé, Carme Pelegri, Jordi Vilaplana, Xavier Ariza, Jordi García, José Martinez-González, Núria Casals, Miguel López, Richard Palmiter, Elisenda Sanz, Albert Quintana, Laura Herrero, Dolors Serra
BACKGROUND: Fatty acid metabolism in the hypothalamus has an important role in food intake, but its specific role in AgRP neurons is poorly understood. Here, we examined whether carnitinea palmitoyltransferase 1A (CPT1A), a key enzyme in mitochondrial fatty acid oxidation, affects energy balance. METHODS: To obtain Cpt1aKO mice and their control littermates, Cpt1a(flox/flox) mice were crossed with tamoxifen-inducible AgRPCreERT2 mice. Food intake and body weight were analyzed weekly in both males and females...
March 25, 2023: Biology of Sex Differences
YuLei Dong, Jiahao Li, Kaili Yang, Shigong Guo, Jiliang Zhai, Yu Zhao
BACKGROUND: To explore the characteristics and clinical management of thoracic spinal stenosis with diffuse idiopathic skeletal hyperostosis (DISH). METHODS: The patients diagnosed with thoracic spondylotic myelopathy who underwent spinal decompression and fusion surgery in a single center between 2012 and 2020 were retrospectively analyzed. All the patients were followed up for at least 2 years. Patients were classified into DISH and non-DISH groups. Demographic, radiographic and clinical parameters were compared between the two groups...
March 25, 2023: Journal of Orthopaedic Surgery and Research
Lin-Zhen Xie, Qi-Long Wang, Qi Zhang, Da He, Wei Tian
BACKGROUND: With the popularization of robot-assisted spinal surgeries, it is still uncertain whether robots with different designs could lead to different results in the accuracy of pedicle screw placement. This study aimed to compare the pedicle screw inserting accuracies among the spinal surgeries assisted by various types of robot and estimate the rank probability of each robot-assisted operative technique involved. METHODS: The electronic literature database of PubMed, Web of Science, EMBASE, CNKI, WANFANG and the Cochrane Library was searched in November 2021...
March 25, 2023: Journal of Orthopaedic Surgery and Research
Mohammad Anas, Tayyab Hasan, Usman Raja, Wajid A Raza
STUDY DESIGN: Prospective observational cohort study. OBJECTIVE: To understand if serum procalcitonin (PCT) is a reliable indicator of sepsis in spinal cord injury (SCI) patients for better prognosis and earlier diagnosis when compared with other common biomarkers such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cells (WBC), blood culture and body temperature. METHODS: From March 2021 to August 2022, data were collected for SCI patients who developed septicaemia...
March 26, 2023: European Spine Journal
Elsa Nunes, Eugenia Gallardo, Sara Morgado-Nunes, José Fonseca-Moutinho
Previous studies using immunoassays for steroid measurements have focused on the association between steroid hormone levels and bone mineral density (BMD) in postmenopausal women, obtaining contradictory results. This study aimed to assess this association using a highly sensitive bioanalytical method. A total of 68 postmenopausal women, aged 65-89 years, were enrolled in a cross-sectional study. Measurements of the BMD of the hip and lumbar spine were performed using dual energy X-ray absorptiometry, and serum hormone levels were quantified by gas chromatography and tandem mass spectrometry...
March 25, 2023: Scientific Reports
Grayson A Doss
Dermatologic diseases are frequently diagnosed in the four-toed hedgehog. Common clinical signs include spine loss, scales and crusts, pruritus, alopecia, and masses. Caparinia tripilis, family Psoroptidae, is the most common mite affecting hedgehogs, and is diagnosed via light microscopy. Dermatophytosis from Trichophyton erinacei infection is a common zoonotic dermatologic disease in pet hedgehogs. Diagnosis is through fungal culture. Neoplasia is another major cause of dermatologic diseases in four-toed hedgehogs...
May 2023: Veterinary Clinics of North America. Exotic Animal Practice
Julia Yi, Matthew M MacAllister, James P Caruso, Paolo Palmisciano, Zachary J Johnson, Giuseppe E Umana, Mazin Al Tamimi, Carlos A Bagley, Salah G Aoun
BACKGROUND AND IMPORTANCE: Nontraumatic pedicle fracture is uncommon, with sparsely described cases of conservative management versus surgical treatment by open fusion or percutaneous fixation. CLINICAL PRESENTATION: We report the case of a 60 year old woman with nontraumatic L4 and L5 pedicle fracture who developed additional pedicle fractures at L3 while undergoing conservative management in a brace. The patient underwent percutaneous pediculosynthesis with screw fixation without fusion at L3-5 bilaterally...
March 23, 2023: World Neurosurgery
Arthur L Jenkins, John O'Donnell, Richard J Chung, Sarah Jenkins, Charlotte Hawks, Daniella Lazarus, Tara McCaffrey, Hiromi Terai, Camryn Harvie
OBJECTIVE: We present the Jenkins classification for Bertolotti's Syndrome, or symptomatic lumbosacral transitional vertebrae (LSTV) and compare this with the existing Castellvi classification in patients presenting for treatment. METHODS: A retrospective cohort study of 150 new patients presenting for treatment of back, hip, groin, and/or leg pain from July 2012 through February 2022. Using MRI, CT, and X-Ray imaging, patients with radiographic finding of LSTV, appropriate clinical presentation, and identification of LSTV as the primary pain generator via diagnostic injections were diagnosed with Bertolotti's syndrome...
March 23, 2023: World Neurosurgery
Rikke Viggers, Jakob Starup-Linde, Peter Vestergaard
OBJECTIVE: Subjects with diabetes mellitus have an increased risk of fractures. We aimed to identify discrepancies in the first type of major osteoporotic fracture (MOF) and anti-osteoporotic therapy between subjects with type 2 diabetes (T2D) and subjects without diabetes. Methods and research design. We conducted a retrospective national cohort study by access to all discharge diagnoses (ICD-10 system) and redeemed drug prescriptions (ATC classification system). We included all subjects alive and Danish citizens in 2010 and identified subjects with T2D diagnosed after the age of 50 between 1998 and 2018...
March 23, 2023: Bone
Seyed Reza Mousavi, Somayeh Akbari, Alireza Rasekhi, Ali Kazeminezhad, Mohammadhadi Amir Shahpari Motlagh, Sanaz Taherpour
BACKGROUND: Different treatments are available for aggressive vertebral hemangioma [AVH], but a consensus is yet to be reached about the best therapeutic approach. PURPOSE: To explore the possibility that selecting a less aggressive therapeutic approach for AVH decreases the intraoperative and postoperative complications while providing similar clinical, radiographic, and disease-free survival results to more aggressive therapeutic methods. STUDY: We report the case of an AVH of the thoracic spine at the T5 level, treated via perioperative selective arterial embolization plus surgical decompression via laminectomy and reconstruction with polymethylmethacrylate (PMMA) vertebroplasty...
March 22, 2023: International Journal of Surgery Case Reports
Zijun Bai, Tiantian Gao, Rui Zhang, Youyuan Lu, Jinlong Tian, Tao Wang, Keke Zhao, Hanqing Wang
PURPOSE: Saikosaponin C (SSc) increases the expression of synaptic proteins and has a unexplored role in the prevention of AD and other neurodegeneration in humans. Therefore, we hypothesized that SSc has the potential to relief of depressive symptoms. Here, our study assessed the role of SSc on depression-like behaviors caused by a chronic social defeat stress (CSDS) in mice and explored the underlying mechanisms. METHODS: Behavioral tests were conducted to verify the efficacy of SSC in treating depression-like behavior in mice...
March 23, 2023: International Immunopharmacology
Lin Yang, Junnan Cheng, Zhijin Liu, Jihui Ju, Shengzhe Liu, Lei Li, Tao Zhang, Ruixing Hou
In this study, the digital subtraction angiography (DSA) data were used to describe the number, course, and distribution of the branches of the lateral circumflex femoral artery (LCFA), in order to provide an imaging basis for the application of the anterolateral thigh flap pedicled with each branch of the LCFA. The number, location, direction, and distribution of the branches of the LCFA were analyzed by selective DSA angiography in 113 patients who needed an anterolateral thigh flap to repair the wound. LCFA usually originates from the deep femoral artery or femoral artery and routinely sends out four main branches: ascending branch, transverse branch, oblique branch, and descending branch...
October 10, 2022: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Chuanyan Yang, Xuezhu Chen, Chenxu Zhang, Xuejiao Lei, Yongling Lu, Yuhai Wang, Hua Feng, Tunan Chen, Yang Yang
BACKGROUND AND AIM: Functional recovery is associated with the preservation of dendritic spines in the penumbra area after stroke. Previous studies found that polymerized microtubules (MTs) serve a crucial role in regulating dendritic spine formation and plasticity. However, the mechanisms that are involved are poorly understood. This study is designed to understand whether the upregulation of acetylated α-tubulin (α-Ac-Tub, a marker for stable, and polymerized MTs) could alleviate injury to the dendritic spines in the penumbra area and motor dysfunction after ischemic stroke...
March 25, 2023: CNS Neuroscience & Therapeutics
Fang-Fei Tao, Zi-Yu Wang, Ying Wang, Qian-Ru Lv, Peng-Peng Cai, Hai-Wen Min, Jian-Wei Ge, Chun-Yu Yin, Rui Cheng
AIMS: Oxygen therapy plays a vital role in the development of bronchopulmonary dysplasia (BPD), which is the independent risk factor for neurodevelopment deficits in premature infants. However, the effect of hippocampal cyclin-dependent kinase 5 (CDK5) on BPD-associated neurodevelopment deficits is not fully understood. METHODS: Mice were placed in a hyperoxia chamber from postnatal Day 1 to Day 7. Hematoxylin and eosin staining was used to evaluate the lung histomorphological characteristics...
March 25, 2023: CNS Neuroscience & Therapeutics
Vincenzo Damico, Liana Murano, Alberto Dal Molin
AIM: To investigate the prevalence and characteristics of chronic postICU pain in survivors of critical illness and to examine the association between pain and psychological disorders. METHODS: The study was carried out in an Italian ICU. Six months after ICU discharge, patients were called back for an interview for assessed chronic pain (CP), pain intensity, pain location and interference of pain with activities of daily living. During the interview a battery of psychometric test was administered for evaluate anxiety, depression, insomnia, fatigue and posttraumatic stress disorder (PTSD)...
July 1, 2022: Professioni Infermieristiche
Shawn Js Seah, Mark Hx Yeo, Jun-Hao Tan, Hwee Weng Dennis Hey
PURPOSE: The incidence of osteoporotic compression fractures (VCFs) have been rising over the past decades. Presently, vertebral cement augmentation procedures such as balloon kyphoplasty and vertebroplasty are common treatments allowing pain relief and functional recovery. However, there is controversy on whether different timeframes for cement augmentation affects clinical outcomes. Hence, this study aimed to compare pain relief and complication rates between early versus late cement augmentation...
March 25, 2023: European Spine Journal
Jens R Chapman, Jeffrey C Wang, Karsten Wiechert
No abstract text is available yet for this article.
April 2023: Global Spine Journal
Lovepreet K Mann, Jong H Won, Jeannine Garnett, Rajan P Patel, Ponnada A Narayana, Ranu Jain, Stephen A Fletcher, Ramesha Papanna
OBJECTIVE: Despite in utero spina bifida (SB) repair, more than two-thirds of patients with SB are unable to ambulate independently, and 1 in 4 children need surgery for tethered cord by school age. The objective of this study was to test the cryopreserved human umbilical cord (HUC) as an antiscarring material to reduce tethering and improve function in a modified in utero SB repair model. METHODS: An SB defect (L2-6 levels) without myelotomy was created in fetuses of timed-pregnant ewes at gestational day (GD) 75...
March 24, 2023: Journal of Neurosurgery
Gillian Shasby
No abstract text is available yet for this article.
March 24, 2023: Journal of Neurosurgery. Spine
Takeru Tsujimoto, Ryo Itoga, Masahiro Kanayama, Fumihiro Oha, Yukitoshi Shimamura, Masaru Tanaka, Yuichi Hasegawa, Syotaro Fukada, Tomoyuki Hashimoto, Masahiko Takahata, Norimasa Iwasaki
OBJECTIVE: Although the number of elderly patients requiring lumbar fusion for lumbar degenerative disorders has increased over time, the postoperative outcomes of lumbar fusion in very elderly patients (> 85 years) remains unknown. This study aimed to evaluate the comprehensive outcomes of lumbar fusion in elderly patients older than 85 years with mid-term follow-up. METHODS: The authors retrospectively researched patients older than 85 years who underwent single- or double-level posterior lumbar interbody fusion or transforaminal lumbar interbody fusion from 2012 to 2019...
March 24, 2023: Journal of Neurosurgery. Spine
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.