David S Lee, Paradi Mirmirani, Patrick E McCleskey, Majid Mehrpouya, Farzam Gorouhi
Distinctive patterns in the cutaneous manifestations of COVID-19 have been recently reported. We conducted a systematic review to identify case reports and case series characterizing cutaneous manifestations of confirmed COVID-19. Key demographic and clinical data from each case were extracted and analyzed. The primary outcome measure was risk factor analysis of skin related outcomes for severe COVID-19 disease. Seventy-one case reports and series comprising 144 cases of cutaneous involvement in COVID-19 were included...
December 15, 2020: Dermatology Online Journal
Badr AbdullGaffar, Suad Abdulrahman
Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder of mature CD4-positive T-cell lymphoid cells associated with retrovirus human T-lymphotropic virus type-1 (HTLV-1) with a wide clinical and pathologic spectrum. We report a case of a 53-year-old African man who presented with fever and skin eruptions on the trunk composed of non-itchy erythematous reticulated macules and papules initially suspected for viral exanthem or drug rash. Skin punch biopsy showed a dermal T-cell lymphoid infiltrate with epidermotropism...
December 22, 2020: Journal of Cutaneous Pathology
Kimberley Ying Ying Lim, Mei Chien Chua, Natalie Woon Hui Tan, Suresh Chandran
The aetiology of febrile exanthems in children is often difficult to distinguish clinically. A diagnosis of Kawasaki disease (KD) should be considered in infants with exanthematous fever. More perplexing is the increasing incidence of an atypical form of KD. Pathogenesis of KD remains unclear even though an aberrant response of the immune system to an unidentified pathogen is often hypothesised. A 30-fold increase in the incidence of KD in Italy during the SARS-CoV-2 pandemic suggests an immune response to a viral trigger...
December 17, 2020: BMJ Case Reports
Luc Hari, Stephan Lautenschlager
CME Dermatology 22/Answers: Measles - Empidemiology and Clinical Manifestations Abstract. Measles is a highly contagious, acute and febrile illness that results from infection with measles virus. The World Health Organization (WHO) estimates a worldwide prevalence of ten million patients per year, leading to approximately 142 000 deaths (case fatality rate 1.4 %). The illness begins with fever, malaise and typically with at least one of the following signs: cough, coryza and/or conjunctivitis. Three to four days later, the characteristical rash appears...
November 2020: Praxis
Fatima N Mirza, Amyn A Malik, Saad B Omer, Aisha Sethi
Recent reports have suggested that there may be dermatologic manifestations of COVID-19. We searched 12 databases for peer-reviewed or pre-print published studies until July 15, 2020, for this PRISMA-compliant review (CRD42020182050). We used the Oxford Center for Evidence-Based Medicine Levels of Evidence to facilitate data synthesis. From 86 retrieved studies, we collated data on 2,560 patients with dermatologic manifestations of COVID-19. The most common findings were chilblains/pernio-like lesion (51.5%), erythematous maculopapular rashes (13...
November 3, 2020: International Journal of Dermatology
Samantha Haraszti, Selin Sendil, Nichole Jensen
BACKGROUND Acute generalized exanthematous pustulosis (AGEP) is a rare exanthem characterized by the abrupt onset of numerous small, non-follicular, sterile pustules arising on an erythematous base. AGEP is often associated with medications; however, it has also been connected to various viral infections including cytomegalovirus, parvovirus B19, and Epstein-Barr virus. Coronavirus disease 2019 (COVID-19) has been associated with a variety of skin findings, including erythematous or patchy rash, urticaria, hives, blisters, petechiae, livedo reticularis, and even AGEP in a patient undergoing treatment with hydroxychloroquine...
October 24, 2020: American Journal of Case Reports
Stephanie L Mawhirt, David Frankel, Althea Marie Diaz
PURPOSE OF REVIEW: COVID-19 (coronavirus viral disease 2019), due to the novel SARS-CoV-2, may present with different types of cutaneous manifestations of varying pathophysiology. During the ongoing pandemic, publications reporting dermatologic findings in COVID-19 continue to emerge. RECENT FINDINGS: Cutaneous vasculopathy and microthrombus-related changes including acral and sacral lesions, retiform purpura, livedo reticularis, and cutaneous vasculitis are notable findings in adult patients...
October 12, 2020: Current Allergy and Asthma Reports
Robert P Daze, David Dorton
Pityriasis rosea (PR) is a benign, self-limiting, papulosquamous disorder characterized by the onset of a herald patch followed by an abrupt eruption of multiple salmon-colored papules and plaques on the trunk and proximal extremities. The individual lesions are often outlined by a collarette of scale and are distributed along the lines of cleavage. While many authors acknowledge an etiologic association with human herpesvirus 6 and human herpesvirus 7, thereby suggesting a viral exanthem, the exact cause remains unclear...
August 15, 2020: Curēus
Paige B Beck, Mustafa Goksel, Shashank Kraleti
Lichen planus has been associated with several precipitating factors, such as drugs, immunizations, and viral infections, including hepatitis C virus (HCV). Eruptive or disseminated lichen planus is a rare variation that most often presents as an acute, widespread exanthem that progresses rapidly and usually lasts for a shorter duration. This variation has not been well studied, and little is known about the etiologies and treatments of this rare form. Thus far, only a few cases of eruptive lichen planus have been reported to be associated with HCV infection...
August 14, 2020: Curēus
M Bandhala Rajan, Praveen Kumar-M, Abhishek Bhardwaj
BACKGROUND: Besides predominant respiratory and gastrointestinal manifestations, reports on cutaneous manifestations in COVID-19 patients are being noted increasingly. OBJECTIVES: To estimate the prevalence of cutaneous manifestations in COVID-19 patients. METHODS: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. A detailed literature search was done in PubMed and Embase from December 1, 2019, till May 1, 2020...
September 16, 2020: International Journal of Dermatology
Luca Delli Colli, Sofianne Gabrielli, Elissa M Abrams, Andrew O'Keefe, Jennifer Lp Protudjer, Elana Lavine, Tracy Pitt, Adelle Atkinson, Thomas Eiwegger, Christine McCusker, Moshe Ben-Shoshan
BACKGROUND: Serum sickness-like reactions (SSLR) are defined by the presence of rash (primarily urticaria), and joint complaints (arthralgia/arthritis) that are believed to occur due to a non-IgE mediated response to medications. However, similar reactions can occur due to viral infections, and it can be difficult to distinguish between the two. This may lead to unnecessary avoidance of the culprit antibiotic. OBJECTIVE: We aimed to evaluate children presenting with suspected SSLRs through a graded oral challenge (GOC)...
September 5, 2020: Journal of Allergy and Clinical Immunology in Practice
Alaina Linafelter, Alaina Burns, Brian R Lee, Angela Myers, Allison Burris, Heather Jones, Jarrod Dusin, Rana E El Feghaly
OBJECTIVE: Acute pharyngitis is one of the most common causes of ambulatory clinic visits; however, group A Streptococcus accounts for less than a third. National guidelines recommend against streptococcal testing in patients with viral features. This study aims to assess the rate of inappropriate streptococcal rapid antigen detection tests (RADT)s in children evaluated in urgent care clinics (UCC)s and emergency department (ED)s at a children's hospital. METHODS: We retrospectively reviewed charts of 10% of children 3 years or older with RADTs ordered between April and September 2018 at EDs and UCCs...
September 4, 2020: Pediatric Emergency Care
Alin Laurentiu Tatu, Thomas Nadasdy, Florin Ciprian Bujoreanu
The medical community in the past months has seen a flourishing of information related to the SARS-CoV-2 virus responsible for the COVID-19 pandemic. From the early days of the pandemic, the SARS-CoV-2 virus has been linked to multiple different types of skin involvement. To the best of our knowledge, we are the first to report on a case of familial clustering of a maculopapular COVID-19 rash. 8 persons presented COVID-19 symptoms, 6 were confirmed via SAR-CoV-2 chemoluminescent immunoassays, and the 4 related by blood presented skin manifestations...
August 14, 2020: Dermatologic Therapy
Jessica M Kwock, Brett Kurpiel, Alejandro A Gru
Cutaneous involvement by leukemia, or leukemia cutis, is a rare manifestation of leukemic disorders, most frequently occurring in children. The skin findings, which usually include multiple violaceous or erythematous nodules on the face, most often follow the classic presenting signs and symptoms of leukemia and occur in patients with an established primary diagnosis. Patients with T-cell acute lymphoblastic leukemia and associated leukemia cutis typically present with a solitary firm red to bluish nodule, often with an accompanying mediastinal mass, that can produce respiratory symptoms...
July 23, 2020: American Journal of Dermatopathology
Helena A Jenkinson, Phyu P Aung, Auris Huen
No abstract text is available yet for this article.
June 2020: Cutis; Cutaneous Medicine for the Practitioner
Nausheen Ahmed, Marcos de Lima, Bethany R Rohr, Benjamin K Tomlinson
No abstract text is available yet for this article.
July 2020: Hematology, Transfusion and Cell Therapy
Raphaella Cohen-Sors, Ali Dadban, Juliette Pezron, Catherine Lok
Asymmetric periflexural exanthem of childhood (APEC) is a self-limited disease characterized by unilateral exanthem. The etiology is unknown, but a viral agent is suspected. Most often there is no formal proof of an associated viral etiology, but several associations between APEC and some viruses have been described. We report a 2-year-old girl with APEC associated with influenza A. This case allows us to provide an additional argument on a probable viral etiology of APEC and a possible etiologic role of influenza A...
May 15, 2020: Dermatology Online Journal
Bayushi Eka Putra, Suko Adiarto, Santi Rahayu Dewayanti, Dafsah Arifa Juzar
Cutaneous manifestation is a newly reported clinical manifestation of COVID-19 infection. The clinical description of cutaneous manifestation is still not fully described. Our patient, a medical personnel, had viral exanthem distributed in the extremities along with "pin and needles sensation" which differ from the previously published paper on cutaneous manifestation. The differential diagnosis of drug-induced skin rash and hand-foot-mouth disease have already been ruled out based on the patient's previous history and course of disease...
May 8, 2020: International Journal of Infectious Diseases: IJID
C-J Su, C-H Lee
No abstract text is available yet for this article.
June 2020: Journal of the European Academy of Dermatology and Venereology: JEADV
Janna M Vassantachart, Anthony H Yeo, Andrew Y Vassantachart, Sharon E Jacob, Linda Golkar
Measles is a viral infection that has a characteristic pattern of prodromal symptoms followed by a rash. Previously considered an inevitable childhood condition, measles is known as the "first" classic childhood exanthem. For most children, measles was a one-time, short-term illness; however, some children developed complications that led to severe sequelae and death. The introduction of the measles vaccine dramatically decreased the number of cases, but the current trend against vaccination has caused outbreaks of the condition...
March 2020: International Journal of Women's Dermatology
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