Xinyi Zhou, Xiaoyu Yang, Shenzhen Huang, Guifeng Lin, Kexin Lei, Qian Wang, Weimin Lin, Hanwen Li, Xingying Qi, Dutmanee Seriwatanachai, Shengyong Yang, Bin Shao, Quan Yuan
N6-methyladenosine (m6 A) modification, installed by METTL3-METTL14 complex, is abundant and critical in eukaryotic mRNA. However, its role in oral mucosal immunity remains ambiguous. Periodontitis is a special but prevalent infectious disease characterized as hyperinflammation of oral mucosa and bone resorption. Here, it is reported that genetic deletion of Mettl3 alleviates periodontal destruction via suppressing NLRP3 inflammasome activation. Mechanistically, the stability of TNFAIP3 (also known as A20) transcript is significantly attenuated upon m6 A modification...
May 2, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)